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Editing gene: CIZ1 (CAeditome ID:25792)

Gene summary for CIZ1

Gene summary

Gene information	Gene symbol	CIZ1
	Gene ID	25792
	Gene name	CDKN1A interacting zinc finger protein 1
	Synonyms	LSFR1\|NP94\|ZNF356
	Cytomap	9q34.11
	Type of gene	protein-coding
	Description	cip1-interacting zinc finger proteinnuclear protein NP94zinc finger protein 356
	Modification date	20210518
	UniProtAcc	Q9ULV3
	Context	- 31252164(CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CIZ1	GO:0005634	Cip1-interacting zinc finger protein	23145069
CIZ1	GO:0005654	Cip1-interacting zinc finger protein	0000052
CIZ1	GO:0005886	Cip1-interacting zinc finger protein	0000052

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RNA A-to-I events for CIZ1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000148337.18

RNA A-to-I editing events in Cancer.

CAediting_712048(128168359, -), CAediting_712049(128168394, -), CAediting_712050(128168408, -), CAediting_712051(128168416, -), CAediting_712052(128168423, -), CAediting_712053(128170573, -), CAediting_712054(128171044, -), CAediting_712055(128171313, -), CAediting_712056(128171316, -), CAediting_712057(128171347, -), CAediting_712058(128173038, -), CAediting_712059(128173089, -), CAediting_712060(128173103, -), CAediting_712061(128173762, -), CAediting_712062(128174791, -), CAediting_712063(128174796, -), CAediting_712064(128174815, -), CAediting_712065(128184555, -), CAediting_712066(128184585, -), CAediting_712067(128184792, -), CAediting_712068(128184796, -), CAediting_712069(128184805, -), CAediting_712070(128184832, -), CAediting_712071(128184863, -), CAediting_712072(128184865, -), CAediting_712073(128184887, -), CAediting_712074(128184929, -), CAediting_712075(128184949, -), CAediting_712076(128185259, -), CAediting_712077(128188676, -), CAediting_712078(128188726, -), CAediting_712079(128188757, -), CAediting_712080(128188770, -), CAediting_712081(128188896, -), CAediting_712082(128188923, -), CAediting_712083(128190753, -), CAediting_712084(128192133, -), CAediting_712085(128192142, -), CAediting_712086(128192189, -), CAediting_712087(128192201, -), CAediting_712088(128192203, -), CAediting_712089(128192205, -), CAediting_712090(128192223, -), CAediting_712091(128192232, -), CAediting_712092(128192244, -), CAediting_712093(128192248, -), CAediting_712094(128192258, -), CAediting_712095(128192270, -), CAediting_712096(128192287, -), CAediting_712097(128192288, -), CAediting_712098(128192308, -), CAediting_712099(128192313, -), CAediting_712100(128192318, -), CAediting_712101(128192337, -), CAediting_712102(128192610, -), CAediting_712103(128192615, -), CAediting_712104(128192635, -), CAediting_712105(128192639, -), CAediting_712106(128192645, -), CAediting_712107(128192663, -), CAediting_712108(128192681, -), CAediting_712109(128192707, -), CAediting_712110(128192710, -), CAediting_712111(128192711, -), CAediting_712112(128192712, -), CAediting_712113(128192713, -), CAediting_712114(128192716, -), CAediting_712115(128192720, -), CAediting_712116(128192721, -), CAediting_712117(128192759, -), CAediting_712118(128192767, -), CAediting_712119(128192815, -), CAediting_712120(128192816, -), CAediting_712121(128193531, -), CAediting_712122(128196447, -), CAediting_712123(128196700, -), CAediting_712124(128196701, -), CAediting_712125(128196728, -), CAediting_712126(128199653, -), CAediting_712127(128199926, -), CAediting_712128(128199927, -), CAediting_712129(128199940, -), CAediting_712130(128199953, -), CAediting_712131(128199966, -), CAediting_712132(128199967, -), CAediting_712133(128199968, -), CAediting_712134(128199971, -), CAediting_712135(128199992, -), CAediting_712136(128200002, -), CAediting_712137(128200016, -), CAediting_712138(128200040, -), CAediting_712139(128200048, -), CAediting_712140(128200056, -), CAediting_712141(128200061, -), CAediting_712142(128200068, -), CAediting_712143(128200084, -),

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RNA editing positional annotations for CIZ1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_712048	chr9_128168359_-	ncRNA_intronic
CAediting_712049	chr9_128168394_-	ncRNA_intronic
CAediting_712050	chr9_128168408_-	ncRNA_intronic
CAediting_712051	chr9_128168416_-	ncRNA_intronic
CAediting_712052	chr9_128168423_-	ncRNA_intronic
CAediting_712053	chr9_128170573_-	ncRNA_intronic
CAediting_712054	chr9_128171044_-	ncRNA_intronic
CAediting_712055	chr9_128171313_-	ncRNA_intronic
CAediting_712056	chr9_128171316_-	ncRNA_intronic
CAediting_712057	chr9_128171347_-	ncRNA_intronic
CAediting_712058	chr9_128173038_-	ncRNA_intronic
CAediting_712059	chr9_128173089_-	ncRNA_intronic
CAediting_712060	chr9_128173103_-	ncRNA_intronic
CAediting_712061	chr9_128173762_-	ncRNA_intronic
CAediting_712062	chr9_128174791_-	ncRNA_intronic
CAediting_712063	chr9_128174796_-	ncRNA_intronic
CAediting_712064	chr9_128174815_-	ncRNA_intronic
CAediting_712065	chr9_128184555_-	ncRNA_intronic
CAediting_712066	chr9_128184585_-	ncRNA_intronic
CAediting_712067	chr9_128184792_-	ncRNA_intronic
CAediting_712068	chr9_128184796_-	ncRNA_intronic
CAediting_712069	chr9_128184805_-	ncRNA_intronic
CAediting_712070	chr9_128184832_-	ncRNA_intronic
CAediting_712071	chr9_128184863_-	ncRNA_intronic
CAediting_712072	chr9_128184865_-	ncRNA_intronic
CAediting_712073	chr9_128184887_-	ncRNA_intronic
CAediting_712074	chr9_128184929_-	ncRNA_intronic
CAediting_712075	chr9_128184949_-	ncRNA_intronic
CAediting_712076	chr9_128185259_-	ncRNA_intronic
CAediting_712077	chr9_128188676_-	ncRNA_intronic
CAediting_712078	chr9_128188726_-	ncRNA_intronic
CAediting_712079	chr9_128188757_-	ncRNA_intronic
CAediting_712080	chr9_128188770_-	ncRNA_intronic
CAediting_712081	chr9_128188896_-	ncRNA_intronic
CAediting_712082	chr9_128188923_-	ncRNA_intronic
CAediting_712083	chr9_128190753_-	exonic
CAediting_712084	chr9_128192133_-	intronic
CAediting_712085	chr9_128192142_-	intronic
CAediting_712086	chr9_128192189_-	intronic
CAediting_712087	chr9_128192201_-	intronic
CAediting_712088	chr9_128192203_-	intronic
CAediting_712089	chr9_128192205_-	intronic
CAediting_712090	chr9_128192223_-	intronic
CAediting_712091	chr9_128192232_-	intronic
CAediting_712092	chr9_128192244_-	intronic
CAediting_712093	chr9_128192248_-	intronic
CAediting_712094	chr9_128192258_-	intronic
CAediting_712095	chr9_128192270_-	intronic
CAediting_712096	chr9_128192287_-	intronic
CAediting_712097	chr9_128192288_-	intronic
CAediting_712098	chr9_128192308_-	intronic
CAediting_712099	chr9_128192313_-	intronic
CAediting_712100	chr9_128192318_-	intronic
CAediting_712101	chr9_128192337_-	intronic
CAediting_712102	chr9_128192610_-	intronic
CAediting_712103	chr9_128192615_-	intronic
CAediting_712104	chr9_128192635_-	intronic
CAediting_712105	chr9_128192639_-	intronic
CAediting_712106	chr9_128192645_-	intronic
CAediting_712107	chr9_128192663_-	intronic
CAediting_712108	chr9_128192681_-	intronic
CAediting_712109	chr9_128192707_-	intronic
CAediting_712110	chr9_128192710_-	intronic
CAediting_712111	chr9_128192711_-	intronic
CAediting_712112	chr9_128192712_-	intronic
CAediting_712113	chr9_128192713_-	intronic
CAediting_712114	chr9_128192716_-	intronic
CAediting_712115	chr9_128192720_-	intronic
CAediting_712116	chr9_128192721_-	intronic
CAediting_712117	chr9_128192759_-	intronic
CAediting_712118	chr9_128192767_-	intronic
CAediting_712119	chr9_128192815_-	intronic
CAediting_712120	chr9_128192816_-	intronic
CAediting_712121	chr9_128193531_-	intronic
CAediting_712122	chr9_128196447_-	intronic
CAediting_712123	chr9_128196700_-	intronic
CAediting_712124	chr9_128196701_-	intronic
CAediting_712125	chr9_128196728_-	intronic
CAediting_712126	chr9_128199653_-	intronic
CAediting_712127	chr9_128199926_-	intronic
CAediting_712128	chr9_128199927_-	intronic
CAediting_712129	chr9_128199940_-	intronic
CAediting_712130	chr9_128199953_-	intronic
CAediting_712131	chr9_128199966_-	intronic
CAediting_712132	chr9_128199967_-	intronic
CAediting_712133	chr9_128199968_-	intronic
CAediting_712134	chr9_128199971_-	intronic
CAediting_712135	chr9_128199992_-	intronic
CAediting_712136	chr9_128200002_-	intronic
CAediting_712137	chr9_128200016_-	intronic
CAediting_712138	chr9_128200040_-	intronic
CAediting_712139	chr9_128200048_-	intronic
CAediting_712140	chr9_128200056_-	intronic
CAediting_712141	chr9_128200061_-	intronic
CAediting_712142	chr9_128200068_-	intronic
CAediting_712143	chr9_128200084_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_712048	chr9_128168359_-	SINE	Alu	AluSx1
CAediting_712049	chr9_128168394_-	SINE	Alu	AluSx1
CAediting_712050	chr9_128168408_-	SINE	Alu	AluSx1
CAediting_712051	chr9_128168416_-	SINE	Alu	AluSx1
CAediting_712052	chr9_128168423_-	SINE	Alu	AluSx1
CAediting_712053	chr9_128170573_-	SINE	Alu	AluSx3
CAediting_712054	chr9_128171044_-	SINE	Alu	AluJo
CAediting_712055	chr9_128171313_-	SINE	Alu	AluJb
CAediting_712056	chr9_128171316_-	SINE	Alu	AluJb
CAediting_712057	chr9_128171347_-	SINE	Alu	AluJb
CAediting_712058	chr9_128173038_-	SINE	Alu	AluJr
CAediting_712059	chr9_128173089_-	SINE	Alu	AluJr
CAediting_712060	chr9_128173103_-	SINE	Alu	AluJr
CAediting_712061	chr9_128173762_-	SINE	Alu	AluY
CAediting_712062	chr9_128174791_-	SINE	Alu	AluSx
CAediting_712063	chr9_128174796_-	SINE	Alu	AluSx
CAediting_712064	chr9_128174815_-	SINE	Alu	AluSx
CAediting_712065	chr9_128184555_-	SINE	Alu	AluJr
CAediting_712066	chr9_128184585_-	SINE	Alu	AluJr
CAediting_712067	chr9_128184792_-	SINE	Alu	AluSq2
CAediting_712068	chr9_128184796_-	SINE	Alu	AluSq2
CAediting_712069	chr9_128184805_-	SINE	Alu	AluSq2
CAediting_712070	chr9_128184832_-	SINE	Alu	AluSq2
CAediting_712071	chr9_128184863_-	SINE	Alu	AluSq2
CAediting_712072	chr9_128184865_-	SINE	Alu	AluSq2
CAediting_712073	chr9_128184887_-	SINE	Alu	AluSq2
CAediting_712074	chr9_128184929_-	SINE	Alu	AluSq2
CAediting_712075	chr9_128184949_-	SINE	Alu	AluSq2
CAediting_712076	chr9_128185259_-	SINE	Alu	AluSp
CAediting_712077	chr9_128188676_-	SINE	Alu	AluSz6
CAediting_712078	chr9_128188726_-	SINE	Alu	AluSz6
CAediting_712079	chr9_128188757_-	SINE	Alu	AluSz6
CAediting_712080	chr9_128188770_-	SINE	Alu	AluSz6
CAediting_712081	chr9_128188896_-	SINE	Alu	AluSc
CAediting_712082	chr9_128188923_-	SINE	Alu	AluSc
CAediting_712083	chr9_128190753_-	Simple_repeat	Simple_repeat	(CTG)n
CAediting_712084	chr9_128192133_-	SINE	Alu	AluJb
CAediting_712085	chr9_128192142_-	SINE	Alu	AluJb
CAediting_712086	chr9_128192189_-	SINE	Alu	AluJb
CAediting_712087	chr9_128192201_-	SINE	Alu	AluJb
CAediting_712088	chr9_128192203_-	SINE	Alu	AluJb
CAediting_712089	chr9_128192205_-	SINE	Alu	AluJb
CAediting_712090	chr9_128192223_-	SINE	Alu	AluJb
CAediting_712091	chr9_128192232_-	SINE	Alu	AluJb
CAediting_712092	chr9_128192244_-	SINE	Alu	AluJb
CAediting_712093	chr9_128192248_-	SINE	Alu	AluJb
CAediting_712094	chr9_128192258_-	SINE	Alu	AluJb
CAediting_712095	chr9_128192270_-	SINE	Alu	AluJb
CAediting_712096	chr9_128192287_-	SINE	Alu	AluJb
CAediting_712097	chr9_128192288_-	SINE	Alu	AluJb
CAediting_712098	chr9_128192308_-	SINE	Alu	AluJb
CAediting_712099	chr9_128192313_-	SINE	Alu	AluJb
CAediting_712100	chr9_128192318_-	SINE	Alu	AluJb
CAediting_712101	chr9_128192337_-	SINE	Alu	AluJb
CAediting_712102	chr9_128192610_-	SINE	Alu	AluSz
CAediting_712103	chr9_128192615_-	SINE	Alu	AluSz
CAediting_712104	chr9_128192635_-	SINE	Alu	AluSz
CAediting_712105	chr9_128192639_-	SINE	Alu	AluSz
CAediting_712106	chr9_128192645_-	SINE	Alu	AluSz
CAediting_712107	chr9_128192663_-	SINE	Alu	AluSz
CAediting_712108	chr9_128192681_-	SINE	Alu	AluSz
CAediting_712109	chr9_128192707_-	SINE	Alu	AluSz
CAediting_712110	chr9_128192710_-	SINE	Alu	AluSz
CAediting_712111	chr9_128192711_-	SINE	Alu	AluSz
CAediting_712112	chr9_128192712_-	SINE	Alu	AluSz
CAediting_712113	chr9_128192713_-	SINE	Alu	AluSz
CAediting_712114	chr9_128192716_-	SINE	Alu	AluSz
CAediting_712115	chr9_128192720_-	SINE	Alu	AluSz
CAediting_712116	chr9_128192721_-	SINE	Alu	AluSz
CAediting_712117	chr9_128192759_-	SINE	Alu	AluSz
CAediting_712118	chr9_128192767_-	SINE	Alu	AluSz
CAediting_712119	chr9_128192815_-	SINE	Alu	AluSz
CAediting_712120	chr9_128192816_-	SINE	Alu	AluSz
CAediting_712121	chr9_128193531_-	SINE	Alu	AluSx1
CAediting_712122	chr9_128196447_-	SINE	Alu	AluJb
CAediting_712123	chr9_128196700_-	SINE	Alu	AluSc
CAediting_712124	chr9_128196701_-	SINE	Alu	AluSc
CAediting_712125	chr9_128196728_-	SINE	Alu	AluSc
CAediting_712126	chr9_128199653_-	SINE	Alu	AluJr
CAediting_712127	chr9_128199926_-	SINE	Alu	AluSz
CAediting_712128	chr9_128199927_-	SINE	Alu	AluSz
CAediting_712129	chr9_128199940_-	SINE	Alu	AluSz
CAediting_712130	chr9_128199953_-	SINE	Alu	AluSz
CAediting_712131	chr9_128199966_-	SINE	Alu	AluSz
CAediting_712132	chr9_128199967_-	SINE	Alu	AluSz
CAediting_712133	chr9_128199968_-	SINE	Alu	AluSz
CAediting_712134	chr9_128199971_-	SINE	Alu	AluSz
CAediting_712135	chr9_128199992_-	SINE	Alu	AluSz
CAediting_712136	chr9_128200002_-	SINE	Alu	AluSz
CAediting_712137	chr9_128200016_-	SINE	Alu	AluSz
CAediting_712138	chr9_128200040_-	SINE	Alu	AluSz
CAediting_712139	chr9_128200048_-	SINE	Alu	AluSz
CAediting_712140	chr9_128200056_-	SINE	Alu	AluSz
CAediting_712141	chr9_128200061_-	SINE	Alu	AluSz
CAediting_712142	chr9_128200068_-	SINE	Alu	AluSz
CAediting_712143	chr9_128200084_-	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for CIZ1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000148337.18.CIZ1.

Correlation between RNA A-to-I editing and PSI for ENSG00000148337.18.CIZ1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CIZ1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CIZ1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CIZ1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CIZ1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CIZ1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CIZ1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CIZ1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CIZ1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CIZ1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CIZ1	C0013421	Dystonia	1	CTD_human
CIZ1	C0033578	Prostatic Neoplasms	1	CTD_human
CIZ1	C0376358	Malignant neoplasm of prostate	1	CTD_human
CIZ1	C0393588	Dystonia, Paroxysmal	1	CTD_human
CIZ1	C0393610	Dystonia, Diurnal	1	CTD_human
CIZ1	C0553580	Ewings sarcoma	1	CTD_human
CIZ1	C0751093	Dystonia, Limb	1	CTD_human
CIZ1	C1865818	DYSTONIA 7, TORSION (disorder)	1	CTD_human
CIZ1	C1865819	CERVICAL DYSTONIA, PRIMARY	1	CTD_human
CIZ1	C3538999	DYSTONIA 23	1	GENOMICS_ENGLAND;ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene