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Editing gene: LCORL (CAeditome ID:254251)

Gene summary for LCORL

Gene summary

Gene information	Gene symbol	LCORL
	Gene ID	254251
	Gene name	ligand dependent nuclear receptor corepressor like
	Synonyms	MLR1
	Cytomap	4p15.31
	Type of gene	protein-coding
	Description	ligand-dependent nuclear receptor corepressor-like proteinLCOR-like proteinMBLK1-related proteintranscription factor MLR1
	Modification date	20210519
	UniProtAcc	Q8N3X6
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for LCORL

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000178177.13

RNA A-to-I editing events in Cancer.

CAediting_351599(17891289, -), CAediting_351600(17891293, -), CAediting_351601(17891345, -), CAediting_351602(17896278, -), CAediting_351603(17896360, -), CAediting_351604(17917060, -), CAediting_351605(17921231, -), CAediting_351606(17921300, -), CAediting_351607(17928296, -), CAediting_351608(17928304, -), CAediting_351609(17928317, -), CAediting_351610(17938091, -), CAediting_351611(17938143, -), CAediting_351612(17938477, -), CAediting_351613(17938484, -), CAediting_351614(17938493, -), CAediting_351615(17938502, -), CAediting_351616(17938554, -), CAediting_351617(17938555, -), CAediting_351618(17938589, -), CAediting_351619(17938619, -), CAediting_351620(17938692, -), CAediting_351621(17940059, -), CAediting_351622(17940083, -), CAediting_351623(17940085, -), CAediting_351624(17940087, -), CAediting_351625(17940093, -), CAediting_351626(17940125, -), CAediting_351627(17941120, -), CAediting_351628(17941431, -), CAediting_351629(17952553, -), CAediting_351630(17952554, -), CAediting_351631(17952580, -), CAediting_351632(17954041, -), CAediting_351633(17978545, -), CAediting_351634(17988472, -), CAediting_351635(17988907, -), CAediting_351636(17990237, -), CAediting_351637(17998753, -), CAediting_351638(18019256, -), CAediting_351639(18019287, -),

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RNA editing positional annotations for LCORL using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_351599	chr4_17891289_-	ncRNA_intronic
CAediting_351600	chr4_17891293_-	ncRNA_intronic
CAediting_351601	chr4_17891345_-	ncRNA_intronic
CAediting_351602	chr4_17896278_-	ncRNA_intronic
CAediting_351603	chr4_17896360_-	ncRNA_intronic
CAediting_351604	chr4_17917060_-	ncRNA_intronic
CAediting_351605	chr4_17921231_-	ncRNA_intronic
CAediting_351606	chr4_17921300_-	ncRNA_intronic
CAediting_351607	chr4_17928296_-	ncRNA_intronic
CAediting_351608	chr4_17928304_-	ncRNA_intronic
CAediting_351609	chr4_17928317_-	ncRNA_intronic
CAediting_351610	chr4_17938091_-	ncRNA_intronic
CAediting_351611	chr4_17938143_-	ncRNA_intronic
CAediting_351612	chr4_17938477_-	ncRNA_intronic
CAediting_351613	chr4_17938484_-	ncRNA_intronic
CAediting_351614	chr4_17938493_-	ncRNA_intronic
CAediting_351615	chr4_17938502_-	ncRNA_intronic
CAediting_351616	chr4_17938554_-	ncRNA_intronic
CAediting_351617	chr4_17938555_-	ncRNA_intronic
CAediting_351618	chr4_17938589_-	ncRNA_intronic
CAediting_351619	chr4_17938619_-	ncRNA_intronic
CAediting_351620	chr4_17938692_-	ncRNA_intronic
CAediting_351621	chr4_17940059_-	ncRNA_intronic
CAediting_351622	chr4_17940083_-	ncRNA_intronic
CAediting_351623	chr4_17940085_-	ncRNA_intronic
CAediting_351624	chr4_17940087_-	ncRNA_intronic
CAediting_351625	chr4_17940093_-	ncRNA_intronic
CAediting_351626	chr4_17940125_-	ncRNA_intronic
CAediting_351627	chr4_17941120_-	ncRNA_intronic
CAediting_351628	chr4_17941431_-	ncRNA_intronic
CAediting_351629	chr4_17952553_-	ncRNA_intronic
CAediting_351630	chr4_17952554_-	ncRNA_intronic
CAediting_351631	chr4_17952580_-	ncRNA_intronic
CAediting_351632	chr4_17954041_-	ncRNA_intronic
CAediting_351633	chr4_17978545_-	ncRNA_intronic
CAediting_351634	chr4_17988472_-	ncRNA_intronic
CAediting_351635	chr4_17988907_-	ncRNA_intronic
CAediting_351636	chr4_17990237_-	ncRNA_intronic
CAediting_351637	chr4_17998753_-	ncRNA_intronic
CAediting_351638	chr4_18019256_-	ncRNA_intronic
CAediting_351639	chr4_18019287_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_351599	chr4_17891289_-	SINE	Alu	AluJb
CAediting_351600	chr4_17891293_-	SINE	Alu	AluJb
CAediting_351601	chr4_17891345_-	SINE	Alu	AluJb
CAediting_351602	chr4_17896278_-	Simple_repeat	Simple_repeat	(TTCT)n
CAediting_351603	chr4_17896360_-	SINE	Alu	AluSq2
CAediting_351604	chr4_17917060_-	SINE	Alu	AluSx
CAediting_351605	chr4_17921231_-	SINE	Alu	AluSx3
CAediting_351606	chr4_17921300_-	SINE	Alu	AluSx3
CAediting_351607	chr4_17928296_-	SINE	Alu	AluJb
CAediting_351608	chr4_17928304_-	SINE	Alu	AluJb
CAediting_351609	chr4_17928317_-	SINE	Alu	AluJb
CAediting_351610	chr4_17938091_-	SINE	Alu	AluSp
CAediting_351611	chr4_17938143_-	SINE	Alu	AluSp
CAediting_351612	chr4_17938477_-	SINE	Alu	AluSp
CAediting_351613	chr4_17938484_-	SINE	Alu	AluSp
CAediting_351614	chr4_17938493_-	SINE	Alu	AluSp
CAediting_351615	chr4_17938502_-	SINE	Alu	AluSp
CAediting_351616	chr4_17938554_-	SINE	Alu	AluSp
CAediting_351617	chr4_17938555_-	SINE	Alu	AluSp
CAediting_351618	chr4_17938589_-	SINE	Alu	AluSp
CAediting_351619	chr4_17938619_-	SINE	Alu	AluSp
CAediting_351620	chr4_17938692_-	SINE	Alu	AluSp
CAediting_351621	chr4_17940059_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351622	chr4_17940083_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351623	chr4_17940085_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351624	chr4_17940087_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351625	chr4_17940093_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351626	chr4_17940125_-	Simple_repeat	Simple_repeat	(AT)n
CAediting_351627	chr4_17941120_-	SINE	Alu	AluY
CAediting_351628	chr4_17941431_-	SINE	Alu	AluY
CAediting_351629	chr4_17952553_-	SINE	Alu	AluY
CAediting_351630	chr4_17952554_-	SINE	Alu	AluY
CAediting_351631	chr4_17952580_-	SINE	Alu	AluY
CAediting_351632	chr4_17954041_-	SINE	Alu	AluY
CAediting_351633	chr4_17978545_-	SINE	Alu	AluJr
CAediting_351634	chr4_17988472_-	SINE	Alu	AluJo
CAediting_351635	chr4_17988907_-	SINE	Alu	AluSz
CAediting_351636	chr4_17990237_-	SINE	Alu	AluY
CAediting_351637	chr4_17998753_-	SINE	Alu	AluJb
CAediting_351638	chr4_18019256_-	SINE	Alu	AluSx1
CAediting_351639	chr4_18019287_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for LCORL

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000178177.13.LCORL.

Correlation between RNA A-to-I editing and PSI for ENSG00000178177.13.LCORL.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LCORL

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LCORL

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LCORL

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000178177.13	ENST00000326877	hsa-miR-4477b	17844061	17844067	7mer-m8	17844060	17844081	141	-12.73
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382224	hsa-miR-200b-3p	17881521	17881527	7mer-m8	17881520	17881541	160	-13.59
CAediting_688080	chr9_63819626_+	ENSG00000178177.13	ENST00000382224	hsa-miR-4477b	17881182	17881188	7mer-m8	17881181	17881202	155	-13.07
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382226	hsa-miR-200b-3p	17881521	17881527	7mer-m8	17881520	17881541	160	-13.59
CAediting_688080	chr9_63819626_+	ENSG00000178177.13	ENST00000382226	hsa-miR-4477b	17881182	17881188	7mer-m8	17881181	17881202	155	-13.07
CAediting_1229414	chr17_67471546_+	ENSG00000178177.13	ENST00000326877	hsa-miR-548aa	17843910	17843916	7mer-m8	17843909	17843934	161	-11.59
CAediting_1054808	chr15_66496985_-	ENSG00000178177.13	ENST00000510451	hsa-miR-4512	17909140	17909146	7mer-m8	17909139	17909160	152	-24.58
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382224	hsa-miR-561-3p	17880950	17880956	7mer-m8	17880949	17880973	144	-13.59
CAediting_396018	chr5_1062918_-	ENSG00000178177.13	ENST00000382224	hsa-miR-4635	17881181	17881187	7mer-m8	17881180	17881200	140	-13.4
CAediting_414656	chr5_72878640_+	ENSG00000178177.13	ENST00000382224	hsa-miR-4804-3p	17883254	17883261	8mer-1a	17883254	17883274	142	-14.43
CAediting_573001	chr7_92204086_-	ENSG00000178177.13	ENST00000382224	hsa-miR-1285-5p	17881038	17881044	7mer-m8	17881037	17881058	146	-16.5
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382226	hsa-miR-561-3p	17880950	17880956	7mer-m8	17880949	17880973	144	-13.59
CAediting_396018	chr5_1062918_-	ENSG00000178177.13	ENST00000382226	hsa-miR-4635	17881181	17881187	7mer-m8	17881180	17881200	140	-13.4
CAediting_414656	chr5_72878640_+	ENSG00000178177.13	ENST00000382226	hsa-miR-4804-3p	17883254	17883261	8mer-1a	17883254	17883274	142	-14.43
CAediting_573001	chr7_92204086_-	ENSG00000178177.13	ENST00000382226	hsa-miR-1285-5p	17881038	17881044	7mer-m8	17881037	17881058	146	-16.5

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000326877	hsa-miR-200b-3p	17845677	17845683	7mer-m8	17845676	17845696	150	-7.69
CAediting_117844	chr1_162342605_+	ENSG00000178177.13	ENST00000326877	hsa-miR-556-3p	17841850	17841857	8mer-1a	17841850	17841868	150	-7.69
CAediting_1351755	chr19_40282625_-	ENSG00000178177.13	ENST00000326877	hsa-miR-641	17842220	17842225	6mer	17842219	17842242	146	-20.07
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000510451	hsa-miR-200b-3p	17845677	17845683	7mer-m8	17845676	17845696	150	-7.69
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382224	hsa-miR-200b-3p	17880980	17880986	7mer-m8	17880979	17880999	149	-9.39
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382224	hsa-miR-200b-3p	17883195	17883202	8mer-1a	17883195	17883215	154	-10.48
CAediting_1229414	chr17_67471546_+	ENSG00000178177.13	ENST00000382224	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_1229415	chr17_67471547_+	ENSG00000178177.13	ENST00000382224	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_1229413	chr17_67471544_+	ENSG00000178177.13	ENST00000382224	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_117844	chr1_162342605_+	ENSG00000178177.13	ENST00000382224	hsa-miR-556-3p	17881542	17881548	7mer-m8	17881541	17881562	148	-10.63
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382224	hsa-miR-561-3p	17881767	17881773	7mer-m8	17881766	17881787	140	-12.57
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382224	hsa-miR-561-3p	17881609	17881616	8mer-1a	17881609	17881630	146	-3.61
CAediting_980496	chr14_31014685_-	ENSG00000178177.13	ENST00000382224	hsa-miR-624-3p	17882216	17882222	7mer-m8	17882215	17882235	149	-10.53
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382226	hsa-miR-200b-3p	17880980	17880986	7mer-m8	17880979	17880999	149	-9.39
CAediting_393	chr1_1167164_+	ENSG00000178177.13	ENST00000382226	hsa-miR-200b-3p	17883195	17883202	8mer-1a	17883195	17883215	154	-10.48
CAediting_1229414	chr17_67471546_+	ENSG00000178177.13	ENST00000382226	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_1229415	chr17_67471547_+	ENSG00000178177.13	ENST00000382226	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_1229413	chr17_67471544_+	ENSG00000178177.13	ENST00000382226	hsa-miR-548aa	17883435	17883440	6mer	17883434	17883456	144	-14.95
CAediting_117844	chr1_162342605_+	ENSG00000178177.13	ENST00000382226	hsa-miR-556-3p	17881542	17881548	7mer-m8	17881541	17881562	148	-10.63
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382226	hsa-miR-561-3p	17881767	17881773	7mer-m8	17881766	17881787	140	-12.57
CAediting_228905	chr2_188297554_+	ENSG00000178177.13	ENST00000382226	hsa-miR-561-3p	17881609	17881616	8mer-1a	17881609	17881630	146	-3.61
CAediting_980496	chr14_31014685_-	ENSG00000178177.13	ENST00000382226	hsa-miR-624-3p	17882216	17882222	7mer-m8	17882215	17882235	149	-10.53

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LCORL

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for LCORL

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for LCORL

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for LCORL

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for LCORL

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LCORL

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
LCORL	C0005612	Birth Weight	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene