Home

Download

Statistics

Examples

Help

Contact

Editing gene: PHF8 (CAeditome ID:23133)

Gene summary for PHF8

Gene summary

Gene information	Gene symbol	PHF8
	Gene ID	23133
	Gene name	PHD finger protein 8
	Synonyms	JHDM1F\|KDM7B\|MRXSSD\|ZNF422
	Cytomap	Xp11.22
	Type of gene	protein-coding
	Description	histone lysine demethylase PHF8[histone H3]-dimethyl-L-lysine(36) demethylase PHF8[histone H3]-dimethyl-L-lysine(9) demethylase PHF8jumonji C domain-containing histone demethylase 1F
	Modification date	20210518
	UniProtAcc	Q9UPP1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PHF8	GO:0003682	Histone lysine demethylase PHF8	20622854
PHF8	GO:0005506	Histone lysine demethylase PHF8	20023638
PHF8	GO:0008270	Histone lysine demethylase PHF8	20023638
PHF8	GO:0016706	Histone lysine demethylase PHF8	20023638
PHF8	GO:0032452	Histone lysine demethylase PHF8	19843542
PHF8	GO:0032454	Histone lysine demethylase PHF8	20023638
PHF8	GO:0032454	Histone lysine demethylase PHF8	20208542
PHF8	GO:0032454	Histone lysine demethylase PHF8	20346720
PHF8	GO:0032454	Histone lysine demethylase PHF8	20622853
PHF8	GO:0032454	Histone lysine demethylase PHF8	20622854
PHF8	GO:0035064	Histone lysine demethylase PHF8	20023638
PHF8	GO:0035064	Histone lysine demethylase PHF8	20208542
PHF8	GO:0035064	Histone lysine demethylase PHF8	20346720
PHF8	GO:0035064	Histone lysine demethylase PHF8	20622853
PHF8	GO:0035064	Histone lysine demethylase PHF8	20622854
PHF8	GO:0035064	Histone lysine demethylase PHF8	21029866
PHF8	GO:0035575	Histone lysine demethylase PHF8	20622853
PHF8	GO:0035575	Histone lysine demethylase PHF8	20622854
PHF8	GO:0051864	Histone lysine demethylase PHF8	20208542
PHF8	GO:0051864	Histone lysine demethylase PHF8	20622853
PHF8	GO:0071558	Histone lysine demethylase PHF8	20622853
PHF8	GO:0071558	Histone lysine demethylase PHF8	20622854
PHF8	GO:0033169	Histone lysine demethylase PHF8	20023638
PHF8	GO:0033169	Histone lysine demethylase PHF8	20208542
PHF8	GO:0033169	Histone lysine demethylase PHF8	20346720
PHF8	GO:0033169	Histone lysine demethylase PHF8	20622853
PHF8	GO:0033169	Histone lysine demethylase PHF8	20622854
PHF8	GO:0035574	Histone lysine demethylase PHF8	20622853
PHF8	GO:0035574	Histone lysine demethylase PHF8	20622854
PHF8	GO:0045893	Histone lysine demethylase PHF8	20622853
PHF8	GO:0045943	Histone lysine demethylase PHF8	20208542
PHF8	GO:0061188	Histone lysine demethylase PHF8	20208542
PHF8	GO:0070544	Histone lysine demethylase PHF8	20208542
PHF8	GO:0070544	Histone lysine demethylase PHF8	20622853
PHF8	GO:0071557	Histone lysine demethylase PHF8	20622853
PHF8	GO:0071557	Histone lysine demethylase PHF8	20622854
PHF8	GO:0005634	Histone lysine demethylase PHF8	19843542
PHF8	GO:0005654	Histone lysine demethylase PHF8	0000052
PHF8	GO:0005730	Histone lysine demethylase PHF8	20208542
PHF8	GO:0031965	Histone lysine demethylase PHF8	0000052

Top

RNA A-to-I events for PHF8

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000172943.17

RNA A-to-I editing events in Cancer.

CAediting_1508783(53938835, -), CAediting_1508784(53938885, -), CAediting_1508785(53944922, -), CAediting_1508786(53948365, -), CAediting_1508787(53949568, -), CAediting_1508788(53951481, -), CAediting_1508789(53952224, -), CAediting_1508790(53952761, -), CAediting_1508791(53955278, -), CAediting_1508792(53955306, -), CAediting_1508793(53955330, -), CAediting_1508794(53955334, -), CAediting_1508795(53955335, -), CAediting_1508796(53955352, -), CAediting_1508797(53955373, -), CAediting_1508798(53955989, -), CAediting_1508799(53956044, -), CAediting_1508800(53956081, -), CAediting_1508801(53956084, -), CAediting_1508802(53956125, -), CAediting_1508803(53956138, -), CAediting_1508804(53956150, -), CAediting_1508805(53956167, -), CAediting_1508806(53956174, -), CAediting_1508807(53956190, -), CAediting_1508808(53956209, -), CAediting_1508809(53956236, -), CAediting_1508810(53957150, -), CAediting_1508811(53957152, -), CAediting_1508812(53958245, -), CAediting_1508813(53958335, -), CAediting_1508814(53960130, -), CAediting_1508815(53960585, -), CAediting_1508816(53960601, -), CAediting_1508817(53961146, -), CAediting_1508818(53961187, -), CAediting_1508819(53961216, -), CAediting_1508820(53961219, -), CAediting_1508821(53961226, -), CAediting_1508822(53965517, -), CAediting_1508823(53965601, -), CAediting_1508824(53979894, -), CAediting_1508825(54013766, -), CAediting_1508826(54018325, -), CAediting_1508827(54018374, -), CAediting_1508828(54018375, -), CAediting_1508829(54018393, -), CAediting_1508830(54021607, -), CAediting_1508831(54021643, -), CAediting_1508832(54026832, -),

Top

RNA editing positional annotations for PHF8 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1508783	chrX_53938835_-	UTR3
CAediting_1508784	chrX_53938885_-	UTR3
CAediting_1508785	chrX_53944922_-	intronic
CAediting_1508786	chrX_53948365_-	intronic
CAediting_1508787	chrX_53949568_-	intronic
CAediting_1508788	chrX_53951481_-	intronic
CAediting_1508789	chrX_53952224_-	intronic
CAediting_1508790	chrX_53952761_-	intronic
CAediting_1508791	chrX_53955278_-	intronic
CAediting_1508792	chrX_53955306_-	intronic
CAediting_1508793	chrX_53955330_-	intronic
CAediting_1508794	chrX_53955334_-	intronic
CAediting_1508795	chrX_53955335_-	intronic
CAediting_1508796	chrX_53955352_-	intronic
CAediting_1508797	chrX_53955373_-	intronic
CAediting_1508798	chrX_53955989_-	intronic
CAediting_1508799	chrX_53956044_-	intronic
CAediting_1508800	chrX_53956081_-	intronic
CAediting_1508801	chrX_53956084_-	intronic
CAediting_1508802	chrX_53956125_-	intronic
CAediting_1508803	chrX_53956138_-	intronic
CAediting_1508804	chrX_53956150_-	intronic
CAediting_1508805	chrX_53956167_-	intronic
CAediting_1508806	chrX_53956174_-	intronic
CAediting_1508807	chrX_53956190_-	intronic
CAediting_1508808	chrX_53956209_-	intronic
CAediting_1508809	chrX_53956236_-	intronic
CAediting_1508810	chrX_53957150_-	intronic
CAediting_1508811	chrX_53957152_-	intronic
CAediting_1508812	chrX_53958245_-	intronic
CAediting_1508813	chrX_53958335_-	intronic
CAediting_1508814	chrX_53960130_-	intronic
CAediting_1508815	chrX_53960585_-	intronic
CAediting_1508816	chrX_53960601_-	intronic
CAediting_1508817	chrX_53961146_-	intronic
CAediting_1508818	chrX_53961187_-	intronic
CAediting_1508819	chrX_53961216_-	intronic
CAediting_1508820	chrX_53961219_-	intronic
CAediting_1508821	chrX_53961226_-	intronic
CAediting_1508822	chrX_53965517_-	intronic
CAediting_1508823	chrX_53965601_-	intronic
CAediting_1508824	chrX_53979894_-	intronic
CAediting_1508825	chrX_54013766_-	ncRNA_intronic
CAediting_1508826	chrX_54018325_-	intronic
CAediting_1508827	chrX_54018374_-	intronic
CAediting_1508828	chrX_54018375_-	intronic
CAediting_1508829	chrX_54018393_-	intronic
CAediting_1508830	chrX_54021607_-	intronic
CAediting_1508831	chrX_54021643_-	intronic
CAediting_1508832	chrX_54026832_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1508785	chrX_53944922_-	SINE	Alu	AluSz6
CAediting_1508786	chrX_53948365_-	SINE	Alu	AluSx1
CAediting_1508787	chrX_53949568_-	SINE	Alu	AluY
CAediting_1508788	chrX_53951481_-	SINE	Alu	AluYm1
CAediting_1508789	chrX_53952224_-	SINE	Alu	AluSx3
CAediting_1508790	chrX_53952761_-	SINE	Alu	AluY
CAediting_1508791	chrX_53955278_-	SINE	Alu	AluJb
CAediting_1508792	chrX_53955306_-	SINE	Alu	AluJb
CAediting_1508793	chrX_53955330_-	SINE	Alu	AluJb
CAediting_1508794	chrX_53955334_-	SINE	Alu	AluJb
CAediting_1508795	chrX_53955335_-	SINE	Alu	AluJb
CAediting_1508796	chrX_53955352_-	SINE	Alu	AluJb
CAediting_1508797	chrX_53955373_-	SINE	Alu	AluJb
CAediting_1508798	chrX_53955989_-	SINE	Alu	AluSx1
CAediting_1508799	chrX_53956044_-	SINE	Alu	AluSx1
CAediting_1508800	chrX_53956081_-	SINE	Alu	AluSx1
CAediting_1508801	chrX_53956084_-	SINE	Alu	AluSx1
CAediting_1508802	chrX_53956125_-	SINE	Alu	AluSx1
CAediting_1508803	chrX_53956138_-	SINE	Alu	AluSx1
CAediting_1508804	chrX_53956150_-	SINE	Alu	AluSx1
CAediting_1508805	chrX_53956167_-	SINE	Alu	AluSx1
CAediting_1508806	chrX_53956174_-	SINE	Alu	AluSx1
CAediting_1508807	chrX_53956190_-	SINE	Alu	AluSx1
CAediting_1508808	chrX_53956209_-	SINE	Alu	AluSx1
CAediting_1508809	chrX_53956236_-	SINE	Alu	AluSx1
CAediting_1508810	chrX_53957150_-	SINE	Alu	AluSc
CAediting_1508811	chrX_53957152_-	SINE	Alu	AluSc
CAediting_1508812	chrX_53958245_-	SINE	Alu	AluSc
CAediting_1508813	chrX_53958335_-	SINE	Alu	AluSc
CAediting_1508814	chrX_53960130_-	SINE	Alu	AluY
CAediting_1508815	chrX_53960585_-	SINE	Alu	AluSx3
CAediting_1508816	chrX_53960601_-	SINE	Alu	AluSx3
CAediting_1508817	chrX_53961146_-	SINE	Alu	AluSz
CAediting_1508818	chrX_53961187_-	SINE	Alu	AluSz
CAediting_1508819	chrX_53961216_-	SINE	Alu	AluSz
CAediting_1508820	chrX_53961219_-	SINE	Alu	AluSz
CAediting_1508821	chrX_53961226_-	SINE	Alu	AluSz
CAediting_1508822	chrX_53965517_-	SINE	Alu	AluSz6
CAediting_1508823	chrX_53965601_-	SINE	Alu	AluSz6
CAediting_1508824	chrX_53979894_-	SINE	Alu	AluJb
CAediting_1508825	chrX_54013766_-	SINE	Alu	AluSx1
CAediting_1508826	chrX_54018325_-	SINE	Alu	AluJr4
CAediting_1508827	chrX_54018374_-	SINE	Alu	AluJr4
CAediting_1508828	chrX_54018375_-	SINE	Alu	AluJr4
CAediting_1508829	chrX_54018393_-	SINE	Alu	AluJr4
CAediting_1508830	chrX_54021607_-	SINE	Alu	AluYa5
CAediting_1508831	chrX_54021643_-	SINE	Alu	AluYa5
CAediting_1508832	chrX_54026832_-	SINE	Alu	AluJo

Top

RNA A-to-I editing events in the alternative splicing sites for PHF8

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172943.17.PHF8.

Correlation between RNA A-to-I editing and PSI for ENSG00000172943.17.PHF8.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for PHF8

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for PHF8

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for PHF8

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1508783	chrX_53938835_-	ENSG00000172943.17	ENST00000357988	hsa-miR-766-3p	53938832	53938838	7mer-m8	53938831	53938852	140.00	-12.12
CAediting_1508784	chrX_53938885_-	ENSG00000172943.17	ENST00000357988	hsa-miR-4782-5p	53938884	53938889	6mer	53938883	53938904	142.00	-11.12

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1508783	chrX_53938835_-	ENSG00000172943.17	ENST00000357988	hsa-miR-1251-5p	53938832	53938838	7mer-m8	53938831	53938851	143	-13.1
CAediting_1508783	chrX_53938835_-	ENSG00000172943.17	ENST00000357988	hsa-miR-1301-5p	53938831	53938837	7mer-m8	53938830	53938848	140	-10.27
CAediting_1508783	chrX_53938835_-	ENSG00000172943.17	ENST00000357988	hsa-miR-6502-5p	53938831	53938837	7mer-m8	53938830	53938851	140	-13.79
CAediting_1508784	chrX_53938885_-	ENSG00000172943.17	ENST00000357988	hsa-miR-6740-5p	53938883	53938888	6mer	53938882	53938904	147	-22.98
CAediting_1508784	chrX_53938885_-	ENSG00000172943.17	ENST00000357988	hsa-miR-7850-5p	53938884	53938890	7mer-m8	53938883	53938902	144	-15.81

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000172943.17	ENST00000443302	hsa-miR-4477b	53943052	53943058	7mer-1a	53943052	53943073	140	-15.83
CAediting_86358	chr1_109598906_+	ENSG00000172943.17	ENST00000357988	hsa-miR-197-5p	53938715	53938722	8mer-1a	53938715	53938738	163	-29.71
CAediting_1399425	chr20_1392958_-	ENSG00000172943.17	ENST00000357988	hsa-miR-6869-5p	53937824	53937831	8mer-1a	53937824	53937845	160	-26.38
CAediting_1399425	chr20_1392958_-	ENSG00000172943.17	ENST00000338946	hsa-miR-6869-5p	53937824	53937831	8mer-1a	53937824	53937845	160	-26.38
CAediting_1399425	chr20_1392958_-	ENSG00000172943.17	ENST00000396282	hsa-miR-6869-5p	53937824	53937831	8mer-1a	53937824	53937845	160	-26.38

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_604450	chr7_133034877_-	ENSG00000172943.17	ENST00000357988	hsa-miR-3654	53938686	53938692	7mer-m8	53938685	53938703	140	-14.39
CAediting_1351755	chr19_40282625_-	ENSG00000172943.17	ENST00000357988	hsa-miR-641	53937104	53937110	7mer-m8	53937103	53937126	143	-14.59
CAediting_1351755	chr19_40282625_-	ENSG00000172943.17	ENST00000338946	hsa-miR-641	53937104	53937110	7mer-m8	53937103	53937126	143	-14.59

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for PHF8

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for PHF8

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for PHF8

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for PHF8

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for PHF8

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PHF8

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PHF8	C1846055	Siderius X-linked mental retardation syndrome	14	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene