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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: EFNA1 (CAeditome ID:1942)

Gene summary for EFNA1

check button Gene summary
Gene informationGene symbol

EFNA1

Gene ID

1942

Gene nameephrin A1
SynonymsB61|ECKLG|EFL1|EPLG1|GMAN|LERK-1|LERK1|TNFAIP4
Cytomap

1q22

Type of geneprotein-coding
Descriptionephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1epididymis secretory sperm binding proteingastric cancer metastasis associated long noncoding RNAimmediate early response protein B61ligand of eph-related kinase 1tumo
Modification date20210518
UniProtAcc

P20827

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
EFNA1

GO:0016477

Ephrin-A1

10655584

EFNA1

GO:0033628

Ephrin-A1

10655584

EFNA1

GO:0034446

Ephrin-A1

10655584

EFNA1

GO:0048013

Ephrin-A1

10655584

EFNA1

GO:0050731

Ephrin-A1

10655584

EFNA1

GO:1902004

Ephrin-A1

24217950


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RNA A-to-I events for EFNA1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000169242.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_107257(155132279, +), CAediting_107258(155132299, +), CAediting_107259(155132313, +), CAediting_107260(155132328, +), CAediting_107261(155132329, +), CAediting_107262(155132344, +), CAediting_107263(155132348, +), CAediting_107264(155132349, +), CAediting_107265(155132352, +), CAediting_107266(155132366, +), CAediting_107267(155132374, +), CAediting_107268(155132375, +), CAediting_107269(155132388, +), CAediting_107270(155132410, +), CAediting_107271(155132415, +), CAediting_107272(155132428, +), CAediting_107273(155132431, +), CAediting_107274(155132433, +), CAediting_107275(155132445, +), CAediting_107276(155132457, +), CAediting_107277(155132482, +), CAediting_107278(155132535, +), CAediting_107279(155132581, +), CAediting_107280(155132589, +), CAediting_107281(155132595, +), CAediting_107282(155132608, +), CAediting_107283(155132612, +), CAediting_107284(155132618, +), CAediting_107285(155132626, +), CAediting_107286(155132627, +), CAediting_107287(155132629, +), CAediting_107288(155132641, +), CAediting_107289(155132642, +), CAediting_107290(155132651, +), CAediting_107291(155132652, +), CAediting_107292(155132657, +), CAediting_107293(155132663, +), CAediting_107294(155132666, +), CAediting_107295(155132668, +), CAediting_107296(155132670, +), CAediting_107297(155132672, +), CAediting_107298(155132674, +), CAediting_107299(155132677, +), CAediting_107300(155132678, +), CAediting_107301(155132679, +), CAediting_107302(155132680, +), CAediting_107303(155132683, +), CAediting_107304(155132688, +), CAediting_107305(155132701, +), CAediting_107306(155132709, +), CAediting_107307(155132715, +), CAediting_107308(155132719, +), CAediting_107309(155132723, +), CAediting_107310(155132724, +), CAediting_107311(155132732, +), CAediting_107312(155132736, +), CAediting_107313(155132739, +), CAediting_107314(155132750, +), CAediting_107315(155132751, +), CAediting_107316(155132755, +), CAediting_107317(155132770, +), CAediting_107318(155132772, +), CAediting_107319(155132776, +), CAediting_107320(155132781, +), CAediting_107321(155132783, +), CAediting_107322(155132786, +), CAediting_107323(155132788, +), CAediting_107324(155132791, +), CAediting_107325(155132811, +), CAediting_107326(155132815, +), CAediting_107327(155132930, +), CAediting_107328(155132934, +), CAediting_107329(155132936, +), CAediting_107330(155132956, +), CAediting_107331(155132972, +), CAediting_107332(155132990, +), CAediting_107333(155132991, +), CAediting_107334(155132997, +), CAediting_107335(155133010, +), CAediting_107336(155133037, +), CAediting_107337(155133040, +), CAediting_107338(155133050, +), CAediting_107339(155133052, +), CAediting_107340(155133056, +), CAediting_107341(155133063, +), CAediting_107342(155133091, +), CAediting_107343(155133094, +), CAediting_107344(155133113, +), CAediting_107345(155133132, +), CAediting_107346(155133156, +), CAediting_107347(155133183, +),

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RNA editing positional annotations for EFNA1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_107257chr1_155132279_+ncRNA_intronic
CAediting_107258chr1_155132299_+ncRNA_intronic
CAediting_107259chr1_155132313_+ncRNA_intronic
CAediting_107260chr1_155132328_+ncRNA_intronic
CAediting_107261chr1_155132329_+ncRNA_intronic
CAediting_107262chr1_155132344_+ncRNA_intronic
CAediting_107263chr1_155132348_+ncRNA_intronic
CAediting_107264chr1_155132349_+ncRNA_intronic
CAediting_107265chr1_155132352_+ncRNA_intronic
CAediting_107266chr1_155132366_+ncRNA_intronic
CAediting_107267chr1_155132374_+ncRNA_intronic
CAediting_107268chr1_155132375_+ncRNA_intronic
CAediting_107269chr1_155132388_+ncRNA_intronic
CAediting_107270chr1_155132410_+ncRNA_intronic
CAediting_107271chr1_155132415_+ncRNA_intronic
CAediting_107272chr1_155132428_+ncRNA_intronic
CAediting_107273chr1_155132431_+ncRNA_intronic
CAediting_107274chr1_155132433_+ncRNA_intronic
CAediting_107275chr1_155132445_+ncRNA_intronic
CAediting_107276chr1_155132457_+ncRNA_intronic
CAediting_107277chr1_155132482_+ncRNA_intronic
CAediting_107278chr1_155132535_+ncRNA_intronic
CAediting_107279chr1_155132581_+ncRNA_intronic
CAediting_107280chr1_155132589_+ncRNA_intronic
CAediting_107281chr1_155132595_+ncRNA_intronic
CAediting_107282chr1_155132608_+ncRNA_intronic
CAediting_107283chr1_155132612_+ncRNA_intronic
CAediting_107284chr1_155132618_+ncRNA_intronic
CAediting_107285chr1_155132626_+ncRNA_intronic
CAediting_107286chr1_155132627_+ncRNA_intronic
CAediting_107287chr1_155132629_+ncRNA_intronic
CAediting_107288chr1_155132641_+ncRNA_intronic
CAediting_107289chr1_155132642_+ncRNA_intronic
CAediting_107290chr1_155132651_+ncRNA_intronic
CAediting_107291chr1_155132652_+ncRNA_intronic
CAediting_107292chr1_155132657_+ncRNA_intronic
CAediting_107293chr1_155132663_+ncRNA_intronic
CAediting_107294chr1_155132666_+ncRNA_intronic
CAediting_107295chr1_155132668_+ncRNA_intronic
CAediting_107296chr1_155132670_+ncRNA_intronic
CAediting_107297chr1_155132672_+ncRNA_intronic
CAediting_107298chr1_155132674_+ncRNA_intronic
CAediting_107299chr1_155132677_+ncRNA_intronic
CAediting_107300chr1_155132678_+ncRNA_intronic
CAediting_107301chr1_155132679_+ncRNA_intronic
CAediting_107302chr1_155132680_+ncRNA_intronic
CAediting_107303chr1_155132683_+ncRNA_intronic
CAediting_107304chr1_155132688_+ncRNA_intronic
CAediting_107305chr1_155132701_+ncRNA_intronic
CAediting_107306chr1_155132709_+ncRNA_intronic
CAediting_107307chr1_155132715_+ncRNA_intronic
CAediting_107308chr1_155132719_+ncRNA_intronic
CAediting_107309chr1_155132723_+ncRNA_intronic
CAediting_107310chr1_155132724_+ncRNA_intronic
CAediting_107311chr1_155132732_+ncRNA_intronic
CAediting_107312chr1_155132736_+ncRNA_intronic
CAediting_107313chr1_155132739_+ncRNA_intronic
CAediting_107314chr1_155132750_+ncRNA_intronic
CAediting_107315chr1_155132751_+ncRNA_intronic
CAediting_107316chr1_155132755_+ncRNA_intronic
CAediting_107317chr1_155132770_+ncRNA_intronic
CAediting_107318chr1_155132772_+ncRNA_intronic
CAediting_107319chr1_155132776_+ncRNA_intronic
CAediting_107320chr1_155132781_+ncRNA_intronic
CAediting_107321chr1_155132783_+ncRNA_intronic
CAediting_107322chr1_155132786_+ncRNA_intronic
CAediting_107323chr1_155132788_+ncRNA_intronic
CAediting_107324chr1_155132791_+ncRNA_intronic
CAediting_107325chr1_155132811_+ncRNA_intronic
CAediting_107326chr1_155132815_+ncRNA_intronic
CAediting_107327chr1_155132930_+ncRNA_intronic
CAediting_107328chr1_155132934_+ncRNA_intronic
CAediting_107329chr1_155132936_+ncRNA_intronic
CAediting_107330chr1_155132956_+ncRNA_intronic
CAediting_107331chr1_155132972_+ncRNA_intronic
CAediting_107332chr1_155132990_+ncRNA_intronic
CAediting_107333chr1_155132991_+ncRNA_intronic
CAediting_107334chr1_155132997_+ncRNA_intronic
CAediting_107335chr1_155133010_+ncRNA_intronic
CAediting_107336chr1_155133037_+ncRNA_intronic
CAediting_107337chr1_155133040_+ncRNA_intronic
CAediting_107338chr1_155133050_+ncRNA_intronic
CAediting_107339chr1_155133052_+ncRNA_intronic
CAediting_107340chr1_155133056_+ncRNA_intronic
CAediting_107341chr1_155133063_+ncRNA_intronic
CAediting_107342chr1_155133091_+ncRNA_intronic
CAediting_107343chr1_155133094_+ncRNA_intronic
CAediting_107344chr1_155133113_+ncRNA_intronic
CAediting_107345chr1_155133132_+ncRNA_intronic
CAediting_107346chr1_155133156_+ncRNA_intronic
CAediting_107347chr1_155133183_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_107257chr1_155132279_+SINEAluAluSq2
CAediting_107258chr1_155132299_+SINEAluAluSq2
CAediting_107259chr1_155132313_+SINEAluAluSq2
CAediting_107260chr1_155132328_+SINEAluAluSq2
CAediting_107261chr1_155132329_+SINEAluAluSq2
CAediting_107262chr1_155132344_+SINEAluAluSq2
CAediting_107263chr1_155132348_+SINEAluAluSq2
CAediting_107264chr1_155132349_+SINEAluAluSq2
CAediting_107265chr1_155132352_+SINEAluAluSq2
CAediting_107266chr1_155132366_+SINEAluAluSq2
CAediting_107267chr1_155132374_+SINEAluAluSq2
CAediting_107268chr1_155132375_+SINEAluAluSq2
CAediting_107269chr1_155132388_+SINEAluAluSq2
CAediting_107270chr1_155132410_+SINEAluAluSq2
CAediting_107271chr1_155132415_+SINEAluAluSq2
CAediting_107272chr1_155132428_+SINEAluAluSq2
CAediting_107273chr1_155132431_+SINEAluAluSq2
CAediting_107274chr1_155132433_+SINEAluAluSq2
CAediting_107275chr1_155132445_+SINEAluAluSq2
CAediting_107276chr1_155132457_+SINEAluAluSq2
CAediting_107277chr1_155132482_+SINEAluAluSq2
CAediting_107278chr1_155132535_+SINEAluAluSq2
CAediting_107279chr1_155132581_+SINEAluAluSx
CAediting_107280chr1_155132589_+SINEAluAluSx
CAediting_107281chr1_155132595_+SINEAluAluSx
CAediting_107282chr1_155132608_+SINEAluAluSx
CAediting_107283chr1_155132612_+SINEAluAluSx
CAediting_107284chr1_155132618_+SINEAluAluSx
CAediting_107285chr1_155132626_+SINEAluAluSx
CAediting_107286chr1_155132627_+SINEAluAluSx
CAediting_107287chr1_155132629_+SINEAluAluSx
CAediting_107288chr1_155132641_+SINEAluAluSx
CAediting_107289chr1_155132642_+SINEAluAluSx
CAediting_107290chr1_155132651_+SINEAluAluSx
CAediting_107291chr1_155132652_+SINEAluAluSx
CAediting_107292chr1_155132657_+SINEAluAluSx
CAediting_107293chr1_155132663_+SINEAluAluSx
CAediting_107294chr1_155132666_+SINEAluAluSx
CAediting_107295chr1_155132668_+SINEAluAluSx
CAediting_107296chr1_155132670_+SINEAluAluSx
CAediting_107297chr1_155132672_+SINEAluAluSx
CAediting_107298chr1_155132674_+SINEAluAluSx
CAediting_107299chr1_155132677_+SINEAluAluSx
CAediting_107300chr1_155132678_+SINEAluAluSx
CAediting_107301chr1_155132679_+SINEAluAluSx
CAediting_107302chr1_155132680_+SINEAluAluSx
CAediting_107303chr1_155132683_+SINEAluAluSx
CAediting_107304chr1_155132688_+SINEAluAluSx
CAediting_107305chr1_155132701_+SINEAluAluSx
CAediting_107306chr1_155132709_+SINEAluAluSx
CAediting_107307chr1_155132715_+SINEAluAluSx
CAediting_107308chr1_155132719_+SINEAluAluSx
CAediting_107309chr1_155132723_+SINEAluAluSx
CAediting_107310chr1_155132724_+SINEAluAluSx
CAediting_107311chr1_155132732_+SINEAluAluSx
CAediting_107312chr1_155132736_+SINEAluAluSx
CAediting_107313chr1_155132739_+SINEAluAluSx
CAediting_107314chr1_155132750_+SINEAluAluSx
CAediting_107315chr1_155132751_+SINEAluAluSx
CAediting_107316chr1_155132755_+SINEAluAluSx
CAediting_107317chr1_155132770_+SINEAluAluSx
CAediting_107318chr1_155132772_+SINEAluAluSx
CAediting_107319chr1_155132776_+SINEAluAluSx
CAediting_107320chr1_155132781_+SINEAluAluSx
CAediting_107321chr1_155132783_+SINEAluAluSx
CAediting_107322chr1_155132786_+SINEAluAluSx
CAediting_107323chr1_155132788_+SINEAluAluSx
CAediting_107324chr1_155132791_+SINEAluAluSx
CAediting_107325chr1_155132811_+SINEAluAluSx
CAediting_107326chr1_155132815_+SINEAluAluSx
CAediting_107327chr1_155132930_+SINEAluAluSx4
CAediting_107328chr1_155132934_+SINEAluAluSx4
CAediting_107329chr1_155132936_+SINEAluAluSx4
CAediting_107330chr1_155132956_+SINEAluAluSx4
CAediting_107331chr1_155132972_+SINEAluAluSx4
CAediting_107332chr1_155132990_+SINEAluAluSx4
CAediting_107333chr1_155132991_+SINEAluAluSx4
CAediting_107334chr1_155132997_+SINEAluAluSx4
CAediting_107335chr1_155133010_+SINEAluAluSx4
CAediting_107336chr1_155133037_+SINEAluAluSx4
CAediting_107337chr1_155133040_+SINEAluAluSx4
CAediting_107338chr1_155133050_+SINEAluAluSx4
CAediting_107339chr1_155133052_+SINEAluAluSx4
CAediting_107340chr1_155133056_+SINEAluAluSx4
CAediting_107341chr1_155133063_+SINEAluAluSx4
CAediting_107342chr1_155133091_+SINEAluAluSx4
CAediting_107343chr1_155133094_+SINEAluAluSx4
CAediting_107344chr1_155133113_+SINEAluAluSx4
CAediting_107345chr1_155133132_+SINEAluAluSx4
CAediting_107346chr1_155133156_+SINEAluAluSx4
CAediting_107347chr1_155133183_+SINEAluAluSx4

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RNA A-to-I editing events in the alternative splicing sites for EFNA1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000169242.10.EFNA1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000169242.10.EFNA1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EFNA1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
BLCA.CAediting_107328.ENSG00000169242.EFNA1.png
Soverview
COAD.CAediting_107316.ENSG00000169242.EFNA1.png
Soverview
COAD.CAediting_107317.ENSG00000169242.EFNA1.png
Soverview
OV.CAediting_107273.ENSG00000169242.EFNA1.png
Soverview
PAAD.CAediting_107317.ENSG00000169242.EFNA1.png
Soverview
STAD.CAediting_107317.ENSG00000169242.EFNA1.png
Soverview

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Protein coding region RNA A-to-I editings for EFNA1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for EFNA1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_77128chr1_85133844_+ENSG00000169242.10ENST00000368406hsa-miR-4423-3p1551346971551347037mer-m8155134680155134704142-18.65

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EFNA1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for EFNA1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_107317chr1_155132770_+0.00105775149043480.292960219933609....
BRCACAediting_107317chr1_155132770_+2.9518198482064e-050.184555969373001....
LIHCCAediting_107317chr1_155132770_+0.02879355544410130.157413536295389....
LUADCAediting_107317chr1_155132770_+4.75724716398108e-050.227420193500861....
PRADCAediting_107317chr1_155132770_+..0.006843333358290380.195587979199925..
KIRCCAediting_107317chr1_155132770_+..0.00885052401663970.176914452532244..
KIRPCAediting_107317chr1_155132770_+..0.01382099403605250.327249880226208..

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Relation with cancer stages for EFNA1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
CESCclinical_stageCAediting_107316chr1_155132755_+0.0146873236856253-0.24337891147954
ESCAclinical_stageCAediting_107317chr1_155132770_+0.04736404810014940.460279507500296
KIRCpathologic_stageCAediting_107316chr1_155132755_+0.02029673106955970.181109305663061
KIRCpathologic_stageCAediting_107328chr1_155132934_+0.005428144956575670.299076081853459
LUSCpathologic_stageCAediting_107316chr1_155132755_+0.04065636629972160.149054613981125

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Relation with survival for EFNA1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
BRCACAediting_107273chr1_155132431_+0.02992987431530010.025655324442300

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RelatedDrugs for EFNA1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EFNA1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
EFNA1C0006142Malignant neoplasm of breast1CTD_human
EFNA1C0678222Breast Carcinoma1CTD_human
EFNA1C1257931Mammary Neoplasms, Human1CTD_human
EFNA1C1458155Mammary Neoplasms1CTD_human
EFNA1C4704874Mammary Carcinoma, Human1CTD_human