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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: IPMK (CAeditome ID:253430)

Gene summary for IPMK

check button Gene summary
Gene informationGene symbol

IPMK

Gene ID

253430

Gene nameinositol polyphosphate multikinase
Synonyms-
Cytomap

10q21.1

Type of geneprotein-coding
Descriptioninositol polyphosphate multikinaseinositol 1,3,4,6-tetrakisphosphate 5-kinase
Modification date20210518
UniProtAcc

Q8NFU5

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
IPMK

GO:0008440

Inositol polyphosphate multikinase

30624931

IPMK

GO:0097243

Inositol polyphosphate multikinase

30624931

IPMK

GO:0032957

Inositol polyphosphate multikinase

30624931

IPMK

GO:0005654

Inositol polyphosphate multikinase

0000052


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RNA A-to-I events for IPMK

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000151151.5

check button RNA A-to-I editing events in Cancer.
CAediting_748903(58202510, -), CAediting_748904(58202517, -), CAediting_748905(58202557, -), CAediting_748906(58202613, -), CAediting_748907(58203441, -), CAediting_748908(58203445, -), CAediting_748909(58204198, -), CAediting_748910(58204754, -), CAediting_748911(58205716, -), CAediting_748912(58205735, -), CAediting_748913(58205755, -), CAediting_748914(58205770, -), CAediting_748915(58206701, -), CAediting_748916(58206725, -), CAediting_748917(58206751, -), CAediting_748918(58206827, -), CAediting_748919(58211329, -), CAediting_748920(58215511, -), CAediting_748921(58216894, -), CAediting_748922(58216919, -), CAediting_748923(58216959, -), CAediting_748924(58217013, -), CAediting_748925(58217026, -), CAediting_748926(58217028, -), CAediting_748927(58217031, -), CAediting_748928(58217037, -), CAediting_748929(58217042, -), CAediting_748930(58217044, -), CAediting_748931(58217045, -), CAediting_748932(58217062, -), CAediting_748933(58217076, -), CAediting_748934(58217081, -), CAediting_748935(58217091, -), CAediting_748936(58217105, -), CAediting_748937(58217113, -), CAediting_748938(58217121, -), CAediting_748939(58217122, -), CAediting_748940(58217128, -), CAediting_748941(58217472, -), CAediting_748942(58217523, -), CAediting_748943(58217566, -), CAediting_748944(58217588, -), CAediting_748945(58221635, -), CAediting_748946(58236134, -), CAediting_748947(58236149, -), CAediting_748948(58237000, -), CAediting_748949(58238974, -), CAediting_748950(58239054, -), CAediting_748951(58248871, -), CAediting_748952(58249478, -), CAediting_748953(58249764, -), CAediting_748954(58250131, -), CAediting_748955(58250132, -), CAediting_748956(58250742, -), CAediting_748957(58252665, -), CAediting_748958(58252667, -), CAediting_748959(58252709, -), CAediting_748960(58252710, -), CAediting_748961(58252715, -), CAediting_748962(58252737, -), CAediting_748963(58252750, -), CAediting_748964(58252751, -), CAediting_748965(58252772, -), CAediting_748966(58252794, -), CAediting_748967(58252800, -), CAediting_748968(58252805, -), CAediting_748969(58252879, -), CAediting_748970(58252884, -), CAediting_748971(58252885, -), CAediting_748972(58252901, -), CAediting_748973(58253472, -), CAediting_748974(58253478, -), CAediting_748975(58253485, -), CAediting_748976(58253546, -), CAediting_748977(58253638, -), CAediting_748978(58259653, -), CAediting_748979(58259757, -),

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RNA editing positional annotations for IPMK using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_748903chr10_58202510_-intronic
CAediting_748904chr10_58202517_-intronic
CAediting_748905chr10_58202557_-intronic
CAediting_748906chr10_58202613_-intronic
CAediting_748907chr10_58203441_-intronic
CAediting_748908chr10_58203445_-intronic
CAediting_748909chr10_58204198_-intronic
CAediting_748910chr10_58204754_-intronic
CAediting_748911chr10_58205716_-intronic
CAediting_748912chr10_58205735_-intronic
CAediting_748913chr10_58205755_-intronic
CAediting_748914chr10_58205770_-intronic
CAediting_748915chr10_58206701_-intronic
CAediting_748916chr10_58206725_-intronic
CAediting_748917chr10_58206751_-intronic
CAediting_748918chr10_58206827_-intronic
CAediting_748919chr10_58211329_-intronic
CAediting_748920chr10_58215511_-intronic
CAediting_748921chr10_58216894_-intronic
CAediting_748922chr10_58216919_-intronic
CAediting_748923chr10_58216959_-intronic
CAediting_748924chr10_58217013_-intronic
CAediting_748925chr10_58217026_-intronic
CAediting_748926chr10_58217028_-intronic
CAediting_748927chr10_58217031_-intronic
CAediting_748928chr10_58217037_-intronic
CAediting_748929chr10_58217042_-intronic
CAediting_748930chr10_58217044_-intronic
CAediting_748931chr10_58217045_-intronic
CAediting_748932chr10_58217062_-intronic
CAediting_748933chr10_58217076_-intronic
CAediting_748934chr10_58217081_-intronic
CAediting_748935chr10_58217091_-intronic
CAediting_748936chr10_58217105_-intronic
CAediting_748937chr10_58217113_-intronic
CAediting_748938chr10_58217121_-intronic
CAediting_748939chr10_58217122_-intronic
CAediting_748940chr10_58217128_-intronic
CAediting_748941chr10_58217472_-intronic
CAediting_748942chr10_58217523_-intronic
CAediting_748943chr10_58217566_-intronic
CAediting_748944chr10_58217588_-intronic
CAediting_748945chr10_58221635_-intronic
CAediting_748946chr10_58236134_-intronic
CAediting_748947chr10_58236149_-intronic
CAediting_748948chr10_58237000_-intronic
CAediting_748949chr10_58238974_-intronic
CAediting_748950chr10_58239054_-intronic
CAediting_748951chr10_58248871_-intronic
CAediting_748952chr10_58249478_-intronic
CAediting_748953chr10_58249764_-intronic
CAediting_748954chr10_58250131_-intronic
CAediting_748955chr10_58250132_-intronic
CAediting_748956chr10_58250742_-intronic
CAediting_748957chr10_58252665_-intronic
CAediting_748958chr10_58252667_-intronic
CAediting_748959chr10_58252709_-intronic
CAediting_748960chr10_58252710_-intronic
CAediting_748961chr10_58252715_-intronic
CAediting_748962chr10_58252737_-intronic
CAediting_748963chr10_58252750_-intronic
CAediting_748964chr10_58252751_-intronic
CAediting_748965chr10_58252772_-intronic
CAediting_748966chr10_58252794_-intronic
CAediting_748967chr10_58252800_-intronic
CAediting_748968chr10_58252805_-intronic
CAediting_748969chr10_58252879_-intronic
CAediting_748970chr10_58252884_-intronic
CAediting_748971chr10_58252885_-intronic
CAediting_748972chr10_58252901_-intronic
CAediting_748973chr10_58253472_-intronic
CAediting_748974chr10_58253478_-intronic
CAediting_748975chr10_58253485_-intronic
CAediting_748976chr10_58253546_-intronic
CAediting_748977chr10_58253638_-intronic
CAediting_748978chr10_58259653_-intronic
CAediting_748979chr10_58259757_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_748903chr10_58202510_-SINEAluAluJr
CAediting_748904chr10_58202517_-SINEAluAluJr
CAediting_748905chr10_58202557_-SINEAluAluJr
CAediting_748906chr10_58202613_-SINEAluAluJr
CAediting_748907chr10_58203441_-SINEAluAluJb
CAediting_748908chr10_58203445_-SINEAluAluJb
CAediting_748909chr10_58204198_-SINEAluAluJo
CAediting_748910chr10_58204754_-SINEAluAluJo
CAediting_748911chr10_58205716_-LINEL1L1PB3
CAediting_748912chr10_58205735_-LINEL1L1PB3
CAediting_748913chr10_58205755_-LINEL1L1PB3
CAediting_748914chr10_58205770_-LINEL1L1PB3
CAediting_748915chr10_58206701_-LINEL1L1PB2
CAediting_748916chr10_58206725_-LINEL1L1PB2
CAediting_748917chr10_58206751_-LINEL1L1PB2
CAediting_748918chr10_58206827_-LINEL1L1PB2
CAediting_748919chr10_58211329_-SINEAluAluSx
CAediting_748920chr10_58215511_-SINEAluAluJb
CAediting_748921chr10_58216894_-SINEAluAluSz6
CAediting_748922chr10_58216919_-SINEAluAluSz6
CAediting_748923chr10_58216959_-SINEAluAluSz6
CAediting_748924chr10_58217013_-SINEAluAluSz6
CAediting_748925chr10_58217026_-SINEAluAluSz6
CAediting_748926chr10_58217028_-SINEAluAluSz6
CAediting_748927chr10_58217031_-SINEAluAluSz6
CAediting_748928chr10_58217037_-SINEAluAluSz6
CAediting_748929chr10_58217042_-SINEAluAluSz6
CAediting_748930chr10_58217044_-SINEAluAluSz6
CAediting_748931chr10_58217045_-SINEAluAluSz6
CAediting_748932chr10_58217062_-SINEAluAluSz6
CAediting_748933chr10_58217076_-SINEAluAluSz6
CAediting_748934chr10_58217081_-SINEAluAluSz6
CAediting_748935chr10_58217091_-SINEAluAluSz6
CAediting_748936chr10_58217105_-SINEAluAluSz6
CAediting_748937chr10_58217113_-SINEAluAluSz6
CAediting_748938chr10_58217121_-SINEAluAluSz6
CAediting_748939chr10_58217122_-SINEAluAluSz6
CAediting_748940chr10_58217128_-SINEAluAluSz6
CAediting_748941chr10_58217472_-SINEAluAluSp
CAediting_748942chr10_58217523_-SINEAluAluSp
CAediting_748943chr10_58217566_-SINEAluAluSp
CAediting_748944chr10_58217588_-SINEAluAluSp
CAediting_748945chr10_58221635_-SINEAluAluJr
CAediting_748946chr10_58236134_-SINEAluAluSz
CAediting_748947chr10_58236149_-SINEAluAluSz
CAediting_748948chr10_58237000_-SINEAluAluJb
CAediting_748949chr10_58238974_-SINEAluAluJr
CAediting_748950chr10_58239054_-SINEAluAluJr
CAediting_748951chr10_58248871_-LINEL1L1MA4
CAediting_748952chr10_58249478_-LINEL1L1MA4
CAediting_748953chr10_58249764_-LINEL1L1MA4
CAediting_748954chr10_58250131_-LINEL1L1MA4
CAediting_748955chr10_58250132_-LINEL1L1MA4
CAediting_748956chr10_58250742_-LINEL1L1MA4
CAediting_748957chr10_58252665_-SINEAluAluSx1
CAediting_748958chr10_58252667_-SINEAluAluSx1
CAediting_748959chr10_58252709_-SINEAluAluSx1
CAediting_748960chr10_58252710_-SINEAluAluSx1
CAediting_748961chr10_58252715_-SINEAluAluSx1
CAediting_748962chr10_58252737_-SINEAluAluSx1
CAediting_748963chr10_58252750_-SINEAluAluSx1
CAediting_748964chr10_58252751_-SINEAluAluSx1
CAediting_748965chr10_58252772_-SINEAluAluSx1
CAediting_748966chr10_58252794_-SINEAluAluSx1
CAediting_748967chr10_58252800_-SINEAluAluSx1
CAediting_748968chr10_58252805_-SINEAluAluSx1
CAediting_748969chr10_58252879_-SINEAluAluSx1
CAediting_748970chr10_58252884_-SINEAluAluSx1
CAediting_748971chr10_58252885_-SINEAluAluSx1
CAediting_748972chr10_58252901_-SINEAluAluSx1
CAediting_748973chr10_58253472_-SINEAluAluSx3
CAediting_748974chr10_58253478_-SINEAluAluSx3
CAediting_748975chr10_58253485_-SINEAluAluSx3
CAediting_748976chr10_58253546_-SINEAluAluSx3
CAediting_748977chr10_58253638_-SINEAluAluSx3
CAediting_748978chr10_58259653_-SINEAluAluJb
CAediting_748979chr10_58259757_-SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for IPMK

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000151151.5.IPMK.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000151151.5.IPMK.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IPMK

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for IPMK

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for IPMK

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000151151.5ENST00000373935hsa-miR-200b-3p58192608581926147mer-m85819260758192630145-12.08
CAediting_688080chr9_63819626_+ENSG00000151151.5ENST00000373935hsa-miR-4477b58194979581949868mer-1a5819497958195000148-12.34
CAediting_86358chr1_109598906_+ENSG00000151151.5ENST00000373935hsa-miR-197-5p58195728581957358mer-1a5819572858195750153-22.96
CAediting_228905chr2_188297554_+ENSG00000151151.5ENST00000373935hsa-miR-561-3p58194514581945207mer-1a5819451458194536146-10.55

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000151151.5ENST00000373935hsa-miR-200b-3p58193380581933867mer-m85819337958193400154-8.79
CAediting_393chr1_1167164_+ENSG00000151151.5ENST00000373935hsa-miR-200b-3p58192470581924767mer-m85819246958192490148-9.48
CAediting_414656chr5_72878640_+ENSG00000151151.5ENST00000373935hsa-miR-4804-3p58195850581958578mer-1a5819585058195870149-12.07
CAediting_1351755chr19_40282625_-ENSG00000151151.5ENST00000373935hsa-miR-64158194045581940528mer-1a5819404558194068145-10.89
CAediting_1351755chr19_40282625_-ENSG00000151151.5ENST00000373935hsa-miR-64158191715581917217mer-m85819171458191736146-11.11

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IPMK

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for IPMK

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for IPMK

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for IPMK

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for IPMK

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IPMK

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource