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Editing gene: DHFR (CAeditome ID:1719)

Gene summary for DHFR

Gene summary

Gene information	Gene symbol	DHFR
	Gene ID	1719
	Gene name	dihydrofolate reductase
	Synonyms	DHFRP1\|DYR
	Cytomap	5q14.1
	Type of gene	protein-coding
	Description	dihydrofolate reductase
	Modification date	20210518
	UniProtAcc	P00374
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DHFR	GO:0000900	Dihydrofolate reductase	8490020
DHFR	GO:0003729	Dihydrofolate reductase	21876184
DHFR	GO:0004146	Dihydrofolate reductase	12096917
DHFR	GO:0004146	Dihydrofolate reductase	21876184
DHFR	GO:0004146	Dihydrofolate reductase	2303423
DHFR	GO:0004146	Dihydrofolate reductase	23707606
DHFR	GO:0005542	Dihydrofolate reductase	2303423
DHFR	GO:0008144	Dihydrofolate reductase	12096917
DHFR	GO:0008144	Dihydrofolate reductase	15039552
DHFR	GO:0051870	Dihydrofolate reductase	2303423
DHFR	GO:0070402	Dihydrofolate reductase	2303423
DHFR	GO:1990825	Dihydrofolate reductase	8490020
DHFR	GO:0017148	Dihydrofolate reductase	8490020
DHFR	GO:0046452	Dihydrofolate reductase	2303423
DHFR	GO:0046452	Dihydrofolate reductase	23707606
DHFR	GO:0046653	Dihydrofolate reductase	12096917
DHFR	GO:0046653	Dihydrofolate reductase	21876184
DHFR	GO:0046654	Dihydrofolate reductase	2303423
DHFR	GO:0005739	Dihydrofolate reductase	0000052

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RNA A-to-I events for DHFR

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000228716.5

RNA A-to-I editing events in Cancer.

CAediting_418558(80626973, -), CAediting_418559(80627361, -), CAediting_418560(80627362, -), CAediting_418561(80627363, -), CAediting_418562(80627381, -), CAediting_418563(80627393, -), CAediting_418564(80627403, -), CAediting_418565(80627418, -), CAediting_418566(80627422, -), CAediting_418567(80627429, -), CAediting_418568(80627448, -), CAediting_418569(80627451, -), CAediting_418570(80627454, -), CAediting_418571(80627461, -), CAediting_418572(80627466, -), CAediting_418573(80627467, -), CAediting_418574(80627474, -), CAediting_418575(80627478, -), CAediting_418576(80627484, -), CAediting_418577(80627490, -), CAediting_418578(80627492, -), CAediting_418579(80627502, -), CAediting_418580(80627513, -), CAediting_418581(80627515, -), CAediting_418582(80627516, -), CAediting_418583(80627517, -), CAediting_418584(80627519, -), CAediting_418585(80627522, -), CAediting_418586(80627523, -), CAediting_418587(80627525, -), CAediting_418588(80627528, -), CAediting_418589(80627534, -), CAediting_418590(80627540, -), CAediting_418591(80627562, -), CAediting_418592(80627569, -), CAediting_418593(80627574, -), CAediting_418594(80627578, -), CAediting_418595(80627582, -), CAediting_418596(80627583, -), CAediting_418597(80627588, -), CAediting_418598(80627599, -), CAediting_418599(80627613, -), CAediting_418600(80627621, -), CAediting_418601(80627623, -), CAediting_418602(80627631, -), CAediting_418603(80627929, -), CAediting_418604(80627931, -), CAediting_418605(80627950, -), CAediting_418606(80627974, -), CAediting_418607(80627982, -), CAediting_418608(80627992, -), CAediting_418609(80627999, -), CAediting_418610(80628012, -), CAediting_418611(80628021, -), CAediting_418612(80628034, -), CAediting_418613(80628036, -), CAediting_418614(80628041, -), CAediting_418615(80628054, -), CAediting_418616(80628062, -), CAediting_418617(80628063, -), CAediting_418618(80628073, -), CAediting_418619(80628076, -), CAediting_418620(80628090, -), CAediting_418621(80628097, -), CAediting_418622(80628100, -), CAediting_418623(80628101, -), CAediting_418624(80628122, -), CAediting_418625(80628126, -), CAediting_418626(80628127, -), CAediting_418627(80628133, -), CAediting_418628(80628147, -), CAediting_418629(80628153, -), CAediting_418630(80628172, -), CAediting_418631(80628176, -), CAediting_418632(80628205, -), CAediting_418633(80630143, -), CAediting_418634(80630153, -), CAediting_418635(80630178, -), CAediting_418636(80630189, -), CAediting_418637(80630423, -), CAediting_418638(80630491, -), CAediting_418639(80630557, -), CAediting_418640(80633486, -), CAediting_418641(80636072, -), CAediting_418642(80636073, -), CAediting_418643(80636085, -), CAediting_418644(80636138, -), CAediting_418645(80636164, -), CAediting_418646(80636188, -), CAediting_418647(80636596, -), CAediting_418648(80636649, -), CAediting_418649(80636704, -), CAediting_418650(80647771, -),

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RNA editing positional annotations for DHFR using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_418558	chr5_80626973_-	UTR3
CAediting_418559	chr5_80627361_-	UTR3
CAediting_418560	chr5_80627362_-	UTR3
CAediting_418561	chr5_80627363_-	UTR3
CAediting_418562	chr5_80627381_-	UTR3
CAediting_418563	chr5_80627393_-	UTR3
CAediting_418564	chr5_80627403_-	UTR3
CAediting_418565	chr5_80627418_-	UTR3
CAediting_418566	chr5_80627422_-	UTR3
CAediting_418567	chr5_80627429_-	UTR3
CAediting_418568	chr5_80627448_-	UTR3
CAediting_418569	chr5_80627451_-	UTR3
CAediting_418570	chr5_80627454_-	UTR3
CAediting_418571	chr5_80627461_-	UTR3
CAediting_418572	chr5_80627466_-	UTR3
CAediting_418573	chr5_80627467_-	UTR3
CAediting_418574	chr5_80627474_-	UTR3
CAediting_418575	chr5_80627478_-	UTR3
CAediting_418576	chr5_80627484_-	UTR3
CAediting_418577	chr5_80627490_-	UTR3
CAediting_418578	chr5_80627492_-	UTR3
CAediting_418579	chr5_80627502_-	UTR3
CAediting_418580	chr5_80627513_-	UTR3
CAediting_418581	chr5_80627515_-	UTR3
CAediting_418582	chr5_80627516_-	UTR3
CAediting_418583	chr5_80627517_-	UTR3
CAediting_418584	chr5_80627519_-	UTR3
CAediting_418585	chr5_80627522_-	UTR3
CAediting_418586	chr5_80627523_-	UTR3
CAediting_418587	chr5_80627525_-	UTR3
CAediting_418588	chr5_80627528_-	UTR3
CAediting_418589	chr5_80627534_-	UTR3
CAediting_418590	chr5_80627540_-	UTR3
CAediting_418591	chr5_80627562_-	UTR3
CAediting_418592	chr5_80627569_-	UTR3
CAediting_418593	chr5_80627574_-	UTR3
CAediting_418594	chr5_80627578_-	UTR3
CAediting_418595	chr5_80627582_-	UTR3
CAediting_418596	chr5_80627583_-	UTR3
CAediting_418597	chr5_80627588_-	UTR3
CAediting_418598	chr5_80627599_-	UTR3
CAediting_418599	chr5_80627613_-	UTR3
CAediting_418600	chr5_80627621_-	UTR3
CAediting_418601	chr5_80627623_-	UTR3
CAediting_418602	chr5_80627631_-	UTR3
CAediting_418603	chr5_80627929_-	UTR3
CAediting_418604	chr5_80627931_-	UTR3
CAediting_418605	chr5_80627950_-	UTR3
CAediting_418606	chr5_80627974_-	UTR3
CAediting_418607	chr5_80627982_-	UTR3
CAediting_418608	chr5_80627992_-	UTR3
CAediting_418609	chr5_80627999_-	UTR3
CAediting_418610	chr5_80628012_-	UTR3
CAediting_418611	chr5_80628021_-	UTR3
CAediting_418612	chr5_80628034_-	UTR3
CAediting_418613	chr5_80628036_-	UTR3
CAediting_418614	chr5_80628041_-	UTR3
CAediting_418615	chr5_80628054_-	UTR3
CAediting_418616	chr5_80628062_-	UTR3
CAediting_418617	chr5_80628063_-	UTR3
CAediting_418618	chr5_80628073_-	UTR3
CAediting_418619	chr5_80628076_-	UTR3
CAediting_418620	chr5_80628090_-	UTR3
CAediting_418621	chr5_80628097_-	UTR3
CAediting_418622	chr5_80628100_-	UTR3
CAediting_418623	chr5_80628101_-	UTR3
CAediting_418624	chr5_80628122_-	UTR3
CAediting_418625	chr5_80628126_-	UTR3
CAediting_418626	chr5_80628127_-	UTR3
CAediting_418627	chr5_80628133_-	UTR3
CAediting_418628	chr5_80628147_-	UTR3
CAediting_418629	chr5_80628153_-	UTR3
CAediting_418630	chr5_80628172_-	UTR3
CAediting_418631	chr5_80628176_-	UTR3
CAediting_418632	chr5_80628205_-	UTR3
CAediting_418633	chr5_80630143_-	ncRNA_intronic
CAediting_418634	chr5_80630153_-	ncRNA_intronic
CAediting_418635	chr5_80630178_-	ncRNA_intronic
CAediting_418636	chr5_80630189_-	ncRNA_intronic
CAediting_418637	chr5_80630423_-	ncRNA_exonic
CAediting_418638	chr5_80630491_-	ncRNA_intronic
CAediting_418639	chr5_80630557_-	ncRNA_intronic
CAediting_418640	chr5_80633486_-	ncRNA_intronic
CAediting_418641	chr5_80636072_-	ncRNA_intronic
CAediting_418642	chr5_80636073_-	ncRNA_intronic
CAediting_418643	chr5_80636085_-	ncRNA_intronic
CAediting_418644	chr5_80636138_-	ncRNA_intronic
CAediting_418645	chr5_80636164_-	ncRNA_intronic
CAediting_418646	chr5_80636188_-	ncRNA_intronic
CAediting_418647	chr5_80636596_-	ncRNA_intronic
CAediting_418648	chr5_80636649_-	ncRNA_intronic
CAediting_418649	chr5_80636704_-	ncRNA_intronic
CAediting_418650	chr5_80647771_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_418558	chr5_80626973_-	SINE	Alu	FLAM_A
CAediting_418559	chr5_80627361_-	SINE	Alu	AluJb
CAediting_418560	chr5_80627362_-	SINE	Alu	AluJb
CAediting_418561	chr5_80627363_-	SINE	Alu	AluJb
CAediting_418562	chr5_80627381_-	SINE	Alu	AluJb
CAediting_418563	chr5_80627393_-	SINE	Alu	AluJb
CAediting_418564	chr5_80627403_-	SINE	Alu	AluJb
CAediting_418565	chr5_80627418_-	SINE	Alu	AluJb
CAediting_418566	chr5_80627422_-	SINE	Alu	AluJb
CAediting_418567	chr5_80627429_-	SINE	Alu	AluJb
CAediting_418568	chr5_80627448_-	SINE	Alu	AluJb
CAediting_418569	chr5_80627451_-	SINE	Alu	AluJb
CAediting_418570	chr5_80627454_-	SINE	Alu	AluJb
CAediting_418571	chr5_80627461_-	SINE	Alu	AluJb
CAediting_418572	chr5_80627466_-	SINE	Alu	AluJb
CAediting_418573	chr5_80627467_-	SINE	Alu	AluJb
CAediting_418574	chr5_80627474_-	SINE	Alu	AluJb
CAediting_418575	chr5_80627478_-	SINE	Alu	AluJb
CAediting_418576	chr5_80627484_-	SINE	Alu	AluJb
CAediting_418577	chr5_80627490_-	SINE	Alu	AluJb
CAediting_418578	chr5_80627492_-	SINE	Alu	AluJb
CAediting_418579	chr5_80627502_-	SINE	Alu	AluJb
CAediting_418580	chr5_80627513_-	SINE	Alu	AluJb
CAediting_418581	chr5_80627515_-	SINE	Alu	AluJb
CAediting_418582	chr5_80627516_-	SINE	Alu	AluJb
CAediting_418583	chr5_80627517_-	SINE	Alu	AluJb
CAediting_418584	chr5_80627519_-	SINE	Alu	AluJb
CAediting_418585	chr5_80627522_-	SINE	Alu	AluJb
CAediting_418586	chr5_80627523_-	SINE	Alu	AluJb
CAediting_418587	chr5_80627525_-	SINE	Alu	AluJb
CAediting_418588	chr5_80627528_-	SINE	Alu	AluJb
CAediting_418589	chr5_80627534_-	SINE	Alu	AluJb
CAediting_418590	chr5_80627540_-	SINE	Alu	AluJb
CAediting_418591	chr5_80627562_-	SINE	Alu	AluJb
CAediting_418592	chr5_80627569_-	SINE	Alu	AluJb
CAediting_418593	chr5_80627574_-	SINE	Alu	AluJb
CAediting_418594	chr5_80627578_-	SINE	Alu	AluJb
CAediting_418595	chr5_80627582_-	SINE	Alu	AluJb
CAediting_418596	chr5_80627583_-	SINE	Alu	AluJb
CAediting_418597	chr5_80627588_-	SINE	Alu	AluJb
CAediting_418598	chr5_80627599_-	SINE	Alu	AluJb
CAediting_418599	chr5_80627613_-	SINE	Alu	AluJb
CAediting_418600	chr5_80627621_-	SINE	Alu	AluJb
CAediting_418601	chr5_80627623_-	SINE	Alu	AluJb
CAediting_418603	chr5_80627929_-	SINE	Alu	AluSq2
CAediting_418604	chr5_80627931_-	SINE	Alu	AluSq2
CAediting_418605	chr5_80627950_-	SINE	Alu	AluSq2
CAediting_418606	chr5_80627974_-	SINE	Alu	AluSq2
CAediting_418607	chr5_80627982_-	SINE	Alu	AluSq2
CAediting_418608	chr5_80627992_-	SINE	Alu	AluSq2
CAediting_418609	chr5_80627999_-	SINE	Alu	AluSq2
CAediting_418610	chr5_80628012_-	SINE	Alu	AluSq2
CAediting_418611	chr5_80628021_-	SINE	Alu	AluSq2
CAediting_418612	chr5_80628034_-	SINE	Alu	AluSq2
CAediting_418613	chr5_80628036_-	SINE	Alu	AluSq2
CAediting_418614	chr5_80628041_-	SINE	Alu	AluSq2
CAediting_418615	chr5_80628054_-	SINE	Alu	AluSq2
CAediting_418616	chr5_80628062_-	SINE	Alu	AluSq2
CAediting_418617	chr5_80628063_-	SINE	Alu	AluSq2
CAediting_418618	chr5_80628073_-	SINE	Alu	AluSq2
CAediting_418619	chr5_80628076_-	SINE	Alu	AluSq2
CAediting_418620	chr5_80628090_-	SINE	Alu	AluSq2
CAediting_418621	chr5_80628097_-	SINE	Alu	AluSq2
CAediting_418622	chr5_80628100_-	SINE	Alu	AluSq2
CAediting_418623	chr5_80628101_-	SINE	Alu	AluSq2
CAediting_418624	chr5_80628122_-	SINE	Alu	AluSq2
CAediting_418625	chr5_80628126_-	SINE	Alu	AluSq2
CAediting_418626	chr5_80628127_-	SINE	Alu	AluSq2
CAediting_418627	chr5_80628133_-	SINE	Alu	AluSq2
CAediting_418628	chr5_80628147_-	SINE	Alu	AluSq2
CAediting_418629	chr5_80628153_-	SINE	Alu	AluSq2
CAediting_418630	chr5_80628172_-	SINE	Alu	AluSq2
CAediting_418631	chr5_80628176_-	SINE	Alu	AluSq2
CAediting_418632	chr5_80628205_-	SINE	Alu	AluSq2
CAediting_418633	chr5_80630143_-	SINE	Alu	AluSx1
CAediting_418634	chr5_80630153_-	SINE	Alu	AluSx1
CAediting_418635	chr5_80630178_-	SINE	Alu	AluSx1
CAediting_418636	chr5_80630189_-	SINE	Alu	AluSx1
CAediting_418637	chr5_80630423_-	SINE	Alu	AluY
CAediting_418638	chr5_80630491_-	SINE	Alu	AluY
CAediting_418639	chr5_80630557_-	SINE	Alu	AluY
CAediting_418640	chr5_80633486_-	SINE	Alu	AluSx
CAediting_418641	chr5_80636072_-	SINE	Alu	AluSx1
CAediting_418642	chr5_80636073_-	SINE	Alu	AluSx1
CAediting_418643	chr5_80636085_-	SINE	Alu	AluSx1
CAediting_418644	chr5_80636138_-	SINE	Alu	AluSx1
CAediting_418645	chr5_80636164_-	SINE	Alu	AluSx1
CAediting_418646	chr5_80636188_-	SINE	Alu	AluSx1
CAediting_418647	chr5_80636596_-	SINE	Alu	AluY
CAediting_418648	chr5_80636649_-	SINE	Alu	AluY
CAediting_418649	chr5_80636704_-	SINE	Alu	AluY
CAediting_418650	chr5_80647771_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for DHFR

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000228716.5.DHFR.

Correlation between RNA A-to-I editing and PSI for ENSG00000228716.5.DHFR.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DHFR

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

BRCA.CAediting_418582.ENSG00000228716.DHFR.png
Soverview

HNSC.CAediting_418581.ENSG00000228716.DHFR.png
Soverview

LGG.CAediting_418572.ENSG00000228716.DHFR.png
Soverview

THYM.CAediting_418578.ENSG00000228716.DHFR.png
Soverview

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Protein coding region RNA A-to-I editings for DHFR

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for DHFR

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_418619	chr5_80628076_-	ENSG00000228716.5	ENST00000505337	hsa-miR-10400-5p	80628073	80628080	8mer-1a	80628073	80628092	156.00	-28.68
CAediting_418619	chr5_80628076_-	ENSG00000228716.5	ENST00000505337	hsa-miR-4467	80628073	80628080	8mer-1a	80628073	80628095	145.00	-25.94
CAediting_418619	chr5_80628076_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6770-3p	80628073	80628079	7mer-m8	80628072	80628093	150.00	-20.76
CAediting_418619	chr5_80628076_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6770-3p	80628073	80628079	7mer-m8	80628072	80628093	150.00	-20.76
CAediting_418619	chr5_80628076_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6770-3p	80628073	80628079	7mer-m8	80628072	80628093	150.00	-20.76
CAediting_418621	chr5_80628097_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3614-5p	80628097	80628103	7mer-m8	80628096	80628119	156.00	-27.22
CAediting_418622	chr5_80628100_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6852-5p	80628099	80628104	6mer	80628098	80628117	153.00	-28.76
CAediting_418623	chr5_80628101_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6771-5p	80628100	80628106	7mer-m8	80628099	80628118	157.00	-30.52
CAediting_418625	chr5_80628126_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3140-5p	80628125	80628131	7mer-m8	80628124	80628144	146.00	-10.22
CAediting_418625	chr5_80628126_-	ENSG00000228716.5	ENST00000505337	hsa-miR-5187-3p	80628126	80628132	7mer-m8	80628125	80628145	140.00	-8.85
CAediting_418625	chr5_80628126_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6078	80628122	80628129	8mer-1a	80628122	80628141	144.00	-20.72
CAediting_418625	chr5_80628126_-	ENSG00000228716.5	ENST00000511032	hsa-miR-3140-5p	80628125	80628131	7mer-m8	80628124	80628144	146.00	-10.22
CAediting_418625	chr5_80628126_-	ENSG00000228716.5	ENST00000511032	hsa-miR-5187-3p	80628126	80628132	7mer-m8	80628125	80628145	140.00	-8.85
CAediting_418611	chr5_80628021_-	ENSG00000228716.5	ENST00000505337	hsa-miR-433-5p	80628020	80628026	7mer-m8	80628019	80628042	159.00	-23.87
CAediting_418612	chr5_80628034_-	ENSG00000228716.5	ENST00000505337	hsa-miR-1224-3p	80628030	80628036	7mer-m8	80628029	80628049	149.00	-22.51
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548ae-3p	80628057	80628063	7mer-m8	80628056	80628076	141.00	-10.65
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548ae-3p	80628057	80628063	7mer-m8	80628056	80628076	141.00	-10.65
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548ah-3p	80628057	80628063	7mer-m8	80628056	80628078	143.00	-11.29
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548aj-3p	80628057	80628063	7mer-m8	80628056	80628076	141.00	-8.54
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548aj-3p	80628057	80628063	7mer-m8	80628056	80628076	141.00	-8.54
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548am-3p	80628057	80628063	7mer-m8	80628056	80628078	143.00	-10.65
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548aq-3p	80628057	80628063	7mer-m8	80628056	80628077	141.00	-10.72
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548j-3p	80628057	80628063	7mer-m8	80628056	80628076	141.00	-10.65
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548x-3p	80628057	80628063	7mer-m8	80628056	80628075	141.00	-8.54
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-548x-3p	80628057	80628063	7mer-m8	80628056	80628075	141.00	-8.54
CAediting_418616	chr5_80628062_-	ENSG00000228716.5	ENST00000505337	hsa-miR-7844-5p	80628059	80628065	7mer-m8	80628058	80628079	164.00	-22.52
CAediting_418617	chr5_80628063_-	ENSG00000228716.5	ENST00000505337	hsa-miR-34a-3p	80628060	80628066	7mer-m8	80628059	80628080	140.00	-8.62
CAediting_418618	chr5_80628073_-	ENSG00000228716.5	ENST00000505337	hsa-miR-10394-3p	80628068	80628074	7mer-m8	80628067	80628089	144.00	-25.78
CAediting_418618	chr5_80628073_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3178	80628068	80628074	7mer-m8	80628067	80628083	145.00	-25.12
CAediting_418620	chr5_80628090_-	ENSG00000228716.5	ENST00000505337	hsa-miR-328-3p	80628087	80628093	7mer-m8	80628086	80628107	150.00	-22.40
CAediting_418624	chr5_80628122_-	ENSG00000228716.5	ENST00000505337	hsa-miR-589-5p	80628117	80628123	7mer-m8	80628116	80628136	150.00	-15.32
CAediting_418624	chr5_80628122_-	ENSG00000228716.5	ENST00000505337	hsa-miR-7153-5p	80628117	80628122	6mer	80628116	80628139	140.00	-18.72
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000505337	hsa-miR-4497	80628131	80628137	7mer-m8	80628130	80628146	155.00	-23.26
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000511032	hsa-miR-4497	80628131	80628137	7mer-m8	80628130	80628146	155.00	-23.26
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000505337	hsa-miR-17-3p	80628147	80628153	7mer-m8	80628146	80628166	148.00	-17.84
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000505337	hsa-miR-485-5p	80628143	80628149	7mer-m8	80628142	80628162	149.00	-18.27
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6884-5p	80628143	80628149	7mer-m8	80628142	80628165	162.00	-22.99
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000511032	hsa-miR-17-3p	80628147	80628153	7mer-m8	80628146	80628166	148.00	-17.84
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000511032	hsa-miR-485-5p	80628143	80628149	7mer-m8	80628142	80628162	149.00	-18.27
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000511032	hsa-miR-6884-5p	80628143	80628149	7mer-m8	80628142	80628165	162.00	-22.99
CAediting_418630	chr5_80628172_-	ENSG00000228716.5	ENST00000505337	hsa-miR-181c-3p	80628167	80628173	7mer-m8	80628166	80628188	147.00	-18.00
CAediting_418630	chr5_80628172_-	ENSG00000228716.5	ENST00000511032	hsa-miR-181c-3p	80628167	80628173	7mer-m8	80628166	80628188	147.00	-18.00

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_418622	chr5_80628100_-	ENSG00000228716.5	ENST00000505337	hsa-miR-12126	80628097	80628104	8mer-1a	80628097	80628120	155	-17.04
CAediting_418623	chr5_80628101_-	ENSG00000228716.5	ENST00000505337	hsa-miR-12126	80628097	80628104	8mer-1a	80628097	80628120	155	-17.04
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000505337	hsa-miR-1298-3p	80628130	80628136	7mer-m8	80628129	80628149	142	-11.38
CAediting_418631	chr5_80628176_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3146	80628175	80628181	7mer-m8	80628174	80628196	146	-14.6
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3192-5p	80628131	80628137	7mer-1a	80628131	80628157	140	-25.29
CAediting_418612	chr5_80628034_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3675-3p	80628033	80628039	7mer-m8	80628032	80628053	145	-12.58
CAediting_418613	chr5_80628036_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3675-3p	80628033	80628039	7mer-m8	80628032	80628053	145	-12.58
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000505337	hsa-miR-377-5p	80628143	80628149	7mer-m8	80628142	80628164	149	-17.67
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000505337	hsa-miR-4314	80628131	80628137	7mer-m8	80628130	80628147	151	-17.05
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000505337	hsa-miR-4646-5p	80628131	80628138	8mer-1a	80628131	80628153	155	-23.8
CAediting_418615	chr5_80628054_-	ENSG00000228716.5	ENST00000505337	hsa-miR-4698	80628049	80628054	6mer	80628048	80628070	140	-12.52
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6086	80628143	80628149	7mer-m8	80628142	80628163	148	-22.85
CAediting_418632	chr5_80628205_-	ENSG00000228716.5	ENST00000505337	hsa-miR-6876-3p	80628203	80628209	7mer-m8	80628202	80628225	141	-11.3
CAediting_418620	chr5_80628090_-	ENSG00000228716.5	ENST00000505337	hsa-miR-7152-3p	80628086	80628092	7mer-m8	80628085	80628108	152	-26.99
CAediting_418611	chr5_80628021_-	ENSG00000228716.5	ENST00000505337	hsa-miR-7855-5p	80628021	80628026	6mer	80628020	80628039	148	-26.03
CAediting_418622	chr5_80628100_-	ENSG00000228716.5	ENST00000505337	hsa-miR-887-5p	80628100	80628106	7mer-m8	80628099	80628118	151	-24.36
CAediting_418623	chr5_80628101_-	ENSG00000228716.5	ENST00000505337	hsa-miR-887-5p	80628100	80628106	7mer-m8	80628099	80628118	151	-24.36
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000511032	hsa-miR-1298-3p	80628130	80628136	7mer-m8	80628129	80628149	142	-11.38
CAediting_418631	chr5_80628176_-	ENSG00000228716.5	ENST00000511032	hsa-miR-3146	80628175	80628181	7mer-m8	80628174	80628196	146	-14.6
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000511032	hsa-miR-3192-5p	80628131	80628137	7mer-1a	80628131	80628157	140	-25.29
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000511032	hsa-miR-377-5p	80628143	80628149	7mer-m8	80628142	80628164	149	-17.67
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000511032	hsa-miR-4314	80628131	80628137	7mer-m8	80628130	80628147	151	-17.05
CAediting_418627	chr5_80628133_-	ENSG00000228716.5	ENST00000511032	hsa-miR-4646-5p	80628131	80628138	8mer-1a	80628131	80628153	155	-23.8
CAediting_418628	chr5_80628147_-	ENSG00000228716.5	ENST00000511032	hsa-miR-6086	80628143	80628149	7mer-m8	80628142	80628163	148	-22.85
CAediting_418632	chr5_80628205_-	ENSG00000228716.5	ENST00000511032	hsa-miR-6876-3p	80628203	80628209	7mer-m8	80628202	80628225	141	-11.3

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000228716.5	ENST00000505337	hsa-miR-1304-3p	80628460	80628466	7mer-m8	80628459	80628478	143	-12.77
CAediting_846604	chr11_93733708_-	ENSG00000228716.5	ENST00000511032	hsa-miR-1304-3p	80628460	80628466	7mer-m8	80628459	80628478	143	-12.77
CAediting_846604	chr11_93733708_-	ENSG00000228716.5	ENST00000504396	hsa-miR-1304-3p	80628460	80628466	7mer-m8	80628459	80628478	143	-12.77
CAediting_442554	chr5_154685830_+	ENSG00000228716.5	ENST00000505337	hsa-miR-1303	80628894	80628900	7mer-m8	80628893	80628912	145	-13.86
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3654	80628326	80628332	7mer-m8	80628325	80628343	142	-16.07
CAediting_442554	chr5_154685830_+	ENSG00000228716.5	ENST00000511032	hsa-miR-1303	80628894	80628900	7mer-m8	80628893	80628912	145	-13.86
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000511032	hsa-miR-3654	80628326	80628332	7mer-m8	80628325	80628343	142	-16.07
CAediting_442554	chr5_154685830_+	ENSG00000228716.5	ENST00000504396	hsa-miR-1303	80628894	80628900	7mer-m8	80628893	80628912	145	-13.86
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000504396	hsa-miR-3654	80628326	80628332	7mer-m8	80628325	80628343	142	-16.07

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000505337	hsa-miR-3654	80628628	80628634	7mer-m8	80628627	80628645	140	-16.37
CAediting_1524209	chrX_134546392_-	ENSG00000228716.5	ENST00000505337	hsa-miR-503-5p	80628322	80628327	6mer	80628321	80628344	144	-25.58
CAediting_980496	chr14_31014685_-	ENSG00000228716.5	ENST00000505337	hsa-miR-624-3p	80628668	80628674	7mer-m8	80628667	80628687	153	-11.98
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000511032	hsa-miR-3654	80628628	80628634	7mer-m8	80628627	80628645	140	-16.37
CAediting_1524209	chrX_134546392_-	ENSG00000228716.5	ENST00000511032	hsa-miR-503-5p	80628322	80628327	6mer	80628321	80628344	144	-25.58
CAediting_980496	chr14_31014685_-	ENSG00000228716.5	ENST00000511032	hsa-miR-624-3p	80628668	80628674	7mer-m8	80628667	80628687	153	-11.98
CAediting_604450	chr7_133034877_-	ENSG00000228716.5	ENST00000504396	hsa-miR-3654	80628628	80628634	7mer-m8	80628627	80628645	140	-16.37
CAediting_1524209	chrX_134546392_-	ENSG00000228716.5	ENST00000504396	hsa-miR-503-5p	80628322	80628327	6mer	80628321	80628344	144	-25.58
CAediting_980496	chr14_31014685_-	ENSG00000228716.5	ENST00000504396	hsa-miR-624-3p	80628668	80628674	7mer-m8	80628667	80628687	153	-11.98

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for DHFR

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000439211.5	protein_coding
ENST00000505337.4	protein_coding
ENST00000511032.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_418558	ENST00000439211.5	chr5_80626973_-	-1294.00	-1293.50	-1360.10
CAediting_418559	ENST00000439211.5	chr5_80627361_-	-1293.50	-1293.50	-1360.10
CAediting_418560	ENST00000439211.5	chr5_80627362_-	-1293.50	-1293.50	-1360.10
CAediting_418561	ENST00000439211.5	chr5_80627363_-	-1293.50	-1293.50	-1360.10
CAediting_418562	ENST00000439211.5	chr5_80627381_-	-1292.80	-1293.50	-1360.10
CAediting_418563	ENST00000439211.5	chr5_80627393_-	-1293.50	-1293.50	-1360.10
CAediting_418564	ENST00000439211.5	chr5_80627403_-	-1293.60	-1293.50	-1360.10
CAediting_418565	ENST00000439211.5	chr5_80627418_-	-1293.50	-1293.50	-1360.10
CAediting_418566	ENST00000439211.5	chr5_80627422_-	-1292.70	-1293.50	-1360.10
CAediting_418567	ENST00000439211.5	chr5_80627429_-	-1293.10	-1293.50	-1360.10
CAediting_418568	ENST00000439211.5	chr5_80627448_-	-1294.80	-1293.50	-1360.10
CAediting_418569	ENST00000439211.5	chr5_80627451_-	-1293.50	-1293.50	-1360.10
CAediting_418570	ENST00000439211.5	chr5_80627454_-	-1294.50	-1293.50	-1360.10
CAediting_418571	ENST00000439211.5	chr5_80627461_-	-1293.20	-1293.50	-1360.10
CAediting_418572	ENST00000439211.5	chr5_80627466_-	-1297.80	-1293.50	-1360.10
CAediting_418573	ENST00000439211.5	chr5_80627467_-	-1296.90	-1293.50	-1360.10
CAediting_418574	ENST00000439211.5	chr5_80627474_-	-1293.50	-1293.50	-1360.10
CAediting_418575	ENST00000439211.5	chr5_80627478_-	-1293.10	-1293.50	-1360.10
CAediting_418576	ENST00000439211.5	chr5_80627484_-	-1294.20	-1293.50	-1360.10
CAediting_418577	ENST00000439211.5	chr5_80627490_-	-1293.10	-1293.50	-1360.10
CAediting_418578	ENST00000439211.5	chr5_80627492_-	-1298.90	-1293.50	-1360.10
CAediting_418579	ENST00000439211.5	chr5_80627502_-	-1298.90	-1293.50	-1360.10
CAediting_418580	ENST00000439211.5	chr5_80627513_-	-1293.50	-1293.50	-1360.10
CAediting_418581	ENST00000439211.5	chr5_80627515_-	-1293.60	-1293.50	-1360.10
CAediting_418582	ENST00000439211.5	chr5_80627516_-	-1293.60	-1293.50	-1360.10
CAediting_418583	ENST00000439211.5	chr5_80627517_-	-1293.20	-1293.50	-1360.10
CAediting_418584	ENST00000439211.5	chr5_80627519_-	-1293.80	-1293.50	-1360.10
CAediting_418585	ENST00000439211.5	chr5_80627522_-	-1293.60	-1293.50	-1360.10
CAediting_418586	ENST00000439211.5	chr5_80627523_-	-1293.60	-1293.50	-1360.10
CAediting_418587	ENST00000439211.5	chr5_80627525_-	-1293.60	-1293.50	-1360.10
CAediting_418588	ENST00000439211.5	chr5_80627528_-	-1293.50	-1293.50	-1360.10
CAediting_418589	ENST00000439211.5	chr5_80627534_-	-1293.10	-1293.50	-1360.10
CAediting_418590	ENST00000439211.5	chr5_80627540_-	-1293.10	-1293.50	-1360.10
CAediting_418591	ENST00000439211.5	chr5_80627562_-	-1292.90	-1293.50	-1360.10
CAediting_418592	ENST00000439211.5	chr5_80627569_-	-1298.60	-1293.50	-1360.10
CAediting_418593	ENST00000439211.5	chr5_80627574_-	-1298.10	-1293.50	-1360.10
CAediting_418594	ENST00000439211.5	chr5_80627578_-	-1298.20	-1293.50	-1360.10
CAediting_418595	ENST00000439211.5	chr5_80627582_-	-1294.70	-1293.50	-1360.10
CAediting_418596	ENST00000439211.5	chr5_80627583_-	-1299.90	-1293.50	-1360.10
CAediting_418597	ENST00000439211.5	chr5_80627588_-	-1292.60	-1293.50	-1360.10
CAediting_418598	ENST00000439211.5	chr5_80627599_-	-1292.80	-1293.50	-1360.10
CAediting_418599	ENST00000439211.5	chr5_80627613_-	-1292.30	-1293.50	-1360.10
CAediting_418600	ENST00000439211.5	chr5_80627621_-	-1297.10	-1293.50	-1360.10
CAediting_418601	ENST00000439211.5	chr5_80627623_-	-1295.20	-1293.50	-1360.10
CAediting_418602	ENST00000439211.5	chr5_80627631_-	-1294.30	-1293.50	-1360.10
CAediting_418603	ENST00000439211.5	chr5_80627929_-	-1297.20	-1293.50	-1360.10
CAediting_418604	ENST00000439211.5	chr5_80627931_-	-1294.30	-1293.50	-1360.10
CAediting_418605	ENST00000439211.5	chr5_80627950_-	-1292.90	-1293.50	-1360.10
CAediting_418606	ENST00000439211.5	chr5_80627974_-	-1297.40	-1293.50	-1360.10
CAediting_418607	ENST00000439211.5	chr5_80627982_-	-1296.10	-1293.50	-1360.10
CAediting_418608	ENST00000439211.5	chr5_80627992_-	-1294.00	-1293.50	-1360.10
CAediting_418609	ENST00000439211.5	chr5_80627999_-	-1296.60	-1293.50	-1360.10
CAediting_418610	ENST00000439211.5	chr5_80628012_-	-1292.70	-1293.50	-1360.10
CAediting_418611	ENST00000439211.5	chr5_80628021_-	-1293.10	-1293.50	-1360.10
CAediting_418612	ENST00000439211.5	chr5_80628034_-	-1292.90	-1293.50	-1360.10
CAediting_418613	ENST00000439211.5	chr5_80628036_-	-1292.60	-1293.50	-1360.10
CAediting_418614	ENST00000439211.5	chr5_80628041_-	-1293.50	-1293.50	-1360.10
CAediting_418615	ENST00000439211.5	chr5_80628054_-	-1298.50	-1293.50	-1360.10
CAediting_418616	ENST00000439211.5	chr5_80628062_-	-1293.50	-1293.50	-1360.10
CAediting_418617	ENST00000439211.5	chr5_80628063_-	-1293.60	-1293.50	-1360.10
CAediting_418618	ENST00000439211.5	chr5_80628073_-	-1293.80	-1293.50	-1360.10
CAediting_418619	ENST00000439211.5	chr5_80628076_-	-1293.10	-1293.50	-1360.10
CAediting_418620	ENST00000439211.5	chr5_80628090_-	-1292.90	-1293.50	-1360.10
CAediting_418621	ENST00000439211.5	chr5_80628097_-	-1293.80	-1293.50	-1360.10
CAediting_418622	ENST00000439211.5	chr5_80628100_-	-1293.10	-1293.50	-1360.10
CAediting_418623	ENST00000439211.5	chr5_80628101_-	-1296.90	-1293.50	-1360.10
CAediting_418624	ENST00000439211.5	chr5_80628122_-	-1295.50	-1293.50	-1360.10
CAediting_418625	ENST00000439211.5	chr5_80628126_-	-1295.90	-1293.50	-1360.10
CAediting_418626	ENST00000439211.5	chr5_80628127_-	-1293.20	-1293.50	-1360.10
CAediting_418627	ENST00000439211.5	chr5_80628133_-	-1296.70	-1293.50	-1360.10
CAediting_418628	ENST00000439211.5	chr5_80628147_-	-1299.80	-1293.50	-1360.10
CAediting_418629	ENST00000439211.5	chr5_80628153_-	-1295.70	-1293.50	-1360.10
CAediting_418630	ENST00000439211.5	chr5_80628172_-	-1295.50	-1293.50	-1360.10
CAediting_418631	ENST00000439211.5	chr5_80628176_-	-1297.00	-1293.50	-1360.10
CAediting_418632	ENST00000439211.5	chr5_80628205_-	-1294.80	-1293.50	-1360.10
CAediting_418611	ENST00000505337.4	chr5_80628021_-	-542.90	-542.40	-568.00
CAediting_418612	ENST00000505337.4	chr5_80628034_-	-543.40	-542.40	-568.00
CAediting_418613	ENST00000505337.4	chr5_80628036_-	-543.40	-542.40	-568.00
CAediting_418614	ENST00000505337.4	chr5_80628041_-	-544.40	-542.40	-568.00
CAediting_418615	ENST00000505337.4	chr5_80628054_-	-543.20	-542.40	-568.00
CAediting_418616	ENST00000505337.4	chr5_80628062_-	-542.40	-542.40	-568.00
CAediting_418617	ENST00000505337.4	chr5_80628063_-	-543.10	-542.40	-568.00
CAediting_418618	ENST00000505337.4	chr5_80628073_-	-546.40	-542.40	-568.00
CAediting_418619	ENST00000505337.4	chr5_80628076_-	-545.70	-542.40	-568.00
CAediting_418620	ENST00000505337.4	chr5_80628090_-	-545.20	-542.40	-568.00
CAediting_418621	ENST00000505337.4	chr5_80628097_-	-544.30	-542.40	-568.00
CAediting_418622	ENST00000505337.4	chr5_80628100_-	-542.40	-542.40	-568.00
CAediting_418623	ENST00000505337.4	chr5_80628101_-	-543.70	-542.40	-568.00
CAediting_418624	ENST00000505337.4	chr5_80628122_-	-542.60	-542.40	-568.00
CAediting_418625	ENST00000505337.4	chr5_80628126_-	-544.70	-542.40	-568.00
CAediting_418626	ENST00000505337.4	chr5_80628127_-	-542.40	-542.40	-568.00
CAediting_418627	ENST00000505337.4	chr5_80628133_-	-541.70	-542.40	-568.00
CAediting_418628	ENST00000505337.4	chr5_80628147_-	-545.40	-542.40	-568.00
CAediting_418629	ENST00000505337.4	chr5_80628153_-	-545.50	-542.40	-568.00
CAediting_418630	ENST00000505337.4	chr5_80628172_-	-543.40	-542.40	-568.00
CAediting_418631	ENST00000505337.4	chr5_80628176_-	-542.10	-542.40	-568.00
CAediting_418632	ENST00000505337.4	chr5_80628205_-	-543.40	-542.40	-568.00
CAediting_418625	ENST00000511032.4	chr5_80628126_-	-409.90	-409.90	-419.40
CAediting_418626	ENST00000511032.4	chr5_80628127_-	-410.50	-409.90	-419.40
CAediting_418627	ENST00000511032.4	chr5_80628133_-	-411.10	-409.90	-419.40
CAediting_418628	ENST00000511032.4	chr5_80628147_-	-412.00	-409.90	-419.40
CAediting_418629	ENST00000511032.4	chr5_80628153_-	-412.90	-409.90	-419.40
CAediting_418630	ENST00000511032.4	chr5_80628172_-	-410.00	-409.90	-419.40
CAediting_418631	ENST00000511032.4	chr5_80628176_-	-411.40	-409.90	-419.40
CAediting_418632	ENST00000511032.4	chr5_80628205_-	-411.20	-409.90	-419.40

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Relation with ADAR for DHFR

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_418572	chr5_80627466_-	0.000253405463995252	0.372710765974054	.	.	.	.
BRCA	CAediting_418572	chr5_80627466_-	.	.	.	.	0.026623302582584	0.168084013650891
LGG	CAediting_418574	chr5_80627474_-	3.69138987225771e-09	0.302464728970019	.	.	.	.
BRCA	CAediting_418574	chr5_80627474_-	6.18995975499761e-36	0.466073765215129	.	.	.	.
LIHC	CAediting_418574	chr5_80627474_-	2.11573431713656e-06	0.328830564385821	.	.	.	.
CESC	CAediting_418574	chr5_80627474_-	2.39012944117765e-05	0.44592867046672	.	.	.	.
LUAD	CAediting_418574	chr5_80627474_-	3.63483609479872e-09	0.399218009081361	.	.	.	.
LUSC	CAediting_418574	chr5_80627474_-	1.93308866020692e-08	0.437552670120956	.	.	.	.
GBM	CAediting_418574	chr5_80627474_-	1.34390143058454e-05	0.563855915005932	.	.	.	.
HNSC	CAediting_418574	chr5_80627474_-	0.0449922270356615	0.226222101642964	.	.	.	.
THCA	CAediting_418574	chr5_80627474_-	0.0268232705595271	0.146322872120968	.	.	.	.
KIRC	CAediting_418574	chr5_80627474_-	0.00038052764389451	0.230869045863154	.	.	.	.
OV	CAediting_418574	chr5_80627474_-	0.000311060814138416	0.270208118140657	.	.	0.0193079995376973	0.177230380091729
PAAD	CAediting_418574	chr5_80627474_-	0.00980494895173833	0.358423629288604	.	.	.	.
PCPG	CAediting_418574	chr5_80627474_-	0.00723837992179436	0.263157449213936	.	.	.	.
SKCM	CAediting_418574	chr5_80627474_-	0.00141692299654083	0.31961543135542	.	.	.	.
SARC	CAediting_418574	chr5_80627474_-	0.00237778956868063	0.333088596870614	.	.	.	.
TGCT	CAediting_418574	chr5_80627474_-	0.000176835196653284	0.445665827616967	.	.	.	.
BLCA	CAediting_418578	chr5_80627492_-	.	.	1.06184094532505e-07	0.453858547337752	.	.
LGG	CAediting_418578	chr5_80627492_-	.	.	3.15227270597822e-41	0.569898544657716	4.73749459572607e-05	0.1878874025331
BRCA	CAediting_418578	chr5_80627492_-	.	.	5.31757963276775e-19	0.328501491557151	.	.
LIHC	CAediting_418578	chr5_80627492_-	.	.	1.01431541639665e-06	0.42736637474711	.	.
LUAD	CAediting_418578	chr5_80627492_-	.	.	0.00389459645573907	0.22093339168662	0.0170485659509321	0.183314858003775
COAD	CAediting_418578	chr5_80627492_-	.	.	.	.	1.71092011827771e-09	0.60226112633033
LUSC	CAediting_418578	chr5_80627492_-	.	.	1.07596320939929e-06	0.392085940536667	.	.
GBM	CAediting_418578	chr5_80627492_-	.	.	4.24043825286853e-06	0.393829289345807	.	.
PRAD	CAediting_418578	chr5_80627492_-	.	.	1.32895722744256e-24	0.49875674587862	.	.
HNSC	CAediting_418578	chr5_80627492_-	.	.	0.000101890089563606	0.335444491007631	.	.
STAD	CAediting_418578	chr5_80627492_-	.	.	1.17816391782396e-09	0.45003878369863	.	.
THCA	CAediting_418578	chr5_80627492_-	.	.	5.76777010429323e-07	0.273458745097523	.	.
KIRC	CAediting_418578	chr5_80627492_-	.	.	3.07992151308861e-10	0.309499084409031	.	.
UCEC	CAediting_418578	chr5_80627492_-	.	.	3.54849937904791e-18	0.664809302883848	0.0020068701188189	0.266535198851947
KIRP	CAediting_418578	chr5_80627492_-	.	.	2.304726383287e-21	0.713611864984628	.	.
ESCA	CAediting_418578	chr5_80627492_-	.	.	7.94826238881495e-10	0.654554686725596	0.0162216263921353	0.286429285240405
OV	CAediting_418578	chr5_80627492_-	.	.	1.84408618869915e-05	0.264207203031259	.	.
PAAD	CAediting_418578	chr5_80627492_-	.	.	6.26741774591351e-05	0.453693009247839	.	.
PCPG	CAediting_418578	chr5_80627492_-	.	.	1.38268456833182e-12	0.591673093466416	.	.
SKCM	CAediting_418578	chr5_80627492_-	.	.	4.72196395089981e-45	0.677029603840925	0.0385116669087027	0.114673771686928
MESO	CAediting_418578	chr5_80627492_-	.	.	1.77054524290605e-09	0.687759217911686	.	.
SARC	CAediting_418578	chr5_80627492_-	.	.	3.7373744630252e-20	0.631001836040219	.	.
LGG	CAediting_418580	chr5_80627513_-	.	.	2.79883394788789e-05	0.488028052442611	0.0137108631141739	0.29979781299712
SKCM	CAediting_418580	chr5_80627513_-	.	.	.	.	0.0147298172288542	0.33971921303355
STAD	CAediting_418581	chr5_80627515_-	.	.	0.000125129300230386	0.32077524215909	.	.
PCPG	CAediting_418581	chr5_80627515_-	.	.	0.0336030366654423	0.259996567033656	.	.
SKCM	CAediting_418581	chr5_80627515_-	.	.	.	.	0.0323879282416357	0.204180062004983
BRCA	CAediting_418606	chr5_80627974_-	3.03030355797567e-06	0.284365410626086	.	.	.	.
LIHC	CAediting_418606	chr5_80627974_-	4.80715378551355e-06	0.480901406343285	.	.	.	.
STAD	CAediting_418606	chr5_80627974_-	.	.	.	.	0.000389258881194833	0.394195479916884
OV	CAediting_418606	chr5_80627974_-	0.000764642336059759	0.286215417960053	.	.	.	.
SKCM	CAediting_418606	chr5_80627974_-	0.00353987253959118	0.380106910952671	.	.	.	.
BRCA	CAediting_418613	chr5_80628036_-	.	.	0.0127427110616709	0.346503228782743	0.00446657854835287	0.391786364105017
LGG	CAediting_418622	chr5_80628100_-	0.00267681979160326	0.204281254974633	.	.	.	.
BRCA	CAediting_418622	chr5_80628100_-	6.61026121626483e-11	0.316270680719793	.	.	.	.
LIHC	CAediting_418622	chr5_80628100_-	0.0024654741005319	0.267449674345642	.	.	.	.
LUAD	CAediting_418622	chr5_80628100_-	0.000474972454732392	0.341452906891225	.	.	.	.
LUSC	CAediting_418622	chr5_80628100_-	0.0434682490460988	0.191175934598127	0.008590801106067	0.247221783914068	.	.
SKCM	CAediting_418622	chr5_80628100_-	0.0385541752915575	0.183836353814786	.	.	.	.
SARC	CAediting_418622	chr5_80628100_-	4.93760702448743e-06	0.529109489782755	.	.	.	.
TGCT	CAediting_418622	chr5_80628100_-	4.99171528159684e-05	0.540963731779522	.	.	.	.
LGG	CAediting_418623	chr5_80628101_-	.	.	0.0487903091618091	0.200627504146378	.	.
BRCA	CAediting_418623	chr5_80628101_-	0.00218345635461567	0.24357541138942	.	.	.	.
LIHC	CAediting_418623	chr5_80628101_-	0.028195167277797	0.307436750354181	.	.	.	.

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Relation with cancer stages for DHFR

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_418581	chr5_80627515_-	0.000785938378473758	0.153712619093719
BRCA	pathologic_stage	CAediting_418613	chr5_80628036_-	0.0411628697872279	0.289865694248374
CESC	clinical_stage	CAediting_418581	chr5_80627515_-	0.01398909418935	-0.329627263245733
ESCA	pathologic_stage	CAediting_418581	chr5_80627515_-	0.0161680648965184	-0.299601083841709
HNSC	clinical_stage	CAediting_418574	chr5_80627474_-	0.0215892117257164	0.261529355029474
KIRP	pathologic_stage	CAediting_418578	chr5_80627492_-	0.0158982973279012	-0.222506289166009
LUAD	pathologic_stage	CAediting_418574	chr5_80627474_-	0.00946216011003025	-0.183537718771663
OV	clinical_stage	CAediting_418578	chr5_80627492_-	0.0268779814228815	0.138885197646449
PAAD	pathologic_stage	CAediting_418574	chr5_80627474_-	0.0101413356061088	0.356913514969295
THCA	pathologic_stage	CAediting_418574	chr5_80627474_-	0.0473320914447465	0.132082093109679
THCA	pathologic_stage	CAediting_418622	chr5_80628100_-	0.0189149591356464	0.288266087941318

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Relation with survival for DHFR

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
SKCM	CAediting_418578	chr5_80627492_-	0.0467769633027464	0.00991756	0.138573

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RelatedDrugs for DHFR

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DHFR	P00374	DB00563	Methotrexate	Dihydrofolate reductase	SmallMoleculeDrug	approved
DHFR	P00374	DB01131	Proguanil	Dihydrofolate reductase	SmallMoleculeDrug	approved
DHFR	P00374	DB00642	Pemetrexed	Dihydrofolate reductase	SmallMoleculeDrug	approved\|investigational
DHFR	P00374	DB01157	Trimetrexate	Dihydrofolate reductase	SmallMoleculeDrug	approved\|investigational
DHFR	P00374	DB06813	Pralatrexate	Dihydrofolate reductase	SmallMoleculeDrug	approved\|investigational
DHFR	P00374	DB00205	Pyrimethamine	Dihydrofolate reductase	SmallMoleculeDrug	approved\|investigational\|vet_approved
DHFR	P00374	DB00157	NADH	Dihydrofolate reductase	SmallMoleculeDrug	approved\|nutraceutical
DHFR	P00374	DB00798	Gentamicin	Dihydrofolate reductase	SmallMoleculeDrug	approved\|vet_approved

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RelatedDiseases for DHFR

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
DHFR	C3151205	Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
DHFR	C0002888	Anemia, Megaloblastic	2	CTD_human
DHFR	C0006142	Malignant neoplasm of breast	2	CTD_human
DHFR	C0025521	Inborn Errors of Metabolism	2	CTD_human
DHFR	C0027765	nervous system disorder	2	CTD_human
DHFR	C0268608	Deficiency of dihydrofolate reductase	2	GENOMICS_ENGLAND
DHFR	C0678222	Breast Carcinoma	2	CTD_human
DHFR	C1257931	Mammary Neoplasms, Human	2	CTD_human
DHFR	C1458155	Mammary Neoplasms	2	CTD_human
DHFR	C4704874	Mammary Carcinoma, Human	2	CTD_human
DHFR	C0000786	Spontaneous abortion	1	CTD_human
DHFR	C0000822	Abortion, Tubal	1	CTD_human
DHFR	C0003873	Rheumatoid Arthritis	1	CTD_human
DHFR	C0004352	Autistic Disorder	1	CTD_human
DHFR	C0009402	Colorectal Carcinoma	1	CTD_human
DHFR	C0009404	Colorectal Neoplasms	1	CTD_human
DHFR	C0013221	Drug toxicity	1	CTD_human
DHFR	C0016412	Folic Acid Deficiency	1	CTD_human
DHFR	C0019193	Hepatitis, Toxic	1	CTD_human
DHFR	C0021361	Female infertility	1	CTD_human
DHFR	C0027627	Neoplasm Metastasis	1	CTD_human
DHFR	C0029463	Osteosarcoma	1	CTD_human
DHFR	C0030312	Pancytopenia	1	CTD_human
DHFR	C0038279	Sterility, Postpartum	1	CTD_human
DHFR	C0041755	Adverse reaction to drug	1	CTD_human
DHFR	C0341869	Subfertility, Female	1	CTD_human
DHFR	C0860207	Drug-Induced Liver Disease	1	CTD_human
DHFR	C0917730	Female sterility	1	CTD_human
DHFR	C1262760	Hepatitis, Drug-Induced	1	CTD_human
DHFR	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
DHFR	C3830362	Early Pregnancy Loss	1	CTD_human
DHFR	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
DHFR	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
DHFR	C4552766	Miscarriage	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene