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Editing gene: CLVS1 (CAeditome ID:157807)

Gene summary for CLVS1

Gene summary

Gene information	Gene symbol	CLVS1
	Gene ID	157807
	Gene name	clavesin 1
	Synonyms	C6orf212L\|CRALBPL\|RLBP1L1
	Cytomap	8q12.2-q12.3
	Type of gene	protein-coding
	Description	clavesin-1clathrin vesicle-associated Sec14 protein 1retinaldehyde-binding protein 1-like 1
	Modification date	20210518
	UniProtAcc	Q8IUQ0
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CLVS1	GO:0080025	Clavesin-1	19651769
CLVS1	GO:0005768	Clavesin-1	19651769

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RNA A-to-I events for CLVS1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000177182.9

RNA A-to-I editing events in Cancer.

CAediting_641910(61149432, +), CAediting_641911(61156027, +), CAediting_641912(61156028, +), CAediting_641913(61156067, +), CAediting_641914(61156094, +), CAediting_641915(61156099, +), CAediting_641916(61156103, +), CAediting_641917(61156107, +), CAediting_641918(61156120, +), CAediting_641919(61156123, +), CAediting_641920(61156134, +), CAediting_641921(61156135, +), CAediting_641922(61156158, +), CAediting_641923(61156165, +), CAediting_641924(61203028, +), CAediting_641925(61463865, +), CAediting_641926(61463966, +),

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RNA editing positional annotations for CLVS1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_641910	chr8_61149432_+	intronic
CAediting_641911	chr8_61156027_+	intronic
CAediting_641912	chr8_61156028_+	intronic
CAediting_641913	chr8_61156067_+	intronic
CAediting_641914	chr8_61156094_+	intronic
CAediting_641915	chr8_61156099_+	intronic
CAediting_641916	chr8_61156103_+	intronic
CAediting_641917	chr8_61156107_+	intronic
CAediting_641918	chr8_61156120_+	intronic
CAediting_641919	chr8_61156123_+	intronic
CAediting_641920	chr8_61156134_+	intronic
CAediting_641921	chr8_61156135_+	intronic
CAediting_641922	chr8_61156158_+	intronic
CAediting_641923	chr8_61156165_+	intronic
CAediting_641924	chr8_61203028_+	ncRNA_exonic
CAediting_641925	chr8_61463865_+	intronic
CAediting_641926	chr8_61463966_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_641910	chr8_61149432_+	SINE	Alu	AluSx
CAediting_641911	chr8_61156027_+	SINE	Alu	AluSx1
CAediting_641912	chr8_61156028_+	SINE	Alu	AluSx1
CAediting_641913	chr8_61156067_+	SINE	Alu	AluSx1
CAediting_641914	chr8_61156094_+	SINE	Alu	AluSx1
CAediting_641915	chr8_61156099_+	SINE	Alu	AluSx1
CAediting_641916	chr8_61156103_+	SINE	Alu	AluSx1
CAediting_641917	chr8_61156107_+	SINE	Alu	AluSx1
CAediting_641918	chr8_61156120_+	SINE	Alu	AluSx1
CAediting_641919	chr8_61156123_+	SINE	Alu	AluSx1
CAediting_641920	chr8_61156134_+	SINE	Alu	AluSx1
CAediting_641921	chr8_61156135_+	SINE	Alu	AluSx1
CAediting_641922	chr8_61156158_+	SINE	Alu	AluSx1
CAediting_641923	chr8_61156165_+	SINE	Alu	AluSx1
CAediting_641925	chr8_61463865_+	SINE	Alu	AluSx1
CAediting_641926	chr8_61463966_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for CLVS1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000177182.9.CLVS1.

Correlation between RNA A-to-I editing and PSI for ENSG00000177182.9.CLVS1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLVS1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CLVS1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CLVS1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000177182.9	ENST00000519846	hsa-miR-195-3p	61501563	61501570	8mer-1a	61501550	61501570	148	-9.36
CAediting_1351755	chr19_40282625_-	ENSG00000177182.9	ENST00000519846	hsa-miR-641	61500308	61500315	8mer-1a	61500292	61500315	140	-15.12
CAediting_117844	chr1_162342605_+	ENSG00000177182.9	ENST00000519846	hsa-miR-556-3p	61501354	61501360	7mer-m8	61501340	61501361	152	-12.14
CAediting_1160181	chr17_7017644_-	ENSG00000177182.9	ENST00000518592	hsa-miR-195-3p	61501563	61501570	8mer-1a	61501550	61501570	148	-9.36
CAediting_1351755	chr19_40282625_-	ENSG00000177182.9	ENST00000518592	hsa-miR-641	61500308	61500315	8mer-1a	61500292	61500315	140	-15.12
CAediting_117844	chr1_162342605_+	ENSG00000177182.9	ENST00000518592	hsa-miR-556-3p	61501354	61501360	7mer-m8	61501340	61501361	152	-12.14

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CLVS1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CLVS1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CLVS1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CLVS1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CLVS1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CLVS1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene