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Editing gene: FLCN (CAeditome ID:201163)

Gene summary for FLCN

Gene summary

Gene information	Gene symbol	FLCN
	Gene ID	201163
	Gene name	folliculin
	Synonyms	BHD\|DENND8B\|FLCL
	Cytomap	17p11.2
	Type of gene	protein-coding
	Description	folliculinBHD skin lesion fibrofolliculoma proteinbirt-Hogg-Dube syndrome protein
	Modification date	20210518
	UniProtAcc	Q8NFG4
	Context	- 33459596(Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
FLCN	GO:0030496	Folliculin	22965878
FLCN	GO:0044291	Folliculin	22965878
FLCN	GO:0005096	Folliculin	24095279
FLCN	GO:0005096	Folliculin	31672913
FLCN	GO:0005096	Folliculin	31704029
FLCN	GO:0044877	Folliculin	17028174
FLCN	GO:0000122	Folliculin	20573232
FLCN	GO:0001932	Folliculin	18663353
FLCN	GO:0009267	Folliculin	24095279
FLCN	GO:0009267	Folliculin	31672913
FLCN	GO:0010508	Folliculin	25126726
FLCN	GO:0030308	Folliculin	20573232
FLCN	GO:0030511	Folliculin	20573232
FLCN	GO:0032008	Folliculin	24081491
FLCN	GO:0032008	Folliculin	24095279
FLCN	GO:0032008	Folliculin	31672913
FLCN	GO:0032008	Folliculin	31704029
FLCN	GO:0032418	Folliculin	27113757
FLCN	GO:0034198	Folliculin	24095279
FLCN	GO:0034198	Folliculin	27113757
FLCN	GO:0034198	Folliculin	31672913
FLCN	GO:0045944	Folliculin	20573232
FLCN	GO:0046578	Folliculin	24081491
FLCN	GO:0046578	Folliculin	24095279
FLCN	GO:0046578	Folliculin	31672913
FLCN	GO:0046578	Folliculin	31704029
FLCN	GO:1900181	Folliculin	21209915
FLCN	GO:0005634	Folliculin	17028174
FLCN	GO:0005634	Folliculin	18663353
FLCN	GO:0005737	Folliculin	17028174
FLCN	GO:0005737	Folliculin	18663353
FLCN	GO:0005737	Folliculin	22965878
FLCN	GO:0005765	Folliculin	24081491
FLCN	GO:0005765	Folliculin	24095279
FLCN	GO:0005765	Folliculin	27113757
FLCN	GO:0005765	Folliculin	29848618
FLCN	GO:0005765	Folliculin	31672913
FLCN	GO:0005813	Folliculin	23784378
FLCN	GO:0005829	Folliculin	0000052
FLCN	GO:0005829	Folliculin	24081491
FLCN	GO:0005829	Folliculin	24095279
FLCN	GO:0005829	Folliculin	29848618
FLCN	GO:0005829	Folliculin	31672913
FLCN	GO:0005886	Folliculin	0000052
FLCN	GO:0005929	Folliculin	23784378
FLCN	GO:0072686	Folliculin	23784378

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RNA A-to-I events for FLCN

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000154803.11

RNA A-to-I editing events in Cancer.

CAediting_1166594(17219662, -), CAediting_1166595(17219679, -), CAediting_1166596(17219681, -), CAediting_1166597(17219718, -), CAediting_1166598(17219793, -), CAediting_1166599(17220136, -), CAediting_1166600(17220148, -), CAediting_1166601(17223191, -), CAediting_1166602(17223199, -), CAediting_1166603(17224598, -), CAediting_1166604(17224604, -), CAediting_1166605(17224623, -), CAediting_1166606(17224632, -), CAediting_1166607(17224641, -), CAediting_1166608(17224647, -), CAediting_1166609(17224651, -), CAediting_1166610(17224657, -), CAediting_1166611(17224660, -), CAediting_1166612(17224664, -), CAediting_1166613(17224673, -), CAediting_1166614(17224676, -), CAediting_1166615(17224696, -), CAediting_1166616(17224700, -), CAediting_1166617(17224703, -), CAediting_1166618(17224704, -), CAediting_1166619(17224705, -), CAediting_1166620(17224706, -), CAediting_1166621(17224707, -), CAediting_1166622(17224708, -), CAediting_1166623(17224709, -), CAediting_1166624(17224711, -), CAediting_1166625(17224714, -), CAediting_1166626(17224715, -), CAediting_1166627(17224720, -), CAediting_1166628(17224742, -), CAediting_1166629(17224754, -), CAediting_1166630(17224765, -), CAediting_1166631(17224805, -), CAediting_1166632(17224810, -), CAediting_1166633(17224811, -), CAediting_1166634(17224848, -), CAediting_1166635(17225321, -), CAediting_1166636(17225328, -), CAediting_1166637(17225336, -), CAediting_1166638(17225369, -), CAediting_1166639(17225386, -), CAediting_1166640(17225398, -), CAediting_1166641(17225405, -), CAediting_1166642(17225456, -), CAediting_1166643(17225506, -), CAediting_1166644(17225518, -), CAediting_1166645(17225531, -), CAediting_1166646(17225545, -), CAediting_1166647(17225554, -), CAediting_1166648(17225588, -), CAediting_1166649(17225603, -), CAediting_1166650(17225613, -), CAediting_1166651(17225630, -), CAediting_1166652(17225631, -), CAediting_1166653(17225665, -), CAediting_1166654(17225697, -), CAediting_1166655(17225705, -), CAediting_1166656(17225773, -), CAediting_1166657(17225799, -), CAediting_1166658(17225812, -), CAediting_1166659(17230409, -), CAediting_1166660(17230419, -), CAediting_1166661(17230431, -), CAediting_1166662(17230528, -), CAediting_1166663(17230626, -), CAediting_1166664(17230849, -), CAediting_1166665(17230918, -), CAediting_1166666(17230934, -), CAediting_1166667(17230952, -), CAediting_1166668(17230953, -), CAediting_1166669(17233250, -), CAediting_1166670(17233649, -), CAediting_1166671(17233653, -), CAediting_1166672(17233786, -), CAediting_1166673(17233821, -), CAediting_1166674(17233822, -), CAediting_1166675(17233926, -), CAediting_1166676(17233927, -), CAediting_1166677(17233969, -), CAediting_1166678(17233983, -), CAediting_1166679(17234323, -), CAediting_1166680(17234332, -), CAediting_1166681(17234349, -), CAediting_1166682(17234380, -), CAediting_1166683(17234385, -), CAediting_1166684(17234415, -), CAediting_1166685(17234416, -), CAediting_1166686(17234425, -), CAediting_1166687(17234656, -), CAediting_1166688(17234664, -), CAediting_1166689(17234718, -), CAediting_1166690(17234721, -), CAediting_1166691(17234784, -), CAediting_1166692(17235403, -),

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RNA editing positional annotations for FLCN using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1166594	chr17_17219662_-	ncRNA_exonic
CAediting_1166595	chr17_17219679_-	ncRNA_exonic
CAediting_1166596	chr17_17219681_-	ncRNA_exonic
CAediting_1166597	chr17_17219718_-	ncRNA_exonic
CAediting_1166598	chr17_17219793_-	ncRNA_exonic
CAediting_1166599	chr17_17220136_-	ncRNA_exonic
CAediting_1166600	chr17_17220148_-	ncRNA_exonic
CAediting_1166601	chr17_17223191_-	ncRNA_intronic
CAediting_1166602	chr17_17223199_-	ncRNA_intronic
CAediting_1166603	chr17_17224598_-	ncRNA_exonic
CAediting_1166604	chr17_17224604_-	ncRNA_exonic
CAediting_1166605	chr17_17224623_-	ncRNA_exonic
CAediting_1166606	chr17_17224632_-	ncRNA_exonic
CAediting_1166607	chr17_17224641_-	ncRNA_exonic
CAediting_1166608	chr17_17224647_-	ncRNA_exonic
CAediting_1166609	chr17_17224651_-	ncRNA_exonic
CAediting_1166610	chr17_17224657_-	ncRNA_exonic
CAediting_1166611	chr17_17224660_-	ncRNA_exonic
CAediting_1166612	chr17_17224664_-	ncRNA_exonic
CAediting_1166613	chr17_17224673_-	ncRNA_exonic
CAediting_1166614	chr17_17224676_-	ncRNA_exonic
CAediting_1166615	chr17_17224696_-	ncRNA_exonic
CAediting_1166616	chr17_17224700_-	ncRNA_exonic
CAediting_1166617	chr17_17224703_-	ncRNA_exonic
CAediting_1166618	chr17_17224704_-	ncRNA_exonic
CAediting_1166619	chr17_17224705_-	ncRNA_exonic
CAediting_1166620	chr17_17224706_-	ncRNA_exonic
CAediting_1166621	chr17_17224707_-	ncRNA_exonic
CAediting_1166622	chr17_17224708_-	ncRNA_exonic
CAediting_1166623	chr17_17224709_-	ncRNA_exonic
CAediting_1166624	chr17_17224711_-	ncRNA_exonic
CAediting_1166625	chr17_17224714_-	ncRNA_exonic
CAediting_1166626	chr17_17224715_-	ncRNA_exonic
CAediting_1166627	chr17_17224720_-	ncRNA_exonic
CAediting_1166628	chr17_17224742_-	ncRNA_exonic
CAediting_1166629	chr17_17224754_-	ncRNA_exonic
CAediting_1166630	chr17_17224765_-	ncRNA_exonic
CAediting_1166631	chr17_17224805_-	ncRNA_exonic
CAediting_1166632	chr17_17224810_-	ncRNA_exonic
CAediting_1166633	chr17_17224811_-	ncRNA_exonic
CAediting_1166634	chr17_17224848_-	ncRNA_exonic
CAediting_1166635	chr17_17225321_-	ncRNA_exonic
CAediting_1166636	chr17_17225328_-	ncRNA_exonic
CAediting_1166637	chr17_17225336_-	ncRNA_exonic
CAediting_1166638	chr17_17225369_-	ncRNA_exonic
CAediting_1166639	chr17_17225386_-	ncRNA_exonic
CAediting_1166640	chr17_17225398_-	ncRNA_exonic
CAediting_1166641	chr17_17225405_-	ncRNA_exonic
CAediting_1166642	chr17_17225456_-	ncRNA_exonic
CAediting_1166643	chr17_17225506_-	ncRNA_exonic
CAediting_1166644	chr17_17225518_-	ncRNA_exonic
CAediting_1166645	chr17_17225531_-	ncRNA_exonic
CAediting_1166646	chr17_17225545_-	ncRNA_exonic
CAediting_1166647	chr17_17225554_-	ncRNA_exonic
CAediting_1166648	chr17_17225588_-	ncRNA_exonic
CAediting_1166649	chr17_17225603_-	ncRNA_exonic
CAediting_1166650	chr17_17225613_-	ncRNA_exonic
CAediting_1166651	chr17_17225630_-	ncRNA_exonic
CAediting_1166652	chr17_17225631_-	ncRNA_exonic
CAediting_1166653	chr17_17225665_-	ncRNA_exonic
CAediting_1166654	chr17_17225697_-	ncRNA_exonic
CAediting_1166655	chr17_17225705_-	ncRNA_exonic
CAediting_1166656	chr17_17225773_-	ncRNA_exonic
CAediting_1166657	chr17_17225799_-	ncRNA_exonic
CAediting_1166658	chr17_17225812_-	ncRNA_exonic
CAediting_1166659	chr17_17230409_-	ncRNA_intronic
CAediting_1166660	chr17_17230419_-	ncRNA_intronic
CAediting_1166661	chr17_17230431_-	ncRNA_intronic
CAediting_1166662	chr17_17230528_-	ncRNA_intronic
CAediting_1166663	chr17_17230626_-	ncRNA_intronic
CAediting_1166664	chr17_17230849_-	ncRNA_intronic
CAediting_1166665	chr17_17230918_-	ncRNA_intronic
CAediting_1166666	chr17_17230934_-	ncRNA_intronic
CAediting_1166667	chr17_17230952_-	ncRNA_intronic
CAediting_1166668	chr17_17230953_-	ncRNA_intronic
CAediting_1166669	chr17_17233250_-	ncRNA_intronic
CAediting_1166670	chr17_17233649_-	ncRNA_intronic
CAediting_1166671	chr17_17233653_-	ncRNA_intronic
CAediting_1166672	chr17_17233786_-	ncRNA_intronic
CAediting_1166673	chr17_17233821_-	ncRNA_intronic
CAediting_1166674	chr17_17233822_-	ncRNA_intronic
CAediting_1166675	chr17_17233926_-	ncRNA_intronic
CAediting_1166676	chr17_17233927_-	ncRNA_intronic
CAediting_1166677	chr17_17233969_-	ncRNA_intronic
CAediting_1166678	chr17_17233983_-	ncRNA_intronic
CAediting_1166679	chr17_17234323_-	ncRNA_intronic
CAediting_1166680	chr17_17234332_-	ncRNA_intronic
CAediting_1166681	chr17_17234349_-	ncRNA_intronic
CAediting_1166682	chr17_17234380_-	ncRNA_intronic
CAediting_1166683	chr17_17234385_-	ncRNA_intronic
CAediting_1166684	chr17_17234415_-	ncRNA_intronic
CAediting_1166685	chr17_17234416_-	ncRNA_intronic
CAediting_1166686	chr17_17234425_-	ncRNA_intronic
CAediting_1166687	chr17_17234656_-	ncRNA_intronic
CAediting_1166688	chr17_17234664_-	ncRNA_intronic
CAediting_1166689	chr17_17234718_-	ncRNA_intronic
CAediting_1166690	chr17_17234721_-	ncRNA_intronic
CAediting_1166691	chr17_17234784_-	ncRNA_intronic
CAediting_1166692	chr17_17235403_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1166594	chr17_17219662_-	SINE	Alu	AluSx4
CAediting_1166595	chr17_17219679_-	SINE	Alu	AluSx4
CAediting_1166596	chr17_17219681_-	SINE	Alu	AluSx4
CAediting_1166597	chr17_17219718_-	SINE	Alu	AluSx4
CAediting_1166598	chr17_17219793_-	SINE	Alu	AluSx4
CAediting_1166599	chr17_17220136_-	SINE	Alu	AluJr
CAediting_1166600	chr17_17220148_-	SINE	Alu	AluJr
CAediting_1166601	chr17_17223191_-	SINE	Alu	AluSx
CAediting_1166602	chr17_17223199_-	SINE	Alu	AluSx
CAediting_1166603	chr17_17224598_-	SINE	Alu	AluSx
CAediting_1166604	chr17_17224604_-	SINE	Alu	AluSx
CAediting_1166605	chr17_17224623_-	SINE	Alu	AluSx
CAediting_1166606	chr17_17224632_-	SINE	Alu	AluSx
CAediting_1166607	chr17_17224641_-	SINE	Alu	AluSx
CAediting_1166608	chr17_17224647_-	SINE	Alu	AluSx
CAediting_1166609	chr17_17224651_-	SINE	Alu	AluSx
CAediting_1166610	chr17_17224657_-	SINE	Alu	AluSx
CAediting_1166611	chr17_17224660_-	SINE	Alu	AluSx
CAediting_1166612	chr17_17224664_-	SINE	Alu	AluSx
CAediting_1166613	chr17_17224673_-	SINE	Alu	AluSx
CAediting_1166614	chr17_17224676_-	SINE	Alu	AluSx
CAediting_1166615	chr17_17224696_-	SINE	Alu	AluSx
CAediting_1166616	chr17_17224700_-	SINE	Alu	AluSx
CAediting_1166617	chr17_17224703_-	SINE	Alu	AluSx
CAediting_1166618	chr17_17224704_-	SINE	Alu	AluSx
CAediting_1166619	chr17_17224705_-	SINE	Alu	AluSx
CAediting_1166620	chr17_17224706_-	SINE	Alu	AluSx
CAediting_1166621	chr17_17224707_-	SINE	Alu	AluSx
CAediting_1166622	chr17_17224708_-	SINE	Alu	AluSx
CAediting_1166623	chr17_17224709_-	SINE	Alu	AluSx
CAediting_1166624	chr17_17224711_-	SINE	Alu	AluSx
CAediting_1166625	chr17_17224714_-	SINE	Alu	AluSx
CAediting_1166626	chr17_17224715_-	SINE	Alu	AluSx
CAediting_1166627	chr17_17224720_-	SINE	Alu	AluSx
CAediting_1166628	chr17_17224742_-	SINE	Alu	AluSx
CAediting_1166629	chr17_17224754_-	SINE	Alu	AluSx
CAediting_1166630	chr17_17224765_-	SINE	Alu	AluSx
CAediting_1166631	chr17_17224805_-	SINE	Alu	AluSx
CAediting_1166632	chr17_17224810_-	SINE	Alu	AluSx
CAediting_1166633	chr17_17224811_-	SINE	Alu	AluSx
CAediting_1166634	chr17_17224848_-	DNA	TcMar-Tigger	Tigger15a
CAediting_1166635	chr17_17225321_-	SINE	Alu	AluJr
CAediting_1166636	chr17_17225328_-	SINE	Alu	AluJr
CAediting_1166637	chr17_17225336_-	SINE	Alu	AluJr
CAediting_1166638	chr17_17225369_-	SINE	Alu	AluJr
CAediting_1166639	chr17_17225386_-	SINE	Alu	AluJr
CAediting_1166640	chr17_17225398_-	SINE	Alu	AluJr
CAediting_1166641	chr17_17225405_-	SINE	Alu	AluJr
CAediting_1166642	chr17_17225456_-	SINE	Alu	AluSx3
CAediting_1166643	chr17_17225506_-	SINE	Alu	AluSx3
CAediting_1166644	chr17_17225518_-	SINE	Alu	AluSx3
CAediting_1166645	chr17_17225531_-	SINE	Alu	AluSx3
CAediting_1166646	chr17_17225545_-	SINE	Alu	AluSx3
CAediting_1166647	chr17_17225554_-	SINE	Alu	AluSx3
CAediting_1166648	chr17_17225588_-	SINE	Alu	AluSx3
CAediting_1166649	chr17_17225603_-	SINE	Alu	AluSx3
CAediting_1166650	chr17_17225613_-	SINE	Alu	AluSx3
CAediting_1166651	chr17_17225630_-	SINE	Alu	AluSx3
CAediting_1166652	chr17_17225631_-	SINE	Alu	AluSx3
CAediting_1166653	chr17_17225665_-	SINE	Alu	AluSx3
CAediting_1166654	chr17_17225697_-	SINE	Alu	AluSx3
CAediting_1166655	chr17_17225705_-	SINE	Alu	AluSx3
CAediting_1166656	chr17_17225773_-	SINE	Alu	AluJr
CAediting_1166657	chr17_17225799_-	SINE	Alu	AluJr
CAediting_1166658	chr17_17225812_-	SINE	Alu	AluJr
CAediting_1166659	chr17_17230409_-	SINE	Alu	AluSz
CAediting_1166660	chr17_17230419_-	SINE	Alu	AluSz
CAediting_1166661	chr17_17230431_-	SINE	Alu	AluSz
CAediting_1166662	chr17_17230528_-	SINE	Alu	AluSz
CAediting_1166663	chr17_17230626_-	SINE	Alu	AluJb
CAediting_1166664	chr17_17230849_-	SINE	Alu	AluJb
CAediting_1166665	chr17_17230918_-	SINE	Alu	AluSz
CAediting_1166666	chr17_17230934_-	SINE	Alu	AluSz
CAediting_1166667	chr17_17230952_-	SINE	Alu	AluSz
CAediting_1166668	chr17_17230953_-	SINE	Alu	AluSz
CAediting_1166669	chr17_17233250_-	SINE	Alu	AluJb
CAediting_1166670	chr17_17233649_-	SINE	Alu	AluJb
CAediting_1166671	chr17_17233653_-	SINE	Alu	AluJb
CAediting_1166672	chr17_17233786_-	SINE	Alu	AluSq2
CAediting_1166673	chr17_17233821_-	SINE	Alu	AluSq2
CAediting_1166674	chr17_17233822_-	SINE	Alu	AluSq2
CAediting_1166675	chr17_17233926_-	SINE	Alu	AluSq2
CAediting_1166676	chr17_17233927_-	SINE	Alu	AluSq2
CAediting_1166677	chr17_17233969_-	SINE	Alu	AluSq2
CAediting_1166678	chr17_17233983_-	SINE	Alu	AluSq2
CAediting_1166679	chr17_17234323_-	SINE	Alu	AluSx
CAediting_1166680	chr17_17234332_-	SINE	Alu	AluSx
CAediting_1166681	chr17_17234349_-	SINE	Alu	AluSx
CAediting_1166682	chr17_17234380_-	SINE	Alu	AluSx
CAediting_1166683	chr17_17234385_-	SINE	Alu	AluSx
CAediting_1166684	chr17_17234415_-	SINE	Alu	AluSx
CAediting_1166685	chr17_17234416_-	SINE	Alu	AluSx
CAediting_1166686	chr17_17234425_-	SINE	Alu	AluSx
CAediting_1166687	chr17_17234656_-	SINE	Alu	AluSx
CAediting_1166688	chr17_17234664_-	SINE	Alu	AluSx
CAediting_1166689	chr17_17234718_-	SINE	Alu	AluSx
CAediting_1166690	chr17_17234721_-	SINE	Alu	AluSx
CAediting_1166691	chr17_17234784_-	SINE	Alu	AluSg
CAediting_1166692	chr17_17235403_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for FLCN

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000154803.11.FLCN.

Correlation between RNA A-to-I editing and PSI for ENSG00000154803.11.FLCN.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FLCN

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for FLCN

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for FLCN

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000154803.11	ENST00000285071	hsa-miR-4512	17213356	17213362	7mer-m8	17213355	17213376	140	-15.41
CAediting_1229414	chr17_67471546_+	ENSG00000154803.11	ENST00000285071	hsa-miR-548aa	17212437	17212443	7mer-m8	17212436	17212460	140	-10.6
CAediting_1160181	chr17_7017644_-	ENSG00000154803.11	ENST00000285071	hsa-miR-195-3p	17212240	17212246	7mer-m8	17212239	17212264	150	-17.16
CAediting_1368054	chr19_46709310_-	ENSG00000154803.11	ENST00000285071	hsa-miR-320e	17213171	17213177	7mer-m8	17213170	17213187	140	-15.73
CAediting_86358	chr1_109598906_+	ENSG00000154803.11	ENST00000285071	hsa-miR-197-5p	17212555	17212562	8mer-1a	17212555	17212583	146	-26.62

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000154803.11	ENST00000285071	hsa-miR-548aa	17212328	17212334	7mer-m8	17212327	17212355	150	-15.11
CAediting_1229414	chr17_67471546_+	ENSG00000154803.11	ENST00000285071	hsa-miR-548aa	17212328	17212334	7mer-m8	17212327	17212355	150	-15.11

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for FLCN

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for FLCN

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for FLCN

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for FLCN

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for FLCN

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FLCN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
FLCN	C0346010	Multiple fibrofolliculomas	11	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
FLCN	C1868193	PNEUMOTHORAX, PRIMARY SPONTANEOUS	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
FLCN	C0007134	Renal Cell Carcinoma	2	CTD_human;GENOMICS_ENGLAND
FLCN	C0018552	Hamartoma	2	CTD_human
FLCN	C0149781	Spontaneous pneumothorax	2	CTD_human;GENOMICS_ENGLAND
FLCN	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	2	CTD_human;UNIPROT
FLCN	C0009782	Connective Tissue Diseases	1	GENOMICS_ENGLAND
FLCN	C0010709	Cyst	1	CTD_human
FLCN	C0023798	Lipoma	1	GENOMICS_ENGLAND
FLCN	C0023903	Liver neoplasms	1	CTD_human
FLCN	C0032326	Pneumothorax	1	CTD_human
FLCN	C0206632	Angiolipoma	1	GENOMICS_ENGLAND
FLCN	C0264558	Tension Pneumothorax	1	CTD_human
FLCN	C0345904	Malignant neoplasm of liver	1	CTD_human
FLCN	C0346255	Oncocytoma, renal	1	CTD_human;GENOMICS_ENGLAND
FLCN	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
FLCN	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
FLCN	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
FLCN	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
FLCN	C1333985	Hereditary clear cell renal cell carcinoma	1	ORPHANET
FLCN	C1378703	Renal carcinoma	1	CGI;GENOMICS_ENGLAND
FLCN	C3149265	Parotid oncocytoma	1	GENOMICS_ENGLAND
FLCN	C3149266	Neural tissue tumors	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene