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Editing gene: GCKR (CAeditome ID:2646)

Gene summary for GCKR

Gene summary

Gene information	Gene symbol	GCKR
	Gene ID	2646
	Gene name	glucokinase regulator
	Synonyms	FGQTL5\|GKRP
	Cytomap	2p23.3
	Type of gene	protein-coding
	Description	glucokinase regulatory proteinglucokinase (hexokinase 4) regulatorhexokinase 4 regulator
	Modification date	20210518
	UniProtAcc	Q14397
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GCKR	GO:0070095	Glucokinase regulatory protein	14627435
GCKR	GO:0070095	Glucokinase regulatory protein	23621087
GCKR	GO:0009750	Glucokinase regulatory protein	14627435
GCKR	GO:0033132	Glucokinase regulatory protein	14627435
GCKR	GO:0033132	Glucokinase regulatory protein	23621087

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RNA A-to-I events for GCKR

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000084734.7

RNA A-to-I editing events in Cancer.

CAediting_164894(27499885, +), CAediting_164895(27504382, +), CAediting_164896(27504383, +), CAediting_164897(27504409, +), CAediting_164898(27504452, +), CAediting_164899(27504457, +), CAediting_164900(27504462, +), CAediting_164901(27504475, +), CAediting_164902(27504487, +), CAediting_164903(27504497, +), CAediting_164904(27504499, +), CAediting_164905(27504510, +), CAediting_164906(27504513, +), CAediting_164907(27504515, +), CAediting_164908(27504523, +), CAediting_164909(27504538, +), CAediting_164910(27504570, +), CAediting_164911(27504582, +), CAediting_164912(27504871, +), CAediting_164913(27504872, +), CAediting_164914(27504892, +), CAediting_164915(27504893, +), CAediting_164916(27504901, +), CAediting_164917(27504911, +), CAediting_164918(27504916, +), CAediting_164919(27504924, +), CAediting_164920(27504966, +), CAediting_164921(27504967, +), CAediting_164922(27504970, +), CAediting_164923(27504972, +), CAediting_164924(27504973, +), CAediting_164925(27504974, +), CAediting_164926(27504975, +), CAediting_164927(27504976, +), CAediting_164928(27504979, +), CAediting_164929(27505005, +), CAediting_164930(27505011, +), CAediting_164931(27505015, +), CAediting_164932(27505046, +), CAediting_164933(27505047, +), CAediting_164934(27505060, +), CAediting_164935(27505067, +), CAediting_164936(27505076, +), CAediting_164937(27505078, +), CAediting_164938(27505180, +), CAediting_164939(27505249, +), CAediting_164940(27505275, +), CAediting_164941(27505281, +), CAediting_164942(27505292, +), CAediting_164943(27505316, +), CAediting_164944(27505317, +), CAediting_164945(27505324, +), CAediting_164946(27505337, +), CAediting_164947(27505348, +), CAediting_164948(27505392, +), CAediting_164949(27509371, +), CAediting_164950(27509395, +), CAediting_164951(27509409, +), CAediting_164952(27509414, +), CAediting_164953(27509473, +), CAediting_164954(27510261, +), CAediting_164955(27513403, +), CAediting_164956(27513409, +), CAediting_164957(27513423, +), CAediting_164958(27513441, +), CAediting_164959(27513449, +),

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RNA editing positional annotations for GCKR using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_164894	chr2_27499885_+	ncRNA_intronic
CAediting_164895	chr2_27504382_+	ncRNA_intronic
CAediting_164896	chr2_27504383_+	ncRNA_intronic
CAediting_164897	chr2_27504409_+	ncRNA_intronic
CAediting_164898	chr2_27504452_+	ncRNA_intronic
CAediting_164899	chr2_27504457_+	ncRNA_intronic
CAediting_164900	chr2_27504462_+	ncRNA_intronic
CAediting_164901	chr2_27504475_+	ncRNA_intronic
CAediting_164902	chr2_27504487_+	ncRNA_intronic
CAediting_164903	chr2_27504497_+	ncRNA_intronic
CAediting_164904	chr2_27504499_+	ncRNA_intronic
CAediting_164905	chr2_27504510_+	ncRNA_intronic
CAediting_164906	chr2_27504513_+	ncRNA_intronic
CAediting_164907	chr2_27504515_+	ncRNA_intronic
CAediting_164908	chr2_27504523_+	ncRNA_intronic
CAediting_164909	chr2_27504538_+	ncRNA_intronic
CAediting_164910	chr2_27504570_+	ncRNA_intronic
CAediting_164911	chr2_27504582_+	ncRNA_intronic
CAediting_164912	chr2_27504871_+	ncRNA_intronic
CAediting_164913	chr2_27504872_+	ncRNA_intronic
CAediting_164914	chr2_27504892_+	ncRNA_intronic
CAediting_164915	chr2_27504893_+	ncRNA_intronic
CAediting_164916	chr2_27504901_+	ncRNA_intronic
CAediting_164917	chr2_27504911_+	ncRNA_intronic
CAediting_164918	chr2_27504916_+	ncRNA_intronic
CAediting_164919	chr2_27504924_+	ncRNA_intronic
CAediting_164920	chr2_27504966_+	ncRNA_intronic
CAediting_164921	chr2_27504967_+	ncRNA_intronic
CAediting_164922	chr2_27504970_+	ncRNA_intronic
CAediting_164923	chr2_27504972_+	ncRNA_intronic
CAediting_164924	chr2_27504973_+	ncRNA_intronic
CAediting_164925	chr2_27504974_+	ncRNA_intronic
CAediting_164926	chr2_27504975_+	ncRNA_intronic
CAediting_164927	chr2_27504976_+	ncRNA_intronic
CAediting_164928	chr2_27504979_+	ncRNA_intronic
CAediting_164929	chr2_27505005_+	ncRNA_intronic
CAediting_164930	chr2_27505011_+	ncRNA_intronic
CAediting_164931	chr2_27505015_+	ncRNA_intronic
CAediting_164932	chr2_27505046_+	ncRNA_intronic
CAediting_164933	chr2_27505047_+	ncRNA_intronic
CAediting_164934	chr2_27505060_+	ncRNA_intronic
CAediting_164935	chr2_27505067_+	ncRNA_intronic
CAediting_164936	chr2_27505076_+	ncRNA_intronic
CAediting_164937	chr2_27505078_+	ncRNA_intronic
CAediting_164938	chr2_27505180_+	ncRNA_intronic
CAediting_164939	chr2_27505249_+	ncRNA_intronic
CAediting_164940	chr2_27505275_+	ncRNA_intronic
CAediting_164941	chr2_27505281_+	ncRNA_intronic
CAediting_164942	chr2_27505292_+	ncRNA_intronic
CAediting_164943	chr2_27505316_+	ncRNA_intronic
CAediting_164944	chr2_27505317_+	ncRNA_intronic
CAediting_164945	chr2_27505324_+	ncRNA_intronic
CAediting_164946	chr2_27505337_+	ncRNA_intronic
CAediting_164947	chr2_27505348_+	ncRNA_intronic
CAediting_164948	chr2_27505392_+	ncRNA_intronic
CAediting_164949	chr2_27509371_+	intronic
CAediting_164950	chr2_27509395_+	intronic
CAediting_164951	chr2_27509409_+	intronic
CAediting_164952	chr2_27509414_+	intronic
CAediting_164953	chr2_27509473_+	intronic
CAediting_164954	chr2_27510261_+	intronic
CAediting_164955	chr2_27513403_+	intronic
CAediting_164956	chr2_27513409_+	intronic
CAediting_164957	chr2_27513423_+	intronic
CAediting_164958	chr2_27513441_+	intronic
CAediting_164959	chr2_27513449_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_164894	chr2_27499885_+	SINE	Alu	AluSx1
CAediting_164895	chr2_27504382_+	SINE	Alu	AluSq2
CAediting_164896	chr2_27504383_+	SINE	Alu	AluSq2
CAediting_164897	chr2_27504409_+	SINE	Alu	AluSq2
CAediting_164898	chr2_27504452_+	SINE	Alu	AluSq2
CAediting_164899	chr2_27504457_+	SINE	Alu	AluSq2
CAediting_164900	chr2_27504462_+	SINE	Alu	AluSq2
CAediting_164901	chr2_27504475_+	SINE	Alu	AluSq2
CAediting_164902	chr2_27504487_+	SINE	Alu	AluSq2
CAediting_164903	chr2_27504497_+	SINE	Alu	AluSq2
CAediting_164904	chr2_27504499_+	SINE	Alu	AluSq2
CAediting_164905	chr2_27504510_+	SINE	Alu	AluSq2
CAediting_164906	chr2_27504513_+	SINE	Alu	AluSq2
CAediting_164907	chr2_27504515_+	SINE	Alu	AluSq2
CAediting_164908	chr2_27504523_+	SINE	Alu	AluSq2
CAediting_164909	chr2_27504538_+	SINE	Alu	AluSq2
CAediting_164910	chr2_27504570_+	SINE	Alu	AluSq2
CAediting_164911	chr2_27504582_+	SINE	Alu	AluSq2
CAediting_164912	chr2_27504871_+	SINE	Alu	AluSx1
CAediting_164913	chr2_27504872_+	SINE	Alu	AluSx1
CAediting_164914	chr2_27504892_+	SINE	Alu	AluSx1
CAediting_164915	chr2_27504893_+	SINE	Alu	AluSx1
CAediting_164916	chr2_27504901_+	SINE	Alu	AluSx1
CAediting_164917	chr2_27504911_+	SINE	Alu	AluSx1
CAediting_164918	chr2_27504916_+	SINE	Alu	AluSx1
CAediting_164919	chr2_27504924_+	SINE	Alu	AluSx1
CAediting_164920	chr2_27504966_+	SINE	Alu	AluSx1
CAediting_164921	chr2_27504967_+	SINE	Alu	AluSx1
CAediting_164922	chr2_27504970_+	SINE	Alu	AluSx1
CAediting_164923	chr2_27504972_+	SINE	Alu	AluSx1
CAediting_164924	chr2_27504973_+	SINE	Alu	AluSx1
CAediting_164925	chr2_27504974_+	SINE	Alu	AluSx1
CAediting_164926	chr2_27504975_+	SINE	Alu	AluSx1
CAediting_164927	chr2_27504976_+	SINE	Alu	AluSx1
CAediting_164928	chr2_27504979_+	SINE	Alu	AluSx1
CAediting_164929	chr2_27505005_+	SINE	Alu	AluSx1
CAediting_164930	chr2_27505011_+	SINE	Alu	AluSx1
CAediting_164931	chr2_27505015_+	SINE	Alu	AluSx1
CAediting_164932	chr2_27505046_+	SINE	Alu	AluSx1
CAediting_164933	chr2_27505047_+	SINE	Alu	AluSx1
CAediting_164934	chr2_27505060_+	SINE	Alu	AluSx1
CAediting_164935	chr2_27505067_+	SINE	Alu	AluSx1
CAediting_164936	chr2_27505076_+	SINE	Alu	AluSx1
CAediting_164937	chr2_27505078_+	SINE	Alu	AluSx1
CAediting_164938	chr2_27505180_+	SINE	Alu	AluY
CAediting_164939	chr2_27505249_+	SINE	Alu	AluY
CAediting_164940	chr2_27505275_+	SINE	Alu	AluY
CAediting_164941	chr2_27505281_+	SINE	Alu	AluY
CAediting_164942	chr2_27505292_+	SINE	Alu	AluY
CAediting_164943	chr2_27505316_+	SINE	Alu	AluY
CAediting_164944	chr2_27505317_+	SINE	Alu	AluY
CAediting_164945	chr2_27505324_+	SINE	Alu	AluY
CAediting_164946	chr2_27505337_+	SINE	Alu	AluY
CAediting_164947	chr2_27505348_+	SINE	Alu	AluY
CAediting_164948	chr2_27505392_+	SINE	Alu	AluY
CAediting_164949	chr2_27509371_+	SINE	Alu	AluJb
CAediting_164950	chr2_27509395_+	SINE	Alu	AluJb
CAediting_164951	chr2_27509409_+	SINE	Alu	AluJb
CAediting_164952	chr2_27509414_+	SINE	Alu	AluJb
CAediting_164953	chr2_27509473_+	SINE	Alu	AluJb
CAediting_164954	chr2_27510261_+	SINE	Alu	AluY
CAediting_164955	chr2_27513403_+	SINE	Alu	AluSz6
CAediting_164956	chr2_27513409_+	SINE	Alu	AluSz6
CAediting_164957	chr2_27513423_+	SINE	Alu	AluSz6
CAediting_164958	chr2_27513441_+	SINE	Alu	AluSz6
CAediting_164959	chr2_27513449_+	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for GCKR

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000084734.7.GCKR.

Correlation between RNA A-to-I editing and PSI for ENSG00000084734.7.GCKR.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GCKR

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GCKR

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GCKR

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000084734.7	ENST00000264717	hsa-miR-548aa	27523620	27523626	7mer-m8	27523603	27523627	147	-14.64

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GCKR

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GCKR

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LIHC	CAediting_164936	chr2_27505076_+	0.00392283837355047	0.297922212913888	.	.	.	.

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Relation with cancer stages for GCKR

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GCKR

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LIHC	CAediting_164936	chr2_27505076_+	0.0261913442726069	0.0307392	16.2655

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RelatedDrugs for GCKR

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GCKR

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GCKR	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
GCKR	C0020557	Hypertriglyceridemia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene