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Editing gene: PLA2R1 (CAeditome ID:22925)

Gene summary for PLA2R1

Gene summary

Gene information	Gene symbol	PLA2R1
	Gene ID	22925
	Gene name	phospholipase A2 receptor 1
	Synonyms	CLEC13C\|PLA2-R\|PLA2G1R\|PLA2IR\|PLA2R
	Cytomap	2q24.2
	Type of gene	protein-coding
	Description	secretory phospholipase A2 receptor180 kDa secretory phospholipase A2 receptorC-type lectin domain family 13 member CM-type receptorphospholipase A2 receptor 1, 180kDphospholipase A2 receptor 1, 180kDa
	Modification date	20210518
	UniProtAcc	Q13018
	Context	- 32751713(Clinical Significance of Expression Changes and Promoter Methylation of PLA2R1 in Tissues of Breast Cancer Patients)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PLA2R1	GO:0072593	Secretory phospholipase A2 receptor	19197340
PLA2R1	GO:0005886	Secretory phospholipase A2 receptor	12225974
PLA2R1	GO:0009986	Secretory phospholipase A2 receptor	15611272
PLA2R1	GO:0043235	Secretory phospholipase A2 receptor	23382219

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RNA A-to-I events for PLA2R1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000153246.10

RNA A-to-I editing events in Cancer.

CAediting_221246(159935099, -), CAediting_221247(159936009, -), CAediting_221248(159936041, -), CAediting_221249(159936048, -), CAediting_221250(159936049, -), CAediting_221251(159936080, -), CAediting_221252(159936124, -), CAediting_221253(159936127, -), CAediting_221254(159936147, -), CAediting_221255(159936148, -), CAediting_221256(159936154, -), CAediting_221257(159936181, -), CAediting_221258(159936186, -), CAediting_221259(159936189, -), CAediting_221260(159936202, -), CAediting_221261(159936225, -), CAediting_221262(159936226, -), CAediting_221263(159936253, -), CAediting_221264(159936259, -), CAediting_221265(159939245, -), CAediting_221266(159939251, -), CAediting_221267(159939256, -), CAediting_221268(159939264, -), CAediting_221269(159939273, -), CAediting_221270(159939286, -), CAediting_221271(159939343, -), CAediting_221272(159939378, -), CAediting_221273(159939382, -), CAediting_221274(159939384, -), CAediting_221275(159939394, -), CAediting_221276(159939406, -), CAediting_221277(159939419, -), CAediting_221278(159939420, -), CAediting_221279(159939436, -), CAediting_221280(159939444, -), CAediting_221281(159939449, -), CAediting_221282(159939454, -), CAediting_221283(159939462, -), CAediting_221284(159939468, -), CAediting_221285(159939470, -), CAediting_221286(159939480, -), CAediting_221287(159939497, -), CAediting_221288(159939501, -), CAediting_221289(159940426, -), CAediting_221290(159940427, -), CAediting_221291(159940431, -), CAediting_221292(159940432, -), CAediting_221293(159940446, -), CAediting_221294(159940451, -), CAediting_221295(159940454, -), CAediting_221296(159940483, -), CAediting_221297(159940484, -), CAediting_221298(159940486, -), CAediting_221299(159940491, -), CAediting_221300(159940495, -), CAediting_221301(159940496, -), CAediting_221302(159940518, -), CAediting_221303(159940522, -), CAediting_221304(159940532, -), CAediting_221305(159940538, -), CAediting_221306(159940542, -), CAediting_221307(159940569, -), CAediting_221308(159945527, -), CAediting_221309(159965408, -), CAediting_221310(160034761, -), CAediting_221311(160034834, -), CAediting_221312(160039115, -), CAediting_221313(160047856, -), CAediting_221314(160047923, -), CAediting_221315(160047963, -), CAediting_221316(160047964, -), CAediting_221317(160047970, -), CAediting_221318(160049698, -), CAediting_221319(160049704, -), CAediting_221320(160049769, -),

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RNA editing positional annotations for PLA2R1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_221246	chr2_159935099_-	ncRNA_intronic
CAediting_221247	chr2_159936009_-	ncRNA_intronic
CAediting_221248	chr2_159936041_-	ncRNA_intronic
CAediting_221249	chr2_159936048_-	ncRNA_intronic
CAediting_221250	chr2_159936049_-	ncRNA_intronic
CAediting_221251	chr2_159936080_-	ncRNA_intronic
CAediting_221252	chr2_159936124_-	ncRNA_intronic
CAediting_221253	chr2_159936127_-	ncRNA_intronic
CAediting_221254	chr2_159936147_-	ncRNA_intronic
CAediting_221255	chr2_159936148_-	ncRNA_intronic
CAediting_221256	chr2_159936154_-	ncRNA_intronic
CAediting_221257	chr2_159936181_-	ncRNA_intronic
CAediting_221258	chr2_159936186_-	ncRNA_intronic
CAediting_221259	chr2_159936189_-	ncRNA_intronic
CAediting_221260	chr2_159936202_-	ncRNA_intronic
CAediting_221261	chr2_159936225_-	ncRNA_intronic
CAediting_221262	chr2_159936226_-	ncRNA_intronic
CAediting_221263	chr2_159936253_-	ncRNA_intronic
CAediting_221264	chr2_159936259_-	ncRNA_intronic
CAediting_221265	chr2_159939245_-	ncRNA_intronic
CAediting_221266	chr2_159939251_-	ncRNA_intronic
CAediting_221267	chr2_159939256_-	ncRNA_intronic
CAediting_221268	chr2_159939264_-	ncRNA_intronic
CAediting_221269	chr2_159939273_-	ncRNA_intronic
CAediting_221270	chr2_159939286_-	ncRNA_intronic
CAediting_221271	chr2_159939343_-	ncRNA_intronic
CAediting_221272	chr2_159939378_-	ncRNA_intronic
CAediting_221273	chr2_159939382_-	ncRNA_intronic
CAediting_221274	chr2_159939384_-	ncRNA_intronic
CAediting_221275	chr2_159939394_-	ncRNA_intronic
CAediting_221276	chr2_159939406_-	ncRNA_intronic
CAediting_221277	chr2_159939419_-	ncRNA_intronic
CAediting_221278	chr2_159939420_-	ncRNA_intronic
CAediting_221279	chr2_159939436_-	ncRNA_intronic
CAediting_221280	chr2_159939444_-	ncRNA_intronic
CAediting_221281	chr2_159939449_-	ncRNA_intronic
CAediting_221282	chr2_159939454_-	ncRNA_intronic
CAediting_221283	chr2_159939462_-	ncRNA_intronic
CAediting_221284	chr2_159939468_-	ncRNA_intronic
CAediting_221285	chr2_159939470_-	ncRNA_intronic
CAediting_221286	chr2_159939480_-	ncRNA_intronic
CAediting_221287	chr2_159939497_-	ncRNA_intronic
CAediting_221288	chr2_159939501_-	ncRNA_intronic
CAediting_221289	chr2_159940426_-	ncRNA_intronic
CAediting_221290	chr2_159940427_-	ncRNA_intronic
CAediting_221291	chr2_159940431_-	ncRNA_intronic
CAediting_221292	chr2_159940432_-	ncRNA_intronic
CAediting_221293	chr2_159940446_-	ncRNA_intronic
CAediting_221294	chr2_159940451_-	ncRNA_intronic
CAediting_221295	chr2_159940454_-	ncRNA_intronic
CAediting_221296	chr2_159940483_-	ncRNA_intronic
CAediting_221297	chr2_159940484_-	ncRNA_intronic
CAediting_221298	chr2_159940486_-	ncRNA_intronic
CAediting_221299	chr2_159940491_-	ncRNA_intronic
CAediting_221300	chr2_159940495_-	ncRNA_intronic
CAediting_221301	chr2_159940496_-	ncRNA_intronic
CAediting_221302	chr2_159940518_-	ncRNA_intronic
CAediting_221303	chr2_159940522_-	ncRNA_intronic
CAediting_221304	chr2_159940532_-	ncRNA_intronic
CAediting_221305	chr2_159940538_-	ncRNA_intronic
CAediting_221306	chr2_159940542_-	ncRNA_intronic
CAediting_221307	chr2_159940569_-	ncRNA_intronic
CAediting_221308	chr2_159945527_-	intronic
CAediting_221309	chr2_159965408_-	intronic
CAediting_221310	chr2_160034761_-	intronic
CAediting_221311	chr2_160034834_-	intronic
CAediting_221312	chr2_160039115_-	intronic
CAediting_221313	chr2_160047856_-	intronic
CAediting_221314	chr2_160047923_-	intronic
CAediting_221315	chr2_160047963_-	intronic
CAediting_221316	chr2_160047964_-	intronic
CAediting_221317	chr2_160047970_-	intronic
CAediting_221318	chr2_160049698_-	intronic
CAediting_221319	chr2_160049704_-	intronic
CAediting_221320	chr2_160049769_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_221246	chr2_159935099_-	LINE	L1	L1MC4a
CAediting_221247	chr2_159936009_-	SINE	Alu	AluY
CAediting_221248	chr2_159936041_-	SINE	Alu	AluY
CAediting_221249	chr2_159936048_-	SINE	Alu	AluY
CAediting_221250	chr2_159936049_-	SINE	Alu	AluY
CAediting_221251	chr2_159936080_-	SINE	Alu	AluY
CAediting_221252	chr2_159936124_-	SINE	Alu	AluY
CAediting_221253	chr2_159936127_-	SINE	Alu	AluY
CAediting_221254	chr2_159936147_-	SINE	Alu	AluY
CAediting_221255	chr2_159936148_-	SINE	Alu	AluY
CAediting_221256	chr2_159936154_-	SINE	Alu	AluY
CAediting_221257	chr2_159936181_-	SINE	Alu	AluY
CAediting_221258	chr2_159936186_-	SINE	Alu	AluY
CAediting_221259	chr2_159936189_-	SINE	Alu	AluY
CAediting_221260	chr2_159936202_-	SINE	Alu	AluY
CAediting_221261	chr2_159936225_-	SINE	Alu	AluY
CAediting_221262	chr2_159936226_-	SINE	Alu	AluY
CAediting_221263	chr2_159936253_-	DNA	hAT-Charlie	Charlie2a
CAediting_221264	chr2_159936259_-	DNA	hAT-Charlie	Charlie2a
CAediting_221265	chr2_159939245_-	SINE	Alu	AluSc5
CAediting_221266	chr2_159939251_-	SINE	Alu	AluSc5
CAediting_221267	chr2_159939256_-	SINE	Alu	AluSc5
CAediting_221268	chr2_159939264_-	SINE	Alu	AluSc5
CAediting_221269	chr2_159939273_-	SINE	Alu	AluSc5
CAediting_221270	chr2_159939286_-	SINE	Alu	AluSc5
CAediting_221271	chr2_159939343_-	SINE	Alu	AluSc5
CAediting_221272	chr2_159939378_-	SINE	Alu	AluSc5
CAediting_221273	chr2_159939382_-	SINE	Alu	AluSc5
CAediting_221274	chr2_159939384_-	SINE	Alu	AluSc5
CAediting_221275	chr2_159939394_-	SINE	Alu	AluSc5
CAediting_221276	chr2_159939406_-	SINE	Alu	AluSc5
CAediting_221277	chr2_159939419_-	SINE	Alu	AluSc5
CAediting_221278	chr2_159939420_-	SINE	Alu	AluSc5
CAediting_221279	chr2_159939436_-	SINE	Alu	AluSc5
CAediting_221280	chr2_159939444_-	SINE	Alu	AluSc5
CAediting_221281	chr2_159939449_-	SINE	Alu	AluSc5
CAediting_221282	chr2_159939454_-	SINE	Alu	AluSc5
CAediting_221283	chr2_159939462_-	SINE	Alu	AluSc5
CAediting_221284	chr2_159939468_-	SINE	Alu	AluSc5
CAediting_221285	chr2_159939470_-	SINE	Alu	AluSc5
CAediting_221286	chr2_159939480_-	SINE	Alu	AluSc5
CAediting_221287	chr2_159939497_-	SINE	Alu	AluSc5
CAediting_221288	chr2_159939501_-	SINE	Alu	AluSc5
CAediting_221289	chr2_159940426_-	SINE	Alu	AluJo
CAediting_221290	chr2_159940427_-	SINE	Alu	AluJo
CAediting_221291	chr2_159940431_-	SINE	Alu	AluJo
CAediting_221292	chr2_159940432_-	SINE	Alu	AluJo
CAediting_221293	chr2_159940446_-	SINE	Alu	AluJo
CAediting_221294	chr2_159940451_-	SINE	Alu	AluJo
CAediting_221295	chr2_159940454_-	SINE	Alu	AluJo
CAediting_221296	chr2_159940483_-	SINE	Alu	AluJo
CAediting_221297	chr2_159940484_-	SINE	Alu	AluJo
CAediting_221298	chr2_159940486_-	SINE	Alu	AluJo
CAediting_221299	chr2_159940491_-	SINE	Alu	AluJo
CAediting_221300	chr2_159940495_-	SINE	Alu	AluJo
CAediting_221301	chr2_159940496_-	SINE	Alu	AluJo
CAediting_221302	chr2_159940518_-	SINE	Alu	AluJo
CAediting_221303	chr2_159940522_-	SINE	Alu	AluJo
CAediting_221304	chr2_159940532_-	SINE	Alu	AluJo
CAediting_221305	chr2_159940538_-	SINE	Alu	AluJo
CAediting_221306	chr2_159940542_-	SINE	Alu	AluJo
CAediting_221308	chr2_159945527_-	LINE	L1	L1PA3
CAediting_221309	chr2_159965408_-	LINE	L1	L1MC1
CAediting_221310	chr2_160034761_-	SINE	Alu	AluJr
CAediting_221311	chr2_160034834_-	SINE	Alu	AluJr
CAediting_221312	chr2_160039115_-	SINE	Alu	AluSx1
CAediting_221313	chr2_160047856_-	SINE	Alu	AluJb
CAediting_221314	chr2_160047923_-	SINE	Alu	AluJb
CAediting_221315	chr2_160047963_-	SINE	Alu	AluJb
CAediting_221316	chr2_160047964_-	SINE	Alu	AluJb
CAediting_221317	chr2_160047970_-	SINE	Alu	AluJb
CAediting_221318	chr2_160049698_-	SINE	Alu	AluSz6
CAediting_221319	chr2_160049704_-	SINE	Alu	AluSz6
CAediting_221320	chr2_160049769_-	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for PLA2R1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_221307	chr2_159940569_-	159940565:159940587	3SS	0+2i	GTTTATTGAATTTTATCAAGAAA	0.68	GTTTATTGAATTTTATCAGGAAA	-7.27
IR	CAediting_221307	chr2_159940569_-	159940565:159940587	3SS	0+2i	GTTTATTGAATTTTATCAAGAAA	0.68	GTTTATTGAATTTTATCAGGAAA	-7.27

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000153246.10.PLA2R1.

Correlation between RNA A-to-I editing and PSI for ENSG00000153246.10.PLA2R1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLA2R1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PLA2R1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PLA2R1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000153246.10	ENST00000392771	hsa-miR-195-3p	159946647	159946653	7mer-m8	159946646	159946667	151	-10.78
CAediting_1160181	chr17_7017644_-	ENSG00000153246.10	ENST00000392771	hsa-miR-195-3p	159946207	159946213	7mer-m8	159946206	159946226	151	-13.49
CAediting_228905	chr2_188297554_+	ENSG00000153246.10	ENST00000392771	hsa-miR-561-3p	159946714	159946720	7mer-m8	159946713	159946734	140	-8.91

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1399425	chr20_1392958_-	ENSG00000153246.10	ENST00000392771	hsa-miR-6869-5p	159946390	159946396	7mer-m8	159946389	159946410	143	-13.82

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PLA2R1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000283243.10	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_221265	ENST00000283243.10	chr2_159939245_-	-2527.17	-2526.87	-2594.40
CAediting_221266	ENST00000283243.10	chr2_159939251_-	-2526.87	-2526.87	-2594.40
CAediting_221267	ENST00000283243.10	chr2_159939256_-	-2528.47	-2526.87	-2594.40
CAediting_221268	ENST00000283243.10	chr2_159939264_-	-2529.37	-2526.87	-2594.40
CAediting_221269	ENST00000283243.10	chr2_159939273_-	-2526.87	-2526.87	-2594.40
CAediting_221270	ENST00000283243.10	chr2_159939286_-	-2527.20	-2526.87	-2594.40
CAediting_221271	ENST00000283243.10	chr2_159939343_-	-2530.00	-2526.87	-2594.40
CAediting_221272	ENST00000283243.10	chr2_159939378_-	-2531.67	-2526.87	-2594.40
CAediting_221273	ENST00000283243.10	chr2_159939382_-	-2526.17	-2526.87	-2594.40
CAediting_221274	ENST00000283243.10	chr2_159939384_-	-2526.87	-2526.87	-2594.40
CAediting_221275	ENST00000283243.10	chr2_159939394_-	-2526.57	-2526.87	-2594.40
CAediting_221276	ENST00000283243.10	chr2_159939406_-	-2526.17	-2526.87	-2594.40
CAediting_221277	ENST00000283243.10	chr2_159939419_-	-2528.07	-2526.87	-2594.40
CAediting_221278	ENST00000283243.10	chr2_159939420_-	-2527.97	-2526.87	-2594.40
CAediting_221279	ENST00000283243.10	chr2_159939436_-	-2526.87	-2526.87	-2594.40
CAediting_221280	ENST00000283243.10	chr2_159939444_-	-2526.17	-2526.87	-2594.40
CAediting_221281	ENST00000283243.10	chr2_159939449_-	-2526.47	-2526.87	-2594.40
CAediting_221282	ENST00000283243.10	chr2_159939454_-	-2526.87	-2526.87	-2594.40
CAediting_221283	ENST00000283243.10	chr2_159939462_-	-2531.97	-2526.87	-2594.40
CAediting_221284	ENST00000283243.10	chr2_159939468_-	-2526.17	-2526.87	-2594.40
CAediting_221285	ENST00000283243.10	chr2_159939470_-	-2533.57	-2526.87	-2594.40
CAediting_221286	ENST00000283243.10	chr2_159939480_-	-2526.17	-2526.87	-2594.40
CAediting_221287	ENST00000283243.10	chr2_159939497_-	-2533.77	-2526.87	-2594.40
CAediting_221288	ENST00000283243.10	chr2_159939501_-	-2533.57	-2526.87	-2594.40
CAediting_221289	ENST00000283243.10	chr2_159940426_-	-2533.37	-2526.87	-2594.40
CAediting_221290	ENST00000283243.10	chr2_159940427_-	-2526.87	-2526.87	-2594.40
CAediting_221291	ENST00000283243.10	chr2_159940431_-	-2526.87	-2526.87	-2594.40
CAediting_221292	ENST00000283243.10	chr2_159940432_-	-2526.57	-2526.87	-2594.40
CAediting_221293	ENST00000283243.10	chr2_159940446_-	-2527.17	-2526.87	-2594.40
CAediting_221294	ENST00000283243.10	chr2_159940451_-	-2526.47	-2526.87	-2594.40
CAediting_221295	ENST00000283243.10	chr2_159940454_-	-2531.97	-2526.87	-2594.40
CAediting_221296	ENST00000283243.10	chr2_159940483_-	-2526.87	-2526.87	-2594.40
CAediting_221297	ENST00000283243.10	chr2_159940484_-	-2530.67	-2526.87	-2594.40
CAediting_221298	ENST00000283243.10	chr2_159940486_-	-2529.97	-2526.87	-2594.40
CAediting_221299	ENST00000283243.10	chr2_159940491_-	-2527.97	-2526.87	-2594.40
CAediting_221300	ENST00000283243.10	chr2_159940495_-	-2529.97	-2526.87	-2594.40
CAediting_221301	ENST00000283243.10	chr2_159940496_-	-2527.27	-2526.87	-2594.40
CAediting_221302	ENST00000283243.10	chr2_159940518_-	-2532.77	-2526.87	-2594.40
CAediting_221303	ENST00000283243.10	chr2_159940522_-	-2526.87	-2526.87	-2594.40
CAediting_221304	ENST00000283243.10	chr2_159940532_-	-2526.47	-2526.87	-2594.40
CAediting_221305	ENST00000283243.10	chr2_159940538_-	-2531.67	-2526.87	-2594.40
CAediting_221306	ENST00000283243.10	chr2_159940542_-	-2526.87	-2526.87	-2594.40
CAediting_221307	ENST00000283243.10	chr2_159940569_-	-2527.87	-2526.87	-2594.40

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Relation with ADAR for PLA2R1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUSC	CAediting_221304	chr2_159940532_-	0.0229040755087785	0.204214022952535	.	.	.	.
ESCA	CAediting_221304	chr2_159940532_-	.	.	0.0369971094455178	0.242959188382339	.	.

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Relation with cancer stages for PLA2R1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
HNSC	clinical_stage	CAediting_221304	chr2_159940532_-	0.0143520525404396	0.249190488463949
HNSC	pathologic_stage	CAediting_221304	chr2_159940532_-	0.0303250958265213	0.242337983173879

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Relation with survival for PLA2R1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PLA2R1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PLA2R1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PLA2R1	C0013146	Drug abuse	1	CTD_human
PLA2R1	C0013170	Drug habituation	1	CTD_human
PLA2R1	C0013222	Drug Use Disorders	1	CTD_human
PLA2R1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
PLA2R1	C0038580	Substance Dependence	1	CTD_human
PLA2R1	C0038586	Substance Use Disorders	1	CTD_human
PLA2R1	C0236969	Substance-Related Disorders	1	CTD_human
PLA2R1	C0740858	Substance abuse problem	1	CTD_human
PLA2R1	C1510472	Drug Dependence	1	CTD_human
PLA2R1	C4316881	Prescription Drug Abuse	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene