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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: FLNA (CAeditome ID:2316) |
Gene summary for FLNA |
 Gene summary |
| Gene information | Gene symbol | FLNA | Gene ID | 2316 |
| Gene name | filamin A | |
| Synonyms | ABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD | |
| Cytomap | Xq28 | |
| Type of gene | protein-coding | |
| Description | filamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin | |
| Modification date | 20210518 | |
| UniProtAcc | P21333 | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FLNA | GO:0090307 | Filamin-A | 18548008 |
| FLNA | GO:0015459 | Filamin-A | 24951510 |
| FLNA | GO:0031267 | Filamin-A | 10051605 |
| FLNA | GO:0034988 | Filamin-A | 1833070 |
| FLNA | GO:0042803 | Filamin-A | 2391361 |
| FLNA | GO:0051015 | Filamin-A | 2391361 |
| FLNA | GO:0051015 | Filamin-A | 25358863 |
| FLNA | GO:0051015 | Filamin-A | 3138234 |
| FLNA | GO:0051015 | Filamin-A | 4044584 |
| FLNA | GO:0016479 | Filamin-A | 22307607 |
| FLNA | GO:0030334 | Filamin-A | 16291724 |
| FLNA | GO:0031532 | Filamin-A | 10051605 |
| FLNA | GO:0034394 | Filamin-A | 18322202 |
| FLNA | GO:0043113 | Filamin-A | 10692483 |
| FLNA | GO:0043433 | Filamin-A | 15684392 |
| FLNA | GO:0044319 | Filamin-A | 16291724 |
| FLNA | GO:0045184 | Filamin-A | 18322202 |
| FLNA | GO:0051764 | Filamin-A | 10051605 |
| FLNA | GO:0072659 | Filamin-A | 24951510 |
| FLNA | GO:1901381 | Filamin-A | 24951510 |
| FLNA | GO:0005634 | Filamin-A | 15684392 |
| FLNA | GO:0005737 | Filamin-A | 15684392 |
| FLNA | GO:0005737 | Filamin-A | 21914078 |
| FLNA | GO:0005737 | Filamin-A | 25468996 |
| FLNA | GO:0005829 | Filamin-A | 0000052 |
| FLNA | GO:0005886 | Filamin-A | 0000052 |
| FLNA | GO:0005886 | Filamin-A | 18322202 |
| FLNA | GO:0005911 | Filamin-A | 16291724 |
| FLNA | GO:0015629 | Filamin-A | 0000052 |
| FLNA | GO:0015629 | Filamin-A | 25358863 |
| FLNA | GO:0031523 | Filamin-A | 18548008 |
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RNA A-to-I events for FLNA |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000196924.13 |
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| RNA A-to-I editing events in Cancer. |
| CAediting_1527831(154351043, -), CAediting_1527832(154351318, -), CAediting_1527833(154351354, -), CAediting_1527834(154351368, -), CAediting_1527835(154351522, -), CAediting_1527836(154351569, -), CAediting_1527837(154363144, -), CAediting_1527838(154363458, -), |
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RNA editing positional annotations for FLNA using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_1527831 | chrX_154351043_- | ncRNA_exonic;splicing |
| CAediting_1527832 | chrX_154351318_- | ncRNA_exonic |
| CAediting_1527833 | chrX_154351354_- | ncRNA_exonic |
| CAediting_1527834 | chrX_154351368_- | ncRNA_exonic |
| CAediting_1527835 | chrX_154351522_- | ncRNA_exonic |
| CAediting_1527836 | chrX_154351569_- | ncRNA_exonic |
| CAediting_1527837 | chrX_154363144_- | intronic |
| CAediting_1527838 | chrX_154363458_- | intronic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_1527837 | chrX_154363144_- | SINE | Alu | AluSp |
| CAediting_1527838 | chrX_154363458_- | SINE | Alu | AluYf1 |
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RNA A-to-I editing events in the alternative splicing sites for FLNA |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | CAediting_1527831 | chrX_154351043_- | 154351032:154351054 | 3SS | 0+9i | GCTGTGCTTCCAGGAGTCAGGGC | -8.52 | GCTGTGCTTCCGGGAGTCAGGGC | -1.6 |
| ES | CAediting_1527831 | chrX_154351043_- | 154351036:154351058 | 3SS | 0+5i | GTCTGCTGTGCTTCCAGGAGTCA | -15.57 | GTCTGCTGTGCTTCCGGGAGTCA | -8.83 |
| ES | CAediting_1527831 | chrX_154351043_- | 154351039:154351061 | 3SS | 0+2i | CATGTCTGCTGTGCTTCCAGGAG | 9.12 | CATGTCTGCTGTGCTTCCGGGAG | 1.17 |
| IR | CAediting_1527831 | chrX_154351043_- | 154351032:154351054 | 3SS | 0+9i | GCTGTGCTTCCAGGAGTCAGGGC | -8.52 | GCTGTGCTTCCGGGAGTCAGGGC | -1.6 |
| IR | CAediting_1527831 | chrX_154351043_- | 154351036:154351058 | 3SS | 0+5i | GTCTGCTGTGCTTCCAGGAGTCA | -15.57 | GTCTGCTGTGCTTCCGGGAGTCA | -8.83 |
| IR | CAediting_1527831 | chrX_154351043_- | 154351039:154351061 | 3SS | 0+2i | CATGTCTGCTGTGCTTCCAGGAG | 9.12 | CATGTCTGCTGTGCTTCCGGGAG | 1.17 |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000196924.13.FLNA. |
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| Correlation between RNA A-to-I editing and PSI for ENSG00000196924.13.FLNA. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FLNA |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for FLNA |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for FLNA |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_688081 | chr9_63819627_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4477b | 154361741 | 154361747 | 7mer-m8 | 154361740 | 154361757 | 142 | -11.74 |
| CAediting_846604 | chr11_93733708_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-1304-3p | 154354200 | 154354206 | 7mer-m8 | 154354199 | 154354223 | 141 | -18.79 |
| CAediting_393 | chr1_1167164_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-200b-3p | 154353612 | 154353618 | 7mer-m8 | 154353611 | 154353630 | 143 | -15.54 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-197-5p | 154364532 | 154364539 | 8mer-1a | 154364532 | 154364553 | 149 | -22.99 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4512 | 154364277 | 154364284 | 8mer-1a | 154364277 | 154364301 | 149 | -22.38 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154364090 | 154364096 | 7mer-m8 | 154364089 | 154364109 | 155 | -16.62 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4512 | 154362532 | 154362538 | 7mer-m8 | 154362531 | 154362554 | 151 | -26.64 |
| CAediting_604450 | chr7_133034877_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-3654 | 154361980 | 154361987 | 8mer-1a | 154361980 | 154361999 | 153 | -19.24 |
| CAediting_573000 | chr7_92204081_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-1285-5p | 154362039 | 154362045 | 7mer-m8 | 154362038 | 154362058 | 158 | -21.12 |
| CAediting_442554 | chr5_154685830_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-1303 | 154361712 | 154361718 | 7mer-m8 | 154361711 | 154361733 | 145 | -16.92 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4512 | 154360474 | 154360479 | 6mer | 154360473 | 154360496 | 143 | -31.49 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4512 | 154360291 | 154360297 | 7mer-m8 | 154360290 | 154360311 | 147 | -23.21 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154360410 | 154360416 | 7mer-m8 | 154360409 | 154360432 | 141 | -13.03 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154360070 | 154360077 | 8mer-1a | 154360070 | 154360090 | 140 | -14.15 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154359602 | 154359608 | 7mer-m8 | 154359601 | 154359621 | 140 | -13.3 |
| CAediting_580943 | chr7_100356700_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-6840-3p | 154359554 | 154359560 | 7mer-m8 | 154359553 | 154359574 | 142 | -25.33 |
| CAediting_524911 | chr7_5495852_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-589-3p | 154359095 | 154359101 | 7mer-m8 | 154359094 | 154359117 | 146 | -17.4 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154358503 | 154358509 | 7mer-m8 | 154358502 | 154358522 | 144 | -12.1 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154357464 | 154357470 | 7mer-m8 | 154357463 | 154357483 | 140 | -14.66 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4423-3p | 154354844 | 154354851 | 8mer-1a | 154354844 | 154354864 | 140 | -15.39 |
| CAediting_573000 | chr7_92204081_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-1285-5p | 154354386 | 154354392 | 7mer-m8 | 154354385 | 154354406 | 154 | -21.12 |
| CAediting_1306323 | chr19_13836462_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-27a-3p | 154354223 | 154354229 | 7mer-m8 | 154354222 | 154354242 | 147 | -17.39 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-4512 | 154352253 | 154352258 | 6mer | 154352252 | 154352273 | 146 | -21.82 |
| CAediting_1399425 | chr20_1392958_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-6869-5p | 154348799 | 154348806 | 8mer-1a | 154348799 | 154348819 | 165 | -28.82 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_604450 | chr7_133034877_- | ENSG00000196924.13 | ENST00000420627 | hsa-miR-3654 | 154362074 | 154362080 | 7mer-m8 | 154362073 | 154362091 | 140 | -17.23 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for FLNA |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for FLNA |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| PRAD | CAediting_1527831 | chrX_154351043_- | 0.048515167983321 | 0.167660656540094 | . | . | . | . |
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Relation with cancer stages for FLNA |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for FLNA |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
| BRCA | CAediting_1527831 | chrX_154351043_- | 0.000370825458820501 | 0.00783027 | 12486200 |
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RelatedDrugs for FLNA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FLNA |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FLNA | C1848213 | Periventricular Heterotopia, X-Linked | 9 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| FLNA | C0025237 | Melnick-Needles Syndrome | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| FLNA | C4707243 | Familial thoracic aortic aneurysm and aortic dissection | 7 | CLINGEN;GENOMICS_ENGLAND |
| FLNA | C0265251 | Oto-Palato-digital syndrome type 1 | 6 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| FLNA | C1844696 | OTOPALATODIGITAL SYNDROME, TYPE II | 6 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| FLNA | C0265293 | Frontometaphyseal dysplasia | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| FLNA | C1846129 | Terminal Osseous Dysplasia and Pigmentary Defects | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| FLNA | C4281559 | FRONTOMETAPHYSEAL DYSPLASIA 1 | 4 | GENOMICS_ENGLAND;UNIPROT |
| FLNA | C0262436 | Cardiac valvular dysplasia, X-linked | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| FLNA | C0543888 | Epileptic encephalopathy | 2 | GENOMICS_ENGLAND |
| FLNA | C1845902 | FG SYNDROME 2 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| FLNA | C1868720 | Periventricular Nodular Heterotopia | 2 | CTD_human |
| FLNA | C2746068 | Congenital idiopathic intestinal pseudoobstruction | 2 | CTD_human;GENOMICS_ENGLAND |
| FLNA | C4551969 | Bilateral Periventricular Nodular Heterotopia | 2 | CTD_human |
| FLNA | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| FLNA | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| FLNA | C0013366 | Dyschondroplasias | 1 | CTD_human |
| FLNA | C0014544 | Epilepsy | 1 | CTD_human |
| FLNA | C0021847 | Intestinal Pseudo-Obstruction | 1 | ORPHANET |
| FLNA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| FLNA | C0026760 | Multiple Epiphyseal Dysplasia | 1 | CTD_human |
| FLNA | C0029422 | Osteochondrodysplasias | 1 | CTD_human |
| FLNA | C0036391 | Schwartz-Jampel Syndrome | 1 | CTD_human |
| FLNA | C0038015 | Spondyloepiphyseal Dysplasia | 1 | CTD_human |
| FLNA | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| FLNA | C0220769 | FG syndrome | 1 | CTD_human |
| FLNA | C0236018 | Aura | 1 | CTD_human |
| FLNA | C0268341 | Ehlers-Danlos syndrome type 5 | 1 | ORPHANET |
| FLNA | C0432272 | Van Buchem disease | 1 | CTD_human |
| FLNA | C0600066 | Malignant Cystosarcoma Phyllodes | 1 | CTD_human |
| FLNA | C0678222 | Breast Carcinoma | 1 | CTD_human |
| FLNA | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| FLNA | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| FLNA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| FLNA | C1845235 | Heterotopia, Periventricular, Ehlers-Danlos Variant | 1 | CTD_human |
| FLNA | C1845546 | FG SYNDROME 4 (disorder) | 1 | CTD_human |
| FLNA | C1845567 | FG SYNDROME 3 | 1 | CTD_human |
| FLNA | C1855733 | Neuronal intestinal pseudoobstruction | 1 | ORPHANET |
| FLNA | C2751260 | Macrothrombocytopenia | 1 | GENOMICS_ENGLAND |
| FLNA | C3541456 | Spondyloepiphyseal Dysplasia Tarda, X-Linked | 1 | CTD_human |
| FLNA | C4551479 | Schwartz-Jampel Syndrome, Type 1 | 1 | CTD_human |
| FLNA | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
