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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: WDR90 (CAeditome ID:197335)

Gene summary for WDR90

check button Gene summary
Gene informationGene symbol

WDR90

Gene ID

197335

Gene nameWD repeat domain 90
SynonymsC16orf15|C16orf16|C16orf17|C16orf18|C16orf19|POC16
Cytomap

16p13.3

Type of geneprotein-coding
DescriptionWD repeat-containing protein 90
Modification date20210518
UniProtAcc

Q96KV7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
WDR90

GO:0005814

WD repeat-containing protein 90

28781053


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RNA A-to-I events for WDR90

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000161996.16
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1077763(654577, +), CAediting_1077764(654593, +), CAediting_1077765(663143, +), CAediting_1077766(663183, +), CAediting_1077767(663188, +), CAediting_1077768(663199, +), CAediting_1077769(663209, +), CAediting_1077770(663223, +), CAediting_1077771(663228, +), CAediting_1077772(663231, +), CAediting_1077773(663237, +), CAediting_1077774(663239, +), CAediting_1077775(663242, +), CAediting_1077776(663251, +), CAediting_1077777(663252, +), CAediting_1077778(663254, +), CAediting_1077779(663260, +), CAediting_1077780(663261, +), CAediting_1077781(663267, +), CAediting_1077782(663273, +), CAediting_1077783(663278, +), CAediting_1077784(663279, +), CAediting_1077785(663280, +), CAediting_1077786(663282, +), CAediting_1077787(663287, +), CAediting_1077788(663288, +), CAediting_1077789(663291, +), CAediting_1077790(663311, +), CAediting_1077791(663317, +), CAediting_1077792(663318, +), CAediting_1077793(663323, +), CAediting_1077794(663327, +), CAediting_1077795(663334, +), CAediting_1077796(663340, +), CAediting_1077797(663344, +), CAediting_1077798(663345, +), CAediting_1077799(663350, +), CAediting_1077800(663358, +), CAediting_1077801(663359, +), CAediting_1077802(663363, +), CAediting_1077803(663370, +), CAediting_1077804(663383, +), CAediting_1077805(663384, +), CAediting_1077806(663388, +), CAediting_1077807(663420, +), CAediting_1077808(663429, +), CAediting_1077809(663436, +), CAediting_1077810(663448, +), CAediting_1077811(663450, +), CAediting_1077812(663488, +), CAediting_1077813(663630, +), CAediting_1077814(663631, +), CAediting_1077815(663879, +), CAediting_1077816(664704, +), CAediting_1077817(664741, +), CAediting_1077818(664754, +), CAediting_1077819(664759, +), CAediting_1077820(664760, +), CAediting_1077821(664779, +), CAediting_1077822(664784, +), CAediting_1077823(664797, +), CAediting_1077824(664806, +), CAediting_1077825(664809, +), CAediting_1077826(664819, +), CAediting_1077827(664845, +), CAediting_1077828(664846, +), CAediting_1077829(664855, +), CAediting_1077830(664864, +), CAediting_1077831(664878, +), CAediting_1077832(664886, +), CAediting_1077833(664890, +), CAediting_1077834(664903, +), CAediting_1077835(664918, +), CAediting_1077836(664926, +), CAediting_1077837(664939, +), CAediting_1077838(664940, +), CAediting_1077839(664941, +), CAediting_1077840(664955, +), CAediting_1077841(664962, +),

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RNA editing positional annotations for WDR90 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1077763chr16_654577_+ncRNA_exonic
CAediting_1077764chr16_654593_+ncRNA_exonic
CAediting_1077765chr16_663143_+ncRNA_exonic;splicing
CAediting_1077766chr16_663183_+ncRNA_exonic
CAediting_1077767chr16_663188_+ncRNA_exonic
CAediting_1077768chr16_663199_+ncRNA_exonic
CAediting_1077769chr16_663209_+ncRNA_exonic
CAediting_1077770chr16_663223_+ncRNA_exonic
CAediting_1077771chr16_663228_+ncRNA_exonic
CAediting_1077772chr16_663231_+ncRNA_exonic
CAediting_1077773chr16_663237_+ncRNA_exonic
CAediting_1077774chr16_663239_+ncRNA_exonic
CAediting_1077775chr16_663242_+ncRNA_exonic
CAediting_1077776chr16_663251_+ncRNA_exonic
CAediting_1077777chr16_663252_+ncRNA_exonic
CAediting_1077778chr16_663254_+ncRNA_exonic
CAediting_1077779chr16_663260_+ncRNA_exonic
CAediting_1077780chr16_663261_+ncRNA_exonic
CAediting_1077781chr16_663267_+ncRNA_exonic
CAediting_1077782chr16_663273_+ncRNA_exonic
CAediting_1077783chr16_663278_+ncRNA_exonic
CAediting_1077784chr16_663279_+ncRNA_exonic
CAediting_1077785chr16_663280_+ncRNA_exonic
CAediting_1077786chr16_663282_+ncRNA_exonic
CAediting_1077787chr16_663287_+ncRNA_exonic
CAediting_1077788chr16_663288_+ncRNA_exonic
CAediting_1077789chr16_663291_+ncRNA_exonic
CAediting_1077790chr16_663311_+ncRNA_exonic
CAediting_1077791chr16_663317_+ncRNA_exonic
CAediting_1077792chr16_663318_+ncRNA_exonic
CAediting_1077793chr16_663323_+ncRNA_exonic
CAediting_1077794chr16_663327_+ncRNA_exonic
CAediting_1077795chr16_663334_+ncRNA_exonic
CAediting_1077796chr16_663340_+ncRNA_exonic
CAediting_1077797chr16_663344_+ncRNA_exonic
CAediting_1077798chr16_663345_+ncRNA_exonic
CAediting_1077799chr16_663350_+ncRNA_exonic
CAediting_1077800chr16_663358_+ncRNA_exonic
CAediting_1077801chr16_663359_+ncRNA_exonic
CAediting_1077802chr16_663363_+ncRNA_exonic
CAediting_1077803chr16_663370_+ncRNA_exonic
CAediting_1077804chr16_663383_+ncRNA_exonic
CAediting_1077805chr16_663384_+ncRNA_exonic
CAediting_1077806chr16_663388_+ncRNA_exonic
CAediting_1077807chr16_663420_+ncRNA_exonic
CAediting_1077808chr16_663429_+ncRNA_exonic
CAediting_1077809chr16_663436_+ncRNA_exonic
CAediting_1077810chr16_663448_+ncRNA_exonic
CAediting_1077811chr16_663450_+ncRNA_exonic
CAediting_1077812chr16_663488_+ncRNA_exonic
CAediting_1077813chr16_663630_+ncRNA_intronic
CAediting_1077814chr16_663631_+ncRNA_intronic
CAediting_1077815chr16_663879_+ncRNA_intronic
CAediting_1077816chr16_664704_+ncRNA_intronic
CAediting_1077817chr16_664741_+ncRNA_intronic
CAediting_1077818chr16_664754_+ncRNA_intronic
CAediting_1077819chr16_664759_+ncRNA_intronic
CAediting_1077820chr16_664760_+ncRNA_intronic
CAediting_1077821chr16_664779_+ncRNA_intronic
CAediting_1077822chr16_664784_+ncRNA_intronic
CAediting_1077823chr16_664797_+ncRNA_intronic
CAediting_1077824chr16_664806_+ncRNA_intronic
CAediting_1077825chr16_664809_+ncRNA_intronic
CAediting_1077826chr16_664819_+ncRNA_intronic
CAediting_1077827chr16_664845_+ncRNA_intronic
CAediting_1077828chr16_664846_+ncRNA_intronic
CAediting_1077829chr16_664855_+ncRNA_intronic
CAediting_1077830chr16_664864_+ncRNA_intronic
CAediting_1077831chr16_664878_+ncRNA_intronic
CAediting_1077832chr16_664886_+ncRNA_intronic
CAediting_1077833chr16_664890_+ncRNA_intronic
CAediting_1077834chr16_664903_+ncRNA_intronic
CAediting_1077835chr16_664918_+ncRNA_intronic
CAediting_1077836chr16_664926_+ncRNA_intronic
CAediting_1077837chr16_664939_+ncRNA_intronic
CAediting_1077838chr16_664940_+ncRNA_intronic
CAediting_1077839chr16_664941_+ncRNA_intronic
CAediting_1077840chr16_664955_+ncRNA_intronic
CAediting_1077841chr16_664962_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1077763chr16_654577_+SINEAluAluY
CAediting_1077764chr16_654593_+SINEAluAluY
CAediting_1077766chr16_663183_+SINEAluAluSx
CAediting_1077767chr16_663188_+SINEAluAluSx
CAediting_1077768chr16_663199_+SINEAluAluSx
CAediting_1077769chr16_663209_+SINEAluAluSx
CAediting_1077770chr16_663223_+SINEAluAluSx
CAediting_1077771chr16_663228_+SINEAluAluSx
CAediting_1077772chr16_663231_+SINEAluAluSx
CAediting_1077773chr16_663237_+SINEAluAluSx
CAediting_1077774chr16_663239_+SINEAluAluSx
CAediting_1077775chr16_663242_+SINEAluAluSx
CAediting_1077776chr16_663251_+SINEAluAluSx
CAediting_1077777chr16_663252_+SINEAluAluSx
CAediting_1077778chr16_663254_+SINEAluAluSx
CAediting_1077779chr16_663260_+SINEAluAluSx
CAediting_1077780chr16_663261_+SINEAluAluSx
CAediting_1077781chr16_663267_+SINEAluAluSx
CAediting_1077782chr16_663273_+SINEAluAluSx
CAediting_1077783chr16_663278_+SINEAluAluSx
CAediting_1077784chr16_663279_+SINEAluAluSx
CAediting_1077785chr16_663280_+SINEAluAluSx
CAediting_1077786chr16_663282_+SINEAluAluSx
CAediting_1077787chr16_663287_+SINEAluAluSx
CAediting_1077788chr16_663288_+SINEAluAluSx
CAediting_1077789chr16_663291_+SINEAluAluSx
CAediting_1077790chr16_663311_+SINEAluAluSx
CAediting_1077791chr16_663317_+SINEAluAluSx
CAediting_1077792chr16_663318_+SINEAluAluSx
CAediting_1077793chr16_663323_+SINEAluAluSx
CAediting_1077794chr16_663327_+SINEAluAluSx
CAediting_1077795chr16_663334_+SINEAluAluSx
CAediting_1077796chr16_663340_+SINEAluAluSx
CAediting_1077797chr16_663344_+SINEAluAluSx
CAediting_1077798chr16_663345_+SINEAluAluSx
CAediting_1077799chr16_663350_+SINEAluAluSx
CAediting_1077800chr16_663358_+SINEAluAluSx
CAediting_1077801chr16_663359_+SINEAluAluSx
CAediting_1077802chr16_663363_+SINEAluAluSx
CAediting_1077803chr16_663370_+SINEAluAluSx
CAediting_1077804chr16_663383_+SINEAluAluSx
CAediting_1077805chr16_663384_+SINEAluAluSx
CAediting_1077806chr16_663388_+SINEAluAluSx
CAediting_1077807chr16_663420_+SINEAluAluSx
CAediting_1077808chr16_663429_+SINEAluAluSx
CAediting_1077809chr16_663436_+SINEAluAluSx
CAediting_1077810chr16_663448_+SINEAluAluSx
CAediting_1077811chr16_663450_+SINEAluAluSx
CAediting_1077816chr16_664704_+SINEAluAluY
CAediting_1077817chr16_664741_+SINEAluAluY
CAediting_1077818chr16_664754_+SINEAluAluY
CAediting_1077819chr16_664759_+SINEAluAluY
CAediting_1077820chr16_664760_+SINEAluAluY
CAediting_1077821chr16_664779_+SINEAluAluY
CAediting_1077822chr16_664784_+SINEAluAluY
CAediting_1077823chr16_664797_+SINEAluAluY
CAediting_1077824chr16_664806_+SINEAluAluY
CAediting_1077825chr16_664809_+SINEAluAluY
CAediting_1077826chr16_664819_+SINEAluAluY
CAediting_1077827chr16_664845_+SINEAluAluY
CAediting_1077828chr16_664846_+SINEAluAluY
CAediting_1077829chr16_664855_+SINEAluAluY
CAediting_1077830chr16_664864_+SINEAluAluY
CAediting_1077831chr16_664878_+SINEAluAluY
CAediting_1077832chr16_664886_+SINEAluAluY
CAediting_1077833chr16_664890_+SINEAluAluY
CAediting_1077834chr16_664903_+SINEAluAluY
CAediting_1077835chr16_664918_+SINEAluAluY
CAediting_1077836chr16_664926_+SINEAluAluY
CAediting_1077837chr16_664939_+SINEAluAluY
CAediting_1077838chr16_664940_+SINEAluAluY
CAediting_1077839chr16_664941_+SINEAluAluY
CAediting_1077840chr16_664955_+SINEAluAluY
CAediting_1077841chr16_664962_+SINEAluAluY

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RNA A-to-I editing events in the alternative splicing sites for WDR90

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1077765chr16_663143_+663124:6631463SS0+1iTGTTTTTTGTAATTGTCAAAGAA-3.78TGTTTTTTGTAATTGTCAAGGAA4.98

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000161996.16.WDR90.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000161996.16.WDR90.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for WDR90

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
READ.CAediting_1077832.ENSG00000161996.WDR90.png
Soverview
UCEC.CAediting_1077831.ENSG00000161996.WDR90.png
Soverview

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Protein coding region RNA A-to-I editings for WDR90

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for WDR90

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_86358chr1_109598906_+ENSG00000161996.16ENST00000552728hsa-miR-197-5p6616556616617mer-m8661642661662153-30.76
CAediting_1368054chr19_46709310_-ENSG00000161996.16ENST00000552728hsa-miR-320e6619786619847mer-m8661968661985144-15.86
CAediting_1229415chr17_67471547_+ENSG00000161996.16ENST00000552728hsa-miR-548aa6669786669847mer-m8666960666985145-10.43
CAediting_1524209chrX_134546392_-ENSG00000161996.16ENST00000552728hsa-miR-503-5p6666986667047mer-m8666682666705147-23.02

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for WDR90

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for WDR90

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_1077782chr16_663273_+0.01052456586207990.253523194022884....
LUSCCAediting_1077782chr16_663273_+0.0006471860393848640.330629235842803....
SKCMCAediting_1077782chr16_663273_+0.006788551873155740.340390181618077....
LGGCAediting_1077792chr16_663318_+..0.03445970073061280.168366607940258..
LUSCCAediting_1077792chr16_663318_+0.002687439916252240.2182943511616550.00120886694390880.234949945684639..
PRADCAediting_1077792chr16_663318_+....0.02877092880255940.196435578037297
SKCMCAediting_1077792chr16_663318_+....0.00136070392126840.255868188849777
SARCCAediting_1077792chr16_663318_+0.03699220663424650.25732603515538....
BLCACAediting_1077798chr16_663345_+....0.03706191553280080.242878458391405
LUSCCAediting_1077798chr16_663345_+0.009334866276879580.306485920561240.008100246344636230.311898844550202..
BLCACAediting_1077831chr16_664878_+0.003739874347487930.320595404263549....
STADCAediting_1077831chr16_664878_+....0.04692894448554470.233360018844818
KIRPCAediting_1077831chr16_664878_+..0.00947187727409520.273618619169601..
BLCACAediting_1077832chr16_664886_+0.04401502194749580.214023115975907....
KIRPCAediting_1077833chr16_664890_+..2.35685595342002e-050.532894991458044..
BLCACAediting_1077838chr16_664940_+....0.03870048340742550.18226710560048
LUSCCAediting_1077838chr16_664940_+..0.04072955248609460.178370758474493..
STADCAediting_1077838chr16_664940_+....0.002209148677691560.307186065353258
OVCAediting_1077838chr16_664940_+0.04600367346363620.150619981583908....

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Relation with cancer stages for WDR90

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_1077781chr16_663267_+0.00932852142091307-0.268251861253196
BRCApathologic_stageCAediting_1077831chr16_664878_+0.0359371603986044-0.134922665461143
KIRPclinical_stageCAediting_1077792chr16_663318_+0.009971949304348890.26884588701956
LUSCpathologic_stageCAediting_1077792chr16_663318_+0.007860880313845630.193824146425122
SKCMpathologic_stageCAediting_1077782chr16_663273_+0.002876524367106380.398022150214686

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Relation with survival for WDR90

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
COADCAediting_1077792chr16_663318_+0.04197363523038220.01127820.0165359

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RelatedDrugs for WDR90

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR90

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource