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Editing gene: ICOSLG (CAeditome ID:23308)

Gene summary for ICOSLG

Gene summary

Gene information	Gene symbol	ICOSLG
	Gene ID	23308
	Gene name	inducible T cell costimulator ligand
	Synonyms	B7-H2\|B7H2\|B7RP-1\|B7RP1\|B7h\|CD275\|GL50\|ICOS-L\|ICOSL\|LICOS
	Cytomap	21q22.3
	Type of gene	protein-coding
	Description	ICOS ligandB7 homolog 2B7 homologue 2B7-like protein Gl50B7-related protein 1transmembrane protein B7-H2 ICOS ligand
	Modification date	20210518
	UniProtAcc	O75144
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ICOSLG	GO:0005886	ICOS ligand	0000052
ICOSLG	GO:0036464	ICOS ligand	0000052

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RNA A-to-I events for ICOSLG

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000160223.15

RNA A-to-I editing events in Cancer.

CAediting_1456266(44223864, -), CAediting_1456267(44223880, -), CAediting_1456268(44223911, -), CAediting_1456269(44223917, -), CAediting_1456270(44223918, -), CAediting_1456271(44223937, -), CAediting_1456272(44224242, -), CAediting_1456273(44224243, -), CAediting_1456274(44224281, -), CAediting_1456275(44224289, -), CAediting_1456276(44224294, -), CAediting_1456277(44224295, -), CAediting_1456278(44224303, -), CAediting_1456279(44224429, -), CAediting_1456280(44224438, -), CAediting_1456281(44224445, -), CAediting_1456282(44224447, -), CAediting_1456283(44224459, -), CAediting_1456284(44224460, -), CAediting_1456285(44224461, -), CAediting_1456286(44224468, -), CAediting_1456287(44224474, -), CAediting_1456288(44224482, -), CAediting_1456289(44224485, -), CAediting_1456290(44224486, -), CAediting_1456291(44224487, -), CAediting_1456292(44224499, -), CAediting_1456293(44224500, -), CAediting_1456294(44224501, -), CAediting_1456295(44224512, -), CAediting_1456296(44224521, -), CAediting_1456297(44224524, -), CAediting_1456298(44224532, -), CAediting_1456299(44224536, -), CAediting_1456300(44224541, -), CAediting_1456301(44224547, -), CAediting_1456302(44224557, -), CAediting_1456303(44224563, -), CAediting_1456304(44224577, -), CAediting_1456305(44224582, -), CAediting_1456306(44224592, -), CAediting_1456307(44224601, -), CAediting_1456308(44224611, -), CAediting_1456309(44224615, -), CAediting_1456310(44224616, -), CAediting_1456311(44224620, -), CAediting_1456312(44224633, -), CAediting_1456313(44224635, -), CAediting_1456314(44224636, -), CAediting_1456315(44224641, -), CAediting_1456316(44224652, -), CAediting_1456317(44224679, -), CAediting_1456318(44224682, -), CAediting_1456319(44224684, -), CAediting_1456320(44224688, -), CAediting_1456321(44224698, -), CAediting_1456322(44225222, -), CAediting_1456323(44232546, -), CAediting_1456324(44232617, -), CAediting_1456325(44232657, -),

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RNA editing positional annotations for ICOSLG using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1456266	chr21_44223864_-	UTR3
CAediting_1456267	chr21_44223880_-	UTR3
CAediting_1456268	chr21_44223911_-	UTR3
CAediting_1456269	chr21_44223917_-	UTR3
CAediting_1456270	chr21_44223918_-	UTR3
CAediting_1456271	chr21_44223937_-	UTR3
CAediting_1456272	chr21_44224242_-	UTR3
CAediting_1456273	chr21_44224243_-	UTR3
CAediting_1456274	chr21_44224281_-	UTR3
CAediting_1456275	chr21_44224289_-	UTR3
CAediting_1456276	chr21_44224294_-	UTR3
CAediting_1456277	chr21_44224295_-	UTR3
CAediting_1456278	chr21_44224303_-	UTR3
CAediting_1456279	chr21_44224429_-	UTR3
CAediting_1456280	chr21_44224438_-	UTR3
CAediting_1456281	chr21_44224445_-	UTR3
CAediting_1456282	chr21_44224447_-	UTR3
CAediting_1456283	chr21_44224459_-	UTR3
CAediting_1456284	chr21_44224460_-	UTR3
CAediting_1456285	chr21_44224461_-	UTR3
CAediting_1456286	chr21_44224468_-	UTR3
CAediting_1456287	chr21_44224474_-	UTR3
CAediting_1456288	chr21_44224482_-	UTR3
CAediting_1456289	chr21_44224485_-	UTR3
CAediting_1456290	chr21_44224486_-	UTR3
CAediting_1456291	chr21_44224487_-	UTR3
CAediting_1456292	chr21_44224499_-	UTR3
CAediting_1456293	chr21_44224500_-	UTR3
CAediting_1456294	chr21_44224501_-	UTR3
CAediting_1456295	chr21_44224512_-	UTR3
CAediting_1456296	chr21_44224521_-	UTR3
CAediting_1456297	chr21_44224524_-	UTR3
CAediting_1456298	chr21_44224532_-	UTR3
CAediting_1456299	chr21_44224536_-	UTR3
CAediting_1456300	chr21_44224541_-	UTR3
CAediting_1456301	chr21_44224547_-	UTR3
CAediting_1456302	chr21_44224557_-	UTR3
CAediting_1456303	chr21_44224563_-	UTR3
CAediting_1456304	chr21_44224577_-	UTR3
CAediting_1456305	chr21_44224582_-	UTR3
CAediting_1456306	chr21_44224592_-	UTR3
CAediting_1456307	chr21_44224601_-	UTR3
CAediting_1456308	chr21_44224611_-	UTR3
CAediting_1456309	chr21_44224615_-	UTR3
CAediting_1456310	chr21_44224616_-	UTR3
CAediting_1456311	chr21_44224620_-	UTR3
CAediting_1456312	chr21_44224633_-	UTR3
CAediting_1456313	chr21_44224635_-	UTR3
CAediting_1456314	chr21_44224636_-	UTR3
CAediting_1456315	chr21_44224641_-	UTR3
CAediting_1456316	chr21_44224652_-	UTR3
CAediting_1456317	chr21_44224679_-	UTR3
CAediting_1456318	chr21_44224682_-	UTR3
CAediting_1456319	chr21_44224684_-	UTR3
CAediting_1456320	chr21_44224688_-	UTR3
CAediting_1456321	chr21_44224698_-	UTR3
CAediting_1456322	chr21_44225222_-	UTR3
CAediting_1456323	chr21_44232546_-	intronic
CAediting_1456324	chr21_44232617_-	intronic
CAediting_1456325	chr21_44232657_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1456266	chr21_44223864_-	SINE	Alu	AluSg4
CAediting_1456267	chr21_44223880_-	SINE	Alu	AluSg4
CAediting_1456268	chr21_44223911_-	SINE	Alu	AluSp
CAediting_1456269	chr21_44223917_-	SINE	Alu	AluSp
CAediting_1456270	chr21_44223918_-	SINE	Alu	AluSp
CAediting_1456271	chr21_44223937_-	SINE	Alu	AluSp
CAediting_1456272	chr21_44224242_-	SINE	Alu	AluSg4
CAediting_1456273	chr21_44224243_-	SINE	Alu	AluSg4
CAediting_1456274	chr21_44224281_-	SINE	Alu	AluSg4
CAediting_1456275	chr21_44224289_-	SINE	Alu	AluSg4
CAediting_1456276	chr21_44224294_-	SINE	Alu	AluSg4
CAediting_1456277	chr21_44224295_-	SINE	Alu	AluSg4
CAediting_1456278	chr21_44224303_-	SINE	Alu	AluSg4
CAediting_1456279	chr21_44224429_-	SINE	Alu	AluSz
CAediting_1456280	chr21_44224438_-	SINE	Alu	AluSz
CAediting_1456281	chr21_44224445_-	SINE	Alu	AluSz
CAediting_1456282	chr21_44224447_-	SINE	Alu	AluSz
CAediting_1456283	chr21_44224459_-	SINE	Alu	AluSz
CAediting_1456284	chr21_44224460_-	SINE	Alu	AluSz
CAediting_1456285	chr21_44224461_-	SINE	Alu	AluSz
CAediting_1456286	chr21_44224468_-	SINE	Alu	AluSz
CAediting_1456287	chr21_44224474_-	SINE	Alu	AluSz
CAediting_1456288	chr21_44224482_-	SINE	Alu	AluSz
CAediting_1456289	chr21_44224485_-	SINE	Alu	AluSz
CAediting_1456290	chr21_44224486_-	SINE	Alu	AluSz
CAediting_1456291	chr21_44224487_-	SINE	Alu	AluSz
CAediting_1456292	chr21_44224499_-	SINE	Alu	AluSz
CAediting_1456293	chr21_44224500_-	SINE	Alu	AluSz
CAediting_1456294	chr21_44224501_-	SINE	Alu	AluSz
CAediting_1456295	chr21_44224512_-	SINE	Alu	AluSz
CAediting_1456296	chr21_44224521_-	SINE	Alu	AluSz
CAediting_1456297	chr21_44224524_-	SINE	Alu	AluSz
CAediting_1456298	chr21_44224532_-	SINE	Alu	AluSz
CAediting_1456299	chr21_44224536_-	SINE	Alu	AluSz
CAediting_1456300	chr21_44224541_-	SINE	Alu	AluSz
CAediting_1456301	chr21_44224547_-	SINE	Alu	AluSz
CAediting_1456302	chr21_44224557_-	SINE	Alu	AluSz
CAediting_1456303	chr21_44224563_-	SINE	Alu	AluSz
CAediting_1456304	chr21_44224577_-	SINE	Alu	AluSz
CAediting_1456305	chr21_44224582_-	SINE	Alu	AluSz
CAediting_1456306	chr21_44224592_-	SINE	Alu	AluSz
CAediting_1456307	chr21_44224601_-	SINE	Alu	AluSz
CAediting_1456308	chr21_44224611_-	SINE	Alu	AluSz
CAediting_1456309	chr21_44224615_-	SINE	Alu	AluSz
CAediting_1456310	chr21_44224616_-	SINE	Alu	AluSz
CAediting_1456311	chr21_44224620_-	SINE	Alu	AluSz
CAediting_1456312	chr21_44224633_-	SINE	Alu	AluSz
CAediting_1456313	chr21_44224635_-	SINE	Alu	AluSz
CAediting_1456314	chr21_44224636_-	SINE	Alu	AluSz
CAediting_1456315	chr21_44224641_-	SINE	Alu	AluSz
CAediting_1456316	chr21_44224652_-	SINE	Alu	AluSz
CAediting_1456317	chr21_44224679_-	SINE	Alu	AluSz
CAediting_1456318	chr21_44224682_-	SINE	Alu	AluSz
CAediting_1456319	chr21_44224684_-	SINE	Alu	AluSz
CAediting_1456320	chr21_44224688_-	SINE	Alu	AluSz
CAediting_1456321	chr21_44224698_-	SINE	Alu	AluSz
CAediting_1456323	chr21_44232546_-	SINE	Alu	AluJo
CAediting_1456324	chr21_44232617_-	SINE	Alu	AluJo
CAediting_1456325	chr21_44232657_-	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for ICOSLG

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000160223.15.ICOSLG.

Correlation between RNA A-to-I editing and PSI for ENSG00000160223.15.ICOSLG.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ICOSLG

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ICOSLG

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ICOSLG

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1456282	chr21_44224447_-	ENSG00000160223.15	ENST00000407780	hsa-miR-106a-3p	44224445	44224450	6mer	44224444	44224465	141.00	-21.13
CAediting_1456283	chr21_44224459_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3189-3p	44224458	44224464	7mer-m8	44224457	44224476	149.00	-21.76
CAediting_1456283	chr21_44224459_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6813-3p	44224457	44224463	7mer-m8	44224456	44224476	140.00	-10.68
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-326	44224458	44224464	7mer-m8	44224457	44224476	140.00	-13.25
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-330-5p	44224458	44224464	7mer-m8	44224457	44224478	140.00	-21.07
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4314	44224459	44224465	7mer-m8	44224458	44224475	142.00	-20.06
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224457	44224463	7mer-m8	44224456	44224479	146.00	-18.63
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224457	44224463	7mer-m8	44224456	44224479	146.00	-18.63
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224457	44224463	7mer-m8	44224456	44224479	146.00	-18.63
CAediting_1456296	chr21_44224521_-	ENSG00000160223.15	ENST00000407780	hsa-miR-433-5p	44224520	44224526	7mer-m8	44224519	44224542	167.00	-28.70
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-340-3p	44224531	44224537	7mer-m8	44224530	44224551	149.00	-17.74
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6827-3p	44224531	44224537	7mer-m8	44224530	44224550	153.00	-17.53
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548ae-3p	44224541	44224547	7mer-1a	44224541	44224560	140.00	-13.66
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548ae-3p	44224541	44224547	7mer-1a	44224541	44224560	140.00	-13.66
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548aj-3p	44224541	44224547	7mer-1a	44224541	44224560	140.00	-16.16
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548aj-3p	44224541	44224547	7mer-1a	44224541	44224560	140.00	-16.16
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548aq-3p	44224541	44224547	7mer-1a	44224541	44224561	140.00	-15.63
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548h-3p	44224541	44224547	7mer-1a	44224541	44224562	140.00	-17.53
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548x-3p	44224541	44224547	7mer-1a	44224541	44224559	140.00	-16.16
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548x-3p	44224541	44224547	7mer-1a	44224541	44224559	140.00	-16.16
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548z	44224541	44224547	7mer-1a	44224541	44224562	140.00	-17.53
CAediting_1456306	chr21_44224592_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6852-5p	44224591	44224596	6mer	44224590	44224609	149.00	-26.62
CAediting_1456310	chr21_44224616_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4444	44224615	44224621	7mer-m8	44224614	44224630	150.00	-25.47
CAediting_1456310	chr21_44224616_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4444	44224615	44224621	7mer-m8	44224614	44224630	150.00	-25.47
CAediting_1456315	chr21_44224641_-	ENSG00000160223.15	ENST00000407780	hsa-miR-891a-5p	44224636	44224643	8mer-1a	44224636	44224656	145.00	-16.46
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4258	44223862	44223868	7mer-m8	44223861	44223877	155.00	-26.11
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4707-3p	44223861	44223867	7mer-m8	44223860	44223883	149.00	-25.41
CAediting_1456270	chr21_44223918_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5007-5p	44223913	44223919	7mer-m8	44223912	44223933	153.00	-18.46
CAediting_1456271	chr21_44223937_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4743-5p	44223934	44223940	7mer-m8	44223933	44223955	149.00	-21.80
CAediting_1456274	chr21_44224281_-	ENSG00000160223.15	ENST00000407780	hsa-miR-150-5p	44224277	44224283	7mer-m8	44224276	44224297	140.00	-15.80
CAediting_1456274	chr21_44224281_-	ENSG00000160223.15	ENST00000407780	hsa-miR-186-3p	44224278	44224285	8mer-1a	44224278	44224302	141.00	-19.75
CAediting_1456274	chr21_44224281_-	ENSG00000160223.15	ENST00000407780	hsa-miR-520g-3p	44224281	44224287	7mer-m8	44224280	44224302	151.00	-15.87
CAediting_1456274	chr21_44224281_-	ENSG00000160223.15	ENST00000407780	hsa-miR-520h	44224281	44224287	7mer-m8	44224280	44224301	150.00	-15.08
CAediting_1456276	chr21_44224294_-	ENSG00000160223.15	ENST00000407780	hsa-miR-8052	44224289	44224295	7mer-1a	44224289	44224307	148.00	-29.06
CAediting_1456278	chr21_44224303_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3622a-5p	44224298	44224304	7mer-m8	44224297	44224320	147.00	-30.07
CAediting_1456280	chr21_44224438_-	ENSG00000160223.15	ENST00000407780	hsa-miR-663b	44224433	44224439	7mer-m8	44224432	44224453	151.00	-29.95
CAediting_1456281	chr21_44224445_-	ENSG00000160223.15	ENST00000407780	hsa-miR-100-5p	44224442	44224448	7mer-m8	44224441	44224463	162.00	-22.89
CAediting_1456281	chr21_44224445_-	ENSG00000160223.15	ENST00000407780	hsa-miR-99a-5p	44224442	44224448	7mer-m8	44224441	44224464	155.00	-21.46
CAediting_1456281	chr21_44224445_-	ENSG00000160223.15	ENST00000407780	hsa-miR-99b-5p	44224442	44224448	7mer-m8	44224441	44224464	155.00	-25.13
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6771-5p	44224459	44224466	8mer-1a	44224459	44224482	158.00	-28.65
CAediting_1456287	chr21_44224474_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7112-5p	44224474	44224480	7mer-m8	44224473	44224494	150.00	-18.92
CAediting_1456290	chr21_44224486_-	ENSG00000160223.15	ENST00000407780	hsa-miR-12119	44224485	44224491	7mer-m8	44224484	44224505	154.00	-21.54
CAediting_1456290	chr21_44224486_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3200-5p	44224484	44224490	7mer-m8	44224483	44224506	141.00	-14.09
CAediting_1456290	chr21_44224486_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7162-3p	44224485	44224492	8mer-1a	44224485	44224505	142.00	-17.81
CAediting_1456291	chr21_44224487_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1298-5p	44224482	44224488	7mer-m8	44224481	44224501	148.00	-16.83
CAediting_1456292	chr21_44224499_-	ENSG00000160223.15	ENST00000407780	hsa-miR-28-5p	44224494	44224500	7mer-m8	44224493	44224514	143.00	-18.76
CAediting_1456292	chr21_44224499_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3139	44224494	44224500	7mer-m8	44224493	44224515	157.00	-23.65
CAediting_1456292	chr21_44224499_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4538	44224497	44224502	6mer	44224496	44224518	143.00	-24.18
CAediting_1456292	chr21_44224499_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4635	44224499	44224504	6mer	44224498	44224518	140.00	-17.86
CAediting_1456292	chr21_44224499_-	ENSG00000160223.15	ENST00000407780	hsa-miR-708-5p	44224494	44224500	7mer-m8	44224493	44224514	162.00	-21.39
CAediting_1456293	chr21_44224500_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4294	44224495	44224501	7mer-m8	44224494	44224511	150.00	-18.29
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7112-5p	44224557	44224562	6mer	44224556	44224577	140.00	-29.93
CAediting_1456303	chr21_44224563_-	ENSG00000160223.15	ENST00000407780	hsa-miR-564	44224559	44224565	7mer-m8	44224558	44224575	158.00	-24.45
CAediting_1456304	chr21_44224577_-	ENSG00000160223.15	ENST00000407780	hsa-miR-100-5p	44224574	44224580	7mer-m8	44224573	44224596	161.00	-24.58
CAediting_1456304	chr21_44224577_-	ENSG00000160223.15	ENST00000407780	hsa-miR-99a-5p	44224574	44224580	7mer-m8	44224573	44224593	160.00	-19.89
CAediting_1456304	chr21_44224577_-	ENSG00000160223.15	ENST00000407780	hsa-miR-99b-5p	44224574	44224580	7mer-m8	44224573	44224596	155.00	-26.01
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3136-3p	44224684	44224691	8mer-1a	44224684	44224705	140.00	-14.04
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7155-3p	44224684	44224691	8mer-1a	44224684	44224702	146.00	-16.17
CAediting_1456322	chr21_44225222_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1972	44225217	44225223	7mer-m8	44225216	44225237	152.00	-29.08
CAediting_1456322	chr21_44225222_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1972	44225217	44225223	7mer-m8	44225216	44225237	152.00	-29.08
CAediting_1456322	chr21_44225222_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4717-5p	44225218	44225224	7mer-m8	44225217	44225240	165.00	-29.26
CAediting_1456272	chr21_44224242_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1200	44224240	44224245	6mer	44224239	44224258	144.00	-23.34
CAediting_1456275	chr21_44224289_-	ENSG00000160223.15	ENST00000407780	hsa-miR-371a-3p	44224284	44224290	7mer-m8	44224283	44224305	144.00	-15.05
CAediting_1456277	chr21_44224295_-	ENSG00000160223.15	ENST00000407780	hsa-miR-513a-5p	44224294	44224300	7mer-m8	44224293	44224310	152.00	-17.32
CAediting_1456277	chr21_44224295_-	ENSG00000160223.15	ENST00000407780	hsa-miR-513a-5p	44224294	44224300	7mer-m8	44224293	44224310	152.00	-17.32
CAediting_1456277	chr21_44224295_-	ENSG00000160223.15	ENST00000407780	hsa-miR-638	44224289	44224295	7mer-1a	44224289	44224313	155.00	-34.17
CAediting_1456288	chr21_44224482_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6502-3p	44224479	44224485	7mer-m8	44224478	44224501	146.00	-16.15

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1456276	chr21_44224294_-	ENSG00000160223.15	ENST00000407780	hsa-miR-10399-5p	44224293	44224299	7mer-m8	44224292	44224313	144	-11.88
CAediting_1456277	chr21_44224295_-	ENSG00000160223.15	ENST00000407780	hsa-miR-10399-5p	44224293	44224299	7mer-m8	44224292	44224313	144	-11.88
CAediting_1456314	chr21_44224636_-	ENSG00000160223.15	ENST00000407780	hsa-miR-106a-3p	44224635	44224642	8mer-1a	44224635	44224654	147	-10.51
CAediting_1456315	chr21_44224641_-	ENSG00000160223.15	ENST00000407780	hsa-miR-106a-3p	44224635	44224642	8mer-1a	44224635	44224654	147	-10.51
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-10a-5p	44224528	44224534	7mer-m8	44224527	44224549	145	-13.67
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-10b-5p	44224528	44224534	7mer-m8	44224527	44224549	140	-13.05
CAediting_1456306	chr21_44224592_-	ENSG00000160223.15	ENST00000407780	hsa-miR-12126	44224589	44224596	8mer-1a	44224589	44224612	147	-13.98
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1285-3p	44224556	44224562	7mer-m8	44224555	44224576	140	-20.35
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1285-3p	44224556	44224562	7mer-m8	44224555	44224576	140	-20.35
CAediting_1456288	chr21_44224482_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1288-5p	44224478	44224484	7mer-m8	44224477	44224499	140	-13.79
CAediting_1456319	chr21_44224684_-	ENSG00000160223.15	ENST00000407780	hsa-miR-149-5p	44224682	44224689	8mer-1a	44224682	44224704	140	-16
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-149-5p	44224682	44224689	8mer-1a	44224682	44224704	140	-16
CAediting_1456308	chr21_44224611_-	ENSG00000160223.15	ENST00000407780	hsa-miR-219b-3p	44224608	44224614	7mer-m8	44224607	44224633	145	-18.47
CAediting_1456308	chr21_44224611_-	ENSG00000160223.15	ENST00000407780	hsa-miR-302f	44224609	44224615	7mer-m8	44224608	44224624	145	-7.47
CAediting_1456267	chr21_44223880_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3129-3p	44223877	44223883	7mer-m8	44223876	44223897	144	-4.63
CAediting_1456271	chr21_44223937_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3135b	44223935	44223941	7mer-m8	44223934	44223951	155	-31.46
CAediting_1456321	chr21_44224698_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3163	44224697	44224703	7mer-m8	44224696	44224716	151	-7.28
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3187-5p	44224556	44224562	7mer-m8	44224555	44224577	153	-27.2
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-32-5p	44224650	44224656	7mer-m8	44224649	44224671	155	-11.87
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-339-5p	44224529	44224535	7mer-m8	44224528	44224552	151	-18.58
CAediting_1456303	chr21_44224563_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3622b-5p	44224559	44224565	7mer-m8	44224558	44224577	143	-17.47
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-363-3p	44224650	44224656	7mer-m8	44224649	44224670	147	-14.38
CAediting_1456271	chr21_44223937_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3652	44223934	44223940	7mer-m8	44223933	44223949	153	-18.69
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3689a-3p	44224460	44224467	8mer-1a	44224460	44224480	148	-21.42
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3689b-3p	44224460	44224467	8mer-1a	44224460	44224480	148	-21.47
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3689c	44224460	44224467	8mer-1a	44224460	44224480	148	-21.47
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-371b-5p	44224687	44224693	7mer-m8	44224686	44224707	146	-7.78
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-373-5p	44224687	44224693	7mer-m8	44224686	44224707	140	-8.34
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3929	44224597	44224603	7mer-m8	44224596	44224619	152	-19.44
CAediting_1456303	chr21_44224563_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4253	44224557	44224564	8mer-1a	44224557	44224574	140	-15.62
CAediting_1456295	chr21_44224512_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4293	44224508	44224514	7mer-m8	44224507	44224523	146	-21.19
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4421	44224530	44224536	7mer-m8	44224529	44224550	154	-16.19
CAediting_1456279	chr21_44224429_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4466	44224427	44224433	7mer-m8	44224426	44224445	142	-21.63
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4478	44224597	44224603	7mer-m8	44224596	44224613	149	-20.76
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4649-3p	44224600	44224606	7mer-m8	44224599	44224619	140	-13.39
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4666a-3p	44224546	44224552	7mer-m8	44224545	44224569	146	-11.52
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4715-3p	44223864	44223870	7mer-m8	44223863	44223883	146	-17.7
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4722-3p	44223862	44223868	7mer-m8	44223861	44223882	144	-20.37
CAediting_1456267	chr21_44223880_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4735-5p	44223879	44223885	7mer-m8	44223878	44223899	140	-4.69
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4763-5p	44223861	44223867	7mer-m8	44223860	44223883	145	-29.23
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-485-5p	44224596	44224602	7mer-m8	44224595	44224617	147	-15.79
CAediting_1456275	chr21_44224289_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5089-5p	44224289	44224295	7mer-m8	44224288	44224307	146	-13.24
CAediting_1456276	chr21_44224294_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5089-5p	44224289	44224295	7mer-m8	44224288	44224307	146	-13.24
CAediting_1456293	chr21_44224500_-	ENSG00000160223.15	ENST00000407780	hsa-miR-510-3p	44224499	44224506	8mer-1a	44224499	44224519	145	-11.83
CAediting_1456294	chr21_44224501_-	ENSG00000160223.15	ENST00000407780	hsa-miR-510-3p	44224499	44224506	8mer-1a	44224499	44224519	145	-11.83
CAediting_1456275	chr21_44224289_-	ENSG00000160223.15	ENST00000407780	hsa-miR-512-3p	44224284	44224290	7mer-m8	44224283	44224304	149	-15
CAediting_1456275	chr21_44224289_-	ENSG00000160223.15	ENST00000407780	hsa-miR-512-3p	44224284	44224290	7mer-m8	44224283	44224304	149	-15
CAediting_1456318	chr21_44224682_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456319	chr21_44224684_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456318	chr21_44224682_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456319	chr21_44224684_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456318	chr21_44224682_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456319	chr21_44224684_-	ENSG00000160223.15	ENST00000407780	hsa-miR-514a-5p	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5186	44224647	44224653	7mer-m8	44224646	44224666	140	-14.44
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5189-5p	44224556	44224562	7mer-m8	44224555	44224576	154	-25.69
CAediting_1456301	chr21_44224547_-	ENSG00000160223.15	ENST00000407780	hsa-miR-548c-3p	44224541	44224547	7mer-1a	44224541	44224561	140	-12.12
CAediting_1456267	chr21_44223880_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5583-5p	44223877	44223883	7mer-m8	44223876	44223897	142	-5.72
CAediting_1456267	chr21_44223880_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5583-5p	44223877	44223883	7mer-m8	44223876	44223897	142	-5.72
CAediting_1456288	chr21_44224482_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5694	44224479	44224485	7mer-m8	44224478	44224497	147	-17.98
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5699-3p	44224530	44224536	7mer-m8	44224529	44224550	153	-17.34
CAediting_1456271	chr21_44223937_-	ENSG00000160223.15	ENST00000407780	hsa-miR-5787	44223934	44223939	6mer	44223933	44223953	141	-24.96
CAediting_1456288	chr21_44224482_-	ENSG00000160223.15	ENST00000407780	hsa-miR-579-3p	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
CAediting_1456289	chr21_44224485_-	ENSG00000160223.15	ENST00000407780	hsa-miR-579-3p	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
CAediting_1456290	chr21_44224486_-	ENSG00000160223.15	ENST00000407780	hsa-miR-579-3p	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
CAediting_1456291	chr21_44224487_-	ENSG00000160223.15	ENST00000407780	hsa-miR-579-3p	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
CAediting_1456299	chr21_44224536_-	ENSG00000160223.15	ENST00000407780	hsa-miR-593-3p	44224532	44224538	7mer-1a	44224532	44224550	140	-19.02
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-612	44224556	44224562	7mer-m8	44224555	44224578	153	-22.29
CAediting_1456287	chr21_44224474_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6134	44224470	44224476	7mer-m8	44224469	44224487	150	-19.15
CAediting_1456320	chr21_44224688_-	ENSG00000160223.15	ENST00000407780	hsa-miR-616-5p	44224687	44224693	7mer-m8	44224686	44224707	140	-6.79
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-619-3p	44224553	44224559	7mer-1a	44224553	44224576	150	-22.79
CAediting_1456275	chr21_44224289_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6506-5p	44224288	44224294	7mer-m8	44224287	44224309	144	-16.21
CAediting_1456287	chr21_44224474_-	ENSG00000160223.15	ENST00000407780	hsa-miR-654-5p	44224472	44224478	7mer-m8	44224471	44224489	152	-19.88
CAediting_1456274	chr21_44224281_-	ENSG00000160223.15	ENST00000407780	hsa-miR-660-3p	44224276	44224281	6mer	44224275	44224296	146	-25.57
CAediting_1456288	chr21_44224482_-	ENSG00000160223.15	ENST00000407780	hsa-miR-664b-3p	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
CAediting_1456289	chr21_44224485_-	ENSG00000160223.15	ENST00000407780	hsa-miR-664b-3p	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
CAediting_1456290	chr21_44224486_-	ENSG00000160223.15	ENST00000407780	hsa-miR-664b-3p	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
CAediting_1456291	chr21_44224487_-	ENSG00000160223.15	ENST00000407780	hsa-miR-664b-3p	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
CAediting_1456266	chr21_44223864_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6720-3p	44223859	44223865	7mer-m8	44223858	44223879	145	-21.66
CAediting_1456279	chr21_44224429_-	ENSG00000160223.15	ENST00000407780	hsa-miR-675-5p	44224427	44224433	7mer-m8	44224426	44224447	149	-25.02
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6779-5p	44224460	44224467	8mer-1a	44224460	44224483	147	-22.57
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6780a-5p	44224460	44224467	8mer-1a	44224460	44224484	143	-21.09
CAediting_1456281	chr21_44224445_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6804-3p	44224440	44224446	7mer-m8	44224439	44224460	149	-24.91
CAediting_1456278	chr21_44224303_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6807-5p	44224303	44224309	7mer-m8	44224302	44224323	145	-22.46
CAediting_1456298	chr21_44224532_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6818-3p	44224532	44224538	7mer-m8	44224531	44224552	140	-13.21
CAediting_1456299	chr21_44224536_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6818-3p	44224532	44224538	7mer-m8	44224531	44224552	140	-13.21
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6860	44224556	44224562	7mer-m8	44224555	44224576	152	-23.99
CAediting_1456277	chr21_44224295_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7151-3p	44224294	44224301	8mer-1a	44224294	44224310	146	-17.62
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7160-5p	44224599	44224605	7mer-m8	44224598	44224617	148	-18.91
CAediting_1456307	chr21_44224601_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7162-3p	44224600	44224605	6mer	44224599	44224617	144	-17.64
CAediting_1456279	chr21_44224429_-	ENSG00000160223.15	ENST00000407780	hsa-miR-764	44224425	44224431	7mer-m8	44224424	44224448	149	-23.05
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7851-3p	44224553	44224560	8mer-1a	44224553	44224574	140	-21.38
CAediting_1456305	chr21_44224582_-	ENSG00000160223.15	ENST00000407780	hsa-miR-7977	44224582	44224588	7mer-m8	44224581	44224598	142	-12.93
CAediting_1456306	chr21_44224592_-	ENSG00000160223.15	ENST00000407780	hsa-miR-887-5p	44224592	44224598	7mer-m8	44224591	44224612	145	-20.79
CAediting_1456284	chr21_44224460_-	ENSG00000160223.15	ENST00000407780	hsa-miR-887-5p	44224459	44224466	8mer-1a	44224459	44224479	140	-10.77
CAediting_1456285	chr21_44224461_-	ENSG00000160223.15	ENST00000407780	hsa-miR-887-5p	44224459	44224466	8mer-1a	44224459	44224479	140	-10.77
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-92a-3p	44224650	44224656	7mer-m8	44224649	44224666	155	-22.79
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-92a-3p	44224650	44224656	7mer-m8	44224649	44224666	155	-22.79
CAediting_1456316	chr21_44224652_-	ENSG00000160223.15	ENST00000407780	hsa-miR-92b-3p	44224650	44224656	7mer-m8	44224649	44224666	155	-21.59
CAediting_1456302	chr21_44224557_-	ENSG00000160223.15	ENST00000407780	hsa-miR-939-3p	44224555	44224561	7mer-m8	44224554	44224574	142	-15.58

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000277117.3	ENST00000623960	hsa-miR-1304-3p	5035358	5035365	8mer-1a	5035342	5035365	159	-31.73
CAediting_980496	chr14_31014685_-	ENSG00000277117.3	ENST00000623960	hsa-miR-624-3p	5036645	5036652	8mer-1a	5036634	5036652	160	-18.07
CAediting_846604	chr11_93733708_-	ENSG00000277117.3	ENST00000623795	hsa-miR-1304-3p	5035358	5035365	8mer-1a	5035342	5035365	159	-31.73
CAediting_748296	chr10_51299626_+	ENSG00000160223.15	ENST00000407780	hsa-miR-605-3p	44225689	44225695	7mer-m8	44225688	44225712	145	-19.55
CAediting_748296	chr10_51299626_+	ENSG00000160223.15	ENST00000407780	hsa-miR-605-3p	44224871	44224877	7mer-m8	44224870	44224890	154	-15.32
CAediting_748296	chr10_51299626_+	ENSG00000160223.15	ENST00000407780	hsa-miR-605-3p	44223765	44223771	7mer-m8	44223764	44223786	154	-14.92
CAediting_846604	chr11_93733708_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1304-3p	44228260	44228267	8mer-1a	44228260	44228283	159	-31.73
CAediting_980496	chr14_31014685_-	ENSG00000160223.15	ENST00000407780	hsa-miR-624-3p	44226956	44226963	8mer-1a	44226956	44226974	160	-18.07
CAediting_393	chr1_1167164_+	ENSG00000160223.15	ENST00000407780	hsa-miR-200b-3p	44223612	44223618	7mer-m8	44223611	44223632	140	-10.7
CAediting_846604	chr11_93733708_-	ENSG00000160223.15	ENST00000400379	hsa-miR-1304-3p	44228260	44228267	8mer-1a	44228260	44228283	159	-31.73
CAediting_980496	chr14_31014685_-	ENSG00000160223.15	ENST00000400379	hsa-miR-624-3p	44226956	44226963	8mer-1a	44226956	44226974	160	-18.07
CAediting_980496	chr14_31014685_-	ENSG00000160223.15	ENST00000400379	hsa-miR-624-3p	44229141	44229147	7mer-m8	44229140	44229160	145	-16.75
CAediting_846604	chr11_93733708_-	ENSG00000160223.15	ENST00000400377	hsa-miR-1304-3p	44228260	44228267	8mer-1a	44228260	44228283	159	-31.73
CAediting_980496	chr14_31014685_-	ENSG00000160223.15	ENST00000400377	hsa-miR-624-3p	44226956	44226963	8mer-1a	44226956	44226974	160	-18.07
CAediting_1160181	chr17_7017644_-	ENSG00000277117.3	ENST00000623903	hsa-miR-195-3p	5028161	5028167	7mer-m8	5028147	5028168	148	-19.34
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623903	hsa-miR-27a-3p	5034626	5034631	6mer	5034625	5034645	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623903	hsa-miR-27a-3p	5034638	5034644	7mer-m8	5034625	5034645	155	-27.33
CAediting_573001	chr7_92204086_-	ENSG00000277117.3	ENST00000623903	hsa-miR-1285-5p	5034628	5034634	7mer-m8	5034617	5034635	143	-18.28
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623960	hsa-miR-27a-3p	5034626	5034631	6mer	5034625	5034645	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623960	hsa-miR-27a-3p	5034638	5034644	7mer-m8	5034625	5034645	155	-27.33
CAediting_86358	chr1_109598906_+	ENSG00000277117.3	ENST00000623960	hsa-miR-197-5p	5035545	5035550	6mer	5035529	5035551	149	-31.98
CAediting_77128	chr1_85133844_+	ENSG00000277117.3	ENST00000623960	hsa-miR-4423-3p	5036230	5036236	7mer-m8	5036217	5036237	153	-25.41
CAediting_77128	chr1_85133844_+	ENSG00000277117.3	ENST00000623960	hsa-miR-4423-3p	5035138	5035144	7mer-m8	5035125	5035145	143	-15.14
CAediting_580943	chr7_100356700_+	ENSG00000277117.3	ENST00000623960	hsa-miR-6840-3p	5036333	5036340	8mer-1a	5036318	5036340	155	-29.38
CAediting_604450	chr7_133034877_-	ENSG00000277117.3	ENST00000623960	hsa-miR-3654	5035399	5035406	8mer-1a	5035388	5035406	147	-18.02
CAediting_573001	chr7_92204086_-	ENSG00000277117.3	ENST00000623960	hsa-miR-1285-5p	5036636	5036642	7mer-m8	5036622	5036643	144	-21.3
CAediting_573001	chr7_92204086_-	ENSG00000277117.3	ENST00000623960	hsa-miR-1285-5p	5034628	5034634	7mer-m8	5034617	5034635	143	-18.28
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623795	hsa-miR-27a-3p	5034626	5034631	6mer	5034625	5034645	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623795	hsa-miR-27a-3p	5034638	5034644	7mer-m8	5034625	5034645	155	-27.33
CAediting_86358	chr1_109598906_+	ENSG00000277117.3	ENST00000623795	hsa-miR-197-5p	5035545	5035550	6mer	5035529	5035551	149	-31.98
CAediting_77128	chr1_85133844_+	ENSG00000277117.3	ENST00000623795	hsa-miR-4423-3p	5035138	5035144	7mer-m8	5035125	5035145	143	-15.14
CAediting_604450	chr7_133034877_-	ENSG00000277117.3	ENST00000623795	hsa-miR-3654	5035399	5035406	8mer-1a	5035388	5035406	147	-18.02
CAediting_573001	chr7_92204086_-	ENSG00000277117.3	ENST00000623795	hsa-miR-1285-5p	5034628	5034634	7mer-m8	5034617	5034635	143	-18.28
CAediting_1054808	chr15_66496985_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4512	44226582	44226588	7mer-m8	44226581	44226601	159	-29.88
CAediting_1054808	chr15_66496985_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4512	44224853	44224860	8mer-1a	44224853	44224874	149	-21.16
CAediting_1229413	chr17_67471544_+	ENSG00000160223.15	ENST00000407780	hsa-miR-548aa	44224501	44224508	8mer-1a	44224501	44224525	144	-12.15
CAediting_1229415	chr17_67471547_+	ENSG00000160223.15	ENST00000407780	hsa-miR-548aa	44226815	44226821	7mer-m8	44226814	44226838	145	-16.63
CAediting_1229415	chr17_67471547_+	ENSG00000160223.15	ENST00000407780	hsa-miR-548aa	44226161	44226167	7mer-m8	44226160	44226184	157	-13.85
CAediting_1229415	chr17_67471547_+	ENSG00000160223.15	ENST00000407780	hsa-miR-548aa	44223290	44223296	7mer-m8	44223289	44223313	156	-18.42
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000407780	hsa-miR-27a-3p	44228994	44228999	6mer	44228980	44229000	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000407780	hsa-miR-27a-3p	44228981	44228987	7mer-m8	44228980	44229000	155	-27.33
CAediting_1368054	chr19_46709310_-	ENSG00000160223.15	ENST00000407780	hsa-miR-320e	44226780	44226787	8mer-1a	44226780	44226796	144	-14.78
CAediting_1368054	chr19_46709310_-	ENSG00000160223.15	ENST00000407780	hsa-miR-320e	44225880	44225886	7mer-m8	44225879	44225897	142	-17.15
CAediting_1368054	chr19_46709310_-	ENSG00000160223.15	ENST00000407780	hsa-miR-320e	44225588	44225595	8mer-1a	44225588	44225605	156	-19.74
CAediting_1368054	chr19_46709310_-	ENSG00000160223.15	ENST00000407780	hsa-miR-320e	44225529	44225536	8mer-1a	44225529	44225546	148	-16.86
CAediting_86358	chr1_109598906_+	ENSG00000160223.15	ENST00000407780	hsa-miR-197-5p	44226561	44226567	7mer-m8	44226560	44226582	140	-19.05
CAediting_86358	chr1_109598906_+	ENSG00000160223.15	ENST00000407780	hsa-miR-197-5p	44228075	44228080	6mer	44228074	44228096	149	-31.98
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000407780	hsa-miR-4423-3p	44227372	44227378	7mer-m8	44227371	44227391	153	-25.41
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000407780	hsa-miR-4423-3p	44228481	44228487	7mer-m8	44228480	44228500	143	-15.14
CAediting_228905	chr2_188297554_+	ENSG00000160223.15	ENST00000407780	hsa-miR-561-3p	44223913	44223919	7mer-m8	44223912	44223931	146	-15.58
CAediting_580943	chr7_100356700_+	ENSG00000160223.15	ENST00000407780	hsa-miR-6840-3p	44227268	44227275	8mer-1a	44227268	44227290	155	-29.38
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3654	44228219	44228226	8mer-1a	44228219	44228237	147	-18.02
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1285-5p	44226966	44226972	7mer-m8	44226965	44226986	144	-21.3
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000407780	hsa-miR-1285-5p	44228991	44228997	7mer-m8	44228990	44229008	143	-18.28
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400379	hsa-miR-27a-3p	44228994	44228999	6mer	44228980	44229000	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400379	hsa-miR-27a-3p	44228981	44228987	7mer-m8	44228980	44229000	155	-27.33
CAediting_86358	chr1_109598906_+	ENSG00000160223.15	ENST00000400379	hsa-miR-197-5p	44228075	44228080	6mer	44228074	44228096	149	-31.98
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000400379	hsa-miR-4423-3p	44228481	44228487	7mer-m8	44228480	44228500	143	-15.14
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000400379	hsa-miR-4423-3p	44227372	44227378	7mer-m8	44227371	44227391	153	-25.41
CAediting_580943	chr7_100356700_+	ENSG00000160223.15	ENST00000400379	hsa-miR-6840-3p	44227268	44227275	8mer-1a	44227268	44227290	155	-29.38
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000400379	hsa-miR-3654	44228219	44228226	8mer-1a	44228219	44228237	147	-18.02
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000400379	hsa-miR-1285-5p	44226966	44226972	7mer-m8	44226965	44226986	144	-21.3
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000400379	hsa-miR-1285-5p	44228991	44228997	7mer-m8	44228990	44229008	143	-18.28
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400377	hsa-miR-27a-3p	44228994	44228999	6mer	44228980	44229000	155	-27.33
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400377	hsa-miR-27a-3p	44228981	44228987	7mer-m8	44228980	44229000	155	-27.33
CAediting_86358	chr1_109598906_+	ENSG00000160223.15	ENST00000400377	hsa-miR-197-5p	44228075	44228080	6mer	44228074	44228096	149	-31.98
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000400377	hsa-miR-4423-3p	44227372	44227378	7mer-m8	44227371	44227391	153	-25.41
CAediting_77128	chr1_85133844_+	ENSG00000160223.15	ENST00000400377	hsa-miR-4423-3p	44228481	44228487	7mer-m8	44228480	44228500	143	-15.14
CAediting_580943	chr7_100356700_+	ENSG00000160223.15	ENST00000400377	hsa-miR-6840-3p	44227268	44227275	8mer-1a	44227268	44227290	155	-29.38
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000400377	hsa-miR-3654	44228219	44228226	8mer-1a	44228219	44228237	147	-18.02
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000400377	hsa-miR-1285-5p	44226966	44226972	7mer-m8	44226965	44226986	144	-21.3
CAediting_573001	chr7_92204086_-	ENSG00000160223.15	ENST00000400377	hsa-miR-1285-5p	44228991	44228997	7mer-m8	44228990	44229008	143	-18.28
CAediting_468389	chr6_31355314_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6891-5p	44226061	44226067	7mer-m8	44226060	44226078	141	-19.55
CAediting_468389	chr6_31355314_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6891-5p	44225767	44225773	7mer-m8	44225766	44225786	149	-22.26
CAediting_1524209	chrX_134546392_-	ENSG00000160223.15	ENST00000407780	hsa-miR-503-5p	44223262	44223268	7mer-1a	44223262	44223286	143	-30.25

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306323	chr19_13836462_-	ENSG00000277117.3	ENST00000623960	hsa-miR-27a-3p	5036246	5036253	8mer-1a	5036231	5036253	151	-15.33
CAediting_1524209	chrX_134546392_-	ENSG00000277117.3	ENST00000623960	hsa-miR-503-5p	5035026	5035031	6mer	5035008	5035032	142	-22.31
CAediting_1524209	chrX_134546392_-	ENSG00000277117.3	ENST00000623795	hsa-miR-503-5p	5035026	5035031	6mer	5035008	5035032	142	-22.31
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000407780	hsa-miR-27a-3p	44227355	44227362	8mer-1a	44227355	44227377	151	-15.33
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000407780	hsa-miR-27a-3p	44223515	44223521	7mer-m8	44223514	44223534	153	-18.26
CAediting_1368054	chr19_46709310_-	ENSG00000160223.15	ENST00000407780	hsa-miR-320e	44227194	44227200	7mer-m8	44227193	44227210	155	-18.69
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000407780	hsa-miR-3654	44227953	44227959	7mer-m8	44227952	44227970	145	-14.75
CAediting_1054808	chr15_66496985_-	ENSG00000160223.15	ENST00000407780	hsa-miR-4512	44225840	44225846	7mer-m8	44225839	44225862	141	-21.78
CAediting_1524209	chrX_134546392_-	ENSG00000160223.15	ENST00000407780	hsa-miR-503-5p	44228594	44228599	6mer	44228593	44228617	142	-22.31
CAediting_1399425	chr20_1392958_-	ENSG00000160223.15	ENST00000407780	hsa-miR-6869-5p	44223221	44223227	7mer-m8	44223220	44223241	146	-17.49
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400379	hsa-miR-27a-3p	44227355	44227362	8mer-1a	44227355	44227377	151	-15.33
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000400379	hsa-miR-3654	44227953	44227959	7mer-m8	44227952	44227970	145	-14.75
CAediting_1524209	chrX_134546392_-	ENSG00000160223.15	ENST00000400379	hsa-miR-503-5p	44228594	44228599	6mer	44228593	44228617	142	-22.31
CAediting_468389	chr6_31355314_-	ENSG00000160223.15	ENST00000400379	hsa-miR-6891-5p	44229060	44229065	6mer	44229059	44229077	148	-22.94
CAediting_1306323	chr19_13836462_-	ENSG00000160223.15	ENST00000400377	hsa-miR-27a-3p	44227355	44227362	8mer-1a	44227355	44227377	151	-15.33
CAediting_604450	chr7_133034877_-	ENSG00000160223.15	ENST00000400377	hsa-miR-3654	44227953	44227959	7mer-m8	44227952	44227970	145	-14.75
CAediting_1524209	chrX_134546392_-	ENSG00000160223.15	ENST00000400377	hsa-miR-503-5p	44228594	44228599	6mer	44228593	44228617	142	-22.31

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ICOSLG

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ICOSLG

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1456270	chr21_44223918_-	0.03395899679585	0.265524762170822	.	.	.	.
BRCA	CAediting_1456298	chr21_44224532_-	2.29973800327074e-06	0.469844820150134	.	.	.	.
BRCA	CAediting_1456300	chr21_44224541_-	0.000115455565255468	0.395258931563704	.	.	0.00838703019504283	0.276297909973625
BRCA	CAediting_1456301	chr21_44224547_-	0.000140761060017246	0.352073128819581	.	.	.	.
BRCA	CAediting_1456314	chr21_44224636_-	0.00434752190802933	0.239645540521359	.	.	.	.

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Relation with cancer stages for ICOSLG

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ICOSLG

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ICOSLG

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ICOSLG

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ICOSLG	C0007570	Celiac Disease	1	CTD_human
ICOSLG	C0009324	Ulcerative Colitis	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene