Home

Download

Statistics

Examples

Help

Contact

Editing gene: CBWD2 (CAeditome ID:150472)

Gene summary for CBWD2

Gene summary

Gene information	Gene symbol	CBWD2
	Gene ID	150472
	Gene name	COBW domain containing 2
	Synonyms	-
	Cytomap	2q14.1
	Type of gene	protein-coding
	Description	COBW domain-containing protein 2cobalamin synthase W domain-containing protein 2cobalamin synthetase W domain-containing protein 2
	Modification date	20210518
	UniProtAcc	Q8IUF1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

RNA A-to-I events for CBWD2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000136682.13

RNA A-to-I editing events in Cancer.

CAediting_208325(113466845, +), CAediting_208326(113466848, +), CAediting_208327(113466853, +), CAediting_208328(113466856, +), CAediting_208329(113466886, +), CAediting_208330(113466887, +), CAediting_208331(113466903, +), CAediting_208332(113466907, +), CAediting_208333(113466912, +), CAediting_208334(113466913, +), CAediting_208335(113466914, +), CAediting_208336(113466917, +), CAediting_208337(113466943, +), CAediting_208338(113466953, +), CAediting_208339(113466973, +), CAediting_208340(113466992, +), CAediting_208341(113469163, +), CAediting_208342(113469165, +), CAediting_208343(113469167, +), CAediting_208344(113469170, +), CAediting_208345(113469175, +), CAediting_208346(113469187, +), CAediting_208347(113469188, +), CAediting_208348(113469194, +), CAediting_208349(113469208, +), CAediting_208350(113469218, +), CAediting_208351(113469223, +), CAediting_208352(113469243, +), CAediting_208353(113469248, +), CAediting_208354(113469272, +), CAediting_208355(113469282, +), CAediting_208356(113469284, +), CAediting_208357(113469298, +), CAediting_208358(113469300, +), CAediting_208359(113469304, +), CAediting_208360(113469308, +), CAediting_208361(113469309, +), CAediting_208362(113469323, +), CAediting_208363(113469350, +), CAediting_208364(113469361, +), CAediting_208365(113469381, +), CAediting_208366(113469404, +), CAediting_208367(113470025, +), CAediting_208368(113470056, +), CAediting_208369(113470066, +), CAediting_208370(113470121, +), CAediting_208371(113470131, +), CAediting_208372(113470157, +), CAediting_208373(113470158, +), CAediting_208374(113470166, +), CAediting_208375(113470181, +), CAediting_208376(113470233, +), CAediting_208377(113470256, +), CAediting_208378(113470270, +),

Top

RNA editing positional annotations for CBWD2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_208325	chr2_113466845_+	intronic
CAediting_208326	chr2_113466848_+	intronic
CAediting_208327	chr2_113466853_+	intronic
CAediting_208328	chr2_113466856_+	intronic
CAediting_208329	chr2_113466886_+	intronic
CAediting_208330	chr2_113466887_+	intronic
CAediting_208331	chr2_113466903_+	intronic
CAediting_208332	chr2_113466907_+	intronic
CAediting_208333	chr2_113466912_+	intronic
CAediting_208334	chr2_113466913_+	intronic
CAediting_208335	chr2_113466914_+	intronic
CAediting_208336	chr2_113466917_+	intronic
CAediting_208337	chr2_113466943_+	intronic
CAediting_208338	chr2_113466953_+	intronic
CAediting_208339	chr2_113466973_+	intronic
CAediting_208340	chr2_113466992_+	intronic
CAediting_208341	chr2_113469163_+	ncRNA_exonic
CAediting_208342	chr2_113469165_+	ncRNA_exonic
CAediting_208343	chr2_113469167_+	ncRNA_exonic
CAediting_208344	chr2_113469170_+	ncRNA_exonic
CAediting_208345	chr2_113469175_+	ncRNA_exonic
CAediting_208346	chr2_113469187_+	ncRNA_exonic
CAediting_208347	chr2_113469188_+	ncRNA_exonic
CAediting_208348	chr2_113469194_+	ncRNA_exonic
CAediting_208349	chr2_113469208_+	ncRNA_exonic
CAediting_208350	chr2_113469218_+	ncRNA_exonic
CAediting_208351	chr2_113469223_+	ncRNA_exonic
CAediting_208352	chr2_113469243_+	ncRNA_exonic
CAediting_208353	chr2_113469248_+	ncRNA_exonic
CAediting_208354	chr2_113469272_+	ncRNA_exonic
CAediting_208355	chr2_113469282_+	ncRNA_exonic
CAediting_208356	chr2_113469284_+	ncRNA_exonic
CAediting_208357	chr2_113469298_+	ncRNA_exonic
CAediting_208358	chr2_113469300_+	ncRNA_exonic
CAediting_208359	chr2_113469304_+	ncRNA_exonic
CAediting_208360	chr2_113469308_+	ncRNA_exonic
CAediting_208361	chr2_113469309_+	ncRNA_exonic
CAediting_208362	chr2_113469323_+	ncRNA_exonic
CAediting_208363	chr2_113469350_+	ncRNA_exonic
CAediting_208364	chr2_113469361_+	ncRNA_exonic
CAediting_208365	chr2_113469381_+	ncRNA_exonic
CAediting_208366	chr2_113469404_+	ncRNA_exonic
CAediting_208367	chr2_113470025_+	ncRNA_exonic
CAediting_208368	chr2_113470056_+	ncRNA_exonic
CAediting_208369	chr2_113470066_+	ncRNA_exonic
CAediting_208370	chr2_113470121_+	ncRNA_exonic
CAediting_208371	chr2_113470131_+	ncRNA_exonic
CAediting_208372	chr2_113470157_+	ncRNA_exonic
CAediting_208373	chr2_113470158_+	ncRNA_exonic
CAediting_208374	chr2_113470166_+	ncRNA_exonic
CAediting_208375	chr2_113470181_+	ncRNA_exonic
CAediting_208376	chr2_113470233_+	ncRNA_exonic
CAediting_208377	chr2_113470256_+	ncRNA_exonic
CAediting_208378	chr2_113470270_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_208325	chr2_113466845_+	SINE	Alu	AluY
CAediting_208326	chr2_113466848_+	SINE	Alu	AluY
CAediting_208327	chr2_113466853_+	SINE	Alu	AluY
CAediting_208328	chr2_113466856_+	SINE	Alu	AluY
CAediting_208329	chr2_113466886_+	SINE	Alu	AluY
CAediting_208330	chr2_113466887_+	SINE	Alu	AluY
CAediting_208331	chr2_113466903_+	SINE	Alu	AluY
CAediting_208332	chr2_113466907_+	SINE	Alu	AluY
CAediting_208333	chr2_113466912_+	SINE	Alu	AluY
CAediting_208334	chr2_113466913_+	SINE	Alu	AluY
CAediting_208335	chr2_113466914_+	SINE	Alu	AluY
CAediting_208336	chr2_113466917_+	SINE	Alu	AluY
CAediting_208337	chr2_113466943_+	SINE	Alu	AluY
CAediting_208338	chr2_113466953_+	SINE	Alu	AluY
CAediting_208339	chr2_113466973_+	SINE	Alu	AluY
CAediting_208340	chr2_113466992_+	SINE	Alu	AluY
CAediting_208341	chr2_113469163_+	SINE	Alu	AluSz6
CAediting_208342	chr2_113469165_+	SINE	Alu	AluSz6
CAediting_208343	chr2_113469167_+	SINE	Alu	AluSz6
CAediting_208344	chr2_113469170_+	SINE	Alu	AluSz6
CAediting_208345	chr2_113469175_+	SINE	Alu	AluSz6
CAediting_208346	chr2_113469187_+	SINE	Alu	AluSz6
CAediting_208347	chr2_113469188_+	SINE	Alu	AluSz6
CAediting_208348	chr2_113469194_+	SINE	Alu	AluSz6
CAediting_208349	chr2_113469208_+	SINE	Alu	AluSz6
CAediting_208350	chr2_113469218_+	SINE	Alu	AluSz6
CAediting_208351	chr2_113469223_+	SINE	Alu	AluSz6
CAediting_208352	chr2_113469243_+	SINE	Alu	AluSz6
CAediting_208353	chr2_113469248_+	SINE	Alu	AluSz6
CAediting_208354	chr2_113469272_+	SINE	Alu	AluSz6
CAediting_208355	chr2_113469282_+	SINE	Alu	AluSz6
CAediting_208356	chr2_113469284_+	SINE	Alu	AluSz6
CAediting_208357	chr2_113469298_+	SINE	Alu	AluSz6
CAediting_208358	chr2_113469300_+	SINE	Alu	AluSz6
CAediting_208359	chr2_113469304_+	SINE	Alu	AluSz6
CAediting_208360	chr2_113469308_+	SINE	Alu	AluSz6
CAediting_208361	chr2_113469309_+	SINE	Alu	AluSz6
CAediting_208362	chr2_113469323_+	SINE	Alu	AluSz6
CAediting_208363	chr2_113469350_+	SINE	Alu	AluSz6
CAediting_208364	chr2_113469361_+	SINE	Alu	AluSz6
CAediting_208365	chr2_113469381_+	SINE	Alu	AluSz6
CAediting_208366	chr2_113469404_+	SINE	Alu	AluSz6
CAediting_208367	chr2_113470025_+	SINE	Alu	AluSc
CAediting_208368	chr2_113470056_+	SINE	Alu	AluSc
CAediting_208369	chr2_113470066_+	SINE	Alu	AluSc
CAediting_208370	chr2_113470121_+	SINE	Alu	AluSc
CAediting_208371	chr2_113470131_+	SINE	Alu	AluSc
CAediting_208372	chr2_113470157_+	SINE	Alu	AluSc
CAediting_208373	chr2_113470158_+	SINE	Alu	AluSc
CAediting_208374	chr2_113470166_+	SINE	Alu	AluSc
CAediting_208375	chr2_113470181_+	SINE	Alu	AluSc
CAediting_208376	chr2_113470233_+	SINE	Alu	AluSc
CAediting_208377	chr2_113470256_+	SINE	Alu	AluSc
CAediting_208378	chr2_113470270_+	SINE	Alu	AluSc

Top

RNA A-to-I editing events in the alternative splicing sites for CBWD2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_208341	chr2_113469163_+	113469148:113469170	3SS	0+5i	ATTTTTATCTTTTTGAGACAGAA	-13.48	ATTTTTATCTTTTTGGGACAGAA	-12.76
ES	CAediting_208342	chr2_113469165_+	113469148:113469170	3SS	0+3i	ATTTTTATCTTTTTGAGACAGAA	-13.48	ATTTTTATCTTTTTGAGGCAGAA	-23.93
ES	CAediting_208343	chr2_113469167_+	113469148:113469170	3SS	0+1i	ATTTTTATCTTTTTGAGACAGAA	-13.48	ATTTTTATCTTTTTGAGACGGAA	-4.73
ES	CAediting_208344	chr2_113469170_+	113469148:113469170	3SS	3+0i	ATTTTTATCTTTTTGAGACAGAA	-13.48	ATTTTTATCTTTTTGAGACAGAG	-14.49
IR	CAediting_208356	chr2_113469284_+	113469283:113469291	5SS	2+0i	CAGGTGTGC	6.46	CGGGTGTGC	4.15
IR	CAediting_208363	chr2_113469350_+	113469349:113469357	5SS	2+0i	CAGGTTGGT	8.08	CGGGTTGGT	3.35

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000136682.13.CBWD2.

Correlation between RNA A-to-I editing and PSI for ENSG00000136682.13.CBWD2.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for CBWD2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for CBWD2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for CBWD2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000136682.13	ENST00000456188	hsa-miR-200b-3p	113457158	113457164	7mer-m8	113457144	113457165	142	-9.73
CAediting_1229415	chr17_67471547_+	ENSG00000136682.13	ENST00000416503	hsa-miR-548aa	113495981	113495987	7mer-m8	113495966	113495988	144	-7.23
CAediting_1160181	chr17_7017644_-	ENSG00000136682.13	ENST00000416503	hsa-miR-195-3p	113496041	113496047	7mer-m8	113496027	113496048	150	-12.46
CAediting_1229415	chr17_67471547_+	ENSG00000136682.13	ENST00000358604	hsa-miR-548aa	113495981	113495987	7mer-m8	113495966	113495988	144	-7.23
CAediting_1160181	chr17_7017644_-	ENSG00000136682.13	ENST00000358604	hsa-miR-195-3p	113496041	113496047	7mer-m8	113496027	113496048	150	-12.46

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for CBWD2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000479583.4	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_208341	ENST00000479583.4	chr2_113469163_+	-848.90	-846.00	-889.50
CAediting_208342	ENST00000479583.4	chr2_113469165_+	-845.40	-846.00	-889.50
CAediting_208343	ENST00000479583.4	chr2_113469167_+	-845.30	-846.00	-889.50
CAediting_208344	ENST00000479583.4	chr2_113469170_+	-849.90	-846.00	-889.50
CAediting_208345	ENST00000479583.4	chr2_113469175_+	-846.00	-846.00	-889.50
CAediting_208346	ENST00000479583.4	chr2_113469187_+	-846.10	-846.00	-889.50
CAediting_208347	ENST00000479583.4	chr2_113469188_+	-846.00	-846.00	-889.50
CAediting_208348	ENST00000479583.4	chr2_113469194_+	-846.30	-846.00	-889.50
CAediting_208349	ENST00000479583.4	chr2_113469208_+	-848.50	-846.00	-889.50
CAediting_208350	ENST00000479583.4	chr2_113469218_+	-847.50	-846.00	-889.50
CAediting_208351	ENST00000479583.4	chr2_113469223_+	-848.30	-846.00	-889.50
CAediting_208352	ENST00000479583.4	chr2_113469243_+	-846.40	-846.00	-889.50
CAediting_208353	ENST00000479583.4	chr2_113469248_+	-848.90	-846.00	-889.50
CAediting_208354	ENST00000479583.4	chr2_113469272_+	-846.00	-846.00	-889.50
CAediting_208355	ENST00000479583.4	chr2_113469282_+	-846.00	-846.00	-889.50
CAediting_208356	ENST00000479583.4	chr2_113469284_+	-848.60	-846.00	-889.50
CAediting_208357	ENST00000479583.4	chr2_113469298_+	-851.40	-846.00	-889.50
CAediting_208358	ENST00000479583.4	chr2_113469300_+	-845.60	-846.00	-889.50
CAediting_208359	ENST00000479583.4	chr2_113469304_+	-845.20	-846.00	-889.50
CAediting_208360	ENST00000479583.4	chr2_113469308_+	-846.50	-846.00	-889.50
CAediting_208361	ENST00000479583.4	chr2_113469309_+	-846.10	-846.00	-889.50
CAediting_208362	ENST00000479583.4	chr2_113469323_+	-847.30	-846.00	-889.50
CAediting_208363	ENST00000479583.4	chr2_113469350_+	-845.30	-846.00	-889.50
CAediting_208364	ENST00000479583.4	chr2_113469361_+	-846.00	-846.00	-889.50
CAediting_208365	ENST00000479583.4	chr2_113469381_+	-847.60	-846.00	-889.50
CAediting_208366	ENST00000479583.4	chr2_113469404_+	-852.60	-846.00	-889.50
CAediting_208367	ENST00000479583.4	chr2_113470025_+	-845.30	-846.00	-889.50
CAediting_208368	ENST00000479583.4	chr2_113470056_+	-846.00	-846.00	-889.50
CAediting_208369	ENST00000479583.4	chr2_113470066_+	-845.60	-846.00	-889.50
CAediting_208370	ENST00000479583.4	chr2_113470121_+	-845.70	-846.00	-889.50
CAediting_208371	ENST00000479583.4	chr2_113470131_+	-847.20	-846.00	-889.50
CAediting_208372	ENST00000479583.4	chr2_113470157_+	-845.70	-846.00	-889.50
CAediting_208373	ENST00000479583.4	chr2_113470158_+	-847.50	-846.00	-889.50
CAediting_208374	ENST00000479583.4	chr2_113470166_+	-846.40	-846.00	-889.50
CAediting_208375	ENST00000479583.4	chr2_113470181_+	-845.30	-846.00	-889.50
CAediting_208376	ENST00000479583.4	chr2_113470233_+	-846.00	-846.00	-889.50
CAediting_208377	ENST00000479583.4	chr2_113470256_+	-846.00	-846.00	-889.50
CAediting_208378	ENST00000479583.4	chr2_113470270_+	-849.40	-846.00	-889.50

Top

Relation with ADAR for CBWD2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for CBWD2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for CBWD2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for CBWD2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for CBWD2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene