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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: LRRN4CL (CAeditome ID:221091)

Gene summary for LRRN4CL

check button Gene summary
Gene informationGene symbol

LRRN4CL

Gene ID

221091

Gene nameLRRN4 C-terminal like
Synonyms-
Cytomap

11q12.3

Type of geneprotein-coding
DescriptionLRRN4 C-terminal-like protein
Modification date20210528
UniProtAcc

Q8ND94

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for LRRN4CL

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000177363.4
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_818836(62686700, -), CAediting_818837(62686701, -), CAediting_818838(62686728, -), CAediting_818839(62686738, -), CAediting_818840(62686743, -), CAediting_818841(62686747, -), CAediting_818842(62686760, -), CAediting_818843(62686767, -), CAediting_818844(62686768, -), CAediting_818845(62686776, -), CAediting_818846(62686779, -), CAediting_818847(62686782, -), CAediting_818848(62686786, -), CAediting_818849(62686792, -), CAediting_818850(62686799, -), CAediting_818851(62686803, -), CAediting_818852(62686809, -), CAediting_818853(62686838, -), CAediting_818854(62686839, -), CAediting_818855(62686840, -), CAediting_818856(62686841, -), CAediting_818857(62686844, -), CAediting_818858(62686847, -), CAediting_818859(62686848, -), CAediting_818860(62686849, -), CAediting_818861(62686850, -), CAediting_818862(62686864, -), CAediting_818863(62686865, -), CAediting_818864(62686866, -), CAediting_818865(62686887, -), CAediting_818866(62686889, -), CAediting_818867(62686898, -), CAediting_818868(62686911, -), CAediting_818869(62686942, -), CAediting_818870(62686950, -), CAediting_818871(62686972, -), CAediting_818872(62687017, -), CAediting_818873(62687023, -), CAediting_818874(62687035, -), CAediting_818875(62687036, -), CAediting_818876(62687037, -), CAediting_818877(62687059, -), CAediting_818878(62687063, -), CAediting_818879(62687075, -), CAediting_818880(62687076, -), CAediting_818881(62687077, -), CAediting_818882(62687099, -), CAediting_818883(62687113, -), CAediting_818884(62687116, -), CAediting_818885(62687132, -), CAediting_818886(62687133, -), CAediting_818887(62687143, -), CAediting_818888(62687146, -), CAediting_818889(62687149, -), CAediting_818890(62687169, -), CAediting_818891(62687172, -), CAediting_818892(62687173, -), CAediting_818893(62687181, -), CAediting_818894(62687194, -), CAediting_818895(62687198, -), CAediting_818896(62687199, -), CAediting_818897(62687212, -), CAediting_818898(62687218, -), CAediting_818899(62687219, -), CAediting_818900(62687224, -), CAediting_818901(62687234, -), CAediting_818902(62687242, -), CAediting_818903(62687243, -), CAediting_818904(62687254, -), CAediting_818905(62687259, -), CAediting_818906(62687276, -),

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RNA editing positional annotations for LRRN4CL using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_818836chr11_62686700_-UTR3
CAediting_818837chr11_62686701_-UTR3
CAediting_818838chr11_62686728_-UTR3
CAediting_818839chr11_62686738_-UTR3
CAediting_818840chr11_62686743_-UTR3
CAediting_818841chr11_62686747_-UTR3
CAediting_818842chr11_62686760_-UTR3
CAediting_818843chr11_62686767_-UTR3
CAediting_818844chr11_62686768_-UTR3
CAediting_818845chr11_62686776_-UTR3
CAediting_818846chr11_62686779_-UTR3
CAediting_818847chr11_62686782_-UTR3
CAediting_818848chr11_62686786_-UTR3
CAediting_818849chr11_62686792_-UTR3
CAediting_818850chr11_62686799_-UTR3
CAediting_818851chr11_62686803_-UTR3
CAediting_818852chr11_62686809_-UTR3
CAediting_818853chr11_62686838_-UTR3
CAediting_818854chr11_62686839_-UTR3
CAediting_818855chr11_62686840_-UTR3
CAediting_818856chr11_62686841_-UTR3
CAediting_818857chr11_62686844_-UTR3
CAediting_818858chr11_62686847_-UTR3
CAediting_818859chr11_62686848_-UTR3
CAediting_818860chr11_62686849_-UTR3
CAediting_818861chr11_62686850_-UTR3
CAediting_818862chr11_62686864_-UTR3
CAediting_818863chr11_62686865_-UTR3
CAediting_818864chr11_62686866_-UTR3
CAediting_818865chr11_62686887_-UTR3
CAediting_818866chr11_62686889_-UTR3
CAediting_818867chr11_62686898_-UTR3
CAediting_818868chr11_62686911_-UTR3
CAediting_818869chr11_62686942_-UTR3
CAediting_818870chr11_62686950_-UTR3
CAediting_818871chr11_62686972_-UTR3
CAediting_818872chr11_62687017_-UTR3
CAediting_818873chr11_62687023_-UTR3
CAediting_818874chr11_62687035_-UTR3
CAediting_818875chr11_62687036_-UTR3
CAediting_818876chr11_62687037_-UTR3
CAediting_818877chr11_62687059_-UTR3
CAediting_818878chr11_62687063_-UTR3
CAediting_818879chr11_62687075_-UTR3
CAediting_818880chr11_62687076_-UTR3
CAediting_818881chr11_62687077_-UTR3
CAediting_818882chr11_62687099_-UTR3
CAediting_818883chr11_62687113_-UTR3
CAediting_818884chr11_62687116_-UTR3
CAediting_818885chr11_62687132_-UTR3
CAediting_818886chr11_62687133_-UTR3
CAediting_818887chr11_62687143_-UTR3
CAediting_818888chr11_62687146_-UTR3
CAediting_818889chr11_62687149_-UTR3
CAediting_818890chr11_62687169_-UTR3
CAediting_818891chr11_62687172_-UTR3
CAediting_818892chr11_62687173_-UTR3
CAediting_818893chr11_62687181_-UTR3
CAediting_818894chr11_62687194_-UTR3
CAediting_818895chr11_62687198_-UTR3
CAediting_818896chr11_62687199_-UTR3
CAediting_818897chr11_62687212_-UTR3
CAediting_818898chr11_62687218_-UTR3
CAediting_818899chr11_62687219_-UTR3
CAediting_818900chr11_62687224_-UTR3
CAediting_818901chr11_62687234_-UTR3
CAediting_818902chr11_62687242_-UTR3
CAediting_818903chr11_62687243_-UTR3
CAediting_818904chr11_62687254_-UTR3
CAediting_818905chr11_62687259_-UTR3
CAediting_818906chr11_62687276_-UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_818836chr11_62686700_-SINEAluAluY
CAediting_818837chr11_62686701_-SINEAluAluY
CAediting_818838chr11_62686728_-SINEAluAluY
CAediting_818839chr11_62686738_-SINEAluAluY
CAediting_818840chr11_62686743_-SINEAluAluY
CAediting_818841chr11_62686747_-SINEAluAluY
CAediting_818842chr11_62686760_-SINEAluAluY
CAediting_818843chr11_62686767_-SINEAluAluY
CAediting_818844chr11_62686768_-SINEAluAluY
CAediting_818845chr11_62686776_-SINEAluAluY
CAediting_818846chr11_62686779_-SINEAluAluY
CAediting_818847chr11_62686782_-SINEAluAluY
CAediting_818848chr11_62686786_-SINEAluAluY
CAediting_818849chr11_62686792_-SINEAluAluY
CAediting_818850chr11_62686799_-SINEAluAluY
CAediting_818851chr11_62686803_-SINEAluAluY
CAediting_818852chr11_62686809_-SINEAluAluY
CAediting_818853chr11_62686838_-SINEAluAluY
CAediting_818854chr11_62686839_-SINEAluAluY
CAediting_818855chr11_62686840_-SINEAluAluY
CAediting_818856chr11_62686841_-SINEAluAluY
CAediting_818857chr11_62686844_-SINEAluAluY
CAediting_818858chr11_62686847_-SINEAluAluY
CAediting_818859chr11_62686848_-SINEAluAluY
CAediting_818860chr11_62686849_-SINEAluAluY
CAediting_818861chr11_62686850_-SINEAluAluY
CAediting_818862chr11_62686864_-SINEAluAluY
CAediting_818863chr11_62686865_-SINEAluAluY
CAediting_818864chr11_62686866_-SINEAluAluY
CAediting_818865chr11_62686887_-SINEAluAluY
CAediting_818866chr11_62686889_-SINEAluAluY
CAediting_818867chr11_62686898_-SINEAluAluY
CAediting_818868chr11_62686911_-SINEAluAluY
CAediting_818869chr11_62686942_-SINEAluAluY
CAediting_818870chr11_62686950_-SINEAluAluY
CAediting_818871chr11_62686972_-DNAhAT-CharlieMER58C
CAediting_818872chr11_62687017_-SINEAluAluSx1
CAediting_818873chr11_62687023_-SINEAluAluSx1
CAediting_818874chr11_62687035_-SINEAluAluSx1
CAediting_818875chr11_62687036_-SINEAluAluSx1
CAediting_818876chr11_62687037_-SINEAluAluSx1
CAediting_818877chr11_62687059_-SINEAluAluSx1
CAediting_818878chr11_62687063_-SINEAluAluSx1
CAediting_818879chr11_62687075_-SINEAluAluSx1
CAediting_818880chr11_62687076_-SINEAluAluSx1
CAediting_818881chr11_62687077_-SINEAluAluSx1
CAediting_818882chr11_62687099_-SINEAluAluSx1
CAediting_818883chr11_62687113_-SINEAluAluSx1
CAediting_818884chr11_62687116_-SINEAluAluSx1
CAediting_818885chr11_62687132_-SINEAluAluSx1
CAediting_818886chr11_62687133_-SINEAluAluSx1
CAediting_818887chr11_62687143_-SINEAluAluSx1
CAediting_818888chr11_62687146_-SINEAluAluSx1
CAediting_818889chr11_62687149_-SINEAluAluSx1
CAediting_818890chr11_62687169_-SINEAluAluSx1
CAediting_818891chr11_62687172_-SINEAluAluSx1
CAediting_818892chr11_62687173_-SINEAluAluSx1
CAediting_818893chr11_62687181_-SINEAluAluSx1
CAediting_818894chr11_62687194_-SINEAluAluSx1
CAediting_818895chr11_62687198_-SINEAluAluSx1
CAediting_818896chr11_62687199_-SINEAluAluSx1
CAediting_818897chr11_62687212_-SINEAluAluSx1
CAediting_818898chr11_62687218_-SINEAluAluSx1
CAediting_818899chr11_62687219_-SINEAluAluSx1
CAediting_818900chr11_62687224_-SINEAluAluSx1
CAediting_818901chr11_62687234_-SINEAluAluSx1
CAediting_818902chr11_62687242_-SINEAluAluSx1
CAediting_818903chr11_62687243_-SINEAluAluSx1
CAediting_818904chr11_62687254_-SINEAluAluSx1
CAediting_818905chr11_62687259_-SINEAluAluSx1
CAediting_818906chr11_62687276_-SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for LRRN4CL

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000177363.4.LRRN4CL.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000177363.4.LRRN4CL.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRRN4CL

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LRRN4CL

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for LRRN4CL

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LRRN4CL

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for LRRN4CL

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
GBMCAediting_818843chr11_62686767_-0.0003100836959381840.472404314926749....
SKCMCAediting_818843chr11_62686767_-4.82262145766084e-100.456865089780191....
SARCCAediting_818843chr11_62686767_-7.40303921132394e-050.525868077954534....
SKCMCAediting_818844chr11_62686768_-1.67671826030545e-050.436790591849371....
LGGCAediting_818852chr11_62686809_-5.10365345681763e-050.376238536920504....
BRCACAediting_818852chr11_62686809_-0.02474875375186780.232767165927683....
GBMCAediting_818852chr11_62686809_-0.03134036915097030.228391790709292....
OVCAediting_818852chr11_62686809_-0.03798337945602870.294362739831275....
SKCMCAediting_818852chr11_62686809_-1.49145703955997e-090.387585514575894....
SARCCAediting_818852chr11_62686809_-2.93619413911491e-100.583255970056008....
SKCMCAediting_818854chr11_62686839_-0.004772782825297880.250876404579816....
SKCMCAediting_818856chr11_62686841_-1.61516556445555e-100.44581453847987....
SARCCAediting_818856chr11_62686841_-1.07474658822277e-090.673479084547184..0.002017647851723080.378918447130296
SKCMCAediting_818869chr11_62686942_-0.0003966464442891380.331909950397367....
GBMCAediting_818872chr11_62687017_-0.02917718456122830.302685634180689....
SKCMCAediting_818872chr11_62687017_-9.41337108388678e-050.357532923647826....
OVCAediting_818873chr11_62687023_-0.03048108661061680.279626774396163....
SKCMCAediting_818873chr11_62687023_-2.45252440981767e-050.294289632113884....
SARCCAediting_818873chr11_62687023_-4.15795937498678e-070.524829035492463....
BRCACAediting_818874chr11_62687035_-0.01751842238777940.225131743203519....
GBMCAediting_818874chr11_62687035_-0.01594831307306690.241690679258838....
KIRCCAediting_818874chr11_62687035_-0.02428739409116460.24422725275637....
OVCAediting_818874chr11_62687035_-0.001384270980829780.397358857495967....
SKCMCAediting_818874chr11_62687035_-9.07110174739237e-100.370884682386817....
SARCCAediting_818874chr11_62687035_-1.19430911103525e-070.464181195523769....
LGGCAediting_818883chr11_62687113_-4.18218502125793e-050.492192541999833....
GBMCAediting_818883chr11_62687113_-0.002233026152966180.321799948712668....
KIRCCAediting_818883chr11_62687113_-0.03765146220076970.256465244857331....
SKCMCAediting_818883chr11_62687113_-1.44084698914992e-200.514186936533747....
UVMCAediting_818883chr11_62687113_-1.90860118788623e-050.521777370501694....
SARCCAediting_818883chr11_62687113_-1.61797318731926e-120.602767118520137....
LGGCAediting_818884chr11_62687116_-0.009972709561816010.322380924651356....
BRCACAediting_818884chr11_62687116_-..0.04652840575834940.198563573519092..
GBMCAediting_818884chr11_62687116_-0.005561878320263380.280929917487203....
SKCMCAediting_818884chr11_62687116_-1.63442131215315e-120.409666591790652....
UVMCAediting_818884chr11_62687116_-1.81789347943888e-060.567836052889465....
SARCCAediting_818884chr11_62687116_-9.34726500577759e-170.68855078403144....
SKCMCAediting_818890chr11_62687169_-0.006679831893583730.314781496122213....
SKCMCAediting_818895chr11_62687198_-0.004153328830218820.263126121316022....
LGGCAediting_818902chr11_62687242_-3.66090220255282e-110.553853664990017....
BRCACAediting_818902chr11_62687242_-6.41474097711838e-050.299070387254701....
GBMCAediting_818902chr11_62687242_-0.02087971001348210.211600919581269....
KIRCCAediting_818902chr11_62687242_-0.01796668228071790.24235479639917....
OVCAediting_818902chr11_62687242_-0.03655016939656420.22583497698797....
SKCMCAediting_818902chr11_62687242_-3.92855271816705e-280.549461578280719....
UVMCAediting_818902chr11_62687242_-3.01319025623847e-060.557774010293543....
SARCCAediting_818902chr11_62687242_-6.25349841990448e-150.599582733126638....
LGGCAediting_818904chr11_62687254_-9.49627800202163e-060.464945908814578....
GBMCAediting_818904chr11_62687254_-0.02122337939132370.233714443239549....
PRADCAediting_818904chr11_62687254_-0.02674661164875790.274780452366442....
STADCAediting_818904chr11_62687254_-0.01490434849884460.342496118516719....
KIRCCAediting_818904chr11_62687254_-0.01307960470859220.271373570915052....
SKCMCAediting_818904chr11_62687254_-2.24027224734389e-160.459205931933574....
SARCCAediting_818904chr11_62687254_-2.23589680217263e-090.523754267135496....

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Relation with cancer stages for LRRN4CL

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for LRRN4CL

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for LRRN4CL

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRN4CL

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource