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Editing gene: RAB12 (CAeditome ID:201475)

Gene summary for RAB12

Gene summary

Gene information	Gene symbol	RAB12
	Gene ID	201475
	Gene name	RAB12, member RAS oncogene family
	Synonyms	-
	Cytomap	18p11.22
	Type of gene	protein-coding
	Description	ras-related protein Rab-12putative Ras-related protein Rab-12
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RAB12	GO:0019003	Ras-related protein Rab-12	20937701

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RNA A-to-I events for RAB12

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000206418.3

RNA A-to-I editing events in Cancer.

CAediting_1252016(8612800, +), CAediting_1252017(8614604, +), CAediting_1252018(8614609, +), CAediting_1252019(8614610, +), CAediting_1252020(8614616, +), CAediting_1252021(8614635, +), CAediting_1252022(8614665, +), CAediting_1252023(8614685, +), CAediting_1252024(8614686, +), CAediting_1252025(8614689, +), CAediting_1252026(8614712, +), CAediting_1252027(8614715, +), CAediting_1252028(8614716, +), CAediting_1252029(8614727, +), CAediting_1252030(8614735, +), CAediting_1252031(8614766, +), CAediting_1252032(8614769, +), CAediting_1252033(8614775, +), CAediting_1252034(8614783, +), CAediting_1252035(8616750, +), CAediting_1252036(8616782, +), CAediting_1252037(8616814, +), CAediting_1252038(8616818, +), CAediting_1252039(8616825, +), CAediting_1252040(8616831, +), CAediting_1252041(8616838, +), CAediting_1252042(8616844, +), CAediting_1252043(8616849, +), CAediting_1252044(8616853, +), CAediting_1252045(8616877, +), CAediting_1252046(8616884, +), CAediting_1252047(8616889, +), CAediting_1252048(8616894, +), CAediting_1252049(8616909, +), CAediting_1252050(8616911, +), CAediting_1252051(8616913, +), CAediting_1252052(8618179, +), CAediting_1252053(8618590, +), CAediting_1252054(8618627, +), CAediting_1252055(8618639, +), CAediting_1252056(8618649, +), CAediting_1252057(8618679, +), CAediting_1252058(8618697, +), CAediting_1252059(8618699, +), CAediting_1252060(8618711, +), CAediting_1252061(8619887, +), CAediting_1252062(8619890, +), CAediting_1252063(8619953, +), CAediting_1252064(8619955, +), CAediting_1252065(8620053, +), CAediting_1252066(8620408, +), CAediting_1252067(8630962, +), CAediting_1252068(8630969, +), CAediting_1252069(8630982, +), CAediting_1252070(8630988, +), CAediting_1252071(8630992, +), CAediting_1252072(8631023, +), CAediting_1252073(8631028, +), CAediting_1252074(8631050, +), CAediting_1252075(8631069, +), CAediting_1252076(8631076, +), CAediting_1252077(8631142, +), CAediting_1252078(8632020, +), CAediting_1252079(8632048, +), CAediting_1252080(8632049, +), CAediting_1252081(8632053, +), CAediting_1252082(8632072, +), CAediting_1252083(8632083, +), CAediting_1252084(8632086, +), CAediting_1252085(8632104, +), CAediting_1252086(8632106, +), CAediting_1252087(8632121, +), CAediting_1252088(8632131, +), CAediting_1252089(8632135, +), CAediting_1252090(8632157, +), CAediting_1252091(8632158, +), CAediting_1252092(8632163, +), CAediting_1252093(8632184, +), CAediting_1252094(8632187, +), CAediting_1252095(8632190, +), CAediting_1252096(8632198, +), CAediting_1252097(8632199, +), CAediting_1252098(8632210, +), CAediting_1252099(8632223, +), CAediting_1252100(8632224, +), CAediting_1252101(8632252, +),

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RNA editing positional annotations for RAB12 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1252016	chr18_8612800_+	intronic
CAediting_1252017	chr18_8614604_+	intronic
CAediting_1252018	chr18_8614609_+	intronic
CAediting_1252019	chr18_8614610_+	intronic
CAediting_1252020	chr18_8614616_+	intronic
CAediting_1252021	chr18_8614635_+	intronic
CAediting_1252022	chr18_8614665_+	intronic
CAediting_1252023	chr18_8614685_+	intronic
CAediting_1252024	chr18_8614686_+	intronic
CAediting_1252025	chr18_8614689_+	intronic
CAediting_1252026	chr18_8614712_+	intronic
CAediting_1252027	chr18_8614715_+	intronic
CAediting_1252028	chr18_8614716_+	intronic
CAediting_1252029	chr18_8614727_+	intronic
CAediting_1252030	chr18_8614735_+	intronic
CAediting_1252031	chr18_8614766_+	intronic
CAediting_1252032	chr18_8614769_+	intronic
CAediting_1252033	chr18_8614775_+	intronic
CAediting_1252034	chr18_8614783_+	intronic
CAediting_1252035	chr18_8616750_+	intronic
CAediting_1252036	chr18_8616782_+	intronic
CAediting_1252037	chr18_8616814_+	intronic
CAediting_1252038	chr18_8616818_+	intronic
CAediting_1252039	chr18_8616825_+	intronic
CAediting_1252040	chr18_8616831_+	intronic
CAediting_1252041	chr18_8616838_+	intronic
CAediting_1252042	chr18_8616844_+	intronic
CAediting_1252043	chr18_8616849_+	intronic
CAediting_1252044	chr18_8616853_+	intronic
CAediting_1252045	chr18_8616877_+	intronic
CAediting_1252046	chr18_8616884_+	intronic
CAediting_1252047	chr18_8616889_+	intronic
CAediting_1252048	chr18_8616894_+	intronic
CAediting_1252049	chr18_8616909_+	intronic
CAediting_1252050	chr18_8616911_+	intronic
CAediting_1252051	chr18_8616913_+	intronic
CAediting_1252052	chr18_8618179_+	intronic
CAediting_1252053	chr18_8618590_+	intronic
CAediting_1252054	chr18_8618627_+	intronic
CAediting_1252055	chr18_8618639_+	intronic
CAediting_1252056	chr18_8618649_+	intronic
CAediting_1252057	chr18_8618679_+	intronic
CAediting_1252058	chr18_8618697_+	intronic
CAediting_1252059	chr18_8618699_+	intronic
CAediting_1252060	chr18_8618711_+	intronic
CAediting_1252061	chr18_8619887_+	intronic
CAediting_1252062	chr18_8619890_+	intronic
CAediting_1252063	chr18_8619953_+	intronic
CAediting_1252064	chr18_8619955_+	intronic
CAediting_1252065	chr18_8620053_+	intronic
CAediting_1252066	chr18_8620408_+	intronic
CAediting_1252067	chr18_8630962_+	intronic
CAediting_1252068	chr18_8630969_+	intronic
CAediting_1252069	chr18_8630982_+	intronic
CAediting_1252070	chr18_8630988_+	intronic
CAediting_1252071	chr18_8630992_+	intronic
CAediting_1252072	chr18_8631023_+	intronic
CAediting_1252073	chr18_8631028_+	intronic
CAediting_1252074	chr18_8631050_+	intronic
CAediting_1252075	chr18_8631069_+	intronic
CAediting_1252076	chr18_8631076_+	intronic
CAediting_1252077	chr18_8631142_+	intronic
CAediting_1252078	chr18_8632020_+	intronic
CAediting_1252079	chr18_8632048_+	intronic
CAediting_1252080	chr18_8632049_+	intronic
CAediting_1252081	chr18_8632053_+	intronic
CAediting_1252082	chr18_8632072_+	intronic
CAediting_1252083	chr18_8632083_+	intronic
CAediting_1252084	chr18_8632086_+	intronic
CAediting_1252085	chr18_8632104_+	intronic
CAediting_1252086	chr18_8632106_+	intronic
CAediting_1252087	chr18_8632121_+	intronic
CAediting_1252088	chr18_8632131_+	intronic
CAediting_1252089	chr18_8632135_+	intronic
CAediting_1252090	chr18_8632157_+	intronic
CAediting_1252091	chr18_8632158_+	intronic
CAediting_1252092	chr18_8632163_+	intronic
CAediting_1252093	chr18_8632184_+	intronic
CAediting_1252094	chr18_8632187_+	intronic
CAediting_1252095	chr18_8632190_+	intronic
CAediting_1252096	chr18_8632198_+	intronic
CAediting_1252097	chr18_8632199_+	intronic
CAediting_1252098	chr18_8632210_+	intronic
CAediting_1252099	chr18_8632223_+	intronic
CAediting_1252100	chr18_8632224_+	intronic
CAediting_1252101	chr18_8632252_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1252016	chr18_8612800_+	SINE	Alu	AluJo
CAediting_1252017	chr18_8614604_+	SINE	Alu	AluSg
CAediting_1252018	chr18_8614609_+	SINE	Alu	AluSg
CAediting_1252019	chr18_8614610_+	SINE	Alu	AluSg
CAediting_1252020	chr18_8614616_+	SINE	Alu	AluSg
CAediting_1252021	chr18_8614635_+	SINE	Alu	AluSg
CAediting_1252022	chr18_8614665_+	SINE	Alu	AluSg
CAediting_1252023	chr18_8614685_+	SINE	Alu	AluSg
CAediting_1252024	chr18_8614686_+	SINE	Alu	AluSg
CAediting_1252025	chr18_8614689_+	SINE	Alu	AluSg
CAediting_1252026	chr18_8614712_+	SINE	Alu	AluSg
CAediting_1252027	chr18_8614715_+	SINE	Alu	AluSg
CAediting_1252028	chr18_8614716_+	SINE	Alu	AluSg
CAediting_1252029	chr18_8614727_+	SINE	Alu	AluSg
CAediting_1252030	chr18_8614735_+	SINE	Alu	AluSg
CAediting_1252031	chr18_8614766_+	SINE	Alu	AluSg
CAediting_1252032	chr18_8614769_+	SINE	Alu	AluSg
CAediting_1252033	chr18_8614775_+	SINE	Alu	AluSg
CAediting_1252034	chr18_8614783_+	SINE	Alu	AluSg
CAediting_1252035	chr18_8616750_+	SINE	Alu	AluJb
CAediting_1252036	chr18_8616782_+	SINE	Alu	AluJb
CAediting_1252037	chr18_8616814_+	SINE	Alu	AluJb
CAediting_1252038	chr18_8616818_+	SINE	Alu	AluJb
CAediting_1252039	chr18_8616825_+	SINE	Alu	AluJb
CAediting_1252040	chr18_8616831_+	SINE	Alu	AluJb
CAediting_1252041	chr18_8616838_+	SINE	Alu	AluJb
CAediting_1252042	chr18_8616844_+	SINE	Alu	AluJb
CAediting_1252043	chr18_8616849_+	SINE	Alu	AluJb
CAediting_1252044	chr18_8616853_+	SINE	Alu	AluJb
CAediting_1252045	chr18_8616877_+	SINE	Alu	AluJb
CAediting_1252046	chr18_8616884_+	SINE	Alu	AluJb
CAediting_1252047	chr18_8616889_+	SINE	Alu	AluJb
CAediting_1252048	chr18_8616894_+	SINE	Alu	AluJb
CAediting_1252049	chr18_8616909_+	SINE	Alu	AluJb
CAediting_1252050	chr18_8616911_+	SINE	Alu	AluJb
CAediting_1252051	chr18_8616913_+	SINE	Alu	AluJb
CAediting_1252053	chr18_8618590_+	SINE	Alu	AluY
CAediting_1252054	chr18_8618627_+	SINE	Alu	AluY
CAediting_1252055	chr18_8618639_+	SINE	Alu	AluY
CAediting_1252056	chr18_8618649_+	SINE	Alu	AluY
CAediting_1252057	chr18_8618679_+	SINE	Alu	AluY
CAediting_1252058	chr18_8618697_+	SINE	Alu	AluY
CAediting_1252059	chr18_8618699_+	SINE	Alu	AluY
CAediting_1252060	chr18_8618711_+	SINE	Alu	AluY
CAediting_1252061	chr18_8619887_+	SINE	Alu	AluJo
CAediting_1252062	chr18_8619890_+	SINE	Alu	AluJo
CAediting_1252063	chr18_8619953_+	SINE	Alu	AluJo
CAediting_1252064	chr18_8619955_+	SINE	Alu	AluJo
CAediting_1252065	chr18_8620053_+	SINE	Alu	AluJo
CAediting_1252067	chr18_8630962_+	SINE	Alu	AluSx1
CAediting_1252068	chr18_8630969_+	SINE	Alu	AluSx1
CAediting_1252069	chr18_8630982_+	SINE	Alu	AluSx1
CAediting_1252070	chr18_8630988_+	SINE	Alu	AluSx1
CAediting_1252071	chr18_8630992_+	SINE	Alu	AluSx1
CAediting_1252072	chr18_8631023_+	SINE	Alu	AluSx1
CAediting_1252073	chr18_8631028_+	SINE	Alu	AluSx1
CAediting_1252074	chr18_8631050_+	SINE	Alu	AluSx1
CAediting_1252075	chr18_8631069_+	SINE	Alu	AluSx1
CAediting_1252076	chr18_8631076_+	SINE	Alu	AluSx1
CAediting_1252077	chr18_8631142_+	SINE	Alu	AluSx1
CAediting_1252078	chr18_8632020_+	SINE	Alu	AluSx
CAediting_1252079	chr18_8632048_+	SINE	Alu	AluSx
CAediting_1252080	chr18_8632049_+	SINE	Alu	AluSx
CAediting_1252081	chr18_8632053_+	SINE	Alu	AluSx
CAediting_1252082	chr18_8632072_+	SINE	Alu	AluSx
CAediting_1252083	chr18_8632083_+	SINE	Alu	AluSx
CAediting_1252084	chr18_8632086_+	SINE	Alu	AluSx
CAediting_1252085	chr18_8632104_+	SINE	Alu	AluSx
CAediting_1252086	chr18_8632106_+	SINE	Alu	AluSx
CAediting_1252087	chr18_8632121_+	SINE	Alu	AluSx
CAediting_1252088	chr18_8632131_+	SINE	Alu	AluSx
CAediting_1252089	chr18_8632135_+	SINE	Alu	AluSx
CAediting_1252090	chr18_8632157_+	SINE	Alu	AluSx
CAediting_1252091	chr18_8632158_+	SINE	Alu	AluSx
CAediting_1252092	chr18_8632163_+	SINE	Alu	AluSx
CAediting_1252093	chr18_8632184_+	SINE	Alu	AluSx
CAediting_1252094	chr18_8632187_+	SINE	Alu	AluSx
CAediting_1252095	chr18_8632190_+	SINE	Alu	AluSx
CAediting_1252096	chr18_8632198_+	SINE	Alu	AluSx
CAediting_1252097	chr18_8632199_+	SINE	Alu	AluSx
CAediting_1252098	chr18_8632210_+	SINE	Alu	AluSx
CAediting_1252099	chr18_8632223_+	SINE	Alu	AluSx
CAediting_1252100	chr18_8632224_+	SINE	Alu	AluSx
CAediting_1252101	chr18_8632252_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for RAB12

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000206418.3.RAB12.

Correlation between RNA A-to-I editing and PSI for ENSG00000206418.3.RAB12.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RAB12

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RAB12

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RAB12

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RAB12

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for RAB12

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1252024	chr18_8614686_+	.	.	0.0225293387353961	0.266754680177354	.	.

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Relation with cancer stages for RAB12

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
STAD	pathologic_stage	CAediting_1252024	chr18_8614686_+	0.0156559934798213	0.287906288451688

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Relation with survival for RAB12

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RAB12

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RAB12

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
RAB12	C0151744	Myocardial Ischemia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene