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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: EPHA2 (CAeditome ID:1969)

Gene summary for EPHA2

check button Gene summary
Gene informationGene symbol

EPHA2

Gene ID

1969

Gene nameEPH receptor A2
SynonymsARCC2|CTPA|CTPP1|CTRCT6|ECK
Cytomap

1p36.13

Type of geneprotein-coding
Descriptionephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECK
Modification date20210531
UniProtAcc

P29317

Context- 34027045(EPHA2, a promising therapeutic target for hepatocellular carcinoma)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
EPHA2

GO:0004714

Ephrin type-A receptor 2

10655584

EPHA2

GO:0008630

Ephrin type-A receptor 2

18339848

EPHA2

GO:0033628

Ephrin type-A receptor 2

10655584

EPHA2

GO:0043491

Ephrin type-A receptor 2

19573808

EPHA2

GO:0048013

Ephrin type-A receptor 2

10655584

EPHA2

GO:0048013

Ephrin type-A receptor 2

20861311

EPHA2

GO:0051898

Ephrin type-A receptor 2

19573808

EPHA2

GO:0005886

Ephrin type-A receptor 2

18794797

EPHA2

GO:0005886

Ephrin type-A receptor 2

20861311

EPHA2

GO:0005887

Ephrin type-A receptor 2

10655584

EPHA2

GO:0005925

Ephrin type-A receptor 2

10655584

EPHA2

GO:0009986

Ephrin type-A receptor 2

25063885

EPHA2

GO:0030027

Ephrin type-A receptor 2

26158630

EPHA2

GO:0031256

Ephrin type-A receptor 2

19573808

EPHA2

GO:0031256

Ephrin type-A receptor 2

20679435

EPHA2

GO:0070160

Ephrin type-A receptor 2

27815408

EPHA2

GO:0005886

Ephrin type-A receptor 2

16862074


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RNA A-to-I events for EPHA2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000142627.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_17005(16130722, -), CAediting_17006(16130727, -), CAediting_17007(16130732, -), CAediting_17008(16130754, -), CAediting_17009(16130758, -), CAediting_17010(16130768, -), CAediting_17011(16130778, -), CAediting_17012(16130789, -), CAediting_17013(16130790, -), CAediting_17014(16130794, -), CAediting_17015(16130797, -), CAediting_17016(16130798, -), CAediting_17017(16130799, -), CAediting_17018(16130823, -), CAediting_17019(16130828, -), CAediting_17020(16130862, -), CAediting_17021(16130902, -), CAediting_17022(16130903, -), CAediting_17023(16130918, -), CAediting_17024(16130919, -), CAediting_17025(16131323, -), CAediting_17026(16131345, -), CAediting_17027(16131363, -), CAediting_17028(16131431, -), CAediting_17029(16131436, -), CAediting_17030(16131468, -), CAediting_17031(16131494, -), CAediting_17032(16131504, -), CAediting_17033(16131517, -), CAediting_17034(16131533, -), CAediting_17035(16131536, -), CAediting_17036(16135788, -), CAediting_17037(16135813, -), CAediting_17038(16135923, -), CAediting_17039(16135928, -), CAediting_17040(16135933, -), CAediting_17041(16135953, -), CAediting_17042(16135963, -), CAediting_17043(16135973, -), CAediting_17044(16135986, -), CAediting_17045(16135991, -), CAediting_17046(16135995, -), CAediting_17047(16136003, -), CAediting_17048(16136009, -), CAediting_17049(16136019, -), CAediting_17050(16136022, -), CAediting_17051(16136031, -), CAediting_17052(16136035, -), CAediting_17053(16136040, -), CAediting_17054(16136044, -), CAediting_17055(16136046, -), CAediting_17056(16136059, -), CAediting_17057(16136066, -), CAediting_17058(16136070, -), CAediting_17059(16136072, -), CAediting_17060(16136081, -), CAediting_17061(16136087, -), CAediting_17062(16136098, -), CAediting_17063(16136117, -), CAediting_17064(16136138, -), CAediting_17065(16136143, -), CAediting_17066(16136144, -), CAediting_17067(16136146, -), CAediting_17068(16136363, -), CAediting_17069(16136375, -), CAediting_17070(16136398, -), CAediting_17071(16136399, -), CAediting_17072(16136403, -), CAediting_17073(16136428, -), CAediting_17074(16136437, -), CAediting_17075(16136454, -), CAediting_17076(16136457, -), CAediting_17077(16136497, -), CAediting_17078(16136507, -), CAediting_17079(16136510, -), CAediting_17080(16136536, -), CAediting_17081(16136537, -), CAediting_17082(16136572, -), CAediting_17083(16136573, -), CAediting_17084(16136612, -), CAediting_17085(16136833, -), CAediting_17086(16136937, -), CAediting_17087(16136994, -), CAediting_17088(16136995, -), CAediting_17089(16137004, -), CAediting_17090(16137026, -), CAediting_17091(16137037, -), CAediting_17092(16137072, -), CAediting_17093(16137073, -), CAediting_17094(16137342, -), CAediting_17095(16137354, -), CAediting_17096(16137355, -), CAediting_17097(16137425, -), CAediting_17098(16137429, -), CAediting_17099(16137431, -), CAediting_17100(16137434, -), CAediting_17101(16137498, -), CAediting_17102(16137511, -), CAediting_17103(16137512, -), CAediting_17104(16137515, -), CAediting_17105(16137516, -), CAediting_17106(16137592, -), CAediting_17107(16137752, -), CAediting_17108(16147945, -), CAediting_17109(16147990, -), CAediting_17110(16148013, -), CAediting_17111(16148058, -),

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RNA editing positional annotations for EPHA2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_17005chr1_16130722_-intronic
CAediting_17006chr1_16130727_-intronic
CAediting_17007chr1_16130732_-intronic
CAediting_17008chr1_16130754_-intronic
CAediting_17009chr1_16130758_-intronic
CAediting_17010chr1_16130768_-intronic
CAediting_17011chr1_16130778_-intronic
CAediting_17012chr1_16130789_-intronic
CAediting_17013chr1_16130790_-intronic
CAediting_17014chr1_16130794_-intronic
CAediting_17015chr1_16130797_-intronic
CAediting_17016chr1_16130798_-intronic
CAediting_17017chr1_16130799_-intronic
CAediting_17018chr1_16130823_-intronic
CAediting_17019chr1_16130828_-intronic
CAediting_17020chr1_16130862_-intronic
CAediting_17021chr1_16130902_-intronic
CAediting_17022chr1_16130903_-intronic
CAediting_17023chr1_16130918_-intronic
CAediting_17024chr1_16130919_-intronic
CAediting_17025chr1_16131323_-intronic
CAediting_17026chr1_16131345_-intronic
CAediting_17027chr1_16131363_-intronic
CAediting_17028chr1_16131431_-intronic
CAediting_17029chr1_16131436_-intronic
CAediting_17030chr1_16131468_-intronic
CAediting_17031chr1_16131494_-intronic
CAediting_17032chr1_16131504_-intronic
CAediting_17033chr1_16131517_-intronic
CAediting_17034chr1_16131533_-intronic
CAediting_17035chr1_16131536_-intronic
CAediting_17036chr1_16135788_-ncRNA_intronic
CAediting_17037chr1_16135813_-ncRNA_intronic
CAediting_17038chr1_16135923_-ncRNA_intronic
CAediting_17039chr1_16135928_-ncRNA_intronic
CAediting_17040chr1_16135933_-ncRNA_intronic
CAediting_17041chr1_16135953_-ncRNA_intronic
CAediting_17042chr1_16135963_-ncRNA_intronic
CAediting_17043chr1_16135973_-ncRNA_intronic
CAediting_17044chr1_16135986_-ncRNA_intronic
CAediting_17045chr1_16135991_-ncRNA_intronic
CAediting_17046chr1_16135995_-ncRNA_intronic
CAediting_17047chr1_16136003_-ncRNA_intronic
CAediting_17048chr1_16136009_-ncRNA_intronic
CAediting_17049chr1_16136019_-ncRNA_intronic
CAediting_17050chr1_16136022_-ncRNA_intronic
CAediting_17051chr1_16136031_-ncRNA_intronic
CAediting_17052chr1_16136035_-ncRNA_intronic
CAediting_17053chr1_16136040_-ncRNA_intronic
CAediting_17054chr1_16136044_-ncRNA_intronic
CAediting_17055chr1_16136046_-ncRNA_intronic
CAediting_17056chr1_16136059_-ncRNA_intronic
CAediting_17057chr1_16136066_-ncRNA_intronic
CAediting_17058chr1_16136070_-ncRNA_intronic
CAediting_17059chr1_16136072_-ncRNA_intronic
CAediting_17060chr1_16136081_-ncRNA_intronic
CAediting_17061chr1_16136087_-ncRNA_intronic
CAediting_17062chr1_16136098_-ncRNA_intronic
CAediting_17063chr1_16136117_-ncRNA_intronic
CAediting_17064chr1_16136138_-ncRNA_intronic
CAediting_17065chr1_16136143_-ncRNA_intronic
CAediting_17066chr1_16136144_-ncRNA_intronic
CAediting_17067chr1_16136146_-ncRNA_intronic
CAediting_17068chr1_16136363_-ncRNA_intronic
CAediting_17069chr1_16136375_-ncRNA_intronic
CAediting_17070chr1_16136398_-ncRNA_intronic
CAediting_17071chr1_16136399_-ncRNA_intronic
CAediting_17072chr1_16136403_-ncRNA_intronic
CAediting_17073chr1_16136428_-ncRNA_intronic
CAediting_17074chr1_16136437_-ncRNA_intronic
CAediting_17075chr1_16136454_-ncRNA_intronic
CAediting_17076chr1_16136457_-ncRNA_intronic
CAediting_17077chr1_16136497_-ncRNA_intronic
CAediting_17078chr1_16136507_-ncRNA_intronic
CAediting_17079chr1_16136510_-ncRNA_intronic
CAediting_17080chr1_16136536_-ncRNA_intronic
CAediting_17081chr1_16136537_-ncRNA_intronic
CAediting_17082chr1_16136572_-ncRNA_intronic
CAediting_17083chr1_16136573_-ncRNA_intronic
CAediting_17084chr1_16136612_-ncRNA_intronic
CAediting_17085chr1_16136833_-ncRNA_intronic
CAediting_17086chr1_16136937_-ncRNA_intronic
CAediting_17087chr1_16136994_-ncRNA_intronic
CAediting_17088chr1_16136995_-ncRNA_intronic
CAediting_17089chr1_16137004_-ncRNA_intronic
CAediting_17090chr1_16137026_-ncRNA_intronic
CAediting_17091chr1_16137037_-ncRNA_intronic
CAediting_17092chr1_16137072_-ncRNA_intronic
CAediting_17093chr1_16137073_-ncRNA_intronic
CAediting_17094chr1_16137342_-ncRNA_intronic
CAediting_17095chr1_16137354_-ncRNA_intronic
CAediting_17096chr1_16137355_-ncRNA_intronic
CAediting_17097chr1_16137425_-ncRNA_intronic
CAediting_17098chr1_16137429_-ncRNA_intronic
CAediting_17099chr1_16137431_-ncRNA_intronic
CAediting_17100chr1_16137434_-ncRNA_intronic
CAediting_17101chr1_16137498_-ncRNA_intronic
CAediting_17102chr1_16137511_-ncRNA_intronic
CAediting_17103chr1_16137512_-ncRNA_intronic
CAediting_17104chr1_16137515_-ncRNA_intronic
CAediting_17105chr1_16137516_-ncRNA_intronic
CAediting_17106chr1_16137592_-ncRNA_intronic
CAediting_17107chr1_16137752_-ncRNA_intronic
CAediting_17108chr1_16147945_-intronic
CAediting_17109chr1_16147990_-intronic
CAediting_17110chr1_16148013_-intronic
CAediting_17111chr1_16148058_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_17005chr1_16130722_-SINEAluAluJb
CAediting_17006chr1_16130727_-SINEAluAluJb
CAediting_17007chr1_16130732_-SINEAluAluJb
CAediting_17008chr1_16130754_-SINEAluAluJb
CAediting_17009chr1_16130758_-SINEAluAluJb
CAediting_17010chr1_16130768_-SINEAluAluJb
CAediting_17011chr1_16130778_-SINEAluAluJb
CAediting_17012chr1_16130789_-SINEAluAluJb
CAediting_17013chr1_16130790_-SINEAluAluJb
CAediting_17014chr1_16130794_-SINEAluAluJb
CAediting_17015chr1_16130797_-SINEAluAluJb
CAediting_17016chr1_16130798_-SINEAluAluJb
CAediting_17017chr1_16130799_-SINEAluAluJb
CAediting_17018chr1_16130823_-SINEAluAluJb
CAediting_17019chr1_16130828_-SINEAluAluJb
CAediting_17020chr1_16130862_-SINEAluAluJb
CAediting_17021chr1_16130902_-SINEAluAluJb
CAediting_17022chr1_16130903_-SINEAluAluJb
CAediting_17023chr1_16130918_-SINEAluAluJb
CAediting_17024chr1_16130919_-SINEAluAluJb
CAediting_17025chr1_16131323_-SINEAluAluSq
CAediting_17026chr1_16131345_-SINEAluAluSq
CAediting_17027chr1_16131363_-SINEAluAluSq
CAediting_17028chr1_16131431_-SINEAluAluSq
CAediting_17029chr1_16131436_-SINEAluAluSq
CAediting_17030chr1_16131468_-SINEAluAluSq
CAediting_17031chr1_16131494_-SINEAluAluSq
CAediting_17032chr1_16131504_-SINEAluAluSq
CAediting_17033chr1_16131517_-SINEAluAluSq
CAediting_17034chr1_16131533_-SINEAluAluSq
CAediting_17035chr1_16131536_-SINEAluAluSq
CAediting_17038chr1_16135923_-SINEAluAluJo
CAediting_17039chr1_16135928_-SINEAluAluJo
CAediting_17040chr1_16135933_-SINEAluAluJo
CAediting_17041chr1_16135953_-SINEAluAluJo
CAediting_17042chr1_16135963_-SINEAluAluJo
CAediting_17043chr1_16135973_-SINEAluAluJo
CAediting_17044chr1_16135986_-SINEAluAluJo
CAediting_17045chr1_16135991_-SINEAluAluJo
CAediting_17046chr1_16135995_-SINEAluAluJo
CAediting_17047chr1_16136003_-SINEAluAluJo
CAediting_17048chr1_16136009_-SINEAluAluJo
CAediting_17049chr1_16136019_-SINEAluAluJo
CAediting_17050chr1_16136022_-SINEAluAluJo
CAediting_17051chr1_16136031_-SINEAluAluJo
CAediting_17052chr1_16136035_-SINEAluAluJo
CAediting_17053chr1_16136040_-SINEAluAluJo
CAediting_17054chr1_16136044_-SINEAluAluJo
CAediting_17055chr1_16136046_-SINEAluAluJo
CAediting_17056chr1_16136059_-SINEAluAluJo
CAediting_17057chr1_16136066_-SINEAluAluJo
CAediting_17058chr1_16136070_-SINEAluAluJo
CAediting_17059chr1_16136072_-SINEAluAluJo
CAediting_17060chr1_16136081_-SINEAluAluJo
CAediting_17061chr1_16136087_-SINEAluAluJo
CAediting_17062chr1_16136098_-SINEAluAluJo
CAediting_17063chr1_16136117_-SINEAluAluJo
CAediting_17064chr1_16136138_-SINEAluAluJo
CAediting_17065chr1_16136143_-SINEAluAluJo
CAediting_17066chr1_16136144_-SINEAluAluJo
CAediting_17067chr1_16136146_-SINEAluAluJo
CAediting_17068chr1_16136363_-SINEAluAluSp
CAediting_17069chr1_16136375_-SINEAluAluSp
CAediting_17070chr1_16136398_-SINEAluAluSp
CAediting_17071chr1_16136399_-SINEAluAluSp
CAediting_17072chr1_16136403_-SINEAluAluSp
CAediting_17073chr1_16136428_-SINEAluAluSp
CAediting_17074chr1_16136437_-SINEAluAluSp
CAediting_17075chr1_16136454_-SINEAluAluSp
CAediting_17076chr1_16136457_-SINEAluAluSp
CAediting_17077chr1_16136497_-SINEAluAluSp
CAediting_17078chr1_16136507_-SINEAluAluSp
CAediting_17079chr1_16136510_-SINEAluAluSp
CAediting_17080chr1_16136536_-SINEAluAluSp
CAediting_17081chr1_16136537_-SINEAluAluSp
CAediting_17082chr1_16136572_-SINEAluAluSp
CAediting_17083chr1_16136573_-SINEAluAluSp
CAediting_17084chr1_16136612_-SINEAluAluSp
CAediting_17085chr1_16136833_-SINEAluAluSp
CAediting_17086chr1_16136937_-SINEAluAluSp
CAediting_17087chr1_16136994_-SINEAluAluSp
CAediting_17088chr1_16136995_-SINEAluAluSp
CAediting_17089chr1_16137004_-SINEAluAluSp
CAediting_17090chr1_16137026_-SINEAluAluSp
CAediting_17091chr1_16137037_-SINEAluAluSp
CAediting_17092chr1_16137072_-SINEAluAluSp
CAediting_17093chr1_16137073_-SINEAluAluSp
CAediting_17094chr1_16137342_-SINEAluAluSx3
CAediting_17095chr1_16137354_-SINEAluAluSx3
CAediting_17096chr1_16137355_-SINEAluAluSx3
CAediting_17097chr1_16137425_-SINEAluAluSx3
CAediting_17098chr1_16137429_-SINEAluAluSx3
CAediting_17099chr1_16137431_-SINEAluAluSx3
CAediting_17100chr1_16137434_-SINEAluAluSx3
CAediting_17101chr1_16137498_-SINEAluAluSx3
CAediting_17102chr1_16137511_-SINEAluAluSx3
CAediting_17103chr1_16137512_-SINEAluAluSx3
CAediting_17104chr1_16137515_-SINEAluAluSx3
CAediting_17105chr1_16137516_-SINEAluAluSx3
CAediting_17106chr1_16137592_-SINEAluAluSx3
CAediting_17107chr1_16137752_-SINEMIRMIR
CAediting_17108chr1_16147945_-SINEAluAluSz6
CAediting_17109chr1_16147990_-SINEAluAluSz6
CAediting_17110chr1_16148013_-SINEAluAluSz6
CAediting_17111chr1_16148058_-SINEAluAluSz6

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RNA A-to-I editing events in the alternative splicing sites for EPHA2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_17036chr1_16135788_-16135768:161357903SS0+18iCCACTGCCTGTCCTGCCCAGAGC6.99CCGCTGCCTGTCCTGCCCAGAGC7.21
ESCAediting_17036chr1_16135788_-16135766:161357883SS0+20iACTGCCTGTCCTGCCCAGAGCCC-2.56GCTGCCTGTCCTGCCCAGAGCCC-3.83

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000142627.12.EPHA2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000142627.12.EPHA2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EPHA2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
PAAD.CAediting_17058.ENSG00000142627.EPHA2.png
Soverview

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Protein coding region RNA A-to-I editings for EPHA2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for EPHA2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000142627.12ENST00000358432hsa-miR-451216124591161245966mer1612459016124610141-30.76
CAediting_396018chr5_1062918_-ENSG00000142627.12ENST00000358432hsa-miR-463516124818161248247mer-m81612481716124837145-18.91
CAediting_524911chr7_5495852_-ENSG00000142627.12ENST00000358432hsa-miR-589-3p16124365161243717mer-m81612436416124391148-13.83
CAediting_573001chr7_92204086_-ENSG00000142627.12ENST00000358432hsa-miR-1285-5p16124767161247737mer-m81612476616124786151-20.5

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1306324chr19_13836464_-ENSG00000142627.12ENST00000358432hsa-miR-27a-3p16124783161247908mer-1a1612478316124803140-14.56

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EPHA2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for EPHA2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_17058chr1_16136070_-..0.04203217021655530.233855280831143..

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Relation with cancer stages for EPHA2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for EPHA2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for EPHA2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
EPHA2P29317DB08896RegorafenibEphrin type-A receptor 2 SmallMoleculeDrugapproved
EPHA2P29317DB01254DasatinibEphrin type-A receptor 2 SmallMoleculeDrugapproved|investigational
EPHA2P29317DB12010FostamatinibEphrin type-A receptor 2 SmallMoleculeDrugapproved|investigational

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RelatedDiseases for EPHA2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
EPHA2C1861825CATARACT, POSTERIOR POLAR, 14CTD_human;GENOMICS_ENGLAND;UNIPROT
EPHA2C0858617Posterior subcapsular cataract2ORPHANET
EPHA2C0006826Malignant Neoplasms1CTD_human
EPHA2C0027651Neoplasms1CTD_human
EPHA2C0028326Noonan Syndrome1CTD_human
EPHA2C0041409Turner Syndrome, Male1CTD_human
EPHA2C0086692Benign Neoplasm1CTD_human
EPHA2C0175704LEOPARD Syndrome1CTD_human
EPHA2C0235874Disease Exacerbation1CTD_human
EPHA2C0266539Congenital total cataract1ORPHANET
EPHA2C0392557Nuclear cataract1ORPHANET
EPHA2C1112705Nuclear non-senile cataract1ORPHANET
EPHA2C1527404Female Pseudo-Turner Syndrome1CTD_human
EPHA2C4551484Leopard Syndrome 11CTD_human
EPHA2C4551602Noonan Syndrome 11CTD_human