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Editing gene: PPM1L (CAeditome ID:151742)

Gene summary for PPM1L

Gene summary

Gene information	Gene symbol	PPM1L
	Gene ID	151742
	Gene name	protein phosphatase, Mg2+/Mn2+ dependent 1L
	Synonyms	PP2C-epsilon\|PP2CE\|PPM1-LIKE
	Cytomap	3q25.33-q26.1
	Type of gene	protein-coding
	Description	protein phosphatase 1LPP2C epsilon
	Modification date	20210518
	UniProtAcc	Q5SGD2
	Context	- 19847890(Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for PPM1L

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000163590.12

RNA A-to-I editing events in Cancer.

CAediting_319672(160761701, +), CAediting_319673(160761706, +), CAediting_319674(160761708, +), CAediting_319675(160761713, +), CAediting_319676(160766353, +), CAediting_319677(160766608, +), CAediting_319678(160766609, +), CAediting_319679(160776635, +), CAediting_319680(160776704, +), CAediting_319681(160777158, +), CAediting_319682(160777241, +), CAediting_319683(160783453, +), CAediting_319684(160783480, +), CAediting_319685(160783493, +), CAediting_319686(160783520, +), CAediting_319687(160783521, +), CAediting_319688(160805520, +), CAediting_319689(160805591, +), CAediting_319690(160805602, +), CAediting_319691(160805642, +), CAediting_319692(160805643, +), CAediting_319693(160805647, +), CAediting_319694(160805704, +), CAediting_319695(160822742, +), CAediting_319696(160822822, +), CAediting_319697(160822834, +), CAediting_319698(160822872, +), CAediting_319699(160834870, +), CAediting_319700(160848298, +), CAediting_319701(160848307, +), CAediting_319702(160848326, +), CAediting_319703(160848327, +), CAediting_319704(160848328, +), CAediting_319705(160850278, +), CAediting_319706(160850311, +), CAediting_319707(160850340, +), CAediting_319708(160850343, +), CAediting_319709(160873677, +), CAediting_319710(160873693, +), CAediting_319711(160965130, +), CAediting_319712(160980413, +), CAediting_319713(160980467, +), CAediting_319714(160980537, +), CAediting_319715(160980588, +), CAediting_319716(160980633, +), CAediting_319717(161019333, +), CAediting_319718(161038445, +), CAediting_319719(161038451, +), CAediting_319720(161038454, +), CAediting_319721(161038526, +), CAediting_319722(161073082, +), CAediting_319723(161073083, +), CAediting_319724(161073588, +), CAediting_319725(161073613, +), CAediting_319726(161073636, +), CAediting_319727(161073655, +), CAediting_319728(161073661, +), CAediting_319729(161073663, +), CAediting_319730(161073666, +), CAediting_319731(161073691, +), CAediting_319732(161073701, +), CAediting_319733(161073703, +), CAediting_319734(161073737, +), CAediting_319735(161073743, +), CAediting_319736(161073750, +), CAediting_319737(161073760, +), CAediting_319738(161073768, +), CAediting_319739(161073786, +), CAediting_319740(161073800, +), CAediting_319741(161073804, +), CAediting_319742(161073823, +), CAediting_319743(161073835, +),

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RNA editing positional annotations for PPM1L using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_319672	chr3_160761701_+	intronic
CAediting_319673	chr3_160761706_+	intronic
CAediting_319674	chr3_160761708_+	intronic
CAediting_319675	chr3_160761713_+	intronic
CAediting_319676	chr3_160766353_+	intronic
CAediting_319677	chr3_160766608_+	intronic
CAediting_319678	chr3_160766609_+	intronic
CAediting_319679	chr3_160776635_+	intronic
CAediting_319680	chr3_160776704_+	intronic
CAediting_319681	chr3_160777158_+	intronic
CAediting_319682	chr3_160777241_+	intronic
CAediting_319683	chr3_160783453_+	intronic
CAediting_319684	chr3_160783480_+	intronic
CAediting_319685	chr3_160783493_+	intronic
CAediting_319686	chr3_160783520_+	intronic
CAediting_319687	chr3_160783521_+	intronic
CAediting_319688	chr3_160805520_+	intronic
CAediting_319689	chr3_160805591_+	intronic
CAediting_319690	chr3_160805602_+	intronic
CAediting_319691	chr3_160805642_+	intronic
CAediting_319692	chr3_160805643_+	intronic
CAediting_319693	chr3_160805647_+	intronic
CAediting_319694	chr3_160805704_+	intronic
CAediting_319695	chr3_160822742_+	intronic
CAediting_319696	chr3_160822822_+	intronic
CAediting_319697	chr3_160822834_+	intronic
CAediting_319698	chr3_160822872_+	intronic
CAediting_319699	chr3_160834870_+	intronic
CAediting_319700	chr3_160848298_+	intronic
CAediting_319701	chr3_160848307_+	intronic
CAediting_319702	chr3_160848326_+	intronic
CAediting_319703	chr3_160848327_+	intronic
CAediting_319704	chr3_160848328_+	intronic
CAediting_319705	chr3_160850278_+	intronic
CAediting_319706	chr3_160850311_+	intronic
CAediting_319707	chr3_160850340_+	intronic
CAediting_319708	chr3_160850343_+	intronic
CAediting_319709	chr3_160873677_+	ncRNA_intronic
CAediting_319710	chr3_160873693_+	ncRNA_intronic
CAediting_319711	chr3_160965130_+	ncRNA_intronic
CAediting_319712	chr3_160980413_+	ncRNA_intronic
CAediting_319713	chr3_160980467_+	ncRNA_intronic
CAediting_319714	chr3_160980537_+	ncRNA_intronic
CAediting_319715	chr3_160980588_+	ncRNA_intronic
CAediting_319716	chr3_160980633_+	ncRNA_intronic
CAediting_319717	chr3_161019333_+	ncRNA_intronic
CAediting_319718	chr3_161038445_+	ncRNA_intronic
CAediting_319719	chr3_161038451_+	ncRNA_intronic
CAediting_319720	chr3_161038454_+	ncRNA_intronic
CAediting_319721	chr3_161038526_+	ncRNA_intronic
CAediting_319722	chr3_161073082_+	UTR3
CAediting_319723	chr3_161073083_+	UTR3
CAediting_319724	chr3_161073588_+	UTR3
CAediting_319725	chr3_161073613_+	UTR3
CAediting_319726	chr3_161073636_+	UTR3
CAediting_319727	chr3_161073655_+	UTR3
CAediting_319728	chr3_161073661_+	UTR3
CAediting_319729	chr3_161073663_+	UTR3
CAediting_319730	chr3_161073666_+	UTR3
CAediting_319731	chr3_161073691_+	UTR3
CAediting_319732	chr3_161073701_+	UTR3
CAediting_319733	chr3_161073703_+	UTR3
CAediting_319734	chr3_161073737_+	UTR3
CAediting_319735	chr3_161073743_+	UTR3
CAediting_319736	chr3_161073750_+	UTR3
CAediting_319737	chr3_161073760_+	UTR3
CAediting_319738	chr3_161073768_+	UTR3
CAediting_319739	chr3_161073786_+	UTR3
CAediting_319740	chr3_161073800_+	UTR3
CAediting_319741	chr3_161073804_+	UTR3
CAediting_319742	chr3_161073823_+	UTR3
CAediting_319743	chr3_161073835_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_319672	chr3_160761701_+	LTR	ERVL-MaLR	THE1B
CAediting_319673	chr3_160761706_+	LTR	ERVL-MaLR	THE1B
CAediting_319674	chr3_160761708_+	LTR	ERVL-MaLR	THE1B
CAediting_319675	chr3_160761713_+	LTR	ERVL-MaLR	THE1B
CAediting_319676	chr3_160766353_+	LTR	ERVL-MaLR	THE1C
CAediting_319677	chr3_160766608_+	LTR	ERVL-MaLR	THE1C
CAediting_319678	chr3_160766609_+	LTR	ERVL-MaLR	THE1C
CAediting_319679	chr3_160776635_+	SINE	Alu	AluSg
CAediting_319680	chr3_160776704_+	SINE	Alu	AluSg
CAediting_319681	chr3_160777158_+	SINE	Alu	AluJr
CAediting_319682	chr3_160777241_+	SINE	Alu	AluJr
CAediting_319683	chr3_160783453_+	SINE	Alu	AluSq2
CAediting_319684	chr3_160783480_+	SINE	Alu	AluSq2
CAediting_319685	chr3_160783493_+	SINE	Alu	AluSq2
CAediting_319686	chr3_160783520_+	SINE	Alu	AluSq2
CAediting_319687	chr3_160783521_+	SINE	Alu	AluSq2
CAediting_319688	chr3_160805520_+	SINE	Alu	AluSx1
CAediting_319689	chr3_160805591_+	SINE	Alu	AluSx1
CAediting_319690	chr3_160805602_+	SINE	Alu	AluSx1
CAediting_319691	chr3_160805642_+	SINE	Alu	AluSx1
CAediting_319692	chr3_160805643_+	SINE	Alu	AluSx1
CAediting_319693	chr3_160805647_+	SINE	Alu	AluSx1
CAediting_319694	chr3_160805704_+	SINE	Alu	AluSx1
CAediting_319696	chr3_160822822_+	LINE	L2	L2a
CAediting_319697	chr3_160822834_+	LINE	L2	L2a
CAediting_319699	chr3_160834870_+	LINE	L1	L1MD2
CAediting_319700	chr3_160848298_+	LINE	L2	L2
CAediting_319701	chr3_160848307_+	LINE	L2	L2
CAediting_319702	chr3_160848326_+	LINE	L2	L2
CAediting_319703	chr3_160848327_+	LINE	L2	L2
CAediting_319704	chr3_160848328_+	LINE	L2	L2
CAediting_319705	chr3_160850278_+	LTR	ERVL	MER21C
CAediting_319706	chr3_160850311_+	LTR	ERVL	MER21C
CAediting_319707	chr3_160850340_+	LTR	ERVL	MER21C
CAediting_319708	chr3_160850343_+	LTR	ERVL	MER21C
CAediting_319709	chr3_160873677_+	SINE	Alu	AluSz
CAediting_319710	chr3_160873693_+	SINE	Alu	AluSz
CAediting_319711	chr3_160965130_+	SINE	Alu	AluY
CAediting_319712	chr3_160980413_+	SINE	Alu	AluJb
CAediting_319713	chr3_160980467_+	SINE	Alu	AluJb
CAediting_319714	chr3_160980537_+	SINE	Alu	AluJb
CAediting_319715	chr3_160980588_+	SINE	Alu	AluJb
CAediting_319716	chr3_160980633_+	SINE	Alu	AluJb
CAediting_319717	chr3_161019333_+	SINE	Alu	AluJr
CAediting_319718	chr3_161038445_+	SINE	Alu	AluJr
CAediting_319719	chr3_161038451_+	SINE	Alu	AluJr
CAediting_319720	chr3_161038454_+	SINE	Alu	AluJr
CAediting_319721	chr3_161038526_+	SINE	Alu	AluJr
CAediting_319722	chr3_161073082_+	DNA	hAT-Charlie	MER103C
CAediting_319723	chr3_161073083_+	DNA	hAT-Charlie	MER103C
CAediting_319724	chr3_161073588_+	SINE	Alu	AluY
CAediting_319725	chr3_161073613_+	SINE	Alu	AluY
CAediting_319726	chr3_161073636_+	SINE	Alu	AluY
CAediting_319727	chr3_161073655_+	SINE	Alu	AluY
CAediting_319728	chr3_161073661_+	SINE	Alu	AluY
CAediting_319729	chr3_161073663_+	SINE	Alu	AluY
CAediting_319730	chr3_161073666_+	SINE	Alu	AluY
CAediting_319731	chr3_161073691_+	SINE	Alu	AluY
CAediting_319732	chr3_161073701_+	SINE	Alu	AluY
CAediting_319733	chr3_161073703_+	SINE	Alu	AluY
CAediting_319734	chr3_161073737_+	SINE	Alu	AluY
CAediting_319735	chr3_161073743_+	SINE	Alu	AluY
CAediting_319736	chr3_161073750_+	SINE	Alu	AluY
CAediting_319737	chr3_161073760_+	SINE	Alu	AluY
CAediting_319738	chr3_161073768_+	SINE	Alu	AluY
CAediting_319739	chr3_161073786_+	SINE	Alu	AluY
CAediting_319740	chr3_161073800_+	SINE	Alu	AluY
CAediting_319741	chr3_161073804_+	SINE	Alu	AluY
CAediting_319742	chr3_161073823_+	SINE	Alu	AluY
CAediting_319743	chr3_161073835_+	SINE	Alu	AluY

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RNA A-to-I editing events in the alternative splicing sites for PPM1L

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000163590.12.PPM1L.

Correlation between RNA A-to-I editing and PSI for ENSG00000163590.12.PPM1L.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PPM1L

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LGG.CAediting_319723.ENSG00000163590.PPM1L.png
Soverview

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Protein coding region RNA A-to-I editings for PPM1L

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PPM1L

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000163590.12	ENST00000464260	hsa-miR-605-3p	161070761	161070767	7mer-m8	161070747	161070768	140	-18.68
CAediting_1306324	chr19_13836464_-	ENSG00000163590.12	ENST00000464260	hsa-miR-27a-3p	161069734	161069740	7mer-m8	161069721	161069741	155	-20.33
CAediting_393	chr1_1167164_+	ENSG00000163590.12	ENST00000464260	hsa-miR-200b-3p	161070961	161070968	8mer-1a	161070947	161070968	143	-11.34
CAediting_1306324	chr19_13836464_-	ENSG00000163590.12	ENST00000295839	hsa-miR-27a-3p	161069734	161069740	7mer-m8	161069721	161069741	155	-20.33
CAediting_1229413	chr17_67471544_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161069354	161069360	7mer-m8	161069330	161069361	148	-13.66
CAediting_1229414	chr17_67471546_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161069285	161069292	8mer-1a	161069268	161069292	147	-12.5
CAediting_86358	chr1_109598906_+	ENSG00000163590.12	ENST00000464260	hsa-miR-197-5p	161069253	161069259	7mer-m8	161069237	161069260	141	-14.84
CAediting_442554	chr5_154685830_+	ENSG00000163590.12	ENST00000464260	hsa-miR-1303	161070874	161070880	7mer-m8	161070855	161070881	141	-17.13
CAediting_1229413	chr17_67471544_+	ENSG00000163590.12	ENST00000295839	hsa-miR-548aa	161069354	161069360	7mer-m8	161069330	161069361	148	-13.66
CAediting_1229414	chr17_67471546_+	ENSG00000163590.12	ENST00000295839	hsa-miR-548aa	161069285	161069292	8mer-1a	161069268	161069292	147	-12.5
CAediting_86358	chr1_109598906_+	ENSG00000163590.12	ENST00000295839	hsa-miR-197-5p	161069253	161069259	7mer-m8	161069237	161069260	141	-14.84
CAediting_468389	chr6_31355314_-	ENSG00000163590.12	ENST00000464260	hsa-miR-6891-5p	161070742	161070748	7mer-m8	161070731	161070749	150	-22.79

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161070180	161070186	7mer-m8	161070163	161070187	145	-9.85
CAediting_1229414	chr17_67471546_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161070180	161070186	7mer-m8	161070163	161070187	145	-9.85
CAediting_1229413	chr17_67471544_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161070677	161070683	7mer-m8	161070660	161070684	140	-7.55
CAediting_1229414	chr17_67471546_+	ENSG00000163590.12	ENST00000464260	hsa-miR-548aa	161070677	161070683	7mer-m8	161070660	161070684	140	-7.55
CAediting_524911	chr7_5495852_-	ENSG00000163590.12	ENST00000464260	hsa-miR-589-3p	161070201	161070208	8mer-1a	161070186	161070208	150	-18.79

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PPM1L

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000498165.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_319722	ENST00000498165.4	chr3_161073082_+	-3022.70	-3022.60	-3045.10
CAediting_319723	ENST00000498165.4	chr3_161073083_+	-3022.30	-3022.60	-3045.10
CAediting_319724	ENST00000498165.4	chr3_161073588_+	-3022.60	-3022.60	-3045.10
CAediting_319725	ENST00000498165.4	chr3_161073613_+	-3027.30	-3022.60	-3045.10
CAediting_319726	ENST00000498165.4	chr3_161073636_+	-3022.60	-3022.60	-3045.10
CAediting_319727	ENST00000498165.4	chr3_161073655_+	-3024.00	-3022.60	-3045.10
CAediting_319728	ENST00000498165.4	chr3_161073661_+	-3022.60	-3022.60	-3045.10
CAediting_319729	ENST00000498165.4	chr3_161073663_+	-3022.60	-3022.60	-3045.10
CAediting_319730	ENST00000498165.4	chr3_161073666_+	-3023.90	-3022.60	-3045.10
CAediting_319731	ENST00000498165.4	chr3_161073691_+	-3025.00	-3022.60	-3045.10
CAediting_319732	ENST00000498165.4	chr3_161073701_+	-3026.70	-3022.60	-3045.10
CAediting_319733	ENST00000498165.4	chr3_161073703_+	-3022.60	-3022.60	-3045.10
CAediting_319734	ENST00000498165.4	chr3_161073737_+	-3024.30	-3022.60	-3045.10
CAediting_319735	ENST00000498165.4	chr3_161073743_+	-3027.00	-3022.60	-3045.10
CAediting_319736	ENST00000498165.4	chr3_161073750_+	-3024.20	-3022.60	-3045.10
CAediting_319737	ENST00000498165.4	chr3_161073760_+	-3022.80	-3022.60	-3045.10
CAediting_319738	ENST00000498165.4	chr3_161073768_+	-3022.30	-3022.60	-3045.10
CAediting_319739	ENST00000498165.4	chr3_161073786_+	-3024.60	-3022.60	-3045.10
CAediting_319740	ENST00000498165.4	chr3_161073800_+	-3024.70	-3022.60	-3045.10
CAediting_319741	ENST00000498165.4	chr3_161073804_+	-3022.60	-3022.60	-3045.10
CAediting_319742	ENST00000498165.4	chr3_161073823_+	-3026.70	-3022.60	-3045.10
CAediting_319743	ENST00000498165.4	chr3_161073835_+	-3022.60	-3022.60	-3045.10

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Relation with ADAR for PPM1L

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_319722	chr3_161073082_+	8.01966631229926e-13	0.654933388668966	.	.	.	.
BRCA	CAediting_319722	chr3_161073082_+	0.000434980970281312	0.331209180168492	.	.	.	.
PCPG	CAediting_319722	chr3_161073082_+	0.00792677327849483	0.334250965540029	.	.	.	.
BLCA	CAediting_319723	chr3_161073083_+	0.00118103235429867	0.312307637197165	.	.	.	.
LGG	CAediting_319723	chr3_161073083_+	8.68095731644869e-20	0.400733001301194	.	.	.	.
BRCA	CAediting_319723	chr3_161073083_+	4.93560968977866e-37	0.54656765675227	.	.	.	.
LIHC	CAediting_319723	chr3_161073083_+	0.000177607534029308	0.425105853995803	.	.	.	.
CESC	CAediting_319723	chr3_161073083_+	3.93634057545502e-11	0.708808646214001	.	.	.	.
LUAD	CAediting_319723	chr3_161073083_+	4.36989445320994e-07	0.505456865393847	.	.	.	.
COAD	CAediting_319723	chr3_161073083_+	9.29101097769345e-06	0.572336481859128	.	.	.	.
LUSC	CAediting_319723	chr3_161073083_+	5.69101458124533e-25	0.624458937393763	.	.	.	.
GBM	CAediting_319723	chr3_161073083_+	4.96135434635795e-06	0.482955809714936	.	.	.	.
PRAD	CAediting_319723	chr3_161073083_+	2.1373161184949e-07	0.385205063108955	.	.	.	.
HNSC	CAediting_319723	chr3_161073083_+	1.18077215438446e-05	0.391278427460277	.	.	.	.
STAD	CAediting_319723	chr3_161073083_+	1.16717070927624e-07	0.319055463765745	.	.	.	.
THCA	CAediting_319723	chr3_161073083_+	3.64649243512358e-05	0.283469670945719	.	.	.	.
KIRC	CAediting_319723	chr3_161073083_+	6.47739735346978e-10	0.311690105569641	.	.	.	.
ESCA	CAediting_319723	chr3_161073083_+	9.87717754149619e-06	0.383921384034582	.	.	.	.
PAAD	CAediting_319723	chr3_161073083_+	0.000128964193370043	0.506181417302483	.	.	.	.
PCPG	CAediting_319723	chr3_161073083_+	3.42632243853287e-13	0.621356222918913	.	.	.	.
SARC	CAediting_319723	chr3_161073083_+	3.53480047387094e-06	0.492185045497582	.	.	.	.

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Relation with cancer stages for PPM1L

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BLCA	pathologic_stage	CAediting_319723	chr3_161073083_+	0.0221117610981445	0.223176007899273

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Relation with survival for PPM1L

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PPM1L

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PPM1L

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PPM1L	C0028754	Obesity	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene