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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: FBXW8 (CAeditome ID:26259)

Gene summary for FBXW8

check button Gene summary
Gene informationGene symbol

FBXW8

Gene ID

26259

Gene nameF-box and WD repeat domain containing 8
SynonymsFBW6|FBW8|FBX29|FBXO29|FBXW6
Cytomap

12q24.22

Type of geneprotein-coding
DescriptionF-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29
Modification date20210518
UniProtAcc

Q8N3Y1

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
FBXW8

GO:0004842

F-box/WD repeat-containing protein 8

24362026

FBXW8

GO:0008283

F-box/WD repeat-containing protein 8

24362026

FBXW8

GO:0016567

F-box/WD repeat-containing protein 8

18498745

FBXW8

GO:0016567

F-box/WD repeat-containing protein 8

24362026

FBXW8

GO:0050775

F-box/WD repeat-containing protein 8

21572988

FBXW8

GO:0005794

F-box/WD repeat-containing protein 8

21572988

FBXW8

GO:0005829

F-box/WD repeat-containing protein 8

0000052

FBXW8

GO:0048471

F-box/WD repeat-containing protein 8

21572988

FBXW8

GO:0031467

F-box/WD repeat-containing protein 8

18498745

FBXW8

GO:0031467

F-box/WD repeat-containing protein 8

21572988

FBXW8

GO:0031467

F-box/WD repeat-containing protein 8

24362026


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RNA A-to-I events for FBXW8

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000174989.11
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_932089(116912211, +), CAediting_932090(116912236, +), CAediting_932091(116912238, +), CAediting_932092(116912410, +), CAediting_932093(116912589, +), CAediting_932094(116913994, +), CAediting_932095(116914006, +), CAediting_932096(116914010, +), CAediting_932097(116914016, +), CAediting_932098(116914017, +), CAediting_932099(116914037, +), CAediting_932100(116914038, +), CAediting_932101(116914111, +), CAediting_932102(116914112, +), CAediting_932103(116914120, +), CAediting_932104(116914152, +), CAediting_932105(116914193, +), CAediting_932106(116914323, +), CAediting_932107(116914324, +), CAediting_932108(116914373, +), CAediting_932109(116914381, +), CAediting_932110(116914383, +), CAediting_932111(116914384, +), CAediting_932112(116914397, +), CAediting_932113(116914452, +), CAediting_932114(116914459, +), CAediting_932115(116914462, +), CAediting_932116(116914493, +), CAediting_932117(116914498, +), CAediting_932118(116914518, +), CAediting_932119(116914528, +), CAediting_932120(116914530, +), CAediting_932121(116914538, +), CAediting_932122(116914548, +), CAediting_932123(116914621, +), CAediting_932124(116914626, +), CAediting_932125(116914651, +), CAediting_932126(116914685, +), CAediting_932127(116914686, +), CAediting_932128(116914693, +), CAediting_932129(116914796, +), CAediting_932130(116914800, +), CAediting_932131(116947492, +), CAediting_932132(116947493, +), CAediting_932133(116947528, +), CAediting_932134(116947575, +), CAediting_932135(116947589, +), CAediting_932136(116947593, +), CAediting_932137(116947611, +), CAediting_932138(116947619, +), CAediting_932139(116947659, +), CAediting_932140(116947660, +), CAediting_932141(116947688, +), CAediting_932142(116947689, +), CAediting_932143(116947704, +), CAediting_932144(116952938, +), CAediting_932145(116953584, +), CAediting_932146(116953608, +), CAediting_932147(116953666, +), CAediting_932148(116953860, +), CAediting_932149(116953861, +), CAediting_932150(116953913, +), CAediting_932151(116953993, +), CAediting_932152(116953994, +), CAediting_932153(116954046, +), CAediting_932154(116954064, +), CAediting_932155(116966836, +), CAediting_932156(116971181, +), CAediting_932157(116971244, +), CAediting_932158(116974665, +), CAediting_932159(116990895, +), CAediting_932160(116990968, +), CAediting_932161(117029624, +), CAediting_932162(117029644, +), CAediting_932163(117029655, +), CAediting_932164(117029660, +), CAediting_932165(117029665, +), CAediting_932166(117029666, +), CAediting_932167(117029674, +), CAediting_932168(117029709, +), CAediting_932169(117029713, +), CAediting_932170(117029727, +), CAediting_932171(117029739, +), CAediting_932172(117029751, +), CAediting_932173(117029762, +), CAediting_932174(117029775, +), CAediting_932175(117029776, +), CAediting_932176(117029784, +), CAediting_932177(117029790, +), CAediting_932178(117029793, +), CAediting_932179(117029795, +), CAediting_932180(117029797, +), CAediting_932181(117029806, +), CAediting_932182(117029821, +), CAediting_932183(117029832, +), CAediting_932184(117029833, +), CAediting_932185(117029834, +), CAediting_932186(117029841, +), CAediting_932187(117029846, +), CAediting_932188(117029848, +), CAediting_932189(117029851, +), CAediting_932190(117029863, +), CAediting_932191(117029872, +), CAediting_932192(117029873, +), CAediting_932193(117029885, +), CAediting_932194(117029887, +), CAediting_932195(117029893, +), CAediting_932196(117029894, +), CAediting_932197(117029907, +),

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RNA editing positional annotations for FBXW8 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_932089chr12_116912211_+intronic
CAediting_932090chr12_116912236_+intronic
CAediting_932091chr12_116912238_+intronic
CAediting_932092chr12_116912410_+intronic
CAediting_932093chr12_116912589_+intronic
CAediting_932094chr12_116913994_+intronic
CAediting_932095chr12_116914006_+intronic
CAediting_932096chr12_116914010_+intronic
CAediting_932097chr12_116914016_+intronic
CAediting_932098chr12_116914017_+intronic
CAediting_932099chr12_116914037_+intronic
CAediting_932100chr12_116914038_+intronic
CAediting_932101chr12_116914111_+intronic
CAediting_932102chr12_116914112_+intronic
CAediting_932103chr12_116914120_+intronic
CAediting_932104chr12_116914152_+intronic
CAediting_932105chr12_116914193_+intronic
CAediting_932106chr12_116914323_+intronic
CAediting_932107chr12_116914324_+intronic
CAediting_932108chr12_116914373_+intronic
CAediting_932109chr12_116914381_+intronic
CAediting_932110chr12_116914383_+intronic
CAediting_932111chr12_116914384_+intronic
CAediting_932112chr12_116914397_+intronic
CAediting_932113chr12_116914452_+intronic
CAediting_932114chr12_116914459_+intronic
CAediting_932115chr12_116914462_+intronic
CAediting_932116chr12_116914493_+intronic
CAediting_932117chr12_116914498_+intronic
CAediting_932118chr12_116914518_+intronic
CAediting_932119chr12_116914528_+intronic
CAediting_932120chr12_116914530_+intronic
CAediting_932121chr12_116914538_+intronic
CAediting_932122chr12_116914548_+intronic
CAediting_932123chr12_116914621_+intronic
CAediting_932124chr12_116914626_+intronic
CAediting_932125chr12_116914651_+intronic
CAediting_932126chr12_116914685_+intronic
CAediting_932127chr12_116914686_+intronic
CAediting_932128chr12_116914693_+intronic
CAediting_932129chr12_116914796_+intronic
CAediting_932130chr12_116914800_+intronic
CAediting_932131chr12_116947492_+intronic
CAediting_932132chr12_116947493_+intronic
CAediting_932133chr12_116947528_+intronic
CAediting_932134chr12_116947575_+intronic
CAediting_932135chr12_116947589_+intronic
CAediting_932136chr12_116947593_+intronic
CAediting_932137chr12_116947611_+intronic
CAediting_932138chr12_116947619_+intronic
CAediting_932139chr12_116947659_+intronic
CAediting_932140chr12_116947660_+intronic
CAediting_932141chr12_116947688_+intronic
CAediting_932142chr12_116947689_+intronic
CAediting_932143chr12_116947704_+intronic
CAediting_932144chr12_116952938_+intronic
CAediting_932145chr12_116953584_+intronic
CAediting_932146chr12_116953608_+intronic
CAediting_932147chr12_116953666_+intronic
CAediting_932148chr12_116953860_+intronic
CAediting_932149chr12_116953861_+intronic
CAediting_932150chr12_116953913_+intronic
CAediting_932151chr12_116953993_+intronic
CAediting_932152chr12_116953994_+intronic
CAediting_932153chr12_116954046_+intronic
CAediting_932154chr12_116954064_+intronic
CAediting_932155chr12_116966836_+intronic
CAediting_932156chr12_116971181_+intronic
CAediting_932157chr12_116971244_+intronic
CAediting_932158chr12_116974665_+intronic
CAediting_932159chr12_116990895_+intronic
CAediting_932160chr12_116990968_+intronic
CAediting_932161chr12_117029624_+UTR3
CAediting_932162chr12_117029644_+UTR3
CAediting_932163chr12_117029655_+UTR3
CAediting_932164chr12_117029660_+UTR3
CAediting_932165chr12_117029665_+UTR3
CAediting_932166chr12_117029666_+UTR3
CAediting_932167chr12_117029674_+UTR3
CAediting_932168chr12_117029709_+UTR3
CAediting_932169chr12_117029713_+UTR3
CAediting_932170chr12_117029727_+UTR3
CAediting_932171chr12_117029739_+UTR3
CAediting_932172chr12_117029751_+UTR3
CAediting_932173chr12_117029762_+UTR3
CAediting_932174chr12_117029775_+UTR3
CAediting_932175chr12_117029776_+UTR3
CAediting_932176chr12_117029784_+UTR3
CAediting_932177chr12_117029790_+UTR3
CAediting_932178chr12_117029793_+UTR3
CAediting_932179chr12_117029795_+UTR3
CAediting_932180chr12_117029797_+UTR3
CAediting_932181chr12_117029806_+UTR3
CAediting_932182chr12_117029821_+UTR3
CAediting_932183chr12_117029832_+UTR3
CAediting_932184chr12_117029833_+UTR3
CAediting_932185chr12_117029834_+UTR3
CAediting_932186chr12_117029841_+UTR3
CAediting_932187chr12_117029846_+UTR3
CAediting_932188chr12_117029848_+UTR3
CAediting_932189chr12_117029851_+UTR3
CAediting_932190chr12_117029863_+UTR3
CAediting_932191chr12_117029872_+UTR3
CAediting_932192chr12_117029873_+UTR3
CAediting_932193chr12_117029885_+UTR3
CAediting_932194chr12_117029887_+UTR3
CAediting_932195chr12_117029893_+UTR3
CAediting_932196chr12_117029894_+UTR3
CAediting_932197chr12_117029907_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_932089chr12_116912211_+SINEAluAluJb
CAediting_932090chr12_116912236_+SINEAluAluJb
CAediting_932091chr12_116912238_+SINEAluAluJb
CAediting_932092chr12_116912410_+SINEAluAluJb
CAediting_932093chr12_116912589_+SINEAluAluY
CAediting_932094chr12_116913994_+SINEAluAluJb
CAediting_932095chr12_116914006_+SINEAluAluJb
CAediting_932096chr12_116914010_+SINEAluAluJb
CAediting_932097chr12_116914016_+SINEAluAluJb
CAediting_932098chr12_116914017_+SINEAluAluJb
CAediting_932099chr12_116914037_+SINEAluAluJb
CAediting_932100chr12_116914038_+SINEAluAluJb
CAediting_932101chr12_116914111_+SINEAluAluJb
CAediting_932102chr12_116914112_+SINEAluAluJb
CAediting_932103chr12_116914120_+SINEAluAluJb
CAediting_932104chr12_116914152_+SINEAluAluJb
CAediting_932105chr12_116914193_+SINEAluAluJb
CAediting_932106chr12_116914323_+SINEAluAluJb
CAediting_932107chr12_116914324_+SINEAluAluJb
CAediting_932108chr12_116914373_+SINEAluAluJb
CAediting_932109chr12_116914381_+SINEAluAluJb
CAediting_932110chr12_116914383_+SINEAluAluJb
CAediting_932111chr12_116914384_+SINEAluAluJb
CAediting_932112chr12_116914397_+SINEAluAluJb
CAediting_932113chr12_116914452_+SINEAluAluJb
CAediting_932114chr12_116914459_+SINEAluAluJb
CAediting_932115chr12_116914462_+SINEAluAluJb
CAediting_932116chr12_116914493_+SINEAluAluJb
CAediting_932117chr12_116914498_+SINEAluAluJb
CAediting_932118chr12_116914518_+SINEAluAluJb
CAediting_932119chr12_116914528_+SINEAluAluJb
CAediting_932120chr12_116914530_+SINEAluAluJb
CAediting_932121chr12_116914538_+SINEAluAluJb
CAediting_932122chr12_116914548_+SINEAluAluJb
CAediting_932123chr12_116914621_+SINEAluAluSp
CAediting_932124chr12_116914626_+SINEAluAluSp
CAediting_932125chr12_116914651_+SINEAluAluSp
CAediting_932126chr12_116914685_+SINEAluAluSp
CAediting_932127chr12_116914686_+SINEAluAluSp
CAediting_932128chr12_116914693_+SINEAluAluSp
CAediting_932129chr12_116914796_+SINEAluAluSp
CAediting_932130chr12_116914800_+SINEAluAluSp
CAediting_932131chr12_116947492_+SINEAluAluSz
CAediting_932132chr12_116947493_+SINEAluAluSz
CAediting_932133chr12_116947528_+SINEAluAluSz
CAediting_932134chr12_116947575_+SINEAluAluSz
CAediting_932135chr12_116947589_+SINEAluAluSz
CAediting_932136chr12_116947593_+SINEAluAluSz
CAediting_932137chr12_116947611_+SINEAluAluSz
CAediting_932138chr12_116947619_+SINEAluAluSz
CAediting_932139chr12_116947659_+SINEAluAluSz
CAediting_932140chr12_116947660_+SINEAluAluSz
CAediting_932141chr12_116947688_+SINEAluAluSz
CAediting_932142chr12_116947689_+SINEAluAluSz
CAediting_932143chr12_116947704_+SINEAluAluSz
CAediting_932144chr12_116952938_+SINEAluAluSz
CAediting_932145chr12_116953584_+SINEAluAluY
CAediting_932146chr12_116953608_+SINEAluAluY
CAediting_932147chr12_116953666_+SINEAluAluY
CAediting_932148chr12_116953860_+SINEAluAluSx1
CAediting_932149chr12_116953861_+SINEAluAluSx1
CAediting_932150chr12_116953913_+SINEAluAluSx1
CAediting_932151chr12_116953993_+SINEAluAluSx1
CAediting_932152chr12_116953994_+SINEAluAluSx1
CAediting_932153chr12_116954046_+SINEAluAluSx1
CAediting_932154chr12_116954064_+SINEAluAluSx1
CAediting_932155chr12_116966836_+SINEAluAluSx1
CAediting_932156chr12_116971181_+SINEAluAluJb
CAediting_932157chr12_116971244_+SINEAluAluJb
CAediting_932158chr12_116974665_+SINEAluAluJb
CAediting_932159chr12_116990895_+SINEAluAluJr
CAediting_932160chr12_116990968_+SINEAluAluJr
CAediting_932161chr12_117029624_+SINEAluAluSx1
CAediting_932162chr12_117029644_+SINEAluAluSx1
CAediting_932163chr12_117029655_+SINEAluAluSx1
CAediting_932164chr12_117029660_+SINEAluAluSx1
CAediting_932165chr12_117029665_+SINEAluAluSx1
CAediting_932166chr12_117029666_+SINEAluAluSx1
CAediting_932167chr12_117029674_+SINEAluAluSx1
CAediting_932168chr12_117029709_+SINEAluAluSx1
CAediting_932169chr12_117029713_+SINEAluAluSx1
CAediting_932170chr12_117029727_+SINEAluAluSx1
CAediting_932171chr12_117029739_+SINEAluAluSx1
CAediting_932172chr12_117029751_+SINEAluAluSx1
CAediting_932173chr12_117029762_+SINEAluAluSx1
CAediting_932174chr12_117029775_+SINEAluAluSx1
CAediting_932175chr12_117029776_+SINEAluAluSx1
CAediting_932176chr12_117029784_+SINEAluAluSx1
CAediting_932177chr12_117029790_+SINEAluAluSx1
CAediting_932178chr12_117029793_+SINEAluAluSx1
CAediting_932179chr12_117029795_+SINEAluAluSx1
CAediting_932180chr12_117029797_+SINEAluAluSx1
CAediting_932181chr12_117029806_+SINEAluAluSx1
CAediting_932182chr12_117029821_+SINEAluAluSx1
CAediting_932183chr12_117029832_+SINEAluAluSx1
CAediting_932184chr12_117029833_+SINEAluAluSx1
CAediting_932185chr12_117029834_+SINEAluAluSx1
CAediting_932186chr12_117029841_+SINEAluAluSx1
CAediting_932187chr12_117029846_+SINEAluAluSx1
CAediting_932188chr12_117029848_+SINEAluAluSx1
CAediting_932189chr12_117029851_+SINEAluAluSx1
CAediting_932190chr12_117029863_+SINEAluAluSx1
CAediting_932191chr12_117029872_+SINEAluAluSx1
CAediting_932192chr12_117029873_+SINEAluAluSx1
CAediting_932193chr12_117029885_+SINEAluAluSx1
CAediting_932194chr12_117029887_+SINEAluAluSx1
CAediting_932195chr12_117029893_+SINEAluAluSx1
CAediting_932196chr12_117029894_+SINEAluAluSx1
CAediting_932197chr12_117029907_+SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for FBXW8

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000174989.11.FBXW8.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000174989.11.FBXW8.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FBXW8

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
GBM.CAediting_932166.ENSG00000174989.FBXW8.png
Soverview
LUSC.CAediting_932166.ENSG00000174989.FBXW8.png
Soverview
PAAD.CAediting_932178.ENSG00000174989.FBXW8.png
Soverview
STAD.CAediting_932166.ENSG00000174989.FBXW8.png
Soverview

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Protein coding region RNA A-to-I editings for FBXW8

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for FBXW8

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_932162chr12_117029644_+ENSG00000174989.11ENST00000455858hsa-miR-1273c1170296391170296446mer117029624117029645152.00-35.21
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-324-3p1170296621170296687mer-m8117029647117029669150.00-24.41
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-42521170296631170296697mer-m8117029650117029670144.00-23.43
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-4793-3p1170296591170296657mer-m8117029643117029666153.00-20.44
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-6807-3p1170296611170296666mer117029645117029667152.00-25.85
CAediting_932171chr12_117029739_+ENSG00000174989.11ENST00000455858hsa-miR-4691-3p1170297361170297427mer-m8117029716117029743150.00-26.36
CAediting_932174chr12_117029775_+ENSG00000174989.11ENST00000455858hsa-miR-3157-5p1170297691170297757mer-m8117029751117029776149.00-20.67
CAediting_932174chr12_117029775_+ENSG00000174989.11ENST00000455858hsa-miR-34a-3p1170297711170297777mer-m8117029757117029778152.00-10.86
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548ae-3p1170297741170297818mer-1a117029759117029781145.00-7.01
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548ae-3p1170297741170297818mer-1a117029759117029781145.00-7.01
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548ah-3p1170297741170297818mer-1a117029758117029781153.00-9.88
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548aj-3p1170297741170297818mer-1a117029759117029781145.00-9.51
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548aj-3p1170297741170297818mer-1a117029759117029781145.00-9.51
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548am-3p1170297741170297818mer-1a117029758117029781153.00-9.88
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548aq-3p1170297741170297818mer-1a117029758117029781145.00-7.39
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548j-3p1170297741170297818mer-1a117029762117029781145.00-6.27
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548x-3p1170297741170297818mer-1a117029760117029781145.00-9.51
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-548x-3p1170297741170297818mer-1a117029760117029781145.00-9.51
CAediting_932175chr12_117029776_+ENSG00000174989.11ENST00000455858hsa-miR-7844-5p1170297721170297787mer-m8117029758117029779157.00-19.61
CAediting_932176chr12_117029784_+ENSG00000174989.11ENST00000455858hsa-miR-424-3p1170297811170297877mer-m8117029768117029788148.00-13.35
CAediting_932182chr12_117029821_+ENSG00000174989.11ENST00000455858hsa-miR-3940-3p1170298181170298247mer-m8117029807117029825144.00-24.53
CAediting_932184chr12_117029833_+ENSG00000174989.11ENST00000455858hsa-miR-43291170298261170298338mer-1a117029815117029833145.00-16.55
CAediting_932185chr12_117029834_+ENSG00000174989.11ENST00000455858hsa-miR-100-3p1170298301170298367mer-m8117029816117029837142.00-12.56
CAediting_932185chr12_117029834_+ENSG00000174989.11ENST00000455858hsa-miR-45381170298301170298356mer117029814117029836147.00-25.25
CAediting_932187chr12_117029846_+ENSG00000174989.11ENST00000455858hsa-miR-1298-5p1170298441170298507mer-m8117029832117029851152.00-17.60
CAediting_932188chr12_117029848_+ENSG00000174989.11ENST00000455858hsa-miR-34b-3p1170298461170298527mer-m8117029832117029853140.00-11.15
CAediting_932188chr12_117029848_+ENSG00000174989.11ENST00000455858hsa-miR-3614-5p1170298441170298507mer-1a117029827117029850143.00-17.67
CAediting_932193chr12_117029885_+ENSG00000174989.11ENST00000455858hsa-miR-106a-3p1170298811170298866mer117029866117029887141.00-21.13
CAediting_932163chr12_117029655_+ENSG00000174989.11ENST00000455858hsa-miR-6512-3p1170296531170296597mer-m8117029637117029660150.00-24.46
CAediting_932163chr12_117029655_+ENSG00000174989.11ENST00000455858hsa-miR-6720-5p1170296531170296597mer-m8117029637117029660154.00-22.63
CAediting_932163chr12_117029655_+ENSG00000174989.11ENST00000455858hsa-miR-6849-3p1170296521170296598mer-1a117029639117029659149.00-18.21
CAediting_932167chr12_117029674_+ENSG00000174989.11ENST00000455858hsa-miR-1911-3p1170296681170296747mer-m8117029655117029675161.00-22.69
CAediting_932167chr12_117029674_+ENSG00000174989.11ENST00000455858hsa-miR-4786-5p1170296711170296777mer-m8117029659117029678157.00-27.38
CAediting_932173chr12_117029762_+ENSG00000174989.11ENST00000455858hsa-miR-885-3p1170297571170297648mer-1a117029740117029764155.00-23.23
CAediting_932181chr12_117029806_+ENSG00000174989.11ENST00000455858hsa-miR-6729-3p1170297991170298057mer-m8117029785117029806148.00-20.56
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-3261170298671170298737mer-m8117029855117029874140.00-13.96
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-330-5p1170298671170298737mer-m8117029851117029874143.00-23.69
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-43141170298661170298727mer-m8117029855117029873143.00-24.03
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-514a-5p1170298681170298747mer-m8117029850117029875151.00-19.66
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-514a-5p1170298681170298747mer-m8117029850117029875151.00-19.66
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-514a-5p1170298681170298747mer-m8117029850117029875151.00-19.66
CAediting_932192chr12_117029873_+ENSG00000174989.11ENST00000455858hsa-miR-3189-3p1170298671170298737mer-m8117029855117029874149.00-25.49
CAediting_932192chr12_117029873_+ENSG00000174989.11ENST00000455858hsa-miR-6813-3p1170298681170298747mer-m8117029855117029875140.00-11.59
CAediting_932194chr12_117029887_+ENSG00000174989.11ENST00000455858hsa-miR-100-5p1170298831170298897mer-m8117029868117029890162.00-22.89
CAediting_932194chr12_117029887_+ENSG00000174989.11ENST00000455858hsa-miR-99a-5p1170298831170298897mer-m8117029867117029890155.00-21.46
CAediting_932194chr12_117029887_+ENSG00000174989.11ENST00000455858hsa-miR-99b-5p1170298831170298897mer-m8117029867117029890155.00-25.13
CAediting_932195chr12_117029893_+ENSG00000174989.11ENST00000455858hsa-miR-1228-3p1170298861170298938mer-1a117029876117029893147.00-21.88
CAediting_932195chr12_117029893_+ENSG00000174989.11ENST00000455858hsa-miR-342-3p1170298881170298947mer-m8117029872117029895159.00-18.80
CAediting_932196chr12_117029894_+ENSG00000174989.11ENST00000455858hsa-miR-192-5p1170298911170298977mer-m8117029879117029898145.00-13.98
CAediting_932196chr12_117029894_+ENSG00000174989.11ENST00000455858hsa-miR-215-5p1170298911170298977mer-m8117029879117029898145.00-13.50
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-6781-5p1170299041170299118mer-1a117029892117029911145.00-22.43

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_932186chr12_117029841_+ENSG00000174989.11ENST00000455858hsa-miR-10393-3p1170298361170298427mer-m8117029819117029843154-16.81
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-1225-5p1170299001170299067mer-m8117029886117029907146-21.01
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-15871170299051170299128mer-1a117029893117029912152-24.52
CAediting_932181chr12_117029806_+ENSG00000174989.11ENST00000455858hsa-miR-195-3p1170298031170298086mer117029787117029809143-16.15
CAediting_932169chr12_117029713_+ENSG00000174989.11ENST00000455858hsa-miR-219b-3p1170297101170297167mer-m8117029697117029717153-15.36
CAediting_932169chr12_117029713_+ENSG00000174989.11ENST00000455858hsa-miR-302f1170297091170297157mer-m8117029700117029716145-6.24
CAediting_932196chr12_117029894_+ENSG00000174989.11ENST00000455858hsa-miR-31641170298921170298987mer-m8117029877117029899145-9.43
CAediting_932182chr12_117029821_+ENSG00000174989.11ENST00000455858hsa-miR-3190-5p1170298151170298217mer-m8117029802117029822147-18.44
CAediting_932165chr12_117029665_+ENSG00000174989.11ENST00000455858hsa-miR-32-5p1170296601170296667mer-m8117029645117029667150-13.03
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-32-5p1170296601170296667mer-m8117029645117029667150-13.03
CAediting_932179chr12_117029795_+ENSG00000174989.11ENST00000455858hsa-miR-340-3p1170297931170297997mer-m8117029779117029800149-16.58
CAediting_932180chr12_117029797_+ENSG00000174989.11ENST00000455858hsa-miR-340-3p1170297931170297997mer-m8117029779117029800149-16.58
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-3620-5p1170299051170299128mer-1a117029892117029912153-24.22
CAediting_932161chr12_117029624_+ENSG00000174989.11ENST00000455858hsa-miR-3622a-3p1170296211170296277mer-m8117029607117029628140-13.47
CAediting_932161chr12_117029624_+ENSG00000174989.11ENST00000455858hsa-miR-3622b-3p1170296211170296277mer-m8117029608117029628141-14.05
CAediting_932165chr12_117029665_+ENSG00000174989.11ENST00000455858hsa-miR-363-3p1170296601170296667mer-m8117029644117029667150-14.79
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-363-3p1170296601170296667mer-m8117029644117029667150-14.79
CAediting_932164chr12_117029660_+ENSG00000174989.11ENST00000455858hsa-miR-3925-3p1170296541170296607mer-m8117029642117029661153-18.58
CAediting_932190chr12_117029863_+ENSG00000174989.11ENST00000455858hsa-miR-39291170298601170298667mer-m8117029845117029867155-20.51
CAediting_932181chr12_117029806_+ENSG00000174989.11ENST00000455858hsa-miR-3942-5p1170298041170298118mer-1a117029784117029811146-12.45
CAediting_932170chr12_117029727_+ENSG00000174989.11ENST00000455858hsa-miR-44781170297241170297307mer-m8117029716117029731149-25.05
CAediting_932190chr12_117029863_+ENSG00000174989.11ENST00000455858hsa-miR-44781170298601170298667mer-m8117029852117029867149-22.23
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-44921170299041170299118mer-1a117029895117029911149-21.14
CAediting_932176chr12_117029784_+ENSG00000174989.11ENST00000455858hsa-miR-44951170297781170297847mer-m8117029763117029785150-10.83
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-44981170299041170299118mer-1a117029893117029911146-22.98
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-45051170299031170299097mer-m8117029891117029910146-24.71
CAediting_932173chr12_117029762_+ENSG00000174989.11ENST00000455858hsa-miR-4536-5p1170297591170297668mer-1a117029747117029766142-19.57
CAediting_932173chr12_117029762_+ENSG00000174989.11ENST00000455858hsa-miR-4536-5p1170297591170297668mer-1a117029747117029766142-19.57
CAediting_932170chr12_117029727_+ENSG00000174989.11ENST00000455858hsa-miR-4649-3p1170297211170297277mer-m8117029708117029728140-14.11
CAediting_932190chr12_117029863_+ENSG00000174989.11ENST00000455858hsa-miR-4649-3p1170298571170298637mer-m8117029844117029864144-15.95
CAediting_932178chr12_117029793_+ENSG00000174989.11ENST00000455858hsa-miR-4684-5p1170297901170297967mer-m8117029775117029797155-13.83
CAediting_932179chr12_117029795_+ENSG00000174989.11ENST00000455858hsa-miR-4684-5p1170297901170297967mer-m8117029775117029797155-13.83
CAediting_932180chr12_117029797_+ENSG00000174989.11ENST00000455858hsa-miR-4684-5p1170297901170297967mer-m8117029775117029797155-13.83
CAediting_932181chr12_117029806_+ENSG00000174989.11ENST00000455858hsa-miR-4703-5p1170298041170298118mer-1a117029789117029811140-8.81
CAediting_932190chr12_117029863_+ENSG00000174989.11ENST00000455858hsa-miR-485-5p1170298611170298677mer-m8117029844117029868146-15.01
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-5001-5p1170299041170299118mer-1a117029888117029911154-22.76
CAediting_932164chr12_117029660_+ENSG00000174989.11ENST00000455858hsa-miR-508-5p1170296551170296617mer-m8117029640117029662140-16.24
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-5589-5p1170299021170299087mer-m8117029885117029909148-26.33
CAediting_932171chr12_117029739_+ENSG00000174989.11ENST00000455858hsa-miR-56901170297361170297427mer-m8117029723117029743145-17.72
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-57871170299031170299097mer-m8117029892117029910147-23.95
CAediting_932187chr12_117029846_+ENSG00000174989.11ENST00000455858hsa-miR-579-3p1170298441170298507mer-m8117029829117029851142-7.23
CAediting_932188chr12_117029848_+ENSG00000174989.11ENST00000455858hsa-miR-579-3p1170298441170298507mer-m8117029829117029851142-7.23
CAediting_932189chr12_117029851_+ENSG00000174989.11ENST00000455858hsa-miR-579-3p1170298441170298507mer-m8117029829117029851142-7.23
CAediting_932178chr12_117029793_+ENSG00000174989.11ENST00000455858hsa-miR-593-3p1170297921170297976mer117029780117029798140-18.96
CAediting_932179chr12_117029795_+ENSG00000174989.11ENST00000455858hsa-miR-593-3p1170297921170297976mer117029780117029798140-18.96
CAediting_932180chr12_117029797_+ENSG00000174989.11ENST00000455858hsa-miR-593-3p1170297921170297976mer117029780117029798140-18.96
CAediting_932187chr12_117029846_+ENSG00000174989.11ENST00000455858hsa-miR-664b-3p1170298441170298507mer-m8117029830117029851140-9.22
CAediting_932188chr12_117029848_+ENSG00000174989.11ENST00000455858hsa-miR-664b-3p1170298441170298507mer-m8117029830117029851140-9.22
CAediting_932189chr12_117029851_+ENSG00000174989.11ENST00000455858hsa-miR-664b-3p1170298441170298507mer-m8117029830117029851140-9.22
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-6776-5p1170299021170299076mer117029890117029908150-25.4
CAediting_932186chr12_117029841_+ENSG00000174989.11ENST00000455858hsa-miR-6801-5p1170298361170298427mer-m8117029821117029843146-18.88
CAediting_932196chr12_117029894_+ENSG00000174989.11ENST00000455858hsa-miR-6820-3p1170298921170298987mer-m8117029879117029899150-16.25
CAediting_932179chr12_117029795_+ENSG00000174989.11ENST00000455858hsa-miR-6827-3p1170297931170297997mer-m8117029780117029800153-17.53
CAediting_932180chr12_117029797_+ENSG00000174989.11ENST00000455858hsa-miR-6827-3p1170297931170297997mer-m8117029780117029800153-17.53
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-6861-5p1170299011170299077mer-m8117029886117029908148-21.99
CAediting_932170chr12_117029727_+ENSG00000174989.11ENST00000455858hsa-miR-7160-5p1170297221170297287mer-m8117029709117029729147-20.02
CAediting_932190chr12_117029863_+ENSG00000174989.11ENST00000455858hsa-miR-7160-5p1170298581170298647mer-m8117029847117029865151-19.38
CAediting_932197chr12_117029907_+ENSG00000174989.11ENST00000455858hsa-miR-7621170299041170299118mer-1a117029890117029911154-26.49
CAediting_932191chr12_117029872_+ENSG00000174989.11ENST00000455858hsa-miR-887-5p1170298651170298728mer-1a117029853117029872143-15.14
CAediting_932165chr12_117029665_+ENSG00000174989.11ENST00000455858hsa-miR-92a-3p1170296601170296667mer-m8117029644117029667149-18.53
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-92a-3p1170296601170296667mer-m8117029644117029667149-18.53
CAediting_932165chr12_117029665_+ENSG00000174989.11ENST00000455858hsa-miR-92a-3p1170296601170296667mer-m8117029644117029667149-18.53
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-92a-3p1170296601170296667mer-m8117029644117029667149-18.53
CAediting_932165chr12_117029665_+ENSG00000174989.11ENST00000455858hsa-miR-92b-3p1170296601170296667mer-m8117029644117029667153-17.29
CAediting_932166chr12_117029666_+ENSG00000174989.11ENST00000455858hsa-miR-92b-3p1170296601170296667mer-m8117029644117029667153-17.29

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000174989.11ENST00000455858hsa-miR-624-3p1170291621170291698mer-1a117029152117029169145-13.51
CAediting_1368054chr19_46709310_-ENSG00000174989.11ENST00000455858hsa-miR-320e1170285141170285207mer-m8117028504117028521145-18.5
CAediting_117844chr1_162342605_+ENSG00000174989.11ENST00000455858hsa-miR-556-3p1170286071170286148mer-1a117028592117028614148-9.45
CAediting_228905chr2_188297554_+ENSG00000174989.11ENST00000455858hsa-miR-561-3p1170294061170294127mer-m8117029391117029413152-9.16
CAediting_442554chr5_154685830_+ENSG00000174989.11ENST00000455858hsa-miR-13031170301961170302027mer-m8117030182117030203144-11.7

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000174989.11ENST00000455858hsa-miR-320e1170284911170284977mer-m8117028482117028498150-18.37

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FBXW8

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for FBXW8

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_932166chr12_117029666_+0.04106838836014870.223413815463106....
LUSCCAediting_932166chr12_117029666_+..0.04115717534424360.1371721311747030.002758927268325160.199998809727029
HNSCCAediting_932166chr12_117029666_+....0.02145264708034170.21619679687183
ESCACAediting_932166chr12_117029666_+..0.01360966415315810.214297118864347..
SKCMCAediting_932166chr12_117029666_+..0.01458121662956670.13751809444018..
SARCCAediting_932166chr12_117029666_+0.03730736561604830.219882144517467....
LGGCAediting_932171chr12_117029739_+0.0003379662320626710.395545217232101....
GBMCAediting_932171chr12_117029739_+0.007513734382292580.293186308529392....
ESCACAediting_932171chr12_117029739_+0.03081967684534560.206973391432701....
LGGCAediting_932174chr12_117029775_+0.002800438855858840.14654249156062....
BRCACAediting_932174chr12_117029775_+1.2445831617157e-060.17401224836598....
LUSCCAediting_932174chr12_117029775_+6.8368444381795e-050.243454837851281..0.009266166310238640.160480798261277
GBMCAediting_932174chr12_117029775_+0.0003449680113286390.332247268649529....
PRADCAediting_932174chr12_117029775_+0.003444321344427060.181820911577553....
HNSCCAediting_932174chr12_117029775_+1.79621964674365e-050.355054996751036....
THCACAediting_932174chr12_117029775_+0.0001155113919999020.198045984895629....
KIRCCAediting_932174chr12_117029775_+0.001190651129340020.180400772144703....
KIRPCAediting_932174chr12_117029775_+0.04043220677181650.164810926436503....
OVCAediting_932174chr12_117029775_+0.008911807340452630.164126202149071....
SKCMCAediting_932174chr12_117029775_+5.49559562590418e-060.243655578905404....
SARCCAediting_932174chr12_117029775_+0.01109020941309320.226485811129941....
LGGCAediting_932178chr12_117029793_+0.000963557453742590.156838126285523....
BRCACAediting_932178chr12_117029793_+0.01030953667429050.0889457075302748....
COADCAediting_932178chr12_117029793_+0.008376284688586950.219703964855223....
LUSCCAediting_932178chr12_117029793_+....0.01866960392364180.136878387865
HNSCCAediting_932178chr12_117029793_+0.0008226115294425020.2394517190235630.02314725351495580.16385564124138..
THCACAediting_932178chr12_117029793_+....0.0443079139295180.101253440459512
KIRCCAediting_932178chr12_117029793_+0.02758278009631830.116943071475846....
BRCACAediting_932183chr12_117029832_+..0.02745796334854320.214210586724758..
STADCAediting_932184chr12_117029833_+..0.04538686186728350.273491959666014..
BRCACAediting_932188chr12_117029848_+..0.000839875958535270.224561957379752..
GBMCAediting_932188chr12_117029848_+0.0008549058747535350.313449577544687....
STADCAediting_932188chr12_117029848_+0.03184854093025540.147823234437825....
KIRCCAediting_932188chr12_117029848_+..0.001459034585194340.401868460806089..
ESCACAediting_932188chr12_117029848_+0.001381429466906350.2875897799068660.04194143975068860.18523746066413..
OVCAediting_932188chr12_117029848_+0.0004051615181378180.220266996984491....
BRCACAediting_932190chr12_117029863_+0.02964223218184270.1463368604299180.0025746602113950.201825973395272..
GBMCAediting_932190chr12_117029863_+0.008151307234518180.235666706136707....
STADCAediting_932190chr12_117029863_+..0.0003019958642130640.229420783745926..
THCACAediting_932190chr12_117029863_+..0.006284294350323620.381365305316669..
ESCACAediting_932190chr12_117029863_+0.008050328192602730.2239263815549880.0003000210743310370.302172621631954..
OVCAediting_932190chr12_117029863_+2.75027921844574e-050.245647882844943....

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Relation with cancer stages for FBXW8

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
HNSCclinical_stageCAediting_932174chr12_117029775_+0.03324903069491080.181381608000963
LUSCpathologic_stageCAediting_932178chr12_117029793_+0.003623866569834360.169449295212751
STADpathologic_stageCAediting_932188chr12_117029848_+0.01683238632906280.166797874758432

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Relation with survival for FBXW8

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LIHCCAediting_932178chr12_117029793_+0.03506000961656890.02096480.0135163
STADCAediting_932188chr12_117029848_+0.04589615448820010.011317116.0132
KIRPCAediting_932174chr12_117029775_+0.007014223025152980.0092751211.169
OVCAediting_932183chr12_117029832_+0.002667246017836410.01099730.00357757

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RelatedDrugs for FBXW8

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXW8

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
FBXW8C0005684Malignant neoplasm of urinary bladder1CTD_human
FBXW8C0005695Bladder Neoplasm1CTD_human