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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SHPK (CAeditome ID:23729)

Gene summary for SHPK

check button Gene summary
Gene informationGene symbol

SHPK

Gene ID

23729

Gene namesedoheptulokinase
SynonymsCARKL|SHK
Cytomap

17p13.2

Type of geneprotein-coding
Descriptionsedoheptulokinasecarbohydrate kinase-like protein
Modification date20210518
UniProtAcc

Q9UHJ6

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SHPK

GO:0050277

Sedoheptulokinase

19413330

SHPK

GO:0005975

Sedoheptulokinase

19413330

SHPK

GO:0016310

Sedoheptulokinase

19413330

SHPK

GO:0071222

Sedoheptulokinase

22682222


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RNA A-to-I events for SHPK

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000197417.7

check button RNA A-to-I editing events in Cancer.
CAediting_1154843(3608906, -), CAediting_1154844(3608907, -), CAediting_1154845(3608919, -), CAediting_1154846(3608921, -), CAediting_1154847(3608922, -), CAediting_1154848(3608939, -), CAediting_1154849(3608949, -), CAediting_1154850(3608957, -), CAediting_1154851(3608959, -), CAediting_1154852(3608964, -), CAediting_1154853(3608968, -), CAediting_1154854(3608977, -), CAediting_1154855(3608981, -), CAediting_1154856(3608988, -), CAediting_1154857(3608989, -), CAediting_1154858(3608994, -), CAediting_1154859(3608997, -), CAediting_1154860(3608998, -), CAediting_1154861(3608999, -), CAediting_1154862(3609003, -), CAediting_1154863(3609013, -), CAediting_1154864(3609016, -), CAediting_1154865(3609020, -), CAediting_1154866(3609024, -), CAediting_1154867(3609029, -), CAediting_1154868(3609030, -), CAediting_1154869(3609062, -), CAediting_1154870(3609065, -), CAediting_1154871(3609089, -), CAediting_1154872(3609093, -), CAediting_1154873(3609099, -), CAediting_1154874(3609102, -), CAediting_1154875(3609104, -), CAediting_1154876(3609105, -), CAediting_1154877(3609113, -), CAediting_1154878(3609118, -), CAediting_1154879(3609123, -), CAediting_1154880(3609127, -), CAediting_1154881(3609135, -), CAediting_1154882(3609136, -), CAediting_1154883(3609141, -), CAediting_1154884(3609142, -), CAediting_1154885(3609150, -), CAediting_1154886(3609153, -), CAediting_1154887(3609159, -), CAediting_1154888(3609177, -), CAediting_1154889(3611457, -), CAediting_1154890(3611469, -), CAediting_1154891(3615920, -), CAediting_1154892(3615922, -), CAediting_1154893(3615952, -), CAediting_1154894(3615965, -), CAediting_1154895(3615991, -), CAediting_1154896(3615992, -), CAediting_1154897(3615998, -), CAediting_1154898(3616005, -), CAediting_1154899(3616014, -), CAediting_1154900(3616018, -), CAediting_1154901(3616022, -), CAediting_1154902(3616026, -), CAediting_1154903(3616047, -), CAediting_1154904(3616057, -), CAediting_1154905(3616124, -), CAediting_1154906(3616125, -), CAediting_1154907(3616131, -), CAediting_1154908(3616840, -), CAediting_1154909(3616849, -), CAediting_1154910(3617036, -), CAediting_1154911(3617075, -), CAediting_1154912(3617136, -), CAediting_1154913(3618174, -), CAediting_1154914(3618179, -), CAediting_1154915(3618189, -), CAediting_1154916(3618192, -), CAediting_1154917(3618199, -), CAediting_1154918(3618326, -), CAediting_1154919(3618384, -), CAediting_1154920(3618525, -), CAediting_1154921(3618537, -), CAediting_1154922(3618658, -), CAediting_1154923(3618663, -), CAediting_1154924(3618671, -), CAediting_1154925(3619476, -), CAediting_1154926(3619478, -), CAediting_1154927(3619490, -), CAediting_1154928(3619650, -), CAediting_1154929(3620435, -), CAediting_1154930(3620627, -), CAediting_1154931(3620698, -), CAediting_1154932(3624726, -), CAediting_1154933(3631651, -), CAediting_1154934(3631660, -), CAediting_1154935(3633064, -), CAediting_1154936(3633116, -), CAediting_1154937(3633156, -), CAediting_1154938(3633157, -),

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RNA editing positional annotations for SHPK using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1154843chr17_3608906_-UTR3
CAediting_1154844chr17_3608907_-UTR3
CAediting_1154845chr17_3608919_-UTR3
CAediting_1154846chr17_3608921_-UTR3
CAediting_1154847chr17_3608922_-UTR3
CAediting_1154848chr17_3608939_-UTR3
CAediting_1154849chr17_3608949_-UTR3
CAediting_1154850chr17_3608957_-UTR3
CAediting_1154851chr17_3608959_-UTR3
CAediting_1154852chr17_3608964_-UTR3
CAediting_1154853chr17_3608968_-UTR3
CAediting_1154854chr17_3608977_-UTR3
CAediting_1154855chr17_3608981_-UTR3
CAediting_1154856chr17_3608988_-UTR3
CAediting_1154857chr17_3608989_-UTR3
CAediting_1154858chr17_3608994_-UTR3
CAediting_1154859chr17_3608997_-UTR3
CAediting_1154860chr17_3608998_-UTR3
CAediting_1154861chr17_3608999_-UTR3
CAediting_1154862chr17_3609003_-UTR3
CAediting_1154863chr17_3609013_-UTR3
CAediting_1154864chr17_3609016_-UTR3
CAediting_1154865chr17_3609020_-UTR3
CAediting_1154866chr17_3609024_-UTR3
CAediting_1154867chr17_3609029_-UTR3
CAediting_1154868chr17_3609030_-UTR3
CAediting_1154869chr17_3609062_-UTR3
CAediting_1154870chr17_3609065_-UTR3
CAediting_1154871chr17_3609089_-UTR3
CAediting_1154872chr17_3609093_-UTR3
CAediting_1154873chr17_3609099_-UTR3
CAediting_1154874chr17_3609102_-UTR3
CAediting_1154875chr17_3609104_-UTR3
CAediting_1154876chr17_3609105_-UTR3
CAediting_1154877chr17_3609113_-UTR3
CAediting_1154878chr17_3609118_-UTR3
CAediting_1154879chr17_3609123_-UTR3
CAediting_1154880chr17_3609127_-UTR3
CAediting_1154881chr17_3609135_-UTR3
CAediting_1154882chr17_3609136_-UTR3
CAediting_1154883chr17_3609141_-UTR3
CAediting_1154884chr17_3609142_-UTR3
CAediting_1154885chr17_3609150_-UTR3
CAediting_1154886chr17_3609153_-UTR3
CAediting_1154887chr17_3609159_-UTR3
CAediting_1154888chr17_3609177_-UTR3
CAediting_1154889chr17_3611457_-intronic
CAediting_1154890chr17_3611469_-intronic
CAediting_1154891chr17_3615920_-intronic
CAediting_1154892chr17_3615922_-intronic
CAediting_1154893chr17_3615952_-intronic
CAediting_1154894chr17_3615965_-intronic
CAediting_1154895chr17_3615991_-intronic
CAediting_1154896chr17_3615992_-intronic
CAediting_1154897chr17_3615998_-intronic
CAediting_1154898chr17_3616005_-intronic
CAediting_1154899chr17_3616014_-intronic
CAediting_1154900chr17_3616018_-intronic
CAediting_1154901chr17_3616022_-intronic
CAediting_1154902chr17_3616026_-intronic
CAediting_1154903chr17_3616047_-intronic
CAediting_1154904chr17_3616057_-intronic
CAediting_1154905chr17_3616124_-intronic
CAediting_1154906chr17_3616125_-intronic
CAediting_1154907chr17_3616131_-intronic
CAediting_1154908chr17_3616840_-intronic
CAediting_1154909chr17_3616849_-intronic
CAediting_1154910chr17_3617036_-intronic
CAediting_1154911chr17_3617075_-intronic
CAediting_1154912chr17_3617136_-intronic
CAediting_1154913chr17_3618174_-intronic
CAediting_1154914chr17_3618179_-intronic
CAediting_1154915chr17_3618189_-intronic
CAediting_1154916chr17_3618192_-intronic
CAediting_1154917chr17_3618199_-intronic
CAediting_1154918chr17_3618326_-intronic
CAediting_1154919chr17_3618384_-intronic
CAediting_1154920chr17_3618525_-intronic
CAediting_1154921chr17_3618537_-intronic
CAediting_1154922chr17_3618658_-intronic
CAediting_1154923chr17_3618663_-intronic
CAediting_1154924chr17_3618671_-intronic
CAediting_1154925chr17_3619476_-ncRNA_intronic
CAediting_1154926chr17_3619478_-ncRNA_intronic
CAediting_1154927chr17_3619490_-ncRNA_intronic
CAediting_1154928chr17_3619650_-ncRNA_intronic
CAediting_1154929chr17_3620435_-intronic
CAediting_1154930chr17_3620627_-intronic
CAediting_1154931chr17_3620698_-intronic
CAediting_1154932chr17_3624726_-intronic
CAediting_1154933chr17_3631651_-intronic
CAediting_1154934chr17_3631660_-intronic
CAediting_1154935chr17_3633064_-intronic
CAediting_1154936chr17_3633116_-intronic
CAediting_1154937chr17_3633156_-intronic
CAediting_1154938chr17_3633157_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1154843chr17_3608906_-SINEAluAluSx
CAediting_1154844chr17_3608907_-SINEAluAluSx
CAediting_1154845chr17_3608919_-SINEAluAluSx
CAediting_1154846chr17_3608921_-SINEAluAluSx
CAediting_1154847chr17_3608922_-SINEAluAluSx
CAediting_1154848chr17_3608939_-SINEAluAluSx
CAediting_1154849chr17_3608949_-SINEAluAluSx
CAediting_1154850chr17_3608957_-SINEAluAluSx
CAediting_1154851chr17_3608959_-SINEAluAluSx
CAediting_1154852chr17_3608964_-SINEAluAluSx
CAediting_1154853chr17_3608968_-SINEAluAluSx
CAediting_1154854chr17_3608977_-SINEAluAluSx
CAediting_1154855chr17_3608981_-SINEAluAluSx
CAediting_1154856chr17_3608988_-SINEAluAluSx
CAediting_1154857chr17_3608989_-SINEAluAluSx
CAediting_1154858chr17_3608994_-SINEAluAluSx
CAediting_1154859chr17_3608997_-SINEAluAluSx
CAediting_1154860chr17_3608998_-SINEAluAluSx
CAediting_1154861chr17_3608999_-SINEAluAluSx
CAediting_1154862chr17_3609003_-SINEAluAluSx
CAediting_1154863chr17_3609013_-SINEAluAluSx
CAediting_1154864chr17_3609016_-SINEAluAluSx
CAediting_1154865chr17_3609020_-SINEAluAluSx
CAediting_1154866chr17_3609024_-SINEAluAluSx
CAediting_1154867chr17_3609029_-SINEAluAluSx
CAediting_1154868chr17_3609030_-SINEAluAluSx
CAediting_1154869chr17_3609062_-SINEAluAluSx
CAediting_1154870chr17_3609065_-SINEAluAluSx
CAediting_1154871chr17_3609089_-SINEAluAluSx
CAediting_1154872chr17_3609093_-SINEAluAluSx
CAediting_1154873chr17_3609099_-SINEAluAluSx
CAediting_1154874chr17_3609102_-SINEAluAluSx
CAediting_1154875chr17_3609104_-SINEAluAluSx
CAediting_1154876chr17_3609105_-SINEAluAluSx
CAediting_1154877chr17_3609113_-SINEAluAluSx
CAediting_1154878chr17_3609118_-SINEAluAluSx
CAediting_1154879chr17_3609123_-SINEAluAluSx
CAediting_1154880chr17_3609127_-SINEAluAluSx
CAediting_1154881chr17_3609135_-SINEAluAluSx
CAediting_1154882chr17_3609136_-SINEAluAluSx
CAediting_1154883chr17_3609141_-SINEAluAluSx
CAediting_1154884chr17_3609142_-SINEAluAluSx
CAediting_1154885chr17_3609150_-SINEAluAluSx
CAediting_1154886chr17_3609153_-SINEAluAluSx
CAediting_1154887chr17_3609159_-SINEAluAluSx
CAediting_1154888chr17_3609177_-SINEAluAluSx
CAediting_1154889chr17_3611457_-SINEAluAluSq
CAediting_1154890chr17_3611469_-SINEAluAluSq
CAediting_1154891chr17_3615920_-SINEAluAluSg7
CAediting_1154892chr17_3615922_-SINEAluAluSg7
CAediting_1154893chr17_3615952_-SINEAluAluSg7
CAediting_1154894chr17_3615965_-SINEAluAluSg7
CAediting_1154895chr17_3615991_-SINEAluAluSg7
CAediting_1154896chr17_3615992_-SINEAluAluSg7
CAediting_1154897chr17_3615998_-SINEAluAluSg7
CAediting_1154898chr17_3616005_-SINEAluAluSg7
CAediting_1154899chr17_3616014_-SINEAluAluSg7
CAediting_1154900chr17_3616018_-SINEAluAluSg7
CAediting_1154901chr17_3616022_-SINEAluAluSg7
CAediting_1154902chr17_3616026_-SINEAluAluSg7
CAediting_1154903chr17_3616047_-SINEAluAluSg7
CAediting_1154904chr17_3616057_-SINEAluAluSg7
CAediting_1154905chr17_3616124_-SINEAluAluSg7
CAediting_1154906chr17_3616125_-SINEAluAluSg7
CAediting_1154907chr17_3616131_-SINEAluAluSg7
CAediting_1154908chr17_3616840_-SINEAluAluSx3
CAediting_1154909chr17_3616849_-SINEAluAluSx3
CAediting_1154910chr17_3617036_-SINEAluAluSz
CAediting_1154911chr17_3617075_-SINEAluAluSz
CAediting_1154912chr17_3617136_-SINEAluAluSz
CAediting_1154913chr17_3618174_-SINEAluAluSg7
CAediting_1154914chr17_3618179_-SINEAluAluSg7
CAediting_1154915chr17_3618189_-SINEAluAluSg7
CAediting_1154916chr17_3618192_-SINEAluAluSg7
CAediting_1154917chr17_3618199_-SINEAluAluSg7
CAediting_1154918chr17_3618326_-SINEAluAluSg7
CAediting_1154919chr17_3618384_-SINEAluAluSg7
CAediting_1154920chr17_3618525_-SINEAluAluSc
CAediting_1154921chr17_3618537_-SINEAluAluSc
CAediting_1154922chr17_3618658_-SINEAluAluSc
CAediting_1154923chr17_3618663_-SINEAluAluSc
CAediting_1154924chr17_3618671_-SINEAluAluSc
CAediting_1154925chr17_3619476_-SINEAluAluSc
CAediting_1154926chr17_3619478_-SINEAluAluSc
CAediting_1154927chr17_3619490_-SINEAluAluSc
CAediting_1154928chr17_3619650_-SINEAluAluSc
CAediting_1154929chr17_3620435_-SINEAluAluY
CAediting_1154930chr17_3620627_-SINEAluAluSg7
CAediting_1154931chr17_3620698_-SINEAluAluSg7
CAediting_1154932chr17_3624726_-SINEAluAluSx3
CAediting_1154933chr17_3631651_-SINEAluAluSx
CAediting_1154934chr17_3631660_-SINEAluAluSx
CAediting_1154935chr17_3633064_-SINEAluAluSz
CAediting_1154936chr17_3633116_-SINEAluAluSz
CAediting_1154937chr17_3633156_-SINEAluAluSz
CAediting_1154938chr17_3633157_-SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for SHPK

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000197417.7.SHPK.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000197417.7.SHPK.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SHPK

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SHPK

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SHPK

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SHPK

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SHPK

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for SHPK

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for SHPK

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SHPK

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHPK

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SHPKC1291373Deficiency of sedoheptulokinase2GENOMICS_ENGLAND;ORPHANET