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Editing gene: GBP3 (CAeditome ID:2635)

Gene summary for GBP3

Gene summary

Gene information	Gene symbol	GBP3
	Gene ID	2635
	Gene name	guanylate binding protein 3
	Synonyms	-
	Cytomap	1p22.2
	Type of gene	protein-coding
	Description	guanylate-binding protein 3GTP-binding protein 3guanine nucleotide-binding protein 3guanylate-binding protein 3 delta C
	Modification date	20210518
	UniProtAcc	Q9H0R5
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GBP3	GO:0042803	Guanylate-binding protein 3	21151871
GBP3	GO:0005737	Guanylate-binding protein 3	17266443
GBP3	GO:0005829	Guanylate-binding protein 3	21151871

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RNA A-to-I events for GBP3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000117226.10

RNA A-to-I editing events in Cancer.

CAediting_78574(89016713, -), CAediting_78575(89016763, -), CAediting_78576(89016788, -), CAediting_78577(89016798, -), CAediting_78578(89016801, -), CAediting_78579(89016869, -), CAediting_78580(89017922, -), CAediting_78581(89017971, -), CAediting_78582(89019357, -), CAediting_78583(89019391, -), CAediting_78584(89019413, -), CAediting_78585(89019426, -), CAediting_78586(89019453, -), CAediting_78587(89019461, -), CAediting_78588(89019465, -), CAediting_78589(89019470, -), CAediting_78590(89019506, -), CAediting_78591(89019507, -), CAediting_78592(89020037, -), CAediting_78593(89020068, -), CAediting_78594(89020074, -), CAediting_78595(89020083, -), CAediting_78596(89020099, -), CAediting_78597(89020123, -), CAediting_78598(89020139, -), CAediting_78599(89020144, -), CAediting_78600(89020152, -), CAediting_78601(89020153, -), CAediting_78602(89020156, -), CAediting_78603(89020157, -), CAediting_78604(89020179, -), CAediting_78605(89020187, -), CAediting_78606(89020194, -), CAediting_78607(89020195, -), CAediting_78608(89020203, -), CAediting_78609(89020231, -), CAediting_78610(89020232, -),

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RNA editing positional annotations for GBP3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_78574	chr1_89016713_-	ncRNA_intronic
CAediting_78575	chr1_89016763_-	ncRNA_intronic
CAediting_78576	chr1_89016788_-	ncRNA_intronic
CAediting_78577	chr1_89016798_-	ncRNA_intronic
CAediting_78578	chr1_89016801_-	ncRNA_intronic
CAediting_78579	chr1_89016869_-	ncRNA_intronic
CAediting_78580	chr1_89017922_-	ncRNA_intronic
CAediting_78581	chr1_89017971_-	ncRNA_intronic
CAediting_78582	chr1_89019357_-	ncRNA_intronic
CAediting_78583	chr1_89019391_-	ncRNA_intronic
CAediting_78584	chr1_89019413_-	ncRNA_intronic
CAediting_78585	chr1_89019426_-	ncRNA_intronic
CAediting_78586	chr1_89019453_-	ncRNA_intronic
CAediting_78587	chr1_89019461_-	ncRNA_intronic
CAediting_78588	chr1_89019465_-	ncRNA_intronic
CAediting_78589	chr1_89019470_-	ncRNA_intronic
CAediting_78590	chr1_89019506_-	ncRNA_intronic
CAediting_78591	chr1_89019507_-	ncRNA_intronic
CAediting_78592	chr1_89020037_-	ncRNA_intronic
CAediting_78593	chr1_89020068_-	ncRNA_intronic
CAediting_78594	chr1_89020074_-	ncRNA_intronic
CAediting_78595	chr1_89020083_-	ncRNA_intronic
CAediting_78596	chr1_89020099_-	ncRNA_intronic
CAediting_78597	chr1_89020123_-	ncRNA_intronic
CAediting_78598	chr1_89020139_-	exonic
CAediting_78599	chr1_89020144_-	exonic
CAediting_78600	chr1_89020152_-	exonic
CAediting_78601	chr1_89020153_-	exonic
CAediting_78602	chr1_89020156_-	exonic
CAediting_78603	chr1_89020157_-	exonic
CAediting_78604	chr1_89020179_-	exonic
CAediting_78605	chr1_89020187_-	exonic
CAediting_78606	chr1_89020194_-	exonic
CAediting_78607	chr1_89020195_-	exonic
CAediting_78608	chr1_89020203_-	exonic
CAediting_78609	chr1_89020231_-	ncRNA_intronic
CAediting_78610	chr1_89020232_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_78574	chr1_89016713_-	SINE	Alu	AluJb
CAediting_78575	chr1_89016763_-	SINE	Alu	AluJb
CAediting_78576	chr1_89016788_-	SINE	Alu	AluJb
CAediting_78577	chr1_89016798_-	SINE	Alu	AluJb
CAediting_78578	chr1_89016801_-	SINE	Alu	AluJb
CAediting_78579	chr1_89016869_-	SINE	Alu	AluJb
CAediting_78580	chr1_89017922_-	SINE	Alu	AluSx1
CAediting_78581	chr1_89017971_-	SINE	Alu	AluSx1
CAediting_78582	chr1_89019357_-	SINE	Alu	AluSp
CAediting_78583	chr1_89019391_-	SINE	Alu	AluSp
CAediting_78584	chr1_89019413_-	SINE	Alu	AluSp
CAediting_78585	chr1_89019426_-	SINE	Alu	AluSp
CAediting_78586	chr1_89019453_-	SINE	Alu	AluSp
CAediting_78587	chr1_89019461_-	SINE	Alu	AluSp
CAediting_78588	chr1_89019465_-	SINE	Alu	AluSp
CAediting_78589	chr1_89019470_-	SINE	Alu	AluSp
CAediting_78590	chr1_89019506_-	SINE	Alu	AluSp
CAediting_78591	chr1_89019507_-	SINE	Alu	AluSp
CAediting_78592	chr1_89020037_-	SINE	Alu	AluJb
CAediting_78593	chr1_89020068_-	SINE	Alu	AluJb
CAediting_78594	chr1_89020074_-	SINE	Alu	AluJb
CAediting_78595	chr1_89020083_-	SINE	Alu	AluJb
CAediting_78596	chr1_89020099_-	SINE	Alu	AluJb
CAediting_78597	chr1_89020123_-	SINE	Alu	AluJb
CAediting_78598	chr1_89020139_-	SINE	Alu	AluJb
CAediting_78599	chr1_89020144_-	SINE	Alu	AluJb
CAediting_78600	chr1_89020152_-	SINE	Alu	AluJb
CAediting_78601	chr1_89020153_-	SINE	Alu	AluJb
CAediting_78602	chr1_89020156_-	SINE	Alu	AluJb
CAediting_78603	chr1_89020157_-	SINE	Alu	AluJb
CAediting_78604	chr1_89020179_-	SINE	Alu	AluJb
CAediting_78605	chr1_89020187_-	SINE	Alu	AluJb
CAediting_78606	chr1_89020194_-	SINE	Alu	AluJb
CAediting_78607	chr1_89020195_-	SINE	Alu	AluJb
CAediting_78608	chr1_89020203_-	SINE	Alu	AluJb
CAediting_78609	chr1_89020231_-	SINE	Alu	AluJb
CAediting_78610	chr1_89020232_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for GBP3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_78597	chr1_89020123_-	89020119:89020127	5SS	0+2i	AGGTAGGAC	-19.75	AGGTGGGAC	-19.22
ES	CAediting_78597	chr1_89020123_-	89020123:89020131	5SS	0+6i	GAGTAGGTA	-18.6	GAGTAGGTG	-17.93
ES	CAediting_78609	chr1_89020231_-	89020209:89020231	3SS	0+20i	AGGTCTTGCTCTTTCCCCAGGCT	8.26	GGGTCTTGCTCTTTCCCCAGGCT	8.55

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000117226.10.GBP3.

Correlation between RNA A-to-I editing and PSI for ENSG00000117226.10.GBP3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GBP3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GBP3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GBP3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_228905	chr2_188297554_+	ENSG00000117226.10	ENST00000493594	hsa-miR-561-3p	89013214	89013220	7mer-m8	89013213	89013233	154	-8.98
CAediting_228905	chr2_188297554_+	ENSG00000117226.10	ENST00000235878	hsa-miR-561-3p	89013214	89013220	7mer-m8	89013213	89013233	154	-8.98

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GBP3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000475853.2	processed_transcript
ENST00000493594.5	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_78598	ENST00000475853.2	chr1_89020139_-	-152.60	-153.30	-166.40
CAediting_78599	ENST00000475853.2	chr1_89020144_-	-153.30	-153.30	-166.40
CAediting_78600	ENST00000475853.2	chr1_89020152_-	-157.20	-153.30	-166.40
CAediting_78601	ENST00000475853.2	chr1_89020153_-	-153.30	-153.30	-166.40
CAediting_78602	ENST00000475853.2	chr1_89020156_-	-154.00	-153.30	-166.40
CAediting_78603	ENST00000475853.2	chr1_89020157_-	-155.90	-153.30	-166.40
CAediting_78604	ENST00000475853.2	chr1_89020179_-	-154.90	-153.30	-166.40
CAediting_78605	ENST00000475853.2	chr1_89020187_-	-156.10	-153.30	-166.40
CAediting_78606	ENST00000475853.2	chr1_89020194_-	-153.30	-153.30	-166.40
CAediting_78607	ENST00000475853.2	chr1_89020195_-	-155.50	-153.30	-166.40
CAediting_78608	ENST00000475853.2	chr1_89020203_-	-157.40	-153.30	-166.40
CAediting_78598	ENST00000493594.5	chr1_89020139_-	-714.90	-713.80	-728.00
CAediting_78599	ENST00000493594.5	chr1_89020144_-	-713.80	-713.80	-728.00
CAediting_78600	ENST00000493594.5	chr1_89020152_-	-717.40	-713.80	-728.00
CAediting_78601	ENST00000493594.5	chr1_89020153_-	-714.00	-713.80	-728.00
CAediting_78602	ENST00000493594.5	chr1_89020156_-	-716.20	-713.80	-728.00
CAediting_78603	ENST00000493594.5	chr1_89020157_-	-716.10	-713.80	-728.00
CAediting_78604	ENST00000493594.5	chr1_89020179_-	-715.20	-713.80	-728.00
CAediting_78605	ENST00000493594.5	chr1_89020187_-	-716.30	-713.80	-728.00
CAediting_78606	ENST00000493594.5	chr1_89020194_-	-713.50	-713.80	-728.00
CAediting_78607	ENST00000493594.5	chr1_89020195_-	-713.90	-713.80	-728.00
CAediting_78608	ENST00000493594.5	chr1_89020203_-	-716.10	-713.80	-728.00

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Relation with ADAR for GBP3

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
KIRC	CAediting_78601	chr1_89020153_-	.	.	0.0460688541160892	0.248347455856724	.	.
CESC	CAediting_78608	chr1_89020203_-	0.0119359446260718	0.307784738742745	.	.	.	.
LUSC	CAediting_78608	chr1_89020203_-	0.0455975111571479	0.191907882299573	.	.	.	.

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Relation with cancer stages for GBP3

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_78599	chr1_89020144_-	0.0276342820250474	0.163283436053242
THCA	pathologic_stage	CAediting_78608	chr1_89020203_-	0.0159146427593681	0.158822884053467

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Relation with survival for GBP3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GBP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GBP3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene