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Editing gene: CNIH3 (CAeditome ID:149111)

Gene summary for CNIH3

Gene summary

Gene information	Gene symbol	CNIH3
	Gene ID	149111
	Gene name	cornichon family AMPA receptor auxiliary protein 3
	Synonyms	CNIH-3
	Cytomap	1q42.12
	Type of gene	protein-coding
	Description	protein cornichon homolog 3cornichon homolog 3
	Modification date	20210518
	UniProtAcc	Q8TBE1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CNIH3	GO:2000311	Protein cornichon homolog 3	20805473

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RNA A-to-I events for CNIH3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000143786.6

RNA A-to-I editing events in Cancer.

CAediting_142286(224439712, +), CAediting_142287(224439751, +), CAediting_142288(224445390, +), CAediting_142289(224445521, +), CAediting_142290(224445531, +), CAediting_142291(224449082, +), CAediting_142292(224449104, +), CAediting_142293(224449589, +), CAediting_142294(224452350, +), CAediting_142295(224452604, +), CAediting_142296(224452615, +), CAediting_142297(224452619, +), CAediting_142298(224452661, +), CAediting_142299(224452667, +), CAediting_142300(224452671, +), CAediting_142301(224452865, +), CAediting_142302(224452866, +), CAediting_142303(224453235, +), CAediting_142304(224453245, +), CAediting_142305(224453250, +), CAediting_142306(224453708, +), CAediting_142307(224456658, +), CAediting_142308(224460064, +), CAediting_142309(224460079, +), CAediting_142310(224460106, +), CAediting_142311(224460127, +), CAediting_142312(224460160, +), CAediting_142313(224460172, +), CAediting_142314(224465846, +), CAediting_142315(224468739, +), CAediting_142316(224471492, +), CAediting_142317(224471493, +), CAediting_142318(224472443, +), CAediting_142319(224483258, +), CAediting_142320(224500594, +), CAediting_142321(224512419, +), CAediting_142322(224513226, +), CAediting_142323(224513228, +), CAediting_142324(224513233, +), CAediting_142325(224513235, +), CAediting_142326(224513238, +), CAediting_142327(224513243, +), CAediting_142328(224513244, +), CAediting_142329(224513278, +), CAediting_142330(224513288, +), CAediting_142331(224513294, +), CAediting_142332(224513296, +), CAediting_142333(224513298, +), CAediting_142334(224514629, +), CAediting_142335(224514703, +), CAediting_142336(224587667, +), CAediting_142337(224587827, +), CAediting_142338(224589977, +), CAediting_142339(224589994, +), CAediting_142340(224590006, +), CAediting_142341(224590016, +), CAediting_142342(224590052, +), CAediting_142343(224590057, +), CAediting_142344(224590060, +), CAediting_142345(224590127, +), CAediting_142346(224590143, +), CAediting_142347(224593225, +), CAediting_142348(224593249, +), CAediting_142349(224595186, +), CAediting_142350(224595213, +), CAediting_142351(224595298, +), CAediting_142352(224596938, +), CAediting_142353(224597031, +), CAediting_142354(224597072, +), CAediting_142355(224597073, +), CAediting_142356(224597078, +), CAediting_142357(224600283, +), CAediting_142358(224633288, +), CAediting_142359(224635750, +), CAediting_142360(224646518, +),

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RNA editing positional annotations for CNIH3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_142286	chr1_224439712_+	ncRNA_intronic
CAediting_142287	chr1_224439751_+	ncRNA_intronic
CAediting_142288	chr1_224445390_+	ncRNA_intronic
CAediting_142289	chr1_224445521_+	ncRNA_intronic
CAediting_142290	chr1_224445531_+	ncRNA_intronic
CAediting_142291	chr1_224449082_+	ncRNA_intronic
CAediting_142292	chr1_224449104_+	ncRNA_intronic
CAediting_142293	chr1_224449589_+	ncRNA_intronic
CAediting_142294	chr1_224452350_+	ncRNA_intronic
CAediting_142295	chr1_224452604_+	ncRNA_intronic
CAediting_142296	chr1_224452615_+	ncRNA_intronic
CAediting_142297	chr1_224452619_+	ncRNA_intronic
CAediting_142298	chr1_224452661_+	ncRNA_intronic
CAediting_142299	chr1_224452667_+	ncRNA_intronic
CAediting_142300	chr1_224452671_+	ncRNA_intronic
CAediting_142301	chr1_224452865_+	ncRNA_intronic
CAediting_142302	chr1_224452866_+	ncRNA_intronic
CAediting_142303	chr1_224453235_+	ncRNA_intronic
CAediting_142304	chr1_224453245_+	ncRNA_intronic
CAediting_142305	chr1_224453250_+	ncRNA_intronic
CAediting_142306	chr1_224453708_+	ncRNA_intronic
CAediting_142307	chr1_224456658_+	ncRNA_intronic
CAediting_142308	chr1_224460064_+	ncRNA_intronic
CAediting_142309	chr1_224460079_+	ncRNA_intronic
CAediting_142310	chr1_224460106_+	ncRNA_intronic
CAediting_142311	chr1_224460127_+	ncRNA_intronic
CAediting_142312	chr1_224460160_+	ncRNA_intronic
CAediting_142313	chr1_224460172_+	ncRNA_intronic
CAediting_142314	chr1_224465846_+	ncRNA_intronic
CAediting_142315	chr1_224468739_+	ncRNA_intronic
CAediting_142316	chr1_224471492_+	ncRNA_intronic
CAediting_142317	chr1_224471493_+	ncRNA_intronic
CAediting_142318	chr1_224472443_+	ncRNA_intronic
CAediting_142319	chr1_224483258_+	ncRNA_intronic
CAediting_142320	chr1_224500594_+	ncRNA_intronic
CAediting_142321	chr1_224512419_+	ncRNA_intronic
CAediting_142322	chr1_224513226_+	ncRNA_intronic
CAediting_142323	chr1_224513228_+	ncRNA_intronic
CAediting_142324	chr1_224513233_+	ncRNA_intronic
CAediting_142325	chr1_224513235_+	ncRNA_intronic
CAediting_142326	chr1_224513238_+	ncRNA_intronic
CAediting_142327	chr1_224513243_+	ncRNA_intronic
CAediting_142328	chr1_224513244_+	ncRNA_intronic
CAediting_142329	chr1_224513278_+	ncRNA_intronic
CAediting_142330	chr1_224513288_+	ncRNA_intronic
CAediting_142331	chr1_224513294_+	ncRNA_intronic
CAediting_142332	chr1_224513296_+	ncRNA_intronic
CAediting_142333	chr1_224513298_+	ncRNA_intronic
CAediting_142334	chr1_224514629_+	ncRNA_intronic
CAediting_142335	chr1_224514703_+	ncRNA_intronic
CAediting_142336	chr1_224587667_+	ncRNA_intronic
CAediting_142337	chr1_224587827_+	ncRNA_intronic
CAediting_142338	chr1_224589977_+	ncRNA_intronic
CAediting_142339	chr1_224589994_+	ncRNA_intronic
CAediting_142340	chr1_224590006_+	ncRNA_intronic
CAediting_142341	chr1_224590016_+	ncRNA_intronic
CAediting_142342	chr1_224590052_+	ncRNA_intronic
CAediting_142343	chr1_224590057_+	ncRNA_intronic
CAediting_142344	chr1_224590060_+	ncRNA_intronic
CAediting_142345	chr1_224590127_+	ncRNA_intronic
CAediting_142346	chr1_224590143_+	ncRNA_intronic
CAediting_142347	chr1_224593225_+	ncRNA_intronic
CAediting_142348	chr1_224593249_+	ncRNA_intronic
CAediting_142349	chr1_224595186_+	ncRNA_intronic
CAediting_142350	chr1_224595213_+	ncRNA_intronic
CAediting_142351	chr1_224595298_+	ncRNA_intronic
CAediting_142352	chr1_224596938_+	ncRNA_intronic
CAediting_142353	chr1_224597031_+	ncRNA_intronic
CAediting_142354	chr1_224597072_+	ncRNA_intronic
CAediting_142355	chr1_224597073_+	ncRNA_intronic
CAediting_142356	chr1_224597078_+	ncRNA_intronic
CAediting_142357	chr1_224600283_+	ncRNA_intronic
CAediting_142358	chr1_224633288_+	ncRNA_intronic
CAediting_142359	chr1_224635750_+	ncRNA_intronic
CAediting_142360	chr1_224646518_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_142286	chr1_224439712_+	SINE	Alu	AluSc
CAediting_142287	chr1_224439751_+	SINE	Alu	AluSc
CAediting_142288	chr1_224445390_+	SINE	Alu	AluSx
CAediting_142289	chr1_224445521_+	SINE	Alu	AluSx
CAediting_142290	chr1_224445531_+	SINE	Alu	AluSx
CAediting_142291	chr1_224449082_+	SINE	Alu	AluSc8
CAediting_142292	chr1_224449104_+	SINE	Alu	AluSc8
CAediting_142293	chr1_224449589_+	SINE	Alu	FRAM
CAediting_142294	chr1_224452350_+	SINE	Alu	AluSz
CAediting_142295	chr1_224452604_+	SINE	Alu	AluY
CAediting_142296	chr1_224452615_+	SINE	Alu	AluY
CAediting_142297	chr1_224452619_+	SINE	Alu	AluY
CAediting_142298	chr1_224452661_+	SINE	Alu	AluY
CAediting_142299	chr1_224452667_+	SINE	Alu	AluY
CAediting_142300	chr1_224452671_+	SINE	Alu	AluY
CAediting_142301	chr1_224452865_+	SINE	Alu	AluSx
CAediting_142302	chr1_224452866_+	SINE	Alu	AluSx
CAediting_142303	chr1_224453235_+	SINE	Alu	AluJb
CAediting_142304	chr1_224453245_+	SINE	Alu	AluJb
CAediting_142305	chr1_224453250_+	SINE	Alu	AluJb
CAediting_142306	chr1_224453708_+	SINE	Alu	FAM
CAediting_142307	chr1_224456658_+	SINE	Alu	AluJb
CAediting_142308	chr1_224460064_+	SINE	Alu	AluJb
CAediting_142309	chr1_224460079_+	SINE	Alu	AluJb
CAediting_142310	chr1_224460106_+	SINE	Alu	AluJb
CAediting_142311	chr1_224460127_+	SINE	Alu	AluJb
CAediting_142312	chr1_224460160_+	SINE	Alu	AluJb
CAediting_142313	chr1_224460172_+	SINE	Alu	AluJb
CAediting_142314	chr1_224465846_+	SINE	Alu	AluSq2
CAediting_142315	chr1_224468739_+	SINE	Alu	AluJr
CAediting_142316	chr1_224471492_+	LINE	L1	L1MA3
CAediting_142317	chr1_224471493_+	LINE	L1	L1MA3
CAediting_142318	chr1_224472443_+	LINE	L1	L1PB1
CAediting_142319	chr1_224483258_+	SINE	Alu	AluSz6
CAediting_142320	chr1_224500594_+	SINE	Alu	AluSz
CAediting_142321	chr1_224512419_+	SINE	Alu	AluJr4
CAediting_142322	chr1_224513226_+	SINE	Alu	AluJb
CAediting_142323	chr1_224513228_+	SINE	Alu	AluJb
CAediting_142324	chr1_224513233_+	SINE	Alu	AluJb
CAediting_142325	chr1_224513235_+	SINE	Alu	AluJb
CAediting_142326	chr1_224513238_+	SINE	Alu	AluJb
CAediting_142327	chr1_224513243_+	SINE	Alu	AluJb
CAediting_142328	chr1_224513244_+	SINE	Alu	AluJb
CAediting_142329	chr1_224513278_+	SINE	Alu	AluJb
CAediting_142330	chr1_224513288_+	SINE	Alu	AluJb
CAediting_142331	chr1_224513294_+	SINE	Alu	AluJb
CAediting_142332	chr1_224513296_+	SINE	Alu	AluJb
CAediting_142333	chr1_224513298_+	SINE	Alu	AluJb
CAediting_142334	chr1_224514629_+	SINE	Alu	AluJb
CAediting_142335	chr1_224514703_+	SINE	Alu	AluJb
CAediting_142336	chr1_224587667_+	SINE	Alu	AluJo
CAediting_142337	chr1_224587827_+	SINE	Alu	AluJo
CAediting_142338	chr1_224589977_+	SINE	Alu	AluSg
CAediting_142339	chr1_224589994_+	SINE	Alu	AluSg
CAediting_142340	chr1_224590006_+	SINE	Alu	AluSg
CAediting_142341	chr1_224590016_+	SINE	Alu	AluSg
CAediting_142342	chr1_224590052_+	SINE	Alu	AluSg
CAediting_142343	chr1_224590057_+	SINE	Alu	AluSg
CAediting_142344	chr1_224590060_+	SINE	Alu	AluSg
CAediting_142345	chr1_224590127_+	SINE	Alu	AluSg
CAediting_142346	chr1_224590143_+	SINE	Alu	AluSg
CAediting_142347	chr1_224593225_+	SINE	Alu	AluJb
CAediting_142348	chr1_224593249_+	SINE	Alu	AluJb
CAediting_142349	chr1_224595186_+	SINE	Alu	AluJo
CAediting_142350	chr1_224595213_+	SINE	Alu	AluJo
CAediting_142351	chr1_224595298_+	SINE	Alu	AluJo
CAediting_142352	chr1_224596938_+	SINE	Alu	AluSq2
CAediting_142353	chr1_224597031_+	SINE	Alu	AluSq2
CAediting_142354	chr1_224597072_+	SINE	Alu	AluSq2
CAediting_142355	chr1_224597073_+	SINE	Alu	AluSq2
CAediting_142356	chr1_224597078_+	SINE	Alu	AluSq2
CAediting_142357	chr1_224600283_+	SINE	Alu	AluSp
CAediting_142358	chr1_224633288_+	SINE	Alu	AluSz6
CAediting_142359	chr1_224635750_+	SINE	Alu	AluJr4
CAediting_142360	chr1_224646518_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for CNIH3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000143786.6.CNIH3.

Correlation between RNA A-to-I editing and PSI for ENSG00000143786.6.CNIH3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CNIH3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CNIH3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CNIH3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CNIH3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CNIH3

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
THCA	CAediting_142329	chr1_224513278_+	0.021850071014445	0.303238974742002	.	.	.	.

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Relation with cancer stages for CNIH3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CNIH3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CNIH3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CNIH3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CNIH3	C0014175	Endometriosis	1	CTD_human
CNIH3	C0036341	Schizophrenia	1	PSYGENET
CNIH3	C0269102	Endometrioma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene