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Editing gene: GABRB3 (CAeditome ID:2562)

Gene summary for GABRB3

Gene summary

Gene information	Gene symbol	GABRB3
	Gene ID	2562
	Gene name	gamma-aminobutyric acid type A receptor subunit beta3
	Synonyms	DEE43\|ECA5\|EIEE43
	Cytomap	15q12
	Type of gene	protein-coding
	Description	gamma-aminobutyric acid receptor subunit beta-3GABA-alpha receptor beta-2 subunitGABAA receptor beta-3 subunitgamma-aminobutyric acid (GABA) A receptor, beta 3gamma-aminobutyric acid A receptor beta 3gamma-aminobutyric acid type A receptor beta3 subu
	Modification date	20210518
	UniProtAcc	P28472
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GABRB3	GO:0022851	Gamma-aminobutyric acid receptor subunit beta-3	9039914
GABRB3	GO:0071420	Gamma-aminobutyric acid receptor subunit beta-3	18281286
GABRB3	GO:1902476	Gamma-aminobutyric acid receptor subunit beta-3	9039914
GABRB3	GO:1904862	Gamma-aminobutyric acid receptor subunit beta-3	25489750
GABRB3	GO:0005886	Gamma-aminobutyric acid receptor subunit beta-3	26950270
GABRB3	GO:1902711	Gamma-aminobutyric acid receptor subunit beta-3	26950270
GABRB3	GO:1902711	Gamma-aminobutyric acid receptor subunit beta-3	9039914

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RNA A-to-I events for GABRB3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000166206.12

RNA A-to-I editing events in Cancer.

CAediting_1024913(26543863, -), CAediting_1024914(26547657, -), CAediting_1024915(26558516, -), CAediting_1024916(26558526, -), CAediting_1024917(26558532, -), CAediting_1024918(26558539, -), CAediting_1024919(26558881, -), CAediting_1024920(26558884, -), CAediting_1024921(26558885, -), CAediting_1024922(26558886, -), CAediting_1024923(26558900, -), CAediting_1024924(26558901, -), CAediting_1024925(26558902, -), CAediting_1024926(26558906, -), CAediting_1024927(26558910, -), CAediting_1024928(26558916, -), CAediting_1024929(26558919, -), CAediting_1024930(26558926, -), CAediting_1024931(26558928, -), CAediting_1024932(26558981, -), CAediting_1024933(26558982, -), CAediting_1024934(26558987, -), CAediting_1024935(26559000, -), CAediting_1024936(26559130, -), CAediting_1024937(26559137, -), CAediting_1024938(26559138, -), CAediting_1024939(26559154, -), CAediting_1024940(26559336, -), CAediting_1024941(26559355, -), CAediting_1024942(26559398, -), CAediting_1024943(26559406, -), CAediting_1024944(26559408, -), CAediting_1024945(26559417, -), CAediting_1024946(26559425, -), CAediting_1024947(26559426, -), CAediting_1024948(26559430, -), CAediting_1024949(26559431, -), CAediting_1024950(26559432, -), CAediting_1024951(26559434, -), CAediting_1024952(26559453, -), CAediting_1024953(26559459, -), CAediting_1024954(26559460, -), CAediting_1024955(26559482, -), CAediting_1024956(26594539, -), CAediting_1024957(26594550, -), CAediting_1024958(26612893, -), CAediting_1024959(26690750, -), CAediting_1024960(26846255, -),

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RNA editing positional annotations for GABRB3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1024913	chr15_26543863_-	UTR3
CAediting_1024914	chr15_26547657_-	ncRNA_exonic
CAediting_1024915	chr15_26558516_-	ncRNA_intronic
CAediting_1024916	chr15_26558526_-	ncRNA_intronic
CAediting_1024917	chr15_26558532_-	ncRNA_intronic
CAediting_1024918	chr15_26558539_-	ncRNA_intronic
CAediting_1024919	chr15_26558881_-	ncRNA_intronic
CAediting_1024920	chr15_26558884_-	ncRNA_intronic
CAediting_1024921	chr15_26558885_-	ncRNA_intronic
CAediting_1024922	chr15_26558886_-	ncRNA_intronic
CAediting_1024923	chr15_26558900_-	ncRNA_intronic
CAediting_1024924	chr15_26558901_-	ncRNA_intronic
CAediting_1024925	chr15_26558902_-	ncRNA_intronic
CAediting_1024926	chr15_26558906_-	ncRNA_intronic
CAediting_1024927	chr15_26558910_-	ncRNA_intronic
CAediting_1024928	chr15_26558916_-	ncRNA_intronic
CAediting_1024929	chr15_26558919_-	ncRNA_intronic
CAediting_1024930	chr15_26558926_-	ncRNA_intronic
CAediting_1024931	chr15_26558928_-	ncRNA_intronic
CAediting_1024932	chr15_26558981_-	ncRNA_intronic
CAediting_1024933	chr15_26558982_-	ncRNA_intronic
CAediting_1024934	chr15_26558987_-	ncRNA_intronic
CAediting_1024935	chr15_26559000_-	ncRNA_intronic
CAediting_1024936	chr15_26559130_-	ncRNA_intronic
CAediting_1024937	chr15_26559137_-	ncRNA_intronic
CAediting_1024938	chr15_26559138_-	ncRNA_intronic
CAediting_1024939	chr15_26559154_-	ncRNA_intronic
CAediting_1024940	chr15_26559336_-	ncRNA_intronic
CAediting_1024941	chr15_26559355_-	ncRNA_intronic
CAediting_1024942	chr15_26559398_-	ncRNA_intronic
CAediting_1024943	chr15_26559406_-	ncRNA_intronic
CAediting_1024944	chr15_26559408_-	ncRNA_intronic
CAediting_1024945	chr15_26559417_-	ncRNA_intronic
CAediting_1024946	chr15_26559425_-	ncRNA_intronic
CAediting_1024947	chr15_26559426_-	ncRNA_intronic
CAediting_1024948	chr15_26559430_-	ncRNA_intronic
CAediting_1024949	chr15_26559431_-	ncRNA_intronic
CAediting_1024950	chr15_26559432_-	ncRNA_intronic
CAediting_1024951	chr15_26559434_-	ncRNA_intronic
CAediting_1024952	chr15_26559453_-	ncRNA_intronic
CAediting_1024953	chr15_26559459_-	ncRNA_intronic
CAediting_1024954	chr15_26559460_-	ncRNA_intronic
CAediting_1024955	chr15_26559482_-	ncRNA_intronic
CAediting_1024956	chr15_26594539_-	ncRNA_intronic
CAediting_1024957	chr15_26594550_-	ncRNA_intronic
CAediting_1024958	chr15_26612893_-	ncRNA_exonic
CAediting_1024959	chr15_26690750_-	ncRNA_intronic
CAediting_1024960	chr15_26846255_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1024915	chr15_26558516_-	LTR	ERVL-MaLR	MSTA
CAediting_1024916	chr15_26558526_-	LTR	ERVL-MaLR	MSTA
CAediting_1024917	chr15_26558532_-	LTR	ERVL-MaLR	MSTA
CAediting_1024918	chr15_26558539_-	LTR	ERVL-MaLR	MSTA
CAediting_1024919	chr15_26558881_-	LTR	ERVL-MaLR	MSTA
CAediting_1024920	chr15_26558884_-	LTR	ERVL-MaLR	MSTA
CAediting_1024921	chr15_26558885_-	LTR	ERVL-MaLR	MSTA
CAediting_1024922	chr15_26558886_-	LTR	ERVL-MaLR	MSTA
CAediting_1024923	chr15_26558900_-	LTR	ERVL-MaLR	MSTA
CAediting_1024924	chr15_26558901_-	LTR	ERVL-MaLR	MSTA
CAediting_1024925	chr15_26558902_-	LTR	ERVL-MaLR	MSTA
CAediting_1024926	chr15_26558906_-	LTR	ERVL-MaLR	MSTA
CAediting_1024927	chr15_26558910_-	LTR	ERVL-MaLR	MSTA
CAediting_1024928	chr15_26558916_-	LTR	ERVL-MaLR	MSTA
CAediting_1024929	chr15_26558919_-	LTR	ERVL-MaLR	MSTA
CAediting_1024930	chr15_26558926_-	LTR	ERVL-MaLR	MSTA
CAediting_1024931	chr15_26558928_-	LTR	ERVL-MaLR	MSTA
CAediting_1024932	chr15_26558981_-	LTR	ERVL-MaLR	MSTA
CAediting_1024933	chr15_26558982_-	LTR	ERVL-MaLR	MSTA
CAediting_1024934	chr15_26558987_-	LTR	ERVL-MaLR	MSTA
CAediting_1024935	chr15_26559000_-	LTR	ERVL-MaLR	MSTA
CAediting_1024936	chr15_26559130_-	LTR	ERVL-MaLR	MSTA
CAediting_1024937	chr15_26559137_-	LTR	ERVL-MaLR	MSTA
CAediting_1024938	chr15_26559138_-	LTR	ERVL-MaLR	MSTA
CAediting_1024939	chr15_26559154_-	LTR	ERVL-MaLR	MSTA
CAediting_1024940	chr15_26559336_-	LTR	ERVL-MaLR	MSTA
CAediting_1024941	chr15_26559355_-	LTR	ERVL-MaLR	MSTA
CAediting_1024942	chr15_26559398_-	LTR	ERVL-MaLR	MSTA
CAediting_1024943	chr15_26559406_-	LTR	ERVL-MaLR	MSTA
CAediting_1024944	chr15_26559408_-	LTR	ERVL-MaLR	MSTA
CAediting_1024945	chr15_26559417_-	LTR	ERVL-MaLR	MSTA
CAediting_1024946	chr15_26559425_-	LTR	ERVL-MaLR	MSTA
CAediting_1024947	chr15_26559426_-	LTR	ERVL-MaLR	MSTA
CAediting_1024948	chr15_26559430_-	LTR	ERVL-MaLR	MSTA
CAediting_1024949	chr15_26559431_-	LTR	ERVL-MaLR	MSTA
CAediting_1024950	chr15_26559432_-	LTR	ERVL-MaLR	MSTA
CAediting_1024951	chr15_26559434_-	LTR	ERVL-MaLR	MSTA
CAediting_1024952	chr15_26559453_-	LTR	ERVL-MaLR	MSTA
CAediting_1024953	chr15_26559459_-	LTR	ERVL-MaLR	MSTA
CAediting_1024954	chr15_26559460_-	LTR	ERVL-MaLR	MSTA
CAediting_1024955	chr15_26559482_-	LTR	ERVL-MaLR	MSTA
CAediting_1024956	chr15_26594539_-	SINE	Alu	AluJo
CAediting_1024957	chr15_26594550_-	SINE	Alu	AluJo
CAediting_1024958	chr15_26612893_-	SINE	Alu	AluJr4
CAediting_1024960	chr15_26846255_-	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for GABRB3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000166206.12.GABRB3.

Correlation between RNA A-to-I editing and PSI for ENSG00000166206.12.GABRB3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GABRB3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

PRAD.CAediting_1024945.ENSG00000166206.GABRB3.png
Soverview

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Protein coding region RNA A-to-I editings for GABRB3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GABRB3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000628124	hsa-miR-5582-5p	26543858	26543864	7mer-m8	26543857	26543878	145.00	-17.40
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000628124	hsa-miR-602	26543862	26543868	7mer-m8	26543861	26543884	151.00	-19.51
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000622697	hsa-miR-5582-5p	26543858	26543864	7mer-m8	26543857	26543878	145.00	-17.40
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000622697	hsa-miR-602	26543862	26543868	7mer-m8	26543861	26543884	151.00	-19.51
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000541819	hsa-miR-5582-5p	26543858	26543864	7mer-m8	26543857	26543878	145.00	-17.40
CAediting_1024913	chr15_26543863_-	ENSG00000166206.12	ENST00000541819	hsa-miR-602	26543862	26543868	7mer-m8	26543861	26543884	151.00	-19.51
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000628124	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000628124	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000628124	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000622697	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000622697	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000622697	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000541819	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000541819	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000541819	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000299267	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000299267	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000299267	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000400188	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000400188	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000400188	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000555632	hsa-miR-377-3p	26547651	26547658	8mer-1a	26547651	26547674	147.00	-12.28
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000555632	hsa-miR-4643	26547654	26547659	6mer	26547653	26547674	143.00	-10.98
CAediting_1024914	chr15_26547657_-	ENSG00000166206.12	ENST00000555632	hsa-miR-4789-3p	26547654	26547660	7mer-m8	26547653	26547676	150.00	-18.33

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000628124	hsa-miR-27a-3p	26545265	26545271	7mer-m8	26545264	26545287	160	-18.09
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000622697	hsa-miR-27a-3p	26545265	26545271	7mer-m8	26545264	26545287	160	-18.09
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000541819	hsa-miR-27a-3p	26545265	26545271	7mer-m8	26545264	26545287	160	-18.09
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000299267	hsa-miR-27a-3p	26545265	26545271	7mer-m8	26545264	26545287	160	-18.09
CAediting_748296	chr10_51299626_+	ENSG00000166206.12	ENST00000555632	hsa-miR-605-3p	26567582	26567588	7mer-m8	26567581	26567603	144	-20.08
CAediting_748296	chr10_51299626_+	ENSG00000166206.12	ENST00000555632	hsa-miR-605-3p	26567655	26567661	7mer-m8	26567654	26567674	162	-21.5
CAediting_748296	chr10_51299626_+	ENSG00000166206.12	ENST00000554556	hsa-miR-605-3p	26567582	26567588	7mer-m8	26567581	26567603	144	-20.08
CAediting_748296	chr10_51299626_+	ENSG00000166206.12	ENST00000554556	hsa-miR-605-3p	26567655	26567661	7mer-m8	26567654	26567674	162	-21.5
CAediting_1054808	chr15_66496985_-	ENSG00000166206.12	ENST00000628124	hsa-miR-4512	26546072	26546079	8mer-1a	26546072	26546095	154	-18.27
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000628124	hsa-miR-548aa	26545774	26545780	7mer-m8	26545773	26545797	148	-13.55
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000628124	hsa-miR-195-3p	26546805	26546811	7mer-m8	26546804	26546825	141	-9.43
CAediting_1351755	chr19_40282625_-	ENSG00000166206.12	ENST00000628124	hsa-miR-641	26543812	26543818	7mer-1a	26543805	26543829	152	-18.76
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000628124	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_1399425	chr20_1392958_-	ENSG00000166206.12	ENST00000628124	hsa-miR-6869-5p	26544702	26544707	6mer	26544701	26544722	142	-21.57
CAediting_1054808	chr15_66496985_-	ENSG00000166206.12	ENST00000622697	hsa-miR-4512	26546072	26546079	8mer-1a	26546072	26546095	154	-18.27
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000622697	hsa-miR-548aa	26545774	26545780	7mer-m8	26545773	26545797	148	-13.55
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000622697	hsa-miR-195-3p	26546805	26546811	7mer-m8	26546804	26546825	141	-9.43
CAediting_1351755	chr19_40282625_-	ENSG00000166206.12	ENST00000622697	hsa-miR-641	26543812	26543818	7mer-1a	26543805	26543829	152	-18.76
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000622697	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_1399425	chr20_1392958_-	ENSG00000166206.12	ENST00000622697	hsa-miR-6869-5p	26544702	26544707	6mer	26544701	26544722	142	-21.57
CAediting_1054808	chr15_66496985_-	ENSG00000166206.12	ENST00000541819	hsa-miR-4512	26546072	26546079	8mer-1a	26546072	26546095	154	-18.27
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000541819	hsa-miR-548aa	26545774	26545780	7mer-m8	26545773	26545797	148	-13.55
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000541819	hsa-miR-195-3p	26546805	26546811	7mer-m8	26546804	26546825	141	-9.43
CAediting_1351755	chr19_40282625_-	ENSG00000166206.12	ENST00000541819	hsa-miR-641	26543812	26543818	7mer-1a	26543805	26543829	152	-18.76
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000541819	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_1399425	chr20_1392958_-	ENSG00000166206.12	ENST00000541819	hsa-miR-6869-5p	26544702	26544707	6mer	26544701	26544722	142	-21.57
CAediting_1054808	chr15_66496985_-	ENSG00000166206.12	ENST00000299267	hsa-miR-4512	26546072	26546079	8mer-1a	26546072	26546095	154	-18.27
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000299267	hsa-miR-548aa	26545774	26545780	7mer-m8	26545773	26545797	148	-13.55
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000299267	hsa-miR-195-3p	26546805	26546811	7mer-m8	26546804	26546825	141	-9.43
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000299267	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000400188	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000555632	hsa-miR-195-3p	26580432	26580438	7mer-1a	26580432	26580453	150	-17.45
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000555632	hsa-miR-195-3p	26567686	26567692	7mer-m8	26567685	26567705	146	-17.09
CAediting_77128	chr1_85133844_+	ENSG00000166206.12	ENST00000555632	hsa-miR-4423-3p	26547571	26547577	7mer-m8	26547570	26547590	140	-14.18
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000554556	hsa-miR-195-3p	26580432	26580438	7mer-1a	26580432	26580453	150	-17.45
CAediting_1160181	chr17_7017644_-	ENSG00000166206.12	ENST00000554556	hsa-miR-195-3p	26567686	26567692	7mer-m8	26567685	26567705	146	-17.09
CAediting_524911	chr7_5495852_-	ENSG00000166206.12	ENST00000556636	hsa-miR-589-3p	26615344	26615350	7mer-m8	26615343	26615362	144	-21.79

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000166206.12	ENST00000628124	hsa-miR-200b-3p	26546407	26546413	7mer-m8	26546406	26546427	140	-10.67
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000628124	hsa-miR-27a-3p	26545486	26545492	7mer-m8	26545485	26545504	146	-11.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000628124	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000628124	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000628124	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000628124	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_228905	chr2_188297554_+	ENSG00000166206.12	ENST00000628124	hsa-miR-561-3p	26545156	26545162	7mer-m8	26545155	26545176	140	-3.7
CAediting_393	chr1_1167164_+	ENSG00000166206.12	ENST00000622697	hsa-miR-200b-3p	26546407	26546413	7mer-m8	26546406	26546427	140	-10.67
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000622697	hsa-miR-27a-3p	26545486	26545492	7mer-m8	26545485	26545504	146	-11.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000622697	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000622697	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000622697	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000622697	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_228905	chr2_188297554_+	ENSG00000166206.12	ENST00000622697	hsa-miR-561-3p	26545156	26545162	7mer-m8	26545155	26545176	140	-3.7
CAediting_393	chr1_1167164_+	ENSG00000166206.12	ENST00000541819	hsa-miR-200b-3p	26546407	26546413	7mer-m8	26546406	26546427	140	-10.67
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000541819	hsa-miR-27a-3p	26545486	26545492	7mer-m8	26545485	26545504	146	-11.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000541819	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000541819	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000541819	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000541819	hsa-miR-548aa	26544316	26544323	8mer-1a	26544316	26544345	152	-11.26
CAediting_228905	chr2_188297554_+	ENSG00000166206.12	ENST00000541819	hsa-miR-561-3p	26545156	26545162	7mer-m8	26545155	26545176	140	-3.7
CAediting_393	chr1_1167164_+	ENSG00000166206.12	ENST00000299267	hsa-miR-200b-3p	26546407	26546413	7mer-m8	26546406	26546427	140	-10.67
CAediting_1306324	chr19_13836464_-	ENSG00000166206.12	ENST00000299267	hsa-miR-27a-3p	26545486	26545492	7mer-m8	26545485	26545504	146	-11.28
CAediting_1229413	chr17_67471544_+	ENSG00000166206.12	ENST00000299267	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_1229415	chr17_67471547_+	ENSG00000166206.12	ENST00000299267	hsa-miR-548aa	26545812	26545819	8mer-1a	26545812	26545836	142	-5.28
CAediting_228905	chr2_188297554_+	ENSG00000166206.12	ENST00000299267	hsa-miR-561-3p	26545156	26545162	7mer-m8	26545155	26545176	140	-3.7

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GABRB3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GABRB3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for GABRB3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GABRB3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GABRB3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GABRB3	P28472	DB00186	Lorazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB00292	Etomidate	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB00543	Amoxapine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB00842	Oxazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB00898	Ethanol	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB01189	Desflurane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB01205	Flumazenil	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB01587	Ketazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB01595	Nitrazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB09118	Stiripentol	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB13872	Lormetazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved
GABRB3	P28472	DB00237	Butabarbital	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00241	Butalbital	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00306	Talbutal	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00349	Clobazam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00371	Meprobamate	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00628	Clorazepic acid	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00683	Midazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01068	Clonazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01215	Estazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01437	Glutethimide	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01544	Flunitrazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01559	Clotiazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01588	Prazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB01589	Quazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit
GABRB3	P28472	DB00404	Alprazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational
GABRB3	P28472	DB00475	Chlordiazepoxide	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational
GABRB3	P28472	DB00690	Flurazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational
GABRB3	P28472	DB01558	Bromazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational
GABRB3	P28472	DB06716	Fospropofol	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational
GABRB3	P28472	DB00829	Diazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|investigational\|vet_approved
GABRB3	P28472	DB00189	Ethchlorvynol	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|withdrawn
GABRB3	P28472	DB00801	Halazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|withdrawn
GABRB3	P28472	DB01107	Methyprylon	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|illicit\|withdrawn
GABRB3	P28472	DB00231	Temazepam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB00402	Eszopiclone	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB00555	Lamotrigine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB00603	Medroxyprogesterone acetate	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB00659	Acamprosate	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB00897	Triazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB01043	Memantine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB11859	Brexanolone	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB11901	Apalutamide	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB12404	Remimazolam	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB12537	Benzodiazepine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational
GABRB3	P28472	DB01708	Prasterone	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|nutraceutical
GABRB3	P28472	DB00228	Enflurane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|vet_approved
GABRB3	P28472	DB00312	Pentobarbital	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|vet_approved
GABRB3	P28472	DB00602	Ivermectin	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|vet_approved
GABRB3	P28472	DB00818	Propofol	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|vet_approved
GABRB3	P28472	DB01028	Methoxyflurane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|investigational\|vet_approved
GABRB3	P28472	DB01956	Taurine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|nutraceutical
GABRB3	P28472	DB00252	Phenytoin	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB00592	Piperazine	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB00753	Isoflurane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB00794	Primidone	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB01159	Halothane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB01236	Sevoflurane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|vet_approved
GABRB3	P28472	DB00431	Lindane	Gamma-aminobutyric acid receptor subunit beta-3	SmallMoleculeDrug	approved\|withdrawn

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RelatedDiseases for GABRB3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GABRB3	C4310712	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 43	6	CTD_human;UNIPROT
GABRB3	C0011570	Mental Depression	5	PSYGENET
GABRB3	C0011581	Depressive disorder	5	PSYGENET
GABRB3	C0001973	Alcoholic Intoxication, Chronic	4	PSYGENET
GABRB3	C2677087	EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 5	3	GENOMICS_ENGLAND;UNIPROT
GABRB3	C0004352	Autistic Disorder	2	CTD_human
GABRB3	C0005586	Bipolar Disorder	2	PSYGENET
GABRB3	C0014544	Epilepsy	2	CTD_human
GABRB3	C0036341	Schizophrenia	2	PSYGENET
GABRB3	C0086237	Epilepsy, Cryptogenic	2	CTD_human
GABRB3	C0236018	Aura	2	CTD_human
GABRB3	C0238111	Lennox-Gastaut syndrome	2	ORPHANET
GABRB3	C0751111	Awakening Epilepsy	2	CTD_human
GABRB3	C0001890	Akinetic Petit Mal	1	CTD_human
GABRB3	C0014553	Absence Epilepsy	1	CTD_human
GABRB3	C0021603	Sleep Initiation and Maintenance Disorders	1	CTD_human
GABRB3	C0033139	Primary Insomnia	1	CTD_human
GABRB3	C0162635	Angelman Syndrome	1	CTD_human
GABRB3	C0270541	Rebound Insomnia	1	CTD_human
GABRB3	C0349255	Nonorganic Insomnia	1	CTD_human
GABRB3	C0376634	Craniofacial Abnormalities	1	CTD_human
GABRB3	C0393759	Transient Insomnia	1	CTD_human
GABRB3	C0541798	Early Awakening	1	CTD_human
GABRB3	C0751124	Epilepsy, Absence, Atypical	1	CTD_human
GABRB3	C0751249	Chronic Insomnia	1	CTD_human
GABRB3	C0751250	Psychophysiological Insomnia	1	CTD_human
GABRB3	C0751251	Secondary Insomnia	1	CTD_human
GABRB3	C0751252	Sleep Initiation Dysfunction	1	CTD_human
GABRB3	C0917801	Sleeplessness	1	CTD_human
GABRB3	C1510586	Autism Spectrum Disorders	1	CTD_human
GABRB3	C1535926	Neurodevelopmental Disorders	1	CTD_human
GABRB3	C1838604	EPILEPSY, CHILDHOOD ABSENCE, 1	1	ORPHANET
GABRB3	C3711376	Isodicentric Chromosome 15 Syndrome	1	CTD_human
GABRB3	C4281785	Childhood Absence Epilepsy	1	CTD_human
GABRB3	C4317339	Juvenile Absence Epilepsy	1	CTD_human
GABRB3	C4552765	Epilepsy, Minor	1	CTD_human
GABRB3	C4553705	Absence Seizure Disorder	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene