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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: S1PR1 (CAeditome ID:1901) |
Gene summary for S1PR1 |
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Gene information | Gene symbol | S1PR1 | Gene ID | 1901 |
Gene name | sphingosine-1-phosphate receptor 1 | |
Synonyms | CD363|CHEDG1|D1S3362|ECGF1|EDG-1|EDG1|S1P1 | |
Cytomap | 1p21.2 | |
Type of gene | protein-coding | |
Description | sphingosine 1-phosphate receptor 1S1P receptor 1S1P receptor Edg-1endothelial differentiation G-protein coupled receptor 1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1sphingosine 1-phosphate receptor EDG1sphingosine 1-phosp | |
Modification date | 20210524 | |
UniProtAcc | P21453 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
S1PR1 | GO:0038036 | Sphingosine 1-phosphate receptor 1 | 22344443 |
S1PR1 | GO:0003376 | Sphingosine 1-phosphate receptor 1 | 22344443 |
S1PR1 | GO:0005654 | Sphingosine 1-phosphate receptor 1 | 0000052 |
S1PR1 | GO:0031226 | Sphingosine 1-phosphate receptor 1 | 22344443 |
S1PR1 | GO:0043231 | Sphingosine 1-phosphate receptor 1 | 0000052 |
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RNA A-to-I events for S1PR1 |
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CAediting_84256(101239209, +), |
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RNA editing positional annotations for S1PR1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_84256 | chr1_101239209_+ | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for S1PR1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for S1PR1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for S1PR1 |
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The effects of the RNA editing to the miRNA binding sites for S1PR1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_688080 | chr9_63819626_+ | ENSG00000170989.8 | ENST00000305352 | hsa-miR-4477b | 101240447 | 101240454 | 8mer-1a | 101240433 | 101240454 | 140 | -10.04 |
CAediting_688080 | chr9_63819626_+ | ENSG00000170989.8 | ENST00000305352 | hsa-miR-4477b | 101240611 | 101240617 | 7mer-m8 | 101240597 | 101240618 | 149 | -13.47 |
CAediting_414656 | chr5_72878640_+ | ENSG00000170989.8 | ENST00000305352 | hsa-miR-4804-3p | 101240417 | 101240423 | 7mer-m8 | 101240404 | 101240424 | 149 | -16.67 |
CAediting_604450 | chr7_133034877_- | ENSG00000170989.8 | ENST00000305352 | hsa-miR-3654 | 101241299 | 101241305 | 7mer-m8 | 101241288 | 101241306 | 140 | -15.87 |
CAediting_468389 | chr6_31355314_- | ENSG00000170989.8 | ENST00000305352 | hsa-miR-6891-5p | 101240445 | 101240452 | 8mer-1a | 101240431 | 101240452 | 155 | -26.81 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_86358 | chr1_109598906_+ | ENSG00000170989.8 | ENST00000305352 | hsa-miR-197-5p | 101240368 | 101240374 | 7mer-m8 | 101240353 | 101240375 | 149 | -18.43 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000170989.8 | ENST00000305352 | hsa-miR-548aa | 101241379 | 101241385 | 7mer-m8 | 101241362 | 101241386 | 146 | -8.39 |
CAediting_1351755 | chr19_40282625_- | ENSG00000170989.8 | ENST00000305352 | hsa-miR-641 | 101241406 | 101241412 | 7mer-m8 | 101241390 | 101241413 | 140 | -11.22 |
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The effects of the RNA editing to the stability of the RNA structures for S1PR1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000305352.6 | protein_coding | ![]() | ![]() |
ENST00000475821.1 | processed_transcript | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_84256 | ENST00000305352.6 | chr1_101239209_+ | -945.30 | -945.30 | -945.30 |
CAediting_84256 | ENST00000475821.1 | chr1_101239209_+ | -279.70 | -278.90 | -279.70 |
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Relation with ADAR for S1PR1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for S1PR1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for S1PR1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for S1PR1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
S1PR1 | P21453 | DB08868 | Fingolimod | Sphingosine 1-phosphate receptor 1 | SmallMoleculeDrug | approved|investigational |
S1PR1 | P21453 | DB09105 | Asfotase alfa | Sphingosine 1-phosphate receptor 1 | BiotechDrug | approved|investigational |
S1PR1 | P21453 | DB12371 | Siponimod | Sphingosine 1-phosphate receptor 1 | SmallMoleculeDrug | approved|investigational |
S1PR1 | P21453 | DB12612 | Ozanimod | Sphingosine 1-phosphate receptor 1 | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for S1PR1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
S1PR1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
S1PR1 | C0007097 | Carcinoma | 1 | CTD_human |
S1PR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
S1PR1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
S1PR1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
S1PR1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
S1PR1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
S1PR1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
S1PR1 | C0205699 | Carcinomatosis | 1 | CTD_human |
S1PR1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
S1PR1 | C2936380 | Neointima | 1 | CTD_human |
S1PR1 | C2936381 | Neointima Formation | 1 | CTD_human |