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Editing gene: FAM169A (CAeditome ID:26049)

Gene summary for FAM169A

Gene summary

Gene information	Gene symbol	FAM169A
	Gene ID	26049
	Gene name	family with sequence similarity 169 member A
	Synonyms	SLAP75
	Cytomap	5q13.3
	Type of gene	protein-coding
	Description	soluble lamin-associated protein of 75 kDaprotein FAM169Asoluble lamina-associated protein of 75 kD
	Modification date	20210518
	UniProtAcc	Q9Y6X4
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for FAM169A

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000198780.10

RNA A-to-I editing events in Cancer.

CAediting_415350(74781592, -), CAediting_415351(74781954, -), CAediting_415352(74781970, -), CAediting_415353(74781971, -), CAediting_415354(74781988, -), CAediting_415355(74811051, -), CAediting_415356(74839601, -), CAediting_415357(74842610, -), CAediting_415358(74842637, -), CAediting_415359(74842640, -), CAediting_415360(74842643, -), CAediting_415361(74842647, -), CAediting_415362(74853840, -), CAediting_415363(74853846, -), CAediting_415364(74853856, -), CAediting_415365(74854273, -), CAediting_415366(74854278, -), CAediting_415367(74854283, -), CAediting_415368(74854313, -), CAediting_415369(74854319, -), CAediting_415370(74859428, -), CAediting_415371(74860650, -), CAediting_415372(74860700, -),

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RNA editing positional annotations for FAM169A using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_415353	chr5_74781971_-	nonsynonymous SNV	ENST00000389156.7	c.A1502G	p.E501G	D	P	N
CAediting_415353	chr5_74781971_-	nonsynonymous SNV	ENST00000510496.4	c.A1322G	p.E441G	D	P	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_415350	chr5_74781592_-	exonic
CAediting_415351	chr5_74781954_-	exonic
CAediting_415352	chr5_74781970_-	exonic
CAediting_415353	chr5_74781971_-	exonic
CAediting_415354	chr5_74781988_-	exonic
CAediting_415355	chr5_74811051_-	intronic
CAediting_415356	chr5_74839601_-	intronic
CAediting_415357	chr5_74842610_-	intronic
CAediting_415358	chr5_74842637_-	intronic
CAediting_415359	chr5_74842640_-	intronic
CAediting_415360	chr5_74842643_-	intronic
CAediting_415361	chr5_74842647_-	intronic
CAediting_415362	chr5_74853840_-	intronic
CAediting_415363	chr5_74853846_-	intronic
CAediting_415364	chr5_74853856_-	intronic
CAediting_415365	chr5_74854273_-	intronic
CAediting_415366	chr5_74854278_-	intronic
CAediting_415367	chr5_74854283_-	intronic
CAediting_415368	chr5_74854313_-	intronic
CAediting_415369	chr5_74854319_-	intronic
CAediting_415370	chr5_74859428_-	intronic
CAediting_415371	chr5_74860650_-	intronic
CAediting_415372	chr5_74860700_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_415355	chr5_74811051_-	SINE	Alu	AluSz6
CAediting_415356	chr5_74839601_-	SINE	Alu	AluSq2
CAediting_415357	chr5_74842610_-	SINE	Alu	AluJr4
CAediting_415358	chr5_74842637_-	SINE	Alu	AluJr4
CAediting_415359	chr5_74842640_-	SINE	Alu	AluJr4
CAediting_415360	chr5_74842643_-	SINE	Alu	AluJr4
CAediting_415361	chr5_74842647_-	SINE	Alu	AluJr4
CAediting_415362	chr5_74853840_-	SINE	Alu	AluYh3
CAediting_415363	chr5_74853846_-	SINE	Alu	AluYh3
CAediting_415364	chr5_74853856_-	SINE	Alu	AluYh3
CAediting_415365	chr5_74854273_-	SINE	Alu	AluSx1
CAediting_415366	chr5_74854278_-	SINE	Alu	AluSx1
CAediting_415367	chr5_74854283_-	SINE	Alu	AluSx1
CAediting_415368	chr5_74854313_-	SINE	Alu	AluSx1
CAediting_415369	chr5_74854319_-	SINE	Alu	AluSx1
CAediting_415370	chr5_74859428_-	SINE	Alu	AluSg
CAediting_415371	chr5_74860650_-	LINE	L2	L2
CAediting_415372	chr5_74860700_-	LINE	L2	L2

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RNA A-to-I editing events in the alternative splicing sites for FAM169A

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198780.10.FAM169A.

Correlation between RNA A-to-I editing and PSI for ENSG00000198780.10.FAM169A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FAM169A

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for FAM169A

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for FAM169A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_415350	chr5_74781592_-	ENSG00000198780.10	ENST00000514215	hsa-miR-892a	74781591	74781597	7mer-m8	74781590	74781610	140.00	-13.84
CAediting_415350	chr5_74781592_-	ENSG00000198780.10	ENST00000510609	hsa-miR-892a	74781591	74781597	7mer-m8	74781590	74781610	140.00	-13.84
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6515-3p	74781952	74781958	7mer-m8	74781951	74781970	150.00	-17.03
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000514215	hsa-miR-877-3p	74781951	74781957	7mer-m8	74781950	74781971	141.00	-15.32
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6515-3p	74781952	74781958	7mer-m8	74781951	74781970	150.00	-17.03
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000510609	hsa-miR-877-3p	74781951	74781957	7mer-m8	74781950	74781971	141.00	-15.32
CAediting_415353	chr5_74781971_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6836-3p	74781966	74781972	7mer-m8	74781965	74781986	141.00	-16.95
CAediting_415353	chr5_74781971_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6836-3p	74781966	74781972	7mer-m8	74781965	74781986	141.00	-16.95
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6072	74781969	74781975	7mer-m8	74781968	74781987	148.00	-15.75
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6870-3p	74781970	74781976	7mer-m8	74781969	74781989	152.00	-15.78
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6891-3p	74781969	74781975	7mer-m8	74781968	74781989	142.00	-18.42
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6072	74781969	74781975	7mer-m8	74781968	74781987	148.00	-15.75
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6870-3p	74781970	74781976	7mer-m8	74781969	74781989	152.00	-15.78
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6891-3p	74781969	74781975	7mer-m8	74781968	74781989	142.00	-18.42

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000514215	hsa-miR-205-5p	74781968	74781974	7mer-m8	74781967	74781987	153	-16.09
CAediting_415353	chr5_74781971_-	ENSG00000198780.10	ENST00000514215	hsa-miR-205-5p	74781968	74781974	7mer-m8	74781967	74781987	153	-16.09
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000514215	hsa-miR-335-3p	74781953	74781959	7mer-m8	74781952	74781974	153	-12.9
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000514215	hsa-miR-6832-3p	74781950	74781956	7mer-m8	74781949	74781968	148	-14.28
CAediting_415354	chr5_74781988_-	ENSG00000198780.10	ENST00000514215	hsa-miR-937-5p	74781988	74781994	7mer-m8	74781987	74782008	155	-28.5
CAediting_415352	chr5_74781970_-	ENSG00000198780.10	ENST00000510609	hsa-miR-205-5p	74781968	74781974	7mer-m8	74781967	74781987	153	-16.09
CAediting_415353	chr5_74781971_-	ENSG00000198780.10	ENST00000510609	hsa-miR-205-5p	74781968	74781974	7mer-m8	74781967	74781987	153	-16.09
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000510609	hsa-miR-335-3p	74781953	74781959	7mer-m8	74781952	74781974	153	-12.9
CAediting_415351	chr5_74781954_-	ENSG00000198780.10	ENST00000510609	hsa-miR-6832-3p	74781950	74781956	7mer-m8	74781949	74781968	148	-14.28
CAediting_415354	chr5_74781988_-	ENSG00000198780.10	ENST00000510609	hsa-miR-937-5p	74781988	74781994	7mer-m8	74781987	74782008	155	-28.5

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_228905	chr2_188297554_+	ENSG00000198780.10	ENST00000514215	hsa-miR-561-3p	74781835	74781841	7mer-m8	74781834	74781857	149	-15.94
CAediting_442554	chr5_154685830_+	ENSG00000198780.10	ENST00000514215	hsa-miR-1303	74780413	74780419	7mer-m8	74780412	74780434	141	-13.38
CAediting_442554	chr5_154685830_+	ENSG00000198780.10	ENST00000510496	hsa-miR-1303	74780413	74780419	7mer-m8	74780412	74780434	141	-13.38
CAediting_442554	chr5_154685830_+	ENSG00000198780.10	ENST00000389156	hsa-miR-1303	74780413	74780419	7mer-m8	74780412	74780434	141	-13.38
CAediting_228905	chr2_188297554_+	ENSG00000198780.10	ENST00000510609	hsa-miR-561-3p	74781835	74781841	7mer-m8	74781834	74781857	149	-15.94
CAediting_442554	chr5_154685830_+	ENSG00000198780.10	ENST00000510609	hsa-miR-1303	74780413	74780419	7mer-m8	74780412	74780434	141	-13.38

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000514215	hsa-miR-200b-3p	74778253	74778259	7mer-m8	74778252	74778271	149	-13.17
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000514215	hsa-miR-200b-3p	74778135	74778140	6mer	74778134	74778155	150	-11.38
CAediting_688080	chr9_63819626_+	ENSG00000198780.10	ENST00000514215	hsa-miR-4477b	74780499	74780506	8mer-1a	74780499	74780520	149	-7.82
CAediting_1229413	chr17_67471544_+	ENSG00000198780.10	ENST00000514215	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229414	chr17_67471546_+	ENSG00000198780.10	ENST00000514215	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229415	chr17_67471547_+	ENSG00000198780.10	ENST00000514215	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000510496	hsa-miR-200b-3p	74778253	74778259	7mer-m8	74778252	74778271	149	-13.17
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000510496	hsa-miR-200b-3p	74778135	74778140	6mer	74778134	74778155	150	-11.38
CAediting_688080	chr9_63819626_+	ENSG00000198780.10	ENST00000510496	hsa-miR-4477b	74780499	74780506	8mer-1a	74780499	74780520	149	-7.82
CAediting_1229413	chr17_67471544_+	ENSG00000198780.10	ENST00000510496	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229414	chr17_67471546_+	ENSG00000198780.10	ENST00000510496	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229415	chr17_67471547_+	ENSG00000198780.10	ENST00000510496	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000389156	hsa-miR-200b-3p	74778253	74778259	7mer-m8	74778252	74778271	149	-13.17
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000389156	hsa-miR-200b-3p	74778135	74778140	6mer	74778134	74778155	150	-11.38
CAediting_688080	chr9_63819626_+	ENSG00000198780.10	ENST00000389156	hsa-miR-4477b	74780499	74780506	8mer-1a	74780499	74780520	149	-7.82
CAediting_1229413	chr17_67471544_+	ENSG00000198780.10	ENST00000389156	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229414	chr17_67471546_+	ENSG00000198780.10	ENST00000389156	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229415	chr17_67471547_+	ENSG00000198780.10	ENST00000389156	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000510609	hsa-miR-200b-3p	74778253	74778259	7mer-m8	74778252	74778271	149	-13.17
CAediting_393	chr1_1167164_+	ENSG00000198780.10	ENST00000510609	hsa-miR-200b-3p	74778135	74778140	6mer	74778134	74778155	150	-11.38
CAediting_688080	chr9_63819626_+	ENSG00000198780.10	ENST00000510609	hsa-miR-4477b	74780499	74780506	8mer-1a	74780499	74780520	149	-7.82
CAediting_1229413	chr17_67471544_+	ENSG00000198780.10	ENST00000510609	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229414	chr17_67471546_+	ENSG00000198780.10	ENST00000510609	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58
CAediting_1229415	chr17_67471547_+	ENSG00000198780.10	ENST00000510609	hsa-miR-548aa	74777793	74777799	7mer-m8	74777792	74777816	143	-8.58

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FAM169A

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000389156.7	protein_coding
ENST00000510496.4	protein_coding
ENST00000510609.4	nonsense_mediated_decay
ENST00000514215.4	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_415350	ENST00000389156.7	chr5_74781592_-	-1487.30	-1487.00	-1492.50
CAediting_415351	ENST00000389156.7	chr5_74781954_-	-1487.10	-1487.00	-1492.50
CAediting_415352	ENST00000389156.7	chr5_74781970_-	-1487.70	-1487.00	-1492.50
CAediting_415353	ENST00000389156.7	chr5_74781971_-	-1487.90	-1487.00	-1492.50
CAediting_415354	ENST00000389156.7	chr5_74781988_-	-1487.00	-1487.00	-1492.50
CAediting_415350	ENST00000510496.4	chr5_74781592_-	-1438.70	-1438.40	-1444.30
CAediting_415351	ENST00000510496.4	chr5_74781954_-	-1438.50	-1438.40	-1444.30
CAediting_415352	ENST00000510496.4	chr5_74781970_-	-1439.50	-1438.40	-1444.30
CAediting_415353	ENST00000510496.4	chr5_74781971_-	-1439.50	-1438.40	-1444.30
CAediting_415354	ENST00000510496.4	chr5_74781988_-	-1437.70	-1438.40	-1444.30
CAediting_415350	ENST00000510609.4	chr5_74781592_-	-1504.60	-1504.30	-1507.90
CAediting_415351	ENST00000510609.4	chr5_74781954_-	-1504.40	-1504.30	-1507.90
CAediting_415352	ENST00000510609.4	chr5_74781970_-	-1507.80	-1504.30	-1507.90
CAediting_415353	ENST00000510609.4	chr5_74781971_-	-1505.50	-1504.30	-1507.90
CAediting_415354	ENST00000510609.4	chr5_74781988_-	-1504.30	-1504.30	-1507.90
CAediting_415350	ENST00000514215.4	chr5_74781592_-	-1438.40	-1438.10	-1441.70
CAediting_415351	ENST00000514215.4	chr5_74781954_-	-1439.10	-1438.10	-1441.70
CAediting_415352	ENST00000514215.4	chr5_74781970_-	-1440.80	-1438.10	-1441.70
CAediting_415353	ENST00000514215.4	chr5_74781971_-	-1438.50	-1438.10	-1441.70
CAediting_415354	ENST00000514215.4	chr5_74781988_-	-1438.10	-1438.10	-1441.70

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Relation with ADAR for FAM169A

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for FAM169A

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for FAM169A

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for FAM169A

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FAM169A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene