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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TARDBP (CAeditome ID:23435)

Gene summary for TARDBP

check button Gene summary
Gene informationGene symbol

TARDBP

Gene ID

23435

Gene nameTAR DNA binding protein
SynonymsALS10|TDP-43
Cytomap

1p36.22

Type of geneprotein-coding
DescriptionTAR DNA-binding protein 43TAR DNA-binding protein-43
Modification date20210524
UniProtAcc

Q13148

.

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TARDBP

GO:0003690

TAR DNA-binding protein 43

7745706

TARDBP

GO:0003723

TAR DNA-binding protein 43

11285240

TARDBP

GO:0003730

TAR DNA-binding protein 43

17481916

TARDBP

GO:0008380

TAR DNA-binding protein 43

11285240

TARDBP

GO:0043922

TAR DNA-binding protein 43

7745706

TARDBP

GO:0061158

TAR DNA-binding protein 43

28335005

TARDBP

GO:0070935

TAR DNA-binding protein 43

17481916

TARDBP

GO:0005634

TAR DNA-binding protein 43

0000054

TARDBP

GO:0005634

TAR DNA-binding protein 43

11285240

TARDBP

GO:0005634

TAR DNA-binding protein 43

17481916

TARDBP

GO:0005634

TAR DNA-binding protein 43

25678563

TARDBP

GO:0005654

TAR DNA-binding protein 43

0000052


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RNA A-to-I events for TARDBP

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000120948.14
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_12443(11015013, +), CAediting_12444(11015046, +), CAediting_12445(11015582, +), CAediting_12446(11016216, +), CAediting_12447(11017121, +), CAediting_12448(11017342, +), CAediting_12449(11017463, +), CAediting_12450(11017475, +), CAediting_12451(11017792, +), CAediting_12452(11017793, +), CAediting_12453(11018424, +), CAediting_12454(11018451, +), CAediting_12455(11019636, +), CAediting_12456(11020645, +), CAediting_12457(11020653, +), CAediting_12458(11020662, +), CAediting_12459(11020669, +), CAediting_12460(11020704, +), CAediting_12461(11020720, +), CAediting_12462(11020728, +), CAediting_12463(11020729, +), CAediting_12464(11020730, +), CAediting_12465(11020754, +), CAediting_12466(11020761, +), CAediting_12467(11020762, +), CAediting_12468(11020764, +), CAediting_12469(11020767, +), CAediting_12470(11020785, +), CAediting_12471(11020799, +), CAediting_12472(11020803, +), CAediting_12473(11020816, +), CAediting_12474(11020820, +), CAediting_12475(11020825, +), CAediting_12476(11020834, +), CAediting_12477(11020835, +), CAediting_12478(11020839, +), CAediting_12479(11020842, +), CAediting_12480(11020848, +), CAediting_12481(11020859, +), CAediting_12482(11020860, +), CAediting_12483(11020866, +), CAediting_12484(11020869, +), CAediting_12485(11020871, +), CAediting_12486(11020879, +), CAediting_12487(11020915, +), CAediting_12488(11021195, +), CAediting_12489(11021203, +), CAediting_12490(11021218, +), CAediting_12491(11021225, +), CAediting_12492(11021238, +), CAediting_12493(11021239, +), CAediting_12494(11021256, +), CAediting_12495(11021265, +), CAediting_12496(11021268, +), CAediting_12497(11021275, +), CAediting_12498(11021278, +), CAediting_12499(11021280, +), CAediting_12500(11021294, +), CAediting_12501(11021305, +), CAediting_12502(11021321, +), CAediting_12503(11021324, +), CAediting_12504(11021326, +), CAediting_12505(11021350, +), CAediting_12506(11021363, +), CAediting_12507(11021393, +), CAediting_12508(11021402, +), CAediting_12509(11021403, +), CAediting_12510(11021415, +), CAediting_12511(11021417, +), CAediting_12512(11021424, +), CAediting_12513(11021457, +), CAediting_12514(11021462, +), CAediting_12515(11021475, +), CAediting_12516(11021484, +), CAediting_12517(11021500, +), CAediting_12518(11021507, +), CAediting_12519(11021512, +), CAediting_12520(11021517, +), CAediting_12521(11021521, +), CAediting_12522(11021530, +), CAediting_12523(11021539, +), CAediting_12524(11021540, +), CAediting_12525(11021552, +), CAediting_12526(11021554, +), CAediting_12527(11021592, +), CAediting_12528(11021606, +), CAediting_12529(11021608, +), CAediting_12530(11021610, +), CAediting_12531(11021618, +), CAediting_12532(11021630, +), CAediting_12533(11021653, +), CAediting_12534(11021654, +), CAediting_12535(11021659, +), CAediting_12536(11021664, +), CAediting_12537(11021667, +), CAediting_12538(11021674, +), CAediting_12539(11021712, +), CAediting_12540(11021718, +), CAediting_12541(11021727, +), CAediting_12542(11021730, +), CAediting_12543(11021734, +), CAediting_12544(11021737, +), CAediting_12545(11021745, +), CAediting_12546(11021750, +), CAediting_12547(11021753, +), CAediting_12548(11021790, +), CAediting_12549(11021792, +), CAediting_12550(11021794, +), CAediting_12551(11021818, +), CAediting_12552(11021826, +), CAediting_12553(11021831, +), CAediting_12554(11021855, +), CAediting_12555(11021877, +), CAediting_12556(11021878, +), CAediting_12557(11021879, +), CAediting_12558(11021893, +), CAediting_12559(11021897, +), CAediting_12560(11021900, +), CAediting_12561(11026305, +),

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RNA editing positional annotations for TARDBP using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_12443chr1_11015013_+ncRNA_intronic
CAediting_12444chr1_11015046_+ncRNA_intronic
CAediting_12445chr1_11015582_+exonic
CAediting_12446chr1_11016216_+ncRNA_intronic
CAediting_12447chr1_11017121_+ncRNA_intronic
CAediting_12448chr1_11017342_+ncRNA_intronic
CAediting_12449chr1_11017463_+ncRNA_intronic
CAediting_12450chr1_11017475_+ncRNA_intronic
CAediting_12451chr1_11017792_+ncRNA_intronic
CAediting_12452chr1_11017793_+ncRNA_intronic
CAediting_12453chr1_11018424_+ncRNA_exonic
CAediting_12454chr1_11018451_+ncRNA_exonic
CAediting_12455chr1_11019636_+intronic
CAediting_12456chr1_11020645_+intronic
CAediting_12457chr1_11020653_+intronic
CAediting_12458chr1_11020662_+intronic
CAediting_12459chr1_11020669_+intronic
CAediting_12460chr1_11020704_+intronic
CAediting_12461chr1_11020720_+intronic
CAediting_12462chr1_11020728_+intronic
CAediting_12463chr1_11020729_+intronic
CAediting_12464chr1_11020730_+intronic
CAediting_12465chr1_11020754_+intronic
CAediting_12466chr1_11020761_+intronic
CAediting_12467chr1_11020762_+intronic
CAediting_12468chr1_11020764_+intronic
CAediting_12469chr1_11020767_+intronic
CAediting_12470chr1_11020785_+intronic
CAediting_12471chr1_11020799_+intronic
CAediting_12472chr1_11020803_+intronic
CAediting_12473chr1_11020816_+intronic
CAediting_12474chr1_11020820_+intronic
CAediting_12475chr1_11020825_+intronic
CAediting_12476chr1_11020834_+intronic
CAediting_12477chr1_11020835_+intronic
CAediting_12478chr1_11020839_+intronic
CAediting_12479chr1_11020842_+intronic
CAediting_12480chr1_11020848_+intronic
CAediting_12481chr1_11020859_+intronic
CAediting_12482chr1_11020860_+intronic
CAediting_12483chr1_11020866_+intronic
CAediting_12484chr1_11020869_+intronic
CAediting_12485chr1_11020871_+intronic
CAediting_12486chr1_11020879_+intronic
CAediting_12487chr1_11020915_+intronic
CAediting_12488chr1_11021195_+intronic
CAediting_12489chr1_11021203_+intronic
CAediting_12490chr1_11021218_+intronic
CAediting_12491chr1_11021225_+intronic
CAediting_12492chr1_11021238_+intronic
CAediting_12493chr1_11021239_+intronic
CAediting_12494chr1_11021256_+intronic
CAediting_12495chr1_11021265_+intronic
CAediting_12496chr1_11021268_+intronic
CAediting_12497chr1_11021275_+intronic
CAediting_12498chr1_11021278_+intronic
CAediting_12499chr1_11021280_+intronic
CAediting_12500chr1_11021294_+intronic
CAediting_12501chr1_11021305_+intronic
CAediting_12502chr1_11021321_+intronic
CAediting_12503chr1_11021324_+intronic
CAediting_12504chr1_11021326_+intronic
CAediting_12505chr1_11021350_+intronic
CAediting_12506chr1_11021363_+intronic
CAediting_12507chr1_11021393_+intronic
CAediting_12508chr1_11021402_+intronic
CAediting_12509chr1_11021403_+intronic
CAediting_12510chr1_11021415_+intronic
CAediting_12511chr1_11021417_+intronic
CAediting_12512chr1_11021424_+intronic
CAediting_12513chr1_11021457_+intronic
CAediting_12514chr1_11021462_+intronic
CAediting_12515chr1_11021475_+intronic
CAediting_12516chr1_11021484_+intronic
CAediting_12517chr1_11021500_+intronic
CAediting_12518chr1_11021507_+intronic
CAediting_12519chr1_11021512_+intronic
CAediting_12520chr1_11021517_+intronic
CAediting_12521chr1_11021521_+intronic
CAediting_12522chr1_11021530_+intronic
CAediting_12523chr1_11021539_+intronic
CAediting_12524chr1_11021540_+intronic
CAediting_12525chr1_11021552_+intronic
CAediting_12526chr1_11021554_+intronic
CAediting_12527chr1_11021592_+intronic
CAediting_12528chr1_11021606_+intronic
CAediting_12529chr1_11021608_+intronic
CAediting_12530chr1_11021610_+intronic
CAediting_12531chr1_11021618_+intronic
CAediting_12532chr1_11021630_+intronic
CAediting_12533chr1_11021653_+intronic
CAediting_12534chr1_11021654_+intronic
CAediting_12535chr1_11021659_+intronic
CAediting_12536chr1_11021664_+intronic
CAediting_12537chr1_11021667_+intronic
CAediting_12538chr1_11021674_+intronic
CAediting_12539chr1_11021712_+intronic
CAediting_12540chr1_11021718_+intronic
CAediting_12541chr1_11021727_+intronic
CAediting_12542chr1_11021730_+intronic
CAediting_12543chr1_11021734_+intronic
CAediting_12544chr1_11021737_+intronic
CAediting_12545chr1_11021745_+intronic
CAediting_12546chr1_11021750_+intronic
CAediting_12547chr1_11021753_+intronic
CAediting_12548chr1_11021790_+intronic
CAediting_12549chr1_11021792_+intronic
CAediting_12550chr1_11021794_+intronic
CAediting_12551chr1_11021818_+intronic
CAediting_12552chr1_11021826_+intronic
CAediting_12553chr1_11021831_+intronic
CAediting_12554chr1_11021855_+intronic
CAediting_12555chr1_11021877_+intronic
CAediting_12556chr1_11021878_+intronic
CAediting_12557chr1_11021879_+intronic
CAediting_12558chr1_11021893_+intronic
CAediting_12559chr1_11021897_+intronic
CAediting_12560chr1_11021900_+intronic
CAediting_12561chr1_11026305_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_12443chr1_11015013_+SINEAluAluSc
CAediting_12444chr1_11015046_+SINEAluAluSc
CAediting_12445chr1_11015582_+SINEAluAluSx
CAediting_12446chr1_11016216_+SINEAluAluSg4
CAediting_12447chr1_11017121_+SINEAluAluJo
CAediting_12448chr1_11017342_+SINEAluAluSx1
CAediting_12449chr1_11017463_+SINEAluAluSx1
CAediting_12450chr1_11017475_+SINEAluAluSx1
CAediting_12451chr1_11017792_+SINEAluAluJr
CAediting_12452chr1_11017793_+SINEAluAluJr
CAediting_12453chr1_11018424_+SINEAluAluSz6
CAediting_12454chr1_11018451_+SINEAluAluSz6
CAediting_12455chr1_11019636_+SINEAluAluY
CAediting_12456chr1_11020645_+SINEAluAluSc
CAediting_12457chr1_11020653_+SINEAluAluSc
CAediting_12458chr1_11020662_+SINEAluAluSc
CAediting_12459chr1_11020669_+SINEAluAluSc
CAediting_12460chr1_11020704_+SINEAluAluSc
CAediting_12461chr1_11020720_+SINEAluAluSc
CAediting_12462chr1_11020728_+SINEAluAluSc
CAediting_12463chr1_11020729_+SINEAluAluSc
CAediting_12464chr1_11020730_+SINEAluAluSc
CAediting_12465chr1_11020754_+SINEAluAluSc
CAediting_12466chr1_11020761_+SINEAluAluSc
CAediting_12467chr1_11020762_+SINEAluAluSc
CAediting_12468chr1_11020764_+SINEAluAluSc
CAediting_12469chr1_11020767_+SINEAluAluSc
CAediting_12470chr1_11020785_+SINEAluAluSc
CAediting_12471chr1_11020799_+SINEAluAluSc
CAediting_12472chr1_11020803_+SINEAluAluSc
CAediting_12473chr1_11020816_+SINEAluAluSc
CAediting_12474chr1_11020820_+SINEAluAluSc
CAediting_12475chr1_11020825_+SINEAluAluSc
CAediting_12476chr1_11020834_+SINEAluAluSc
CAediting_12477chr1_11020835_+SINEAluAluSc
CAediting_12478chr1_11020839_+SINEAluAluSc
CAediting_12479chr1_11020842_+SINEAluAluSc
CAediting_12480chr1_11020848_+SINEAluAluSc
CAediting_12481chr1_11020859_+SINEAluAluSc
CAediting_12482chr1_11020860_+SINEAluAluSc
CAediting_12483chr1_11020866_+SINEAluAluSc
CAediting_12484chr1_11020869_+SINEAluAluSc
CAediting_12485chr1_11020871_+SINEAluAluSc
CAediting_12486chr1_11020879_+SINEAluAluSc
CAediting_12487chr1_11020915_+SINEAluAluSc
CAediting_12488chr1_11021195_+SINEAluAluSq2
CAediting_12489chr1_11021203_+SINEAluAluSq2
CAediting_12490chr1_11021218_+SINEAluAluSq2
CAediting_12491chr1_11021225_+SINEAluAluSq2
CAediting_12492chr1_11021238_+SINEAluAluSq2
CAediting_12493chr1_11021239_+SINEAluAluSq2
CAediting_12494chr1_11021256_+SINEAluAluSq2
CAediting_12495chr1_11021265_+SINEAluAluSq2
CAediting_12496chr1_11021268_+SINEAluAluSq2
CAediting_12497chr1_11021275_+SINEAluAluSq2
CAediting_12498chr1_11021278_+SINEAluAluSq2
CAediting_12499chr1_11021280_+SINEAluAluSq2
CAediting_12500chr1_11021294_+SINEAluAluSq2
CAediting_12501chr1_11021305_+SINEAluAluSq2
CAediting_12502chr1_11021321_+SINEAluAluSq2
CAediting_12503chr1_11021324_+SINEAluAluSq2
CAediting_12504chr1_11021326_+SINEAluAluSq2
CAediting_12505chr1_11021350_+SINEAluAluSq2
CAediting_12506chr1_11021363_+SINEAluAluSq2
CAediting_12507chr1_11021393_+SINEAluAluSq2
CAediting_12508chr1_11021402_+SINEAluAluSq2
CAediting_12509chr1_11021403_+SINEAluAluSq2
CAediting_12510chr1_11021415_+SINEAluAluSq2
CAediting_12511chr1_11021417_+SINEAluAluSq2
CAediting_12512chr1_11021424_+SINEAluAluSq2
CAediting_12513chr1_11021457_+SINEAluAluSx
CAediting_12514chr1_11021462_+SINEAluAluSx
CAediting_12515chr1_11021475_+SINEAluAluSx
CAediting_12516chr1_11021484_+SINEAluAluSx
CAediting_12517chr1_11021500_+SINEAluAluSx
CAediting_12518chr1_11021507_+SINEAluAluSx
CAediting_12519chr1_11021512_+SINEAluAluSx
CAediting_12520chr1_11021517_+SINEAluAluSx
CAediting_12521chr1_11021521_+SINEAluAluSx
CAediting_12522chr1_11021530_+SINEAluAluSx
CAediting_12523chr1_11021539_+SINEAluAluSx
CAediting_12524chr1_11021540_+SINEAluAluSx
CAediting_12525chr1_11021552_+SINEAluAluSx
CAediting_12526chr1_11021554_+SINEAluAluSx
CAediting_12527chr1_11021592_+SINEAluAluJr
CAediting_12528chr1_11021606_+SINEAluAluJr
CAediting_12529chr1_11021608_+SINEAluAluJr
CAediting_12530chr1_11021610_+SINEAluAluJr
CAediting_12531chr1_11021618_+SINEAluAluJr
CAediting_12532chr1_11021630_+SINEAluAluJr
CAediting_12533chr1_11021653_+SINEAluAluJr
CAediting_12534chr1_11021654_+SINEAluAluJr
CAediting_12535chr1_11021659_+SINEAluAluJr
CAediting_12536chr1_11021664_+SINEAluAluJr
CAediting_12537chr1_11021667_+SINEAluAluJr
CAediting_12538chr1_11021674_+SINEAluAluJr
CAediting_12539chr1_11021712_+SINEAluAluJr
CAediting_12540chr1_11021718_+SINEAluAluJr
CAediting_12541chr1_11021727_+SINEAluAluJr
CAediting_12542chr1_11021730_+SINEAluAluJr
CAediting_12543chr1_11021734_+SINEAluAluJr
CAediting_12544chr1_11021737_+SINEAluAluJr
CAediting_12545chr1_11021745_+SINEAluAluJr
CAediting_12546chr1_11021750_+SINEAluAluJr
CAediting_12547chr1_11021753_+SINEAluAluJr
CAediting_12548chr1_11021790_+SINEAluAluJr
CAediting_12549chr1_11021792_+SINEAluAluJr
CAediting_12550chr1_11021794_+SINEAluAluJr
CAediting_12551chr1_11021818_+SINEAluAluJr
CAediting_12552chr1_11021826_+SINEAluAluJr
CAediting_12553chr1_11021831_+SINEAluAluJr
CAediting_12554chr1_11021855_+SINEAluAluJr
CAediting_12555chr1_11021877_+SINEAluAluJr
CAediting_12556chr1_11021878_+SINEAluAluJr
CAediting_12557chr1_11021879_+SINEAluAluJr
CAediting_12558chr1_11021893_+SINEAluAluJr
CAediting_12559chr1_11021897_+SINEAluAluJr
CAediting_12560chr1_11021900_+SINEAluAluJr

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RNA A-to-I editing events in the alternative splicing sites for TARDBP

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000120948.14.TARDBP.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000120948.14.TARDBP.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TARDBP

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TARDBP

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TARDBP

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_12446chr1_11016216_+ENSG00000120948.14ENST00000472476hsa-miR-1228-3p11016214110162218mer-1a1101620411016221147.00-21.88

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_12446chr1_11016216_+ENSG00000120948.14ENST00000472476hsa-miR-216b-3p11016214110162218mer-1a1101619611016221144-14.9
CAediting_12446chr1_11016216_+ENSG00000120948.14ENST00000472476hsa-miR-6500-3p11016212110162187mer-m81101619911016219140-14.27

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000120948.14ENST00000439080hsa-miR-200b-3p11022356110223638mer-1a1102234011022363143-12.06
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000439080hsa-miR-548aa11018770110187767mer-m81101875511018777162-15.5
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000439080hsa-miR-548aa11022251110222577mer-m81102223111022258153-19.5
CAediting_1229414chr17_67471546_+ENSG00000120948.14ENST00000472476hsa-miR-548aa11016153110161597mer-m81101613611016160140-12.74
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000472476hsa-miR-548aa11018770110187767mer-m81101875511018777162-15.5
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000315091hsa-miR-548aa11023568110235747mer-m81102354911023575152-14.3
CAediting_1399425chr20_1392958_-ENSG00000120948.14ENST00000315091hsa-miR-6869-5p11023938110239447mer-m81102392311023945148-21.18
CAediting_573000chr7_92204081_-ENSG00000120948.14ENST00000315091hsa-miR-1285-5p11023545110235517mer-m81102353211023552151-15.61
CAediting_1160181chr17_7017644_-ENSG00000120948.14ENST00000473869hsa-miR-195-3p11024713110247208mer-1a1102469811024720147-16.63
CAediting_1160181chr17_7017644_-ENSG00000120948.14ENST00000473869hsa-miR-195-3p11024790110247978mer-1a1102477211024797149-14.07
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000617172hsa-miR-548aa11023568110235747mer-m81102354911023575152-14.3
CAediting_573000chr7_92204081_-ENSG00000120948.14ENST00000617172hsa-miR-1285-5p11023545110235517mer-m81102353211023552151-15.61
CAediting_1399425chr20_1392958_-ENSG00000120948.14ENST00000620632hsa-miR-6869-5p11023938110239447mer-m81102392311023945148-21.18
CAediting_1399425chr20_1392958_-ENSG00000120948.14ENST00000610369hsa-miR-6869-5p11023938110239447mer-m81102392311023945148-21.18

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000120948.14ENST00000439080hsa-miR-200b-3p11022787110227937mer-m81102277411022794154-13.09
CAediting_1229415chr17_67471547_+ENSG00000120948.14ENST00000439080hsa-miR-548aa11022593110226008mer-1a1102257511022600151-16.06
CAediting_117844chr1_162342605_+ENSG00000120948.14ENST00000439080hsa-miR-556-3p11022276110222827mer-m81102226411022283153-16.25
CAediting_117844chr1_162342605_+ENSG00000120948.14ENST00000439080hsa-miR-556-3p11022459110224668mer-1a1102244311022466143-8.6
CAediting_846604chr11_93733708_-ENSG00000120948.14ENST00000315091hsa-miR-1304-3p11023888110238947mer-m81102387311023895146-14.28
CAediting_748296chr10_51299626_+ENSG00000120948.14ENST00000473869hsa-miR-605-3p11024428110244347mer-m81102440511024435149-20.03

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TARDBP

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000240185.6protein_codingSoverviewSoverview
ENST00000472476.4nonsense_mediated_decaySoverviewSoverview
ENST00000476201.4protein_codingSoverviewSoverview
ENST00000613864.3processed_transcriptSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_12561ENST00000240185.6chr1_11026305_+-1571.10-1566.70-1571.10
CAediting_12446ENST00000472476.4chr1_11016216_+-329.90-330.20-329.90
CAediting_12445ENST00000476201.4chr1_11015582_+-317.60-318.40-317.60
CAediting_12453ENST00000613864.3chr1_11018424_+-200.50-200.80-202.30
CAediting_12454ENST00000613864.3chr1_11018451_+-202.60-200.80-202.30

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Relation with ADAR for TARDBP

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_12484chr1_11020869_+0.01417911506972470.341516796039527....
BRCACAediting_12484chr1_11020869_+9.32534460928185e-060.372505511463709....
LUSCCAediting_12484chr1_11020869_+0.01083168620697470.2368070577104860.0001814807066688870.342219631487183..
THCACAediting_12484chr1_11020869_+0.0004810542202153230.420882552382278....
SKCMCAediting_12484chr1_11020869_+0.02633934971020150.2395219742445270.0007260903525386570.35753159362737..
BRCACAediting_12485chr1_11020871_+0.0004396017453853940.379382101910097....
BRCACAediting_12493chr1_11021239_+0.0009804975220689390.317114579589192....
LIHCCAediting_12493chr1_11021239_+1.80858678525611e-060.474089988591529....
BRCACAediting_12494chr1_11021256_+....0.03408401467505340.286301067881035
BLCACAediting_12496chr1_11021268_+0.00302994812718710.373476274595177....
BRCACAediting_12496chr1_11021268_+0.0005635381902839540.36034059496434....
LUADCAediting_12496chr1_11021268_+0.04468999173544910.210990755516725....
LUSCCAediting_12496chr1_11021268_+0.04583820429863580.203265602698522....
SKCMCAediting_12496chr1_11021268_+..0.003646149876293830.331711835095277..
LIHCCAediting_12502chr1_11021321_+4.51828199609685e-060.507828184091555....
LUSCCAediting_12530chr1_11021610_+0.04921821029147060.244961227412364....
BLCACAediting_12543chr1_11021734_+0.01676844324010970.184869197539774....
LGGCAediting_12543chr1_11021734_+..0.02348228934220030.197872356417787..
BRCACAediting_12543chr1_11021734_+0.0004755488194741630.172012240689446....
LIHCCAediting_12543chr1_11021734_+3.61574138104255e-060.329671519724254....
LUADCAediting_12543chr1_11021734_+8.97690389152979e-050.254815486870218....
LUSCCAediting_12543chr1_11021734_+5.68615032894133e-090.370014760070563..0.0009200786398647740.21569889723953
HNSCCAediting_12543chr1_11021734_+0.01301787805929590.227057047223625....
THCACAediting_12543chr1_11021734_+0.003938635040073870.207692822448919....
UCECCAediting_12543chr1_11021734_+1.43120481353677e-050.402522175391487....
ESCACAediting_12543chr1_11021734_+..0.0007193205924016590.323457176641669..

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Relation with cancer stages for TARDBP

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_12543chr1_11021734_+0.02891954546823820.108836374643096
HNSCpathologic_stageCAediting_12473chr1_11020816_+0.01610725876583340.304522881400572
KIRCpathologic_stageCAediting_12543chr1_11021734_+0.04788497089011110.162915680612342
KIRPpathologic_stageCAediting_12543chr1_11021734_+0.04200915130566370.263399898983507
SKCMpathologic_stageCAediting_12484chr1_11020869_+0.0111359214651362-0.289703182784769
SKCMpathologic_stageCAediting_12543chr1_11021734_+0.03723811593820480.176891469187814

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Relation with survival for TARDBP

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TARDBP

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TARDBP

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
TARDBPC2677565AMYOTROPHIC LATERAL SCLEROSIS 10 (disorder)14GENOMICS_ENGLAND;UNIPROT
TARDBPC0002736Amyotrophic Lateral Sclerosis7CTD_human;ORPHANET
TARDBPC0393554Amyotrophic Lateral Sclerosis With Dementia6CTD_human
TARDBPC0543859Amyotrophic Lateral Sclerosis, Guam Form6CTD_human
TARDBPC0338451Frontotemporal dementia2GENOMICS_ENGLAND
TARDBPC0751072Frontotemporal Lobar Degeneration2CTD_human