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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: EIF2S1 (CAeditome ID:1965) |
Gene summary for EIF2S1 |
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Gene information | Gene symbol | EIF2S1 | Gene ID | 1965 |
Gene name | eukaryotic translation initiation factor 2 subunit alpha | |
Synonyms | EIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A | |
Cytomap | 14q23.3 | |
Type of gene | protein-coding | |
Description | eukaryotic translation initiation factor 2 subunit 1eIF-2-alphaeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | |
Modification date | 20210518 | |
UniProtAcc | P05198 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
EIF2S1 | GO:0003743 | Eukaryotic translation initiation factor 2 subunit 1 | 16289705 |
EIF2S1 | GO:0043022 | Eukaryotic translation initiation factor 2 subunit 1 | 17894550 |
EIF2S1 | GO:0034976 | Eukaryotic translation initiation factor 2 subunit 1 | 33384352 |
EIF2S1 | GO:0036499 | Eukaryotic translation initiation factor 2 subunit 1 | 33384352 |
EIF2S1 | GO:0005829 | Eukaryotic translation initiation factor 2 subunit 1 | 0000052 |
EIF2S1 | GO:0005850 | Eukaryotic translation initiation factor 2 subunit 1 | 23063529 |
EIF2S1 | GO:0005851 | Eukaryotic translation initiation factor 2 subunit 1 | 11323413 |
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RNA A-to-I events for EIF2S1 |
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CAediting_998853(67366144, +), CAediting_998854(67366226, +), CAediting_998855(67366260, +), CAediting_998856(67366289, +), CAediting_998857(67367659, +), CAediting_998858(67367672, +), CAediting_998859(67367675, +), CAediting_998860(67367715, +), CAediting_998861(67367738, +), CAediting_998862(67370830, +), CAediting_998863(67370873, +), CAediting_998864(67370874, +), CAediting_998865(67370875, +), CAediting_998866(67371137, +), CAediting_998867(67371141, +), CAediting_998868(67371160, +), CAediting_998869(67371214, +), CAediting_998870(67371219, +), CAediting_998871(67382266, +), CAediting_998872(67382281, +), CAediting_998873(67384576, +), CAediting_998874(67384596, +), CAediting_998875(67384725, +), CAediting_998876(67384746, +), CAediting_998877(67384748, +), CAediting_998878(67385323, +), CAediting_998879(67385349, +), CAediting_998880(67385350, +), CAediting_998881(67385358, +), CAediting_998882(67385381, +), CAediting_998883(67385430, +), |
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RNA editing positional annotations for EIF2S1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_998853 | chr14_67366144_+ | ncRNA_intronic |
CAediting_998854 | chr14_67366226_+ | ncRNA_intronic |
CAediting_998855 | chr14_67366260_+ | ncRNA_intronic |
CAediting_998856 | chr14_67366289_+ | ncRNA_intronic |
CAediting_998857 | chr14_67367659_+ | ncRNA_intronic |
CAediting_998858 | chr14_67367672_+ | ncRNA_intronic |
CAediting_998859 | chr14_67367675_+ | ncRNA_intronic |
CAediting_998860 | chr14_67367715_+ | ncRNA_intronic |
CAediting_998861 | chr14_67367738_+ | ncRNA_intronic |
CAediting_998862 | chr14_67370830_+ | ncRNA_intronic |
CAediting_998863 | chr14_67370873_+ | ncRNA_intronic |
CAediting_998864 | chr14_67370874_+ | ncRNA_intronic |
CAediting_998865 | chr14_67370875_+ | ncRNA_intronic |
CAediting_998866 | chr14_67371137_+ | ncRNA_intronic |
CAediting_998867 | chr14_67371141_+ | ncRNA_intronic |
CAediting_998868 | chr14_67371160_+ | ncRNA_intronic |
CAediting_998869 | chr14_67371214_+ | ncRNA_intronic |
CAediting_998870 | chr14_67371219_+ | ncRNA_intronic |
CAediting_998871 | chr14_67382266_+ | intronic |
CAediting_998872 | chr14_67382281_+ | intronic |
CAediting_998873 | chr14_67384576_+ | UTR3 |
CAediting_998874 | chr14_67384596_+ | UTR3 |
CAediting_998875 | chr14_67384725_+ | UTR3 |
CAediting_998876 | chr14_67384746_+ | UTR3 |
CAediting_998877 | chr14_67384748_+ | UTR3 |
CAediting_998878 | chr14_67385323_+ | UTR3 |
CAediting_998879 | chr14_67385349_+ | UTR3 |
CAediting_998880 | chr14_67385350_+ | UTR3 |
CAediting_998881 | chr14_67385358_+ | UTR3 |
CAediting_998882 | chr14_67385381_+ | UTR3 |
CAediting_998883 | chr14_67385430_+ | UTR3 |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_998853 | chr14_67366144_+ | SINE | Alu | AluJo |
CAediting_998854 | chr14_67366226_+ | SINE | Alu | AluJo |
CAediting_998855 | chr14_67366260_+ | SINE | Alu | AluJo |
CAediting_998856 | chr14_67366289_+ | SINE | Alu | AluJo |
CAediting_998857 | chr14_67367659_+ | SINE | Alu | AluJb |
CAediting_998858 | chr14_67367672_+ | SINE | Alu | AluJb |
CAediting_998859 | chr14_67367675_+ | SINE | Alu | AluJb |
CAediting_998860 | chr14_67367715_+ | SINE | Alu | AluJb |
CAediting_998861 | chr14_67367738_+ | SINE | Alu | AluJb |
CAediting_998862 | chr14_67370830_+ | SINE | Alu | AluJb |
CAediting_998863 | chr14_67370873_+ | SINE | Alu | AluJb |
CAediting_998864 | chr14_67370874_+ | SINE | Alu | AluJb |
CAediting_998865 | chr14_67370875_+ | SINE | Alu | AluJb |
CAediting_998866 | chr14_67371137_+ | SINE | Alu | AluJr |
CAediting_998867 | chr14_67371141_+ | SINE | Alu | AluJr |
CAediting_998868 | chr14_67371160_+ | SINE | Alu | AluJr |
CAediting_998869 | chr14_67371214_+ | SINE | Alu | AluJr |
CAediting_998870 | chr14_67371219_+ | SINE | Alu | AluJr |
CAediting_998878 | chr14_67385323_+ | SINE | Alu | AluJr4 |
CAediting_998879 | chr14_67385349_+ | SINE | Alu | AluJr4 |
CAediting_998880 | chr14_67385350_+ | SINE | Alu | AluJr4 |
CAediting_998881 | chr14_67385358_+ | SINE | Alu | AluJr4 |
CAediting_998882 | chr14_67385381_+ | SINE | Alu | AluJr4 |
CAediting_998883 | chr14_67385430_+ | SINE | Alu | AluJr4 |
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RNA A-to-I editing events in the alternative splicing sites for EIF2S1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EIF2S1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for EIF2S1 |
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The effects of the RNA editing to the miRNA binding sites for EIF2S1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_998878 | chr14_67385323_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-6807-5p | 67385321 | 67385327 | 7mer-m8 | 67385305 | 67385328 | 150.00 | -21.37 |
CAediting_998880 | chr14_67385350_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-4313 | 67385348 | 67385354 | 7mer-m8 | 67385335 | 67385355 | 146.00 | -20.12 |
CAediting_998873 | chr14_67384576_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-7113-5p | 67384570 | 67384577 | 8mer-1a | 67384557 | 67384577 | 145.00 | -21.21 |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-3918 | 67385428 | 67385434 | 7mer-m8 | 67385415 | 67385435 | 140.00 | -19.23 |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-4312 | 67385425 | 67385430 | 6mer | 67385414 | 67385431 | 147.00 | -32.00 |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-4512 | 67385427 | 67385433 | 7mer-m8 | 67385413 | 67385434 | 160.00 | -31.86 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378a-3p | 67384746 | 67384753 | 8mer-1a | 67384730 | 67384753 | 154.00 | -18.74 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378b | 67384746 | 67384753 | 8mer-1a | 67384733 | 67384753 | 155.00 | -20.66 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378c | 67384746 | 67384753 | 8mer-1a | 67384727 | 67384753 | 161.00 | -20.73 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378d | 67384746 | 67384753 | 8mer-1a | 67384732 | 67384753 | 152.00 | -17.06 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378d | 67384746 | 67384753 | 8mer-1a | 67384732 | 67384753 | 152.00 | -17.06 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378e | 67384746 | 67384753 | 8mer-1a | 67384733 | 67384753 | 152.00 | -16.93 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378f | 67384746 | 67384753 | 8mer-1a | 67384732 | 67384753 | 156.00 | -18.74 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378h | 67384746 | 67384753 | 8mer-1a | 67384733 | 67384753 | 145.00 | -15.74 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-378i | 67384746 | 67384753 | 8mer-1a | 67384731 | 67384753 | 154.00 | -18.74 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-422a | 67384746 | 67384753 | 8mer-1a | 67384730 | 67384753 | 154.00 | -18.74 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-5009-5p | 67384745 | 67384751 | 7mer-m8 | 67384731 | 67384752 | 145.00 | -15.88 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-8058 | 67384745 | 67384751 | 7mer-m8 | 67384731 | 67384752 | 147.00 | -15.12 |
CAediting_998881 | chr14_67385358_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-874-3p | 67385355 | 67385361 | 7mer-m8 | 67385341 | 67385362 | 160.00 | -33.53 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-1182 | 67385427 | 67385433 | 7mer-m8 | 67385412 | 67385434 | 150 | -19.57 |
CAediting_998882 | chr14_67385381_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-193a-3p | 67385376 | 67385382 | 7mer-m8 | 67385364 | 67385383 | 152 | -20.35 |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-193a-5p | 67385426 | 67385432 | 7mer-m8 | 67385413 | 67385433 | 141 | -13.52 |
CAediting_998882 | chr14_67385381_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-193b-3p | 67385376 | 67385382 | 7mer-m8 | 67385364 | 67385383 | 152 | -20.35 |
CAediting_998882 | chr14_67385381_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-3176 | 67385375 | 67385381 | 7mer-m8 | 67385364 | 67385382 | 140 | -17.57 |
CAediting_998883 | chr14_67385430_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-431-5p | 67385424 | 67385430 | 7mer-m8 | 67385413 | 67385431 | 147 | -19.33 |
CAediting_998882 | chr14_67385381_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-653-3p | 67385378 | 67385384 | 7mer-m8 | 67385361 | 67385385 | 141 | -16.81 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-6839-5p | 67384746 | 67384753 | 8mer-1a | 67384732 | 67384753 | 150 | -16.67 |
CAediting_998882 | chr14_67385381_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-6878-3p | 67385374 | 67385380 | 7mer-m8 | 67385359 | 67385381 | 154 | -27.54 |
CAediting_998876 | chr14_67384746_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-876-5p | 67384744 | 67384751 | 8mer-1a | 67384730 | 67384751 | 140 | -10.4 |
CAediting_998877 | chr14_67384748_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-876-5p | 67384744 | 67384751 | 8mer-1a | 67384730 | 67384751 | 140 | -10.4 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-605-3p | 67383593 | 67383599 | 7mer-m8 | 67383579 | 67383600 | 151 | -16.09 |
CAediting_980496 | chr14_31014685_- | ENSG00000134001.11 | ENST00000256383 | hsa-miR-624-3p | 67385429 | 67385435 | 7mer-m8 | 67385414 | 67385436 | 154 | -20.19 |
CAediting_748296 | chr10_51299626_+ | ENSG00000134001.11 | ENST00000466499 | hsa-miR-605-3p | 67383593 | 67383599 | 7mer-m8 | 67383579 | 67383600 | 151 | -16.09 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-548aa | 67384773 | 67384779 | 7mer-m8 | 67384753 | 67384780 | 145 | -13.96 |
CAediting_117844 | chr1_162342605_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-556-3p | 67386453 | 67386459 | 7mer-m8 | 67386439 | 67386460 | 148 | -12.22 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_393 | chr1_1167164_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-200b-3p | 67385130 | 67385136 | 7mer-m8 | 67385115 | 67385137 | 141 | -12.01 |
CAediting_393 | chr1_1167164_+ | ENSG00000134001.11 | ENST00000256383 | hsa-miR-200b-3p | 67383518 | 67383524 | 7mer-m8 | 67383504 | 67383525 | 140 | -9.74 |
CAediting_393 | chr1_1167164_+ | ENSG00000134001.11 | ENST00000466499 | hsa-miR-200b-3p | 67383518 | 67383524 | 7mer-m8 | 67383504 | 67383525 | 140 | -9.74 |
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The effects of the RNA editing to the stability of the RNA structures for EIF2S1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for EIF2S1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
LGG | CAediting_998878 | chr14_67385323_+ | 1.62238279102112e-06 | 0.501153717343991 | . | . | . | . |
BRCA | CAediting_998878 | chr14_67385323_+ | 1.48271420173539e-11 | 0.345444324307803 | . | . | . | . |
LIHC | CAediting_998878 | chr14_67385323_+ | 0.00556488071287629 | 0.325775678673011 | . | . | . | . |
LUAD | CAediting_998878 | chr14_67385323_+ | 0.00836662524103142 | 0.254895929643346 | . | . | . | . |
LUSC | CAediting_998878 | chr14_67385323_+ | 0.00059464185667424 | 0.360897784793787 | . | . | . | . |
THCA | CAediting_998878 | chr14_67385323_+ | 0.0379807854805119 | 0.256039928074115 | . | . | . | . |
BRCA | CAediting_998880 | chr14_67385350_+ | 2.8672372851826e-06 | 0.320184384285504 | . | . | . | . |
LIHC | CAediting_998880 | chr14_67385350_+ | 0.00958630024694243 | 0.29731121315728 | . | . | . | . |
LUAD | CAediting_998880 | chr14_67385350_+ | 0.00507693822815458 | 0.336091777405395 | . | . | . | . |
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Relation with cancer stages for EIF2S1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
BRCA | pathologic_stage | CAediting_998878 | chr14_67385323_+ | 0.0408292429495693 | 0.108920459995412 |
UCEC | clinical_stage | CAediting_998878 | chr14_67385323_+ | 0.0385523930887611 | 0.244392609561216 |
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Relation with survival for EIF2S1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for EIF2S1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF2S1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
EIF2S1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
EIF2S1 | C0009241 | Cognition Disorders | 1 | CTD_human |
EIF2S1 | C0011265 | Presenile dementia | 1 | CTD_human |
EIF2S1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
EIF2S1 | C0029463 | Osteosarcoma | 1 | CTD_human |
EIF2S1 | C0036341 | Schizophrenia | 1 | PSYGENET |
EIF2S1 | C0038220 | Status Epilepticus | 1 | CTD_human |
EIF2S1 | C0270823 | Petit mal status | 1 | CTD_human |
EIF2S1 | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human |
EIF2S1 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
EIF2S1 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
EIF2S1 | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human |
EIF2S1 | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human |
EIF2S1 | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human |
EIF2S1 | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human |
EIF2S1 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
EIF2S1 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
EIF2S1 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |