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Editing gene: HAVCR1 (CAeditome ID:26762)

Gene summary for HAVCR1

Gene summary

Gene information	Gene symbol	HAVCR1
	Gene ID	26762
	Gene name	hepatitis A virus cellular receptor 1
	Synonyms	CD365\|HAVCR\|HAVCR-1\|KIM-1\|KIM1\|TIM\|TIM-1\|TIM1\|TIMD-1\|TIMD1
	Cytomap	5q33.3
	Type of gene	protein-coding
	Description	hepatitis A virus cellular receptor 1T cell immunoglobin domain and mucin domain protein 1T-cell immunoglobulin mucin family member 1T-cell immunoglobulin mucin receptor 1T-cell membrane protein 1kidney injury molecule 1
	Modification date	20210531
	UniProtAcc	Q96D42
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
HAVCR1	GO:0001618	Hepatitis A virus cellular receptor 1	21536871
HAVCR1	GO:0031514	Hepatitis A virus cellular receptor 1	21536871

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RNA A-to-I events for HAVCR1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000113249.11

RNA A-to-I editing events in Cancer.

CAediting_443397(157030409, -), CAediting_443398(157033977, -), CAediting_443399(157036092, -), CAediting_443400(157036132, -), CAediting_443401(157036140, -), CAediting_443402(157036173, -), CAediting_443403(157036234, -), CAediting_443404(157036289, -), CAediting_443405(157036736, -), CAediting_443406(157036809, -), CAediting_443407(157036832, -), CAediting_443408(157036945, -), CAediting_443409(157036953, -), CAediting_443410(157037002, -), CAediting_443411(157037003, -), CAediting_443412(157037011, -), CAediting_443413(157038879, -), CAediting_443414(157039010, -), CAediting_443415(157039068, -), CAediting_443416(157039513, -), CAediting_443417(157055621, -), CAediting_443418(157055622, -), CAediting_443419(157055732, -),

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RNA editing positional annotations for HAVCR1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_443397	chr5_157030409_-	ncRNA_intronic
CAediting_443398	chr5_157033977_-	ncRNA_intronic
CAediting_443399	chr5_157036092_-	ncRNA_intronic
CAediting_443400	chr5_157036132_-	ncRNA_intronic
CAediting_443401	chr5_157036140_-	ncRNA_intronic
CAediting_443402	chr5_157036173_-	ncRNA_intronic
CAediting_443403	chr5_157036234_-	ncRNA_intronic
CAediting_443404	chr5_157036289_-	ncRNA_intronic
CAediting_443405	chr5_157036736_-	ncRNA_intronic
CAediting_443406	chr5_157036809_-	ncRNA_intronic
CAediting_443407	chr5_157036832_-	ncRNA_intronic
CAediting_443408	chr5_157036945_-	ncRNA_intronic
CAediting_443409	chr5_157036953_-	ncRNA_intronic
CAediting_443410	chr5_157037002_-	ncRNA_intronic
CAediting_443411	chr5_157037003_-	ncRNA_intronic
CAediting_443412	chr5_157037011_-	ncRNA_intronic
CAediting_443413	chr5_157038879_-	ncRNA_intronic
CAediting_443414	chr5_157039010_-	ncRNA_intronic
CAediting_443415	chr5_157039068_-	ncRNA_intronic
CAediting_443416	chr5_157039513_-	ncRNA_intronic
CAediting_443417	chr5_157055621_-	intronic
CAediting_443418	chr5_157055622_-	intronic
CAediting_443419	chr5_157055732_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_443397	chr5_157030409_-	SINE	Alu	AluJr4
CAediting_443398	chr5_157033977_-	SINE	Alu	AluSg
CAediting_443399	chr5_157036092_-	SINE	Alu	AluSx
CAediting_443400	chr5_157036132_-	SINE	Alu	AluSx
CAediting_443401	chr5_157036140_-	SINE	Alu	AluSx
CAediting_443402	chr5_157036173_-	SINE	Alu	AluSx
CAediting_443403	chr5_157036234_-	SINE	Alu	AluY
CAediting_443404	chr5_157036289_-	SINE	Alu	AluY
CAediting_443405	chr5_157036736_-	SINE	Alu	AluJo
CAediting_443406	chr5_157036809_-	SINE	Alu	AluJo
CAediting_443407	chr5_157036832_-	SINE	Alu	AluJo
CAediting_443408	chr5_157036945_-	SINE	Alu	AluJo
CAediting_443409	chr5_157036953_-	SINE	Alu	AluJo
CAediting_443410	chr5_157037002_-	SINE	Alu	AluJo
CAediting_443411	chr5_157037003_-	SINE	Alu	AluJo
CAediting_443412	chr5_157037011_-	SINE	Alu	AluJo
CAediting_443413	chr5_157038879_-	SINE	Alu	AluJb
CAediting_443414	chr5_157039010_-	SINE	Alu	AluJb
CAediting_443415	chr5_157039068_-	SINE	Alu	AluJb
CAediting_443416	chr5_157039513_-	SINE	Alu	AluSx1
CAediting_443417	chr5_157055621_-	SINE	Alu	AluSx1
CAediting_443418	chr5_157055622_-	SINE	Alu	AluSx1
CAediting_443419	chr5_157055732_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for HAVCR1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000113249.11.HAVCR1.

Correlation between RNA A-to-I editing and PSI for ENSG00000113249.11.HAVCR1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HAVCR1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for HAVCR1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for HAVCR1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HAVCR1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for HAVCR1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for HAVCR1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_443410	chr5_157037002_-	0.0278695768435826	0.261076821863294

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Relation with survival for HAVCR1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for HAVCR1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HAVCR1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
HAVCR1	C0022660	Kidney Failure, Acute	10	CTD_human
HAVCR1	C1565662	Acute Kidney Insufficiency	10	CTD_human
HAVCR1	C2609414	Acute kidney injury	10	CTD_human
HAVCR1	C0022658	Kidney Diseases	7	CTD_human
HAVCR1	C0013221	Drug toxicity	3	CTD_human
HAVCR1	C0041755	Adverse reaction to drug	3	CTD_human
HAVCR1	C0017668	Focal glomerulosclerosis	1	CTD_human
HAVCR1	C0019193	Hepatitis, Toxic	1	CTD_human
HAVCR1	C0027540	Necrosis	1	CTD_human
HAVCR1	C0033687	Proteinuria	1	CTD_human
HAVCR1	C0086432	Hyalinosis, Segmental Glomerular	1	CTD_human
HAVCR1	C0860207	Drug-Induced Liver Disease	1	CTD_human
HAVCR1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
HAVCR1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
HAVCR1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
HAVCR1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene