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Editing gene: ZC3H3 (CAeditome ID:23144)

Gene summary for ZC3H3

Gene summary

Gene information	Gene symbol	ZC3H3
	Gene ID	23144
	Gene name	zinc finger CCCH-type containing 3
	Synonyms	SMICL\|ZC3HDC3
	Cytomap	8q24.3
	Type of gene	protein-coding
	Description	zinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3
	Modification date	20210518
	UniProtAcc	Q8IXZ2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ZC3H3	GO:0005634	Zinc finger CCCH domain-containing protein 3	16115198
ZC3H3	GO:0005634	Zinc finger CCCH domain-containing protein 3	19364924

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RNA A-to-I events for ZC3H3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000014164.6

RNA A-to-I editing events in Cancer.

CAediting_669922(143443007, -), CAediting_669923(143443028, -), CAediting_669924(143443054, -), CAediting_669925(143443141, -), CAediting_669926(143443145, -), CAediting_669927(143443163, -), CAediting_669928(143443173, -), CAediting_669929(143443177, -), CAediting_669930(143443185, -), CAediting_669931(143443198, -), CAediting_669932(143443202, -), CAediting_669933(143443203, -), CAediting_669934(143443209, -), CAediting_669935(143443271, -), CAediting_669936(143444103, -), CAediting_669937(143444131, -), CAediting_669938(143444139, -), CAediting_669939(143444176, -), CAediting_669940(143444253, -), CAediting_669941(143445335, -), CAediting_669942(143447871, -), CAediting_669943(143447912, -), CAediting_669944(143448006, -), CAediting_669945(143448012, -), CAediting_669946(143449477, -), CAediting_669947(143449517, -), CAediting_669948(143449589, -), CAediting_669949(143449590, -), CAediting_669950(143449626, -), CAediting_669951(143450309, -), CAediting_669952(143450329, -), CAediting_669953(143450345, -), CAediting_669954(143450408, -), CAediting_669955(143450413, -), CAediting_669956(143450460, -), CAediting_669957(143451551, -), CAediting_669958(143453202, -), CAediting_669959(143453277, -), CAediting_669960(143454108, -), CAediting_669961(143454119, -), CAediting_669962(143454178, -), CAediting_669963(143454179, -), CAediting_669964(143454187, -), CAediting_669965(143454193, -), CAediting_669966(143454210, -), CAediting_669967(143454214, -), CAediting_669968(143454219, -), CAediting_669969(143454220, -), CAediting_669970(143454230, -), CAediting_669971(143454307, -), CAediting_669972(143454309, -), CAediting_669973(143454310, -), CAediting_669974(143454316, -), CAediting_669975(143454333, -), CAediting_669976(143454347, -), CAediting_669977(143454358, -), CAediting_669978(143454363, -), CAediting_669979(143454364, -), CAediting_669980(143454370, -), CAediting_669981(143454382, -), CAediting_669982(143454386, -), CAediting_669983(143454453, -), CAediting_669984(143454468, -), CAediting_669985(143454473, -), CAediting_669986(143454521, -), CAediting_669987(143454530, -), CAediting_669988(143454544, -), CAediting_669989(143454554, -), CAediting_669990(143454570, -), CAediting_669991(143454591, -), CAediting_669992(143454595, -), CAediting_669993(143454606, -), CAediting_669994(143454608, -), CAediting_669995(143454609, -), CAediting_669996(143454614, -), CAediting_669997(143454616, -), CAediting_669998(143454639, -), CAediting_669999(143454645, -), CAediting_670000(143454683, -), CAediting_670001(143455071, -), CAediting_670002(143455109, -), CAediting_670003(143455122, -), CAediting_670004(143455134, -), CAediting_670005(143455151, -), CAediting_670006(143455190, -), CAediting_670007(143455192, -), CAediting_670008(143455202, -), CAediting_670009(143455857, -), CAediting_670010(143455861, -), CAediting_670011(143455873, -), CAediting_670012(143457480, -), CAediting_670013(143457487, -), CAediting_670014(143463264, -), CAediting_670015(143495725, -), CAediting_670016(143533772, -), CAediting_670017(143540509, -),

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RNA editing positional annotations for ZC3H3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_669922	chr8_143443007_-	intronic
CAediting_669923	chr8_143443028_-	intronic
CAediting_669924	chr8_143443054_-	intronic
CAediting_669925	chr8_143443141_-	intronic
CAediting_669926	chr8_143443145_-	intronic
CAediting_669927	chr8_143443163_-	intronic
CAediting_669928	chr8_143443173_-	intronic
CAediting_669929	chr8_143443177_-	intronic
CAediting_669930	chr8_143443185_-	intronic
CAediting_669931	chr8_143443198_-	intronic
CAediting_669932	chr8_143443202_-	intronic
CAediting_669933	chr8_143443203_-	intronic
CAediting_669934	chr8_143443209_-	intronic
CAediting_669935	chr8_143443271_-	intronic
CAediting_669936	chr8_143444103_-	intronic
CAediting_669937	chr8_143444131_-	intronic
CAediting_669938	chr8_143444139_-	intronic
CAediting_669939	chr8_143444176_-	intronic
CAediting_669940	chr8_143444253_-	intronic
CAediting_669941	chr8_143445335_-	intronic
CAediting_669942	chr8_143447871_-	intronic
CAediting_669943	chr8_143447912_-	intronic
CAediting_669944	chr8_143448006_-	intronic
CAediting_669945	chr8_143448012_-	intronic
CAediting_669946	chr8_143449477_-	intronic
CAediting_669947	chr8_143449517_-	intronic
CAediting_669948	chr8_143449589_-	intronic
CAediting_669949	chr8_143449590_-	intronic
CAediting_669950	chr8_143449626_-	intronic
CAediting_669951	chr8_143450309_-	intronic
CAediting_669952	chr8_143450329_-	intronic
CAediting_669953	chr8_143450345_-	intronic
CAediting_669954	chr8_143450408_-	intronic
CAediting_669955	chr8_143450413_-	intronic
CAediting_669956	chr8_143450460_-	intronic
CAediting_669957	chr8_143451551_-	intronic
CAediting_669958	chr8_143453202_-	intronic
CAediting_669959	chr8_143453277_-	intronic
CAediting_669960	chr8_143454108_-	intronic
CAediting_669961	chr8_143454119_-	intronic
CAediting_669962	chr8_143454178_-	intronic
CAediting_669963	chr8_143454179_-	intronic
CAediting_669964	chr8_143454187_-	intronic
CAediting_669965	chr8_143454193_-	intronic
CAediting_669966	chr8_143454210_-	intronic
CAediting_669967	chr8_143454214_-	intronic
CAediting_669968	chr8_143454219_-	intronic
CAediting_669969	chr8_143454220_-	intronic
CAediting_669970	chr8_143454230_-	intronic
CAediting_669971	chr8_143454307_-	intronic
CAediting_669972	chr8_143454309_-	intronic
CAediting_669973	chr8_143454310_-	intronic
CAediting_669974	chr8_143454316_-	intronic
CAediting_669975	chr8_143454333_-	intronic
CAediting_669976	chr8_143454347_-	intronic
CAediting_669977	chr8_143454358_-	intronic
CAediting_669978	chr8_143454363_-	intronic
CAediting_669979	chr8_143454364_-	intronic
CAediting_669980	chr8_143454370_-	intronic
CAediting_669981	chr8_143454382_-	intronic
CAediting_669982	chr8_143454386_-	intronic
CAediting_669983	chr8_143454453_-	intronic
CAediting_669984	chr8_143454468_-	intronic
CAediting_669985	chr8_143454473_-	intronic
CAediting_669986	chr8_143454521_-	intronic
CAediting_669987	chr8_143454530_-	intronic
CAediting_669988	chr8_143454544_-	intronic
CAediting_669989	chr8_143454554_-	intronic
CAediting_669990	chr8_143454570_-	intronic
CAediting_669991	chr8_143454591_-	intronic
CAediting_669992	chr8_143454595_-	intronic
CAediting_669993	chr8_143454606_-	intronic
CAediting_669994	chr8_143454608_-	intronic
CAediting_669995	chr8_143454609_-	intronic
CAediting_669996	chr8_143454614_-	intronic
CAediting_669997	chr8_143454616_-	intronic
CAediting_669998	chr8_143454639_-	intronic
CAediting_669999	chr8_143454645_-	intronic
CAediting_670000	chr8_143454683_-	intronic
CAediting_670001	chr8_143455071_-	intronic
CAediting_670002	chr8_143455109_-	intronic
CAediting_670003	chr8_143455122_-	intronic
CAediting_670004	chr8_143455134_-	intronic
CAediting_670005	chr8_143455151_-	intronic
CAediting_670006	chr8_143455190_-	intronic
CAediting_670007	chr8_143455192_-	intronic
CAediting_670008	chr8_143455202_-	intronic
CAediting_670009	chr8_143455857_-	intronic
CAediting_670010	chr8_143455861_-	intronic
CAediting_670011	chr8_143455873_-	intronic
CAediting_670012	chr8_143457480_-	intronic
CAediting_670013	chr8_143457487_-	intronic
CAediting_670014	chr8_143463264_-	intronic
CAediting_670015	chr8_143495725_-	intronic
CAediting_670016	chr8_143533772_-	intronic
CAediting_670017	chr8_143540509_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_669922	chr8_143443007_-	SINE	Alu	AluSz
CAediting_669923	chr8_143443028_-	SINE	Alu	AluSz
CAediting_669924	chr8_143443054_-	SINE	Alu	AluSz
CAediting_669925	chr8_143443141_-	SINE	Alu	AluSz
CAediting_669926	chr8_143443145_-	SINE	Alu	AluSz
CAediting_669927	chr8_143443163_-	SINE	Alu	AluSz
CAediting_669928	chr8_143443173_-	SINE	Alu	AluSz
CAediting_669929	chr8_143443177_-	SINE	Alu	AluSz
CAediting_669930	chr8_143443185_-	SINE	Alu	AluSz
CAediting_669931	chr8_143443198_-	SINE	Alu	AluSz
CAediting_669932	chr8_143443202_-	SINE	Alu	AluSz
CAediting_669933	chr8_143443203_-	SINE	Alu	AluSz
CAediting_669934	chr8_143443209_-	SINE	Alu	AluSz
CAediting_669935	chr8_143443271_-	SINE	Alu	AluSz
CAediting_669936	chr8_143444103_-	SINE	Alu	AluY
CAediting_669937	chr8_143444131_-	SINE	Alu	AluY
CAediting_669938	chr8_143444139_-	SINE	Alu	AluY
CAediting_669939	chr8_143444176_-	SINE	Alu	AluY
CAediting_669940	chr8_143444253_-	SINE	Alu	AluY
CAediting_669941	chr8_143445335_-	SINE	Alu	AluSp
CAediting_669942	chr8_143447871_-	SINE	Alu	AluSp
CAediting_669943	chr8_143447912_-	SINE	Alu	AluSp
CAediting_669944	chr8_143448006_-	SINE	Alu	AluSp
CAediting_669945	chr8_143448012_-	SINE	Alu	AluSp
CAediting_669946	chr8_143449477_-	SINE	Alu	AluSx
CAediting_669947	chr8_143449517_-	SINE	Alu	AluSx
CAediting_669948	chr8_143449589_-	SINE	Alu	AluSx
CAediting_669949	chr8_143449590_-	SINE	Alu	AluSx
CAediting_669950	chr8_143449626_-	SINE	Alu	AluSx
CAediting_669951	chr8_143450309_-	SINE	Alu	AluSz6
CAediting_669952	chr8_143450329_-	SINE	Alu	AluSz6
CAediting_669953	chr8_143450345_-	SINE	Alu	AluSz6
CAediting_669954	chr8_143450408_-	SINE	Alu	AluSz6
CAediting_669955	chr8_143450413_-	SINE	Alu	AluSz6
CAediting_669956	chr8_143450460_-	SINE	Alu	AluSz6
CAediting_669957	chr8_143451551_-	SINE	Alu	AluSg
CAediting_669958	chr8_143453202_-	SINE	Alu	AluJo
CAediting_669959	chr8_143453277_-	SINE	Alu	AluJo
CAediting_669960	chr8_143454108_-	SINE	Alu	AluSq
CAediting_669961	chr8_143454119_-	SINE	Alu	AluSq
CAediting_669962	chr8_143454178_-	SINE	Alu	AluSq
CAediting_669963	chr8_143454179_-	SINE	Alu	AluSq
CAediting_669964	chr8_143454187_-	SINE	Alu	AluSq
CAediting_669965	chr8_143454193_-	SINE	Alu	AluSq
CAediting_669966	chr8_143454210_-	SINE	Alu	AluSq
CAediting_669967	chr8_143454214_-	SINE	Alu	AluSq
CAediting_669968	chr8_143454219_-	SINE	Alu	AluSq
CAediting_669969	chr8_143454220_-	SINE	Alu	AluSq
CAediting_669970	chr8_143454230_-	SINE	Alu	AluSq
CAediting_669971	chr8_143454307_-	SINE	Alu	AluSq
CAediting_669972	chr8_143454309_-	SINE	Alu	AluSq
CAediting_669973	chr8_143454310_-	SINE	Alu	AluSq
CAediting_669974	chr8_143454316_-	SINE	Alu	AluSq
CAediting_669975	chr8_143454333_-	SINE	Alu	AluSq
CAediting_669976	chr8_143454347_-	SINE	Alu	AluSq
CAediting_669977	chr8_143454358_-	SINE	Alu	AluSq
CAediting_669978	chr8_143454363_-	SINE	Alu	AluSq
CAediting_669979	chr8_143454364_-	SINE	Alu	AluSq
CAediting_669980	chr8_143454370_-	SINE	Alu	AluSq
CAediting_669981	chr8_143454382_-	SINE	Alu	AluSq
CAediting_669982	chr8_143454386_-	SINE	Alu	AluSq
CAediting_669983	chr8_143454453_-	SINE	Alu	AluY
CAediting_669984	chr8_143454468_-	SINE	Alu	AluY
CAediting_669985	chr8_143454473_-	SINE	Alu	AluY
CAediting_669986	chr8_143454521_-	SINE	Alu	AluY
CAediting_669987	chr8_143454530_-	SINE	Alu	AluY
CAediting_669988	chr8_143454544_-	SINE	Alu	AluY
CAediting_669989	chr8_143454554_-	SINE	Alu	AluY
CAediting_669990	chr8_143454570_-	SINE	Alu	AluY
CAediting_669991	chr8_143454591_-	SINE	Alu	AluY
CAediting_669992	chr8_143454595_-	SINE	Alu	AluY
CAediting_669993	chr8_143454606_-	SINE	Alu	AluY
CAediting_669994	chr8_143454608_-	SINE	Alu	AluY
CAediting_669995	chr8_143454609_-	SINE	Alu	AluY
CAediting_669996	chr8_143454614_-	SINE	Alu	AluY
CAediting_669997	chr8_143454616_-	SINE	Alu	AluY
CAediting_669998	chr8_143454639_-	SINE	Alu	AluY
CAediting_669999	chr8_143454645_-	SINE	Alu	AluY
CAediting_670000	chr8_143454683_-	SINE	Alu	AluY
CAediting_670001	chr8_143455071_-	SINE	Alu	AluSg
CAediting_670002	chr8_143455109_-	SINE	Alu	AluSg
CAediting_670003	chr8_143455122_-	SINE	Alu	AluSg
CAediting_670004	chr8_143455134_-	SINE	Alu	AluSg
CAediting_670005	chr8_143455151_-	SINE	Alu	AluSg
CAediting_670006	chr8_143455190_-	SINE	Alu	AluSg
CAediting_670007	chr8_143455192_-	SINE	Alu	AluSg
CAediting_670008	chr8_143455202_-	SINE	Alu	AluSg
CAediting_670009	chr8_143455857_-	SINE	Alu	AluSz
CAediting_670010	chr8_143455861_-	SINE	Alu	AluSz
CAediting_670011	chr8_143455873_-	SINE	Alu	AluSz
CAediting_670012	chr8_143457480_-	SINE	Alu	AluJo
CAediting_670013	chr8_143457487_-	SINE	Alu	AluJo
CAediting_670014	chr8_143463264_-	SINE	Alu	AluSq2
CAediting_670015	chr8_143495725_-	SINE	Alu	AluJo
CAediting_670016	chr8_143533772_-	SINE	Alu	AluSx1
CAediting_670017	chr8_143540509_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for ZC3H3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000014164.6.ZC3H3.

Correlation between RNA A-to-I editing and PSI for ENSG00000014164.6.ZC3H3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZC3H3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZC3H3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZC3H3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZC3H3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZC3H3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ZC3H3

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
OV	clinical_stage	CAediting_669928	chr8_143443173_-	0.0415164964584151	0.195601919092391

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Relation with survival for ZC3H3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ZC3H3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZC3H3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene