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Editing gene: PIKFYVE (CAeditome ID:200576)

Gene summary for PIKFYVE

Gene summary

Gene information	Gene symbol	PIKFYVE
	Gene ID	200576
	Gene name	phosphoinositide kinase, FYVE-type zinc finger containing
	Synonyms	CFD\|FAB1\|HEL37\|PIP5K\|PIP5K3\|ZFYVE29
	Cytomap	2q34
	Type of gene	protein-coding
	Description	1-phosphatidylinositol 3-phosphate 5-kinasePIPkin-IIIepididymis luminal protein 37phosphatidylinositol 3-phosphate 5-kinase type IIIphosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type IIIphosphoinositide kinase, FYVE finger containin
	Modification date	20210518
	UniProtAcc	Q9Y2I7
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PIKFYVE	GO:0000285	1-phosphatidylinositol 3-phosphate 5-kinase	22621786
PIKFYVE	GO:0052810	1-phosphatidylinositol 3-phosphate 5-kinase	22621786
PIKFYVE	GO:0019065	1-phosphatidylinositol 3-phosphate 5-kinase	32221306
PIKFYVE	GO:0019886	1-phosphatidylinositol 3-phosphate 5-kinase	30612035
PIKFYVE	GO:0030593	1-phosphatidylinositol 3-phosphate 5-kinase	28779020
PIKFYVE	GO:0032438	1-phosphatidylinositol 3-phosphate 5-kinase	29584722
PIKFYVE	GO:0090382	1-phosphatidylinositol 3-phosphate 5-kinase	27623384
PIKFYVE	GO:0090385	1-phosphatidylinositol 3-phosphate 5-kinase	28779020
PIKFYVE	GO:1903426	1-phosphatidylinositol 3-phosphate 5-kinase	28779020
PIKFYVE	GO:0010008	1-phosphatidylinositol 3-phosphate 5-kinase	17556371
PIKFYVE	GO:0030670	1-phosphatidylinositol 3-phosphate 5-kinase	30612035
PIKFYVE	GO:0031901	1-phosphatidylinositol 3-phosphate 5-kinase	16448788
PIKFYVE	GO:0031901	1-phosphatidylinositol 3-phosphate 5-kinase	16954148
PIKFYVE	GO:0031901	1-phosphatidylinositol 3-phosphate 5-kinase	30612035
PIKFYVE	GO:0043231	1-phosphatidylinositol 3-phosphate 5-kinase	0000052
PIKFYVE	GO:0045121	1-phosphatidylinositol 3-phosphate 5-kinase	15046600

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RNA A-to-I events for PIKFYVE

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000115020.15

RNA A-to-I editing events in Cancer.

CAediting_240950(208307014, +), CAediting_240951(208308057, +), CAediting_240952(208308080, +), CAediting_240953(208308081, +), CAediting_240954(208308127, +), CAediting_240955(208308135, +), CAediting_240956(208308143, +), CAediting_240957(208308149, +), CAediting_240958(208308153, +), CAediting_240959(208308166, +), CAediting_240960(208308170, +), CAediting_240961(208308184, +), CAediting_240962(208308197, +), CAediting_240963(208308198, +), CAediting_240964(208308203, +), CAediting_240965(208308208, +), CAediting_240966(208308220, +), CAediting_240967(208308221, +), CAediting_240968(208308222, +), CAediting_240969(208308223, +), CAediting_240970(208308234, +), CAediting_240971(208308236, +), CAediting_240972(208308237, +), CAediting_240973(208308238, +), CAediting_240974(208308239, +), CAediting_240975(208308240, +), CAediting_240976(208308241, +), CAediting_240977(208308243, +), CAediting_240978(208308245, +), CAediting_240979(208308246, +), CAediting_240980(208308247, +), CAediting_240981(208308248, +), CAediting_240982(208308249, +), CAediting_240983(208308250, +), CAediting_240984(208308251, +), CAediting_240985(208308254, +), CAediting_240986(208308290, +), CAediting_240987(208308297, +), CAediting_240988(208308303, +), CAediting_240989(208308310, +), CAediting_240990(208308321, +), CAediting_240991(208308329, +), CAediting_240992(208308346, +), CAediting_240993(208308350, +), CAediting_240994(208308733, +), CAediting_240995(208308764, +), CAediting_240996(208308782, +), CAediting_240997(208308788, +), CAediting_240998(208308825, +), CAediting_240999(208308833, +), CAediting_241000(208308834, +), CAediting_241001(208308847, +), CAediting_241002(208308873, +), CAediting_241003(208308874, +), CAediting_241004(208308882, +), CAediting_241005(208308888, +), CAediting_241006(208308897, +), CAediting_241007(208308905, +), CAediting_241008(208308917, +), CAediting_241009(208308929, +), CAediting_241010(208308942, +), CAediting_241011(208308946, +), CAediting_241012(208308959, +), CAediting_241013(208308969, +), CAediting_241014(208308982, +), CAediting_241015(208308984, +), CAediting_241016(208322121, +), CAediting_241017(208322194, +), CAediting_241018(208322198, +), CAediting_241019(208322215, +), CAediting_241020(208322224, +), CAediting_241021(208322231, +), CAediting_241022(208322234, +), CAediting_241023(208322260, +), CAediting_241024(208322298, +), CAediting_241025(208322330, +), CAediting_241026(208331506, +), CAediting_241027(208356357, +), CAediting_241028(208356363, +), CAediting_241029(208356376, +), CAediting_241030(208356389, +), CAediting_241031(208356397, +), CAediting_241032(208356466, +), CAediting_241033(208356472, +), CAediting_241034(208356482, +), CAediting_241035(208356491, +), CAediting_241036(208356494, +), CAediting_241037(208356495, +), CAediting_241038(208356503, +), CAediting_241039(208356504, +), CAediting_241040(208356523, +), CAediting_241041(208356533, +), CAediting_241042(208356534, +), CAediting_241043(208356539, +), CAediting_241044(208356540, +), CAediting_241045(208356560, +), CAediting_241046(208356565, +), CAediting_241047(208356574, +), CAediting_241048(208356575, +), CAediting_241049(208356582, +), CAediting_241050(208356609, +), CAediting_241051(208356633, +), CAediting_241052(208356636, +), CAediting_241053(208356666, +),

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RNA editing positional annotations for PIKFYVE using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_240950	chr2_208307014_+	intronic
CAediting_240951	chr2_208308057_+	intronic
CAediting_240952	chr2_208308080_+	intronic
CAediting_240953	chr2_208308081_+	intronic
CAediting_240954	chr2_208308127_+	intronic
CAediting_240955	chr2_208308135_+	intronic
CAediting_240956	chr2_208308143_+	intronic
CAediting_240957	chr2_208308149_+	intronic
CAediting_240958	chr2_208308153_+	intronic
CAediting_240959	chr2_208308166_+	intronic
CAediting_240960	chr2_208308170_+	intronic
CAediting_240961	chr2_208308184_+	intronic
CAediting_240962	chr2_208308197_+	intronic
CAediting_240963	chr2_208308198_+	intronic
CAediting_240964	chr2_208308203_+	intronic
CAediting_240965	chr2_208308208_+	intronic
CAediting_240966	chr2_208308220_+	intronic
CAediting_240967	chr2_208308221_+	intronic
CAediting_240968	chr2_208308222_+	intronic
CAediting_240969	chr2_208308223_+	intronic
CAediting_240970	chr2_208308234_+	intronic
CAediting_240971	chr2_208308236_+	intronic
CAediting_240972	chr2_208308237_+	intronic
CAediting_240973	chr2_208308238_+	intronic
CAediting_240974	chr2_208308239_+	intronic
CAediting_240975	chr2_208308240_+	intronic
CAediting_240976	chr2_208308241_+	intronic
CAediting_240977	chr2_208308243_+	intronic
CAediting_240978	chr2_208308245_+	intronic
CAediting_240979	chr2_208308246_+	intronic
CAediting_240980	chr2_208308247_+	intronic
CAediting_240981	chr2_208308248_+	intronic
CAediting_240982	chr2_208308249_+	intronic
CAediting_240983	chr2_208308250_+	intronic
CAediting_240984	chr2_208308251_+	intronic
CAediting_240985	chr2_208308254_+	intronic
CAediting_240986	chr2_208308290_+	intronic
CAediting_240987	chr2_208308297_+	intronic
CAediting_240988	chr2_208308303_+	intronic
CAediting_240989	chr2_208308310_+	intronic
CAediting_240990	chr2_208308321_+	intronic
CAediting_240991	chr2_208308329_+	intronic
CAediting_240992	chr2_208308346_+	intronic
CAediting_240993	chr2_208308350_+	intronic
CAediting_240994	chr2_208308733_+	intronic
CAediting_240995	chr2_208308764_+	intronic
CAediting_240996	chr2_208308782_+	intronic
CAediting_240997	chr2_208308788_+	intronic
CAediting_240998	chr2_208308825_+	intronic
CAediting_240999	chr2_208308833_+	intronic
CAediting_241000	chr2_208308834_+	intronic
CAediting_241001	chr2_208308847_+	intronic
CAediting_241002	chr2_208308873_+	intronic
CAediting_241003	chr2_208308874_+	intronic
CAediting_241004	chr2_208308882_+	intronic
CAediting_241005	chr2_208308888_+	intronic
CAediting_241006	chr2_208308897_+	intronic
CAediting_241007	chr2_208308905_+	intronic
CAediting_241008	chr2_208308917_+	intronic
CAediting_241009	chr2_208308929_+	intronic
CAediting_241010	chr2_208308942_+	intronic
CAediting_241011	chr2_208308946_+	intronic
CAediting_241012	chr2_208308959_+	intronic
CAediting_241013	chr2_208308969_+	intronic
CAediting_241014	chr2_208308982_+	intronic
CAediting_241015	chr2_208308984_+	intronic
CAediting_241016	chr2_208322121_+	intronic
CAediting_241017	chr2_208322194_+	intronic
CAediting_241018	chr2_208322198_+	intronic
CAediting_241019	chr2_208322215_+	intronic
CAediting_241020	chr2_208322224_+	intronic
CAediting_241021	chr2_208322231_+	intronic
CAediting_241022	chr2_208322234_+	intronic
CAediting_241023	chr2_208322260_+	intronic
CAediting_241024	chr2_208322298_+	intronic
CAediting_241025	chr2_208322330_+	intronic
CAediting_241026	chr2_208331506_+	intronic
CAediting_241027	chr2_208356357_+	UTR3
CAediting_241028	chr2_208356363_+	UTR3
CAediting_241029	chr2_208356376_+	UTR3
CAediting_241030	chr2_208356389_+	UTR3
CAediting_241031	chr2_208356397_+	UTR3
CAediting_241032	chr2_208356466_+	UTR3
CAediting_241033	chr2_208356472_+	UTR3
CAediting_241034	chr2_208356482_+	UTR3
CAediting_241035	chr2_208356491_+	UTR3
CAediting_241036	chr2_208356494_+	UTR3
CAediting_241037	chr2_208356495_+	UTR3
CAediting_241038	chr2_208356503_+	UTR3
CAediting_241039	chr2_208356504_+	UTR3
CAediting_241040	chr2_208356523_+	UTR3
CAediting_241041	chr2_208356533_+	UTR3
CAediting_241042	chr2_208356534_+	UTR3
CAediting_241043	chr2_208356539_+	UTR3
CAediting_241044	chr2_208356540_+	UTR3
CAediting_241045	chr2_208356560_+	UTR3
CAediting_241046	chr2_208356565_+	UTR3
CAediting_241047	chr2_208356574_+	UTR3
CAediting_241048	chr2_208356575_+	UTR3
CAediting_241049	chr2_208356582_+	UTR3
CAediting_241050	chr2_208356609_+	UTR3
CAediting_241051	chr2_208356633_+	UTR3
CAediting_241052	chr2_208356636_+	UTR3
CAediting_241053	chr2_208356666_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_240950	chr2_208307014_+	SINE	Alu	AluSz6
CAediting_240952	chr2_208308080_+	LINE	L1	L1MA7
CAediting_240953	chr2_208308081_+	LINE	L1	L1MA7
CAediting_240954	chr2_208308127_+	SINE	Alu	AluJb
CAediting_240955	chr2_208308135_+	SINE	Alu	AluJb
CAediting_240956	chr2_208308143_+	SINE	Alu	AluJb
CAediting_240957	chr2_208308149_+	SINE	Alu	AluJb
CAediting_240958	chr2_208308153_+	SINE	Alu	AluJb
CAediting_240959	chr2_208308166_+	SINE	Alu	AluJb
CAediting_240960	chr2_208308170_+	SINE	Alu	AluJb
CAediting_240961	chr2_208308184_+	SINE	Alu	AluJb
CAediting_240962	chr2_208308197_+	SINE	Alu	AluJb
CAediting_240963	chr2_208308198_+	SINE	Alu	AluJb
CAediting_240964	chr2_208308203_+	SINE	Alu	AluJb
CAediting_240965	chr2_208308208_+	SINE	Alu	AluJb
CAediting_240966	chr2_208308220_+	SINE	Alu	AluJb
CAediting_240967	chr2_208308221_+	SINE	Alu	AluJb
CAediting_240968	chr2_208308222_+	SINE	Alu	AluJb
CAediting_240969	chr2_208308223_+	SINE	Alu	AluJb
CAediting_240970	chr2_208308234_+	SINE	Alu	AluJb
CAediting_240971	chr2_208308236_+	SINE	Alu	AluJb
CAediting_240972	chr2_208308237_+	SINE	Alu	AluJb
CAediting_240973	chr2_208308238_+	SINE	Alu	AluJb
CAediting_240974	chr2_208308239_+	SINE	Alu	AluJb
CAediting_240975	chr2_208308240_+	SINE	Alu	AluJb
CAediting_240976	chr2_208308241_+	SINE	Alu	AluJb
CAediting_240977	chr2_208308243_+	SINE	Alu	AluJb
CAediting_240978	chr2_208308245_+	SINE	Alu	AluJb
CAediting_240979	chr2_208308246_+	SINE	Alu	AluJb
CAediting_240980	chr2_208308247_+	SINE	Alu	AluJb
CAediting_240981	chr2_208308248_+	SINE	Alu	AluJb
CAediting_240982	chr2_208308249_+	SINE	Alu	AluJb
CAediting_240983	chr2_208308250_+	SINE	Alu	AluJb
CAediting_240984	chr2_208308251_+	SINE	Alu	AluJb
CAediting_240985	chr2_208308254_+	SINE	Alu	AluJb
CAediting_240986	chr2_208308290_+	SINE	Alu	AluJb
CAediting_240987	chr2_208308297_+	SINE	Alu	AluJb
CAediting_240988	chr2_208308303_+	SINE	Alu	AluJb
CAediting_240989	chr2_208308310_+	SINE	Alu	AluJb
CAediting_240990	chr2_208308321_+	SINE	Alu	AluJb
CAediting_240991	chr2_208308329_+	SINE	Alu	AluJb
CAediting_240992	chr2_208308346_+	SINE	Alu	AluJb
CAediting_240993	chr2_208308350_+	SINE	Alu	AluJb
CAediting_240994	chr2_208308733_+	SINE	Alu	AluSq2
CAediting_240995	chr2_208308764_+	SINE	Alu	AluSq2
CAediting_240996	chr2_208308782_+	SINE	Alu	AluSq2
CAediting_240997	chr2_208308788_+	SINE	Alu	AluSq2
CAediting_240998	chr2_208308825_+	SINE	Alu	AluSq2
CAediting_240999	chr2_208308833_+	SINE	Alu	AluSq2
CAediting_241000	chr2_208308834_+	SINE	Alu	AluSq2
CAediting_241001	chr2_208308847_+	SINE	Alu	AluSq2
CAediting_241002	chr2_208308873_+	SINE	Alu	AluSq2
CAediting_241003	chr2_208308874_+	SINE	Alu	AluSq2
CAediting_241004	chr2_208308882_+	SINE	Alu	AluSq2
CAediting_241005	chr2_208308888_+	SINE	Alu	AluSq2
CAediting_241006	chr2_208308897_+	SINE	Alu	AluSq2
CAediting_241007	chr2_208308905_+	SINE	Alu	AluSq2
CAediting_241008	chr2_208308917_+	SINE	Alu	AluSq2
CAediting_241009	chr2_208308929_+	SINE	Alu	AluSq2
CAediting_241010	chr2_208308942_+	SINE	Alu	AluSq2
CAediting_241011	chr2_208308946_+	SINE	Alu	AluSq2
CAediting_241012	chr2_208308959_+	SINE	Alu	AluSq2
CAediting_241013	chr2_208308969_+	SINE	Alu	AluSq2
CAediting_241014	chr2_208308982_+	SINE	Alu	AluSq2
CAediting_241015	chr2_208308984_+	SINE	Alu	AluSq2
CAediting_241016	chr2_208322121_+	SINE	Alu	AluJr4
CAediting_241017	chr2_208322194_+	SINE	Alu	AluJr4
CAediting_241018	chr2_208322198_+	SINE	Alu	AluJr4
CAediting_241019	chr2_208322215_+	SINE	Alu	AluJr4
CAediting_241020	chr2_208322224_+	SINE	Alu	AluJr4
CAediting_241021	chr2_208322231_+	SINE	Alu	AluJr4
CAediting_241022	chr2_208322234_+	SINE	Alu	AluJr4
CAediting_241023	chr2_208322260_+	SINE	Alu	AluJr4
CAediting_241024	chr2_208322298_+	SINE	Alu	AluJr4
CAediting_241025	chr2_208322330_+	SINE	Alu	AluJr4
CAediting_241026	chr2_208331506_+	SINE	Alu	AluSx
CAediting_241029	chr2_208356376_+	SINE	Alu	AluSx
CAediting_241030	chr2_208356389_+	SINE	Alu	AluSx
CAediting_241031	chr2_208356397_+	SINE	Alu	AluSx
CAediting_241032	chr2_208356466_+	SINE	Alu	AluSx
CAediting_241033	chr2_208356472_+	SINE	Alu	AluSx
CAediting_241034	chr2_208356482_+	SINE	Alu	AluSx
CAediting_241035	chr2_208356491_+	SINE	Alu	AluSx
CAediting_241036	chr2_208356494_+	SINE	Alu	AluSx
CAediting_241037	chr2_208356495_+	SINE	Alu	AluSx
CAediting_241038	chr2_208356503_+	SINE	Alu	AluSx
CAediting_241039	chr2_208356504_+	SINE	Alu	AluSx
CAediting_241040	chr2_208356523_+	SINE	Alu	AluSx
CAediting_241041	chr2_208356533_+	SINE	Alu	AluSx
CAediting_241042	chr2_208356534_+	SINE	Alu	AluSx
CAediting_241043	chr2_208356539_+	SINE	Alu	AluSx
CAediting_241044	chr2_208356540_+	SINE	Alu	AluSx
CAediting_241045	chr2_208356560_+	SINE	Alu	AluSx
CAediting_241046	chr2_208356565_+	SINE	Alu	AluSx
CAediting_241047	chr2_208356574_+	SINE	Alu	AluSx
CAediting_241048	chr2_208356575_+	SINE	Alu	AluSx
CAediting_241049	chr2_208356582_+	SINE	Alu	AluSx
CAediting_241050	chr2_208356609_+	SINE	Alu	AluSx
CAediting_241051	chr2_208356633_+	SINE	Alu	AluSx
CAediting_241052	chr2_208356636_+	SINE	Alu	AluSx
CAediting_241053	chr2_208356666_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for PIKFYVE

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000115020.15.PIKFYVE.

Correlation between RNA A-to-I editing and PSI for ENSG00000115020.15.PIKFYVE.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PIKFYVE

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PIKFYVE

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PIKFYVE

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000115020.15	ENST00000443896	hsa-miR-4477b	208288744	208288751	8mer-1a	208288732	208288751	158	-16.07
CAediting_846604	chr11_93733708_-	ENSG00000115020.15	ENST00000443896	hsa-miR-1304-3p	208325786	208325792	7mer-m8	208325775	208325793	143	-14.99
CAediting_688080	chr9_63819626_+	ENSG00000115020.15	ENST00000443896	hsa-miR-4477b	208326079	208326085	7mer-m8	208326065	208326086	142	-12.12
CAediting_1399425	chr20_1392958_-	ENSG00000115020.15	ENST00000392202	hsa-miR-6869-5p	208305394	208305399	6mer	208305380	208305400	146	-27.46
CAediting_524911	chr7_5495852_-	ENSG00000115020.15	ENST00000443896	hsa-miR-589-3p	208285832	208285838	7mer-m8	208285818	208285839	152	-15.17
CAediting_1229415	chr17_67471547_+	ENSG00000115020.15	ENST00000443896	hsa-miR-548aa	208317904	208317910	7mer-m8	208317883	208317911	146	-14.46
CAediting_1160181	chr17_7017644_-	ENSG00000115020.15	ENST00000443896	hsa-miR-195-3p	208317923	208317929	7mer-m8	208317912	208317930	146	-8.77
CAediting_604450	chr7_133034877_-	ENSG00000115020.15	ENST00000443896	hsa-miR-3654	208324165	208324171	7mer-m8	208324154	208324172	145	-13.89
CAediting_468389	chr6_31355314_-	ENSG00000115020.15	ENST00000392202	hsa-miR-6891-5p	208305164	208305170	7mer-m8	208305153	208305171	149	-24.06
CAediting_468389	chr6_31355314_-	ENSG00000115020.15	ENST00000443896	hsa-miR-6891-5p	208325905	208325911	7mer-m8	208325894	208325912	145	-16.17
CAediting_468389	chr6_31355314_-	ENSG00000115020.15	ENST00000443896	hsa-miR-6891-5p	208326073	208326078	6mer	208326065	208326084	143	-26.52
CAediting_468389	chr6_31355314_-	ENSG00000115020.15	ENST00000443896	hsa-miR-6891-5p	208326078	208326084	7mer-1a	208326065	208326084	143	-26.52

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PIKFYVE

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000264380.7	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_241027	ENST00000264380.7	chr2_208356357_+	-2777.90	-2777.90	-2812.10
CAediting_241028	ENST00000264380.7	chr2_208356363_+	-2777.90	-2777.90	-2812.10
CAediting_241029	ENST00000264380.7	chr2_208356376_+	-2777.80	-2777.90	-2812.10
CAediting_241030	ENST00000264380.7	chr2_208356389_+	-2778.80	-2777.90	-2812.10
CAediting_241031	ENST00000264380.7	chr2_208356397_+	-2777.90	-2777.90	-2812.10
CAediting_241032	ENST00000264380.7	chr2_208356466_+	-2780.00	-2777.90	-2812.10
CAediting_241033	ENST00000264380.7	chr2_208356472_+	-2781.50	-2777.90	-2812.10
CAediting_241034	ENST00000264380.7	chr2_208356482_+	-2779.80	-2777.90	-2812.10
CAediting_241035	ENST00000264380.7	chr2_208356491_+	-2777.90	-2777.90	-2812.10
CAediting_241036	ENST00000264380.7	chr2_208356494_+	-2782.00	-2777.90	-2812.10
CAediting_241037	ENST00000264380.7	chr2_208356495_+	-2777.90	-2777.90	-2812.10
CAediting_241038	ENST00000264380.7	chr2_208356503_+	-2778.50	-2777.90	-2812.10
CAediting_241039	ENST00000264380.7	chr2_208356504_+	-2780.30	-2777.90	-2812.10
CAediting_241040	ENST00000264380.7	chr2_208356523_+	-2778.60	-2777.90	-2812.10
CAediting_241041	ENST00000264380.7	chr2_208356533_+	-2780.20	-2777.90	-2812.10
CAediting_241042	ENST00000264380.7	chr2_208356534_+	-2780.70	-2777.90	-2812.10
CAediting_241043	ENST00000264380.7	chr2_208356539_+	-2777.60	-2777.90	-2812.10
CAediting_241044	ENST00000264380.7	chr2_208356540_+	-2780.40	-2777.90	-2812.10
CAediting_241045	ENST00000264380.7	chr2_208356560_+	-2777.20	-2777.90	-2812.10
CAediting_241046	ENST00000264380.7	chr2_208356565_+	-2779.10	-2777.90	-2812.10
CAediting_241047	ENST00000264380.7	chr2_208356574_+	-2779.80	-2777.90	-2812.10
CAediting_241048	ENST00000264380.7	chr2_208356575_+	-2780.00	-2777.90	-2812.10
CAediting_241049	ENST00000264380.7	chr2_208356582_+	-2779.50	-2777.90	-2812.10
CAediting_241050	ENST00000264380.7	chr2_208356609_+	-2780.30	-2777.90	-2812.10
CAediting_241051	ENST00000264380.7	chr2_208356633_+	-2777.90	-2777.90	-2812.10
CAediting_241052	ENST00000264380.7	chr2_208356636_+	-2777.20	-2777.90	-2812.10
CAediting_241053	ENST00000264380.7	chr2_208356666_+	-2782.50	-2777.90	-2812.10

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Relation with ADAR for PIKFYVE

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for PIKFYVE

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PIKFYVE

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PIKFYVE

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PIKFYVE

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PIKFYVE	C1562113	Fleck corneal dystrophy	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene