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Editing gene: DPYS (CAeditome ID:1807)

Gene summary for DPYS

Gene summary

Gene information	Gene symbol	DPYS
	Gene ID	1807
	Gene name	dihydropyrimidinase
	Synonyms	DHP\|DHPase
	Cytomap	8q22.3
	Type of gene	protein-coding
	Description	dihydropyrimidinasedihydropyrimidine amidohydrolasehydantoinase
	Modification date	20210518
	UniProtAcc	Q14117
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DPYS	GO:0004157	Dihydropyrimidinase	10410956
DPYS	GO:0004157	Dihydropyrimidinase	9718352
DPYS	GO:0006208	Dihydropyrimidinase	9718352
DPYS	GO:0006212	Dihydropyrimidinase	10410956

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RNA A-to-I events for DPYS

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000147647.11

RNA A-to-I editing events in Cancer.

CAediting_656349(104383649, -), CAediting_656350(104383707, -), CAediting_656351(104383734, -), CAediting_656352(104383739, -), CAediting_656353(104383740, -), CAediting_656354(104383766, -), CAediting_656355(104383770, -), CAediting_656356(104383775, -), CAediting_656357(104383784, -), CAediting_656358(104383795, -), CAediting_656359(104383796, -), CAediting_656360(104383797, -), CAediting_656361(104383805, -), CAediting_656362(104383806, -), CAediting_656363(104383815, -), CAediting_656364(104383820, -), CAediting_656365(104383821, -), CAediting_656366(104383829, -), CAediting_656367(104383834, -), CAediting_656368(104383839, -), CAediting_656369(104383848, -), CAediting_656370(104383852, -), CAediting_656371(104383857, -), CAediting_656372(104383874, -), CAediting_656373(104383875, -), CAediting_656374(104383883, -), CAediting_656375(104386276, -), CAediting_656376(104386288, -), CAediting_656377(104386289, -), CAediting_656378(104386298, -), CAediting_656379(104386315, -), CAediting_656380(104386316, -), CAediting_656381(104386328, -), CAediting_656382(104386344, -), CAediting_656383(104386367, -), CAediting_656384(104386370, -), CAediting_656385(104386384, -), CAediting_656386(104386385, -), CAediting_656387(104386398, -), CAediting_656388(104386403, -), CAediting_656389(104386409, -), CAediting_656390(104386411, -), CAediting_656391(104386421, -), CAediting_656392(104386424, -), CAediting_656393(104386433, -), CAediting_656394(104386450, -), CAediting_656395(104386451, -), CAediting_656396(104386464, -), CAediting_656397(104386486, -), CAediting_656398(104386489, -), CAediting_656399(104386502, -), CAediting_656400(104386515, -), CAediting_656401(104386519, -), CAediting_656402(104386559, -), CAediting_656403(104386560, -), CAediting_656404(104386675, -), CAediting_656405(104386680, -), CAediting_656406(104386693, -), CAediting_656407(104386700, -), CAediting_656408(104386718, -), CAediting_656409(104386720, -), CAediting_656410(104386725, -), CAediting_656411(104386730, -), CAediting_656412(104386733, -), CAediting_656413(104386736, -), CAediting_656414(104386744, -), CAediting_656415(104386760, -), CAediting_656416(104386765, -), CAediting_656417(104386766, -), CAediting_656418(104386768, -), CAediting_656419(104386779, -), CAediting_656420(104386792, -), CAediting_656421(104386798, -), CAediting_656422(104386805, -), CAediting_656423(104386806, -), CAediting_656424(104386807, -), CAediting_656425(104386810, -), CAediting_656426(104386821, -), CAediting_656427(104386822, -), CAediting_656428(104386846, -), CAediting_656429(104386847, -), CAediting_656430(104386855, -), CAediting_656431(104386860, -), CAediting_656432(104386865, -), CAediting_656433(104386877, -), CAediting_656434(104386900, -), CAediting_656435(104386907, -), CAediting_656436(104386909, -), CAediting_656437(104386923, -), CAediting_656438(104390622, -), CAediting_656439(104390695, -), CAediting_656440(104390771, -), CAediting_656441(104390778, -), CAediting_656442(104390780, -), CAediting_656443(104391862, -),

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RNA editing positional annotations for DPYS using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_656349	chr8_104383649_-	ncRNA_intronic
CAediting_656350	chr8_104383707_-	ncRNA_intronic
CAediting_656351	chr8_104383734_-	ncRNA_intronic
CAediting_656352	chr8_104383739_-	ncRNA_intronic
CAediting_656353	chr8_104383740_-	ncRNA_intronic
CAediting_656354	chr8_104383766_-	ncRNA_intronic
CAediting_656355	chr8_104383770_-	ncRNA_intronic
CAediting_656356	chr8_104383775_-	ncRNA_intronic
CAediting_656357	chr8_104383784_-	ncRNA_intronic
CAediting_656358	chr8_104383795_-	ncRNA_intronic
CAediting_656359	chr8_104383796_-	ncRNA_intronic
CAediting_656360	chr8_104383797_-	ncRNA_intronic
CAediting_656361	chr8_104383805_-	ncRNA_intronic
CAediting_656362	chr8_104383806_-	ncRNA_intronic
CAediting_656363	chr8_104383815_-	ncRNA_intronic
CAediting_656364	chr8_104383820_-	ncRNA_intronic
CAediting_656365	chr8_104383821_-	ncRNA_intronic
CAediting_656366	chr8_104383829_-	ncRNA_intronic
CAediting_656367	chr8_104383834_-	ncRNA_intronic
CAediting_656368	chr8_104383839_-	ncRNA_intronic
CAediting_656369	chr8_104383848_-	ncRNA_intronic
CAediting_656370	chr8_104383852_-	ncRNA_intronic
CAediting_656371	chr8_104383857_-	ncRNA_intronic
CAediting_656372	chr8_104383874_-	ncRNA_intronic
CAediting_656373	chr8_104383875_-	ncRNA_intronic
CAediting_656374	chr8_104383883_-	ncRNA_intronic
CAediting_656375	chr8_104386276_-	ncRNA_intronic
CAediting_656376	chr8_104386288_-	ncRNA_intronic
CAediting_656377	chr8_104386289_-	ncRNA_intronic
CAediting_656378	chr8_104386298_-	ncRNA_intronic
CAediting_656379	chr8_104386315_-	ncRNA_intronic
CAediting_656380	chr8_104386316_-	ncRNA_intronic
CAediting_656381	chr8_104386328_-	ncRNA_intronic
CAediting_656382	chr8_104386344_-	ncRNA_intronic
CAediting_656383	chr8_104386367_-	ncRNA_intronic
CAediting_656384	chr8_104386370_-	ncRNA_intronic
CAediting_656385	chr8_104386384_-	ncRNA_intronic
CAediting_656386	chr8_104386385_-	ncRNA_intronic
CAediting_656387	chr8_104386398_-	ncRNA_intronic
CAediting_656388	chr8_104386403_-	ncRNA_intronic
CAediting_656389	chr8_104386409_-	ncRNA_intronic
CAediting_656390	chr8_104386411_-	ncRNA_intronic
CAediting_656391	chr8_104386421_-	ncRNA_intronic
CAediting_656392	chr8_104386424_-	ncRNA_intronic
CAediting_656393	chr8_104386433_-	ncRNA_intronic
CAediting_656394	chr8_104386450_-	ncRNA_intronic
CAediting_656395	chr8_104386451_-	ncRNA_intronic
CAediting_656396	chr8_104386464_-	ncRNA_intronic
CAediting_656397	chr8_104386486_-	ncRNA_intronic
CAediting_656398	chr8_104386489_-	ncRNA_intronic
CAediting_656399	chr8_104386502_-	ncRNA_intronic
CAediting_656400	chr8_104386515_-	ncRNA_intronic
CAediting_656401	chr8_104386519_-	ncRNA_intronic
CAediting_656402	chr8_104386559_-	ncRNA_intronic
CAediting_656403	chr8_104386560_-	ncRNA_intronic
CAediting_656404	chr8_104386675_-	ncRNA_intronic
CAediting_656405	chr8_104386680_-	ncRNA_intronic
CAediting_656406	chr8_104386693_-	ncRNA_intronic
CAediting_656407	chr8_104386700_-	ncRNA_intronic
CAediting_656408	chr8_104386718_-	ncRNA_intronic
CAediting_656409	chr8_104386720_-	ncRNA_intronic
CAediting_656410	chr8_104386725_-	ncRNA_intronic
CAediting_656411	chr8_104386730_-	ncRNA_intronic
CAediting_656412	chr8_104386733_-	ncRNA_intronic
CAediting_656413	chr8_104386736_-	ncRNA_intronic
CAediting_656414	chr8_104386744_-	ncRNA_intronic
CAediting_656415	chr8_104386760_-	ncRNA_intronic
CAediting_656416	chr8_104386765_-	ncRNA_intronic
CAediting_656417	chr8_104386766_-	ncRNA_intronic
CAediting_656418	chr8_104386768_-	ncRNA_intronic
CAediting_656419	chr8_104386779_-	ncRNA_intronic
CAediting_656420	chr8_104386792_-	ncRNA_intronic
CAediting_656421	chr8_104386798_-	ncRNA_intronic
CAediting_656422	chr8_104386805_-	ncRNA_intronic
CAediting_656423	chr8_104386806_-	ncRNA_intronic
CAediting_656424	chr8_104386807_-	ncRNA_intronic
CAediting_656425	chr8_104386810_-	ncRNA_intronic
CAediting_656426	chr8_104386821_-	ncRNA_intronic
CAediting_656427	chr8_104386822_-	ncRNA_intronic
CAediting_656428	chr8_104386846_-	ncRNA_intronic
CAediting_656429	chr8_104386847_-	ncRNA_intronic
CAediting_656430	chr8_104386855_-	ncRNA_intronic
CAediting_656431	chr8_104386860_-	ncRNA_intronic
CAediting_656432	chr8_104386865_-	ncRNA_intronic
CAediting_656433	chr8_104386877_-	ncRNA_intronic
CAediting_656434	chr8_104386900_-	ncRNA_intronic
CAediting_656435	chr8_104386907_-	ncRNA_intronic
CAediting_656436	chr8_104386909_-	ncRNA_intronic
CAediting_656437	chr8_104386923_-	ncRNA_intronic
CAediting_656438	chr8_104390622_-	ncRNA_intronic
CAediting_656439	chr8_104390695_-	ncRNA_intronic
CAediting_656440	chr8_104390771_-	ncRNA_intronic
CAediting_656441	chr8_104390778_-	ncRNA_intronic
CAediting_656442	chr8_104390780_-	ncRNA_intronic
CAediting_656443	chr8_104391862_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_656349	chr8_104383649_-	SINE	Alu	AluSz6
CAediting_656350	chr8_104383707_-	SINE	Alu	AluSz6
CAediting_656351	chr8_104383734_-	SINE	Alu	AluSz6
CAediting_656352	chr8_104383739_-	SINE	Alu	AluSz6
CAediting_656353	chr8_104383740_-	SINE	Alu	AluSz6
CAediting_656354	chr8_104383766_-	SINE	Alu	AluSz6
CAediting_656355	chr8_104383770_-	SINE	Alu	AluSz6
CAediting_656356	chr8_104383775_-	SINE	Alu	AluSz6
CAediting_656357	chr8_104383784_-	SINE	Alu	AluSz6
CAediting_656358	chr8_104383795_-	SINE	Alu	AluSz6
CAediting_656359	chr8_104383796_-	SINE	Alu	AluSz6
CAediting_656360	chr8_104383797_-	SINE	Alu	AluSz6
CAediting_656361	chr8_104383805_-	SINE	Alu	AluSz6
CAediting_656362	chr8_104383806_-	SINE	Alu	AluSz6
CAediting_656363	chr8_104383815_-	SINE	Alu	AluSz6
CAediting_656364	chr8_104383820_-	SINE	Alu	AluSz6
CAediting_656365	chr8_104383821_-	SINE	Alu	AluSz6
CAediting_656366	chr8_104383829_-	SINE	Alu	AluSz6
CAediting_656367	chr8_104383834_-	SINE	Alu	AluSz6
CAediting_656368	chr8_104383839_-	SINE	Alu	AluSz6
CAediting_656369	chr8_104383848_-	SINE	Alu	AluSz6
CAediting_656370	chr8_104383852_-	SINE	Alu	AluSz6
CAediting_656371	chr8_104383857_-	SINE	Alu	AluSz6
CAediting_656372	chr8_104383874_-	SINE	Alu	AluSz6
CAediting_656373	chr8_104383875_-	SINE	Alu	AluSz6
CAediting_656374	chr8_104383883_-	SINE	Alu	AluSz6
CAediting_656375	chr8_104386276_-	SINE	Alu	AluSz
CAediting_656376	chr8_104386288_-	SINE	Alu	AluSz
CAediting_656377	chr8_104386289_-	SINE	Alu	AluSz
CAediting_656378	chr8_104386298_-	SINE	Alu	AluSz
CAediting_656379	chr8_104386315_-	SINE	Alu	AluSz
CAediting_656380	chr8_104386316_-	SINE	Alu	AluSz
CAediting_656381	chr8_104386328_-	SINE	Alu	AluSz
CAediting_656382	chr8_104386344_-	SINE	Alu	AluSz
CAediting_656383	chr8_104386367_-	SINE	Alu	AluSz
CAediting_656384	chr8_104386370_-	SINE	Alu	AluSz
CAediting_656385	chr8_104386384_-	SINE	Alu	AluSz
CAediting_656386	chr8_104386385_-	SINE	Alu	AluSz
CAediting_656387	chr8_104386398_-	SINE	Alu	AluSz
CAediting_656388	chr8_104386403_-	SINE	Alu	AluSz
CAediting_656389	chr8_104386409_-	SINE	Alu	AluSz
CAediting_656390	chr8_104386411_-	SINE	Alu	AluSz
CAediting_656391	chr8_104386421_-	SINE	Alu	AluSz
CAediting_656392	chr8_104386424_-	SINE	Alu	AluSz
CAediting_656393	chr8_104386433_-	SINE	Alu	AluSz
CAediting_656394	chr8_104386450_-	SINE	Alu	AluSz
CAediting_656395	chr8_104386451_-	SINE	Alu	AluSz
CAediting_656396	chr8_104386464_-	SINE	Alu	AluSz
CAediting_656397	chr8_104386486_-	SINE	Alu	AluSz
CAediting_656398	chr8_104386489_-	SINE	Alu	AluSz
CAediting_656399	chr8_104386502_-	SINE	Alu	AluSz
CAediting_656400	chr8_104386515_-	SINE	Alu	AluSz
CAediting_656401	chr8_104386519_-	SINE	Alu	AluSz
CAediting_656404	chr8_104386675_-	SINE	Alu	AluSx
CAediting_656405	chr8_104386680_-	SINE	Alu	AluSx
CAediting_656406	chr8_104386693_-	SINE	Alu	AluSx
CAediting_656407	chr8_104386700_-	SINE	Alu	AluSx
CAediting_656408	chr8_104386718_-	SINE	Alu	AluSx
CAediting_656409	chr8_104386720_-	SINE	Alu	AluSx
CAediting_656410	chr8_104386725_-	SINE	Alu	AluSx
CAediting_656411	chr8_104386730_-	SINE	Alu	AluSx
CAediting_656412	chr8_104386733_-	SINE	Alu	AluSx
CAediting_656413	chr8_104386736_-	SINE	Alu	AluSx
CAediting_656414	chr8_104386744_-	SINE	Alu	AluSx
CAediting_656415	chr8_104386760_-	SINE	Alu	AluSx
CAediting_656416	chr8_104386765_-	SINE	Alu	AluSx
CAediting_656417	chr8_104386766_-	SINE	Alu	AluSx
CAediting_656418	chr8_104386768_-	SINE	Alu	AluSx
CAediting_656419	chr8_104386779_-	SINE	Alu	AluSx
CAediting_656420	chr8_104386792_-	SINE	Alu	AluSx
CAediting_656421	chr8_104386798_-	SINE	Alu	AluSx
CAediting_656422	chr8_104386805_-	SINE	Alu	AluSx
CAediting_656423	chr8_104386806_-	SINE	Alu	AluSx
CAediting_656424	chr8_104386807_-	SINE	Alu	AluSx
CAediting_656425	chr8_104386810_-	SINE	Alu	AluSx
CAediting_656426	chr8_104386821_-	SINE	Alu	AluSx
CAediting_656427	chr8_104386822_-	SINE	Alu	AluSx
CAediting_656428	chr8_104386846_-	SINE	Alu	AluSx
CAediting_656429	chr8_104386847_-	SINE	Alu	AluSx
CAediting_656430	chr8_104386855_-	SINE	Alu	AluSx
CAediting_656431	chr8_104386860_-	SINE	Alu	AluSx
CAediting_656432	chr8_104386865_-	SINE	Alu	AluSx
CAediting_656433	chr8_104386877_-	SINE	Alu	AluSx
CAediting_656434	chr8_104386900_-	SINE	Alu	AluSx
CAediting_656435	chr8_104386907_-	SINE	Alu	AluSx
CAediting_656436	chr8_104386909_-	SINE	Alu	AluSx
CAediting_656437	chr8_104386923_-	SINE	Alu	AluSx
CAediting_656438	chr8_104390622_-	SINE	Alu	AluSz6
CAediting_656439	chr8_104390695_-	SINE	Alu	AluSz6
CAediting_656440	chr8_104390771_-	SINE	Alu	AluSz6
CAediting_656441	chr8_104390778_-	SINE	Alu	AluSz6
CAediting_656442	chr8_104390780_-	SINE	Alu	AluSz6
CAediting_656443	chr8_104391862_-	SINE	Alu	AluJr4

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RNA A-to-I editing events in the alternative splicing sites for DPYS

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000147647.11.DPYS.

Correlation between RNA A-to-I editing and PSI for ENSG00000147647.11.DPYS.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DPYS

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

KIRC.CAediting_656403.ENSG00000147647.DPYS.png
Soverview

LIHC.CAediting_656425.ENSG00000147647.DPYS.png
Soverview

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Protein coding region RNA A-to-I editings for DPYS

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for DPYS

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DPYS

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for DPYS

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for DPYS

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_656402	chr8_104386559_-	0.0233400946261395	0.308266564727601

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Relation with survival for DPYS

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for DPYS

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DPYS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
DPYS	C0342803	Dihydropyrimidinase deficiency	2	CTD_human;ORPHANET;UNIPROT
DPYS	C3495551	Dihydropyrimidinuria	2	ORPHANET
DPYS	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene