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Editing gene: IFFO1 (CAeditome ID:25900)

Gene summary for IFFO1

Gene summary

Gene information	Gene symbol	IFFO1
	Gene ID	25900
	Gene name	intermediate filament family orphan 1
	Synonyms	HOM-TES-103\|IFFO
	Cytomap	12p13.31
	Type of gene	protein-coding
	Description	non-homologous end joining factor IFFO1NHEJ factor IFFO1intermediate filament-like MGC:2625
	Modification date	20210518
	UniProtAcc	Q0D2I5
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
IFFO1	GO:1990683	Non-homologous end joining factor IFFO1	31548606
IFFO1	GO:0005654	Non-homologous end joining factor IFFO1	31548606
IFFO1	GO:0016363	Non-homologous end joining factor IFFO1	31548606
IFFO1	GO:0035861	Non-homologous end joining factor IFFO1	31548606

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RNA A-to-I events for IFFO1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000010295.18

RNA A-to-I editing events in Cancer.

CAediting_865083(6540557, -), CAediting_865084(6543305, -), CAediting_865085(6547304, -), CAediting_865086(6547313, -), CAediting_865087(6547318, -), CAediting_865088(6547330, -), CAediting_865089(6547383, -), CAediting_865090(6547465, -), CAediting_865091(6547471, -), CAediting_865092(6547675, -),

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RNA editing positional annotations for IFFO1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_865083	chr12_6540557_-	nonsynonymous SNV	ENST00000336604.7	c.A1615G	p.S539G	D	B	N
CAediting_865083	chr12_6540557_-	nonsynonymous SNV	ENST00000356896.7	c.A1618G	p.S540G	D	B	N
CAediting_865083	chr12_6540557_-	nonsynonymous SNV	ENST00000396840.5	c.A1606G	p.S536G	D	B	N
CAediting_865083	chr12_6540557_-	nonsynonymous SNV	ENST00000465801.4	c.A694G	p.S232G	D	B	N
CAediting_865083	chr12_6540557_-	nonsynonymous SNV	ENST00000619571.3	c.A1642G	p.S548G	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_865083	chr12_6540557_-	exonic
CAediting_865084	chr12_6543305_-	ncRNA_intronic
CAediting_865085	chr12_6547304_-	ncRNA_intronic
CAediting_865086	chr12_6547313_-	ncRNA_intronic
CAediting_865087	chr12_6547318_-	ncRNA_intronic
CAediting_865088	chr12_6547330_-	ncRNA_intronic
CAediting_865089	chr12_6547383_-	ncRNA_intronic
CAediting_865090	chr12_6547465_-	ncRNA_intronic
CAediting_865091	chr12_6547471_-	ncRNA_intronic
CAediting_865092	chr12_6547675_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_865084	chr12_6543305_-	DNA	hAT-Charlie	MER1A
CAediting_865085	chr12_6547304_-	SINE	Alu	AluJb
CAediting_865086	chr12_6547313_-	SINE	Alu	AluJb
CAediting_865087	chr12_6547318_-	SINE	Alu	AluJb
CAediting_865088	chr12_6547330_-	SINE	Alu	AluJb
CAediting_865089	chr12_6547383_-	SINE	Alu	AluJb
CAediting_865090	chr12_6547465_-	SINE	Alu	AluJo
CAediting_865091	chr12_6547471_-	SINE	Alu	AluJo
CAediting_865092	chr12_6547675_-	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for IFFO1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000010295.18.IFFO1.

Correlation between RNA A-to-I editing and PSI for ENSG00000010295.18.IFFO1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IFFO1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for IFFO1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for IFFO1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000010295.18	ENST00000465801	hsa-miR-1304-3p	6540431	6540437	7mer-m8	6540430	6540450	149	-22.78
CAediting_688080	chr9_63819626_+	ENSG00000010295.18	ENST00000465801	hsa-miR-4477b	6538971	6538978	8mer-1a	6538971	6538990	148	-13.95
CAediting_846604	chr11_93733708_-	ENSG00000010295.18	ENST00000336604	hsa-miR-1304-3p	6540431	6540437	7mer-m8	6540430	6540450	149	-22.78
CAediting_846604	chr11_93733708_-	ENSG00000010295.18	ENST00000396840	hsa-miR-1304-3p	6540431	6540437	7mer-m8	6540430	6540450	149	-22.78
CAediting_1306324	chr19_13836464_-	ENSG00000010295.18	ENST00000487279	hsa-miR-27a-3p	6549778	6549784	7mer-m8	6549777	6549797	149	-17.31
CAediting_846604	chr11_93733708_-	ENSG00000010295.18	ENST00000487279	hsa-miR-1304-3p	6540431	6540437	7mer-m8	6540430	6540450	149	-22.78
CAediting_846604	chr11_93733708_-	ENSG00000010295.18	ENST00000356896	hsa-miR-1304-3p	6540431	6540437	7mer-m8	6540430	6540450	149	-22.78
CAediting_1368054	chr19_46709310_-	ENSG00000010295.18	ENST00000465801	hsa-miR-320e	6540107	6540114	8mer-1a	6540107	6540124	147	-15.92
CAediting_1399425	chr20_1392958_-	ENSG00000010295.18	ENST00000465801	hsa-miR-6869-5p	6539034	6539041	8mer-1a	6539034	6539053	160	-29.9
CAediting_228905	chr2_188297554_+	ENSG00000010295.18	ENST00000465801	hsa-miR-561-3p	6539477	6539482	6mer	6539476	6539496	142	-17.48
CAediting_1368054	chr19_46709310_-	ENSG00000010295.18	ENST00000336604	hsa-miR-320e	6540107	6540114	8mer-1a	6540107	6540124	147	-15.92
CAediting_1368054	chr19_46709310_-	ENSG00000010295.18	ENST00000396840	hsa-miR-320e	6540107	6540114	8mer-1a	6540107	6540124	147	-15.92
CAediting_1229414	chr17_67471546_+	ENSG00000010295.18	ENST00000487279	hsa-miR-548aa	6550714	6550720	7mer-m8	6550713	6550739	158	-16.06
CAediting_1368054	chr19_46709310_-	ENSG00000010295.18	ENST00000487279	hsa-miR-320e	6540107	6540114	8mer-1a	6540107	6540124	147	-15.92
CAediting_1368054	chr19_46709310_-	ENSG00000010295.18	ENST00000356896	hsa-miR-320e	6540107	6540114	8mer-1a	6540107	6540124	147	-15.92

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000010295.18	ENST00000465801	hsa-miR-4512	6540452	6540458	7mer-m8	6540451	6540473	146	-17.74
CAediting_748296	chr10_51299626_+	ENSG00000010295.18	ENST00000465801	hsa-miR-605-3p	6540236	6540243	8mer-1a	6540236	6540256	150	-16.71
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000465801	hsa-miR-624-3p	6540169	6540175	7mer-m8	6540168	6540188	141	-10.99
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000465801	hsa-miR-624-3p	6539955	6539961	7mer-m8	6539954	6539974	140	-15.68
CAediting_1054808	chr15_66496985_-	ENSG00000010295.18	ENST00000336604	hsa-miR-4512	6540452	6540458	7mer-m8	6540451	6540473	146	-17.74
CAediting_748296	chr10_51299626_+	ENSG00000010295.18	ENST00000336604	hsa-miR-605-3p	6540236	6540243	8mer-1a	6540236	6540256	150	-16.71
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000336604	hsa-miR-624-3p	6540169	6540175	7mer-m8	6540168	6540188	141	-10.99
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000336604	hsa-miR-624-3p	6539955	6539961	7mer-m8	6539954	6539974	140	-15.68
CAediting_1054808	chr15_66496985_-	ENSG00000010295.18	ENST00000396840	hsa-miR-4512	6540452	6540458	7mer-m8	6540451	6540473	146	-17.74
CAediting_748296	chr10_51299626_+	ENSG00000010295.18	ENST00000396840	hsa-miR-605-3p	6540236	6540243	8mer-1a	6540236	6540256	150	-16.71
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000396840	hsa-miR-624-3p	6540169	6540175	7mer-m8	6540168	6540188	141	-10.99
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000396840	hsa-miR-624-3p	6539955	6539961	7mer-m8	6539954	6539974	140	-15.68
CAediting_1054808	chr15_66496985_-	ENSG00000010295.18	ENST00000487279	hsa-miR-4512	6540452	6540458	7mer-m8	6540451	6540473	146	-17.74
CAediting_748296	chr10_51299626_+	ENSG00000010295.18	ENST00000487279	hsa-miR-605-3p	6540236	6540243	8mer-1a	6540236	6540256	150	-16.71
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000487279	hsa-miR-624-3p	6540169	6540175	7mer-m8	6540168	6540188	141	-10.99
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000487279	hsa-miR-624-3p	6539955	6539961	7mer-m8	6539954	6539974	140	-15.68
CAediting_1054808	chr15_66496985_-	ENSG00000010295.18	ENST00000356896	hsa-miR-4512	6540452	6540458	7mer-m8	6540451	6540473	146	-17.74
CAediting_748296	chr10_51299626_+	ENSG00000010295.18	ENST00000356896	hsa-miR-605-3p	6540236	6540243	8mer-1a	6540236	6540256	150	-16.71
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000356896	hsa-miR-624-3p	6540169	6540175	7mer-m8	6540168	6540188	141	-10.99
CAediting_980496	chr14_31014685_-	ENSG00000010295.18	ENST00000356896	hsa-miR-624-3p	6539955	6539961	7mer-m8	6539954	6539974	140	-15.68

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IFFO1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for IFFO1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for IFFO1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for IFFO1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for IFFO1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IFFO1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene