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Editing gene: EFCAB3 (CAeditome ID:146779)

Gene summary for EFCAB3

Gene summary

Gene information	Gene symbol	EFCAB3
	Gene ID	146779
	Gene name	EF-hand calcium binding domain 3
	Synonyms	-
	Cytomap	17q23.2
	Type of gene	protein-coding
	Description	EF-hand calcium-binding domain-containing protein 3
	Modification date	20210518
	UniProtAcc	Q8N7B9
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for EFCAB3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000172421.6

RNA A-to-I editing events in Cancer.

CAediting_1223038(62403839, +), CAediting_1223039(62411611, +), CAediting_1223040(62411614, +), CAediting_1223041(62411615, +), CAediting_1223042(62411636, +), CAediting_1223043(62411638, +), CAediting_1223044(62411646, +), CAediting_1223045(62411647, +), CAediting_1223046(62411656, +), CAediting_1223047(62412256, +), CAediting_1223048(62412268, +), CAediting_1223049(62412282, +), CAediting_1223050(62412291, +), CAediting_1223051(62412483, +), CAediting_1223052(62412485, +), CAediting_1223053(62412487, +), CAediting_1223054(62412496, +), CAediting_1223055(62412504, +), CAediting_1223056(62412520, +), CAediting_1223057(62412524, +), CAediting_1223058(62412531, +), CAediting_1223059(62412534, +), CAediting_1223060(62412539, +), CAediting_1223061(62412558, +), CAediting_1223062(62412565, +), CAediting_1223063(62412568, +), CAediting_1223064(62412577, +), CAediting_1223065(62412591, +), CAediting_1223066(62412594, +), CAediting_1223067(62412604, +), CAediting_1223068(62412626, +), CAediting_1223069(62412630, +), CAediting_1223070(62412639, +), CAediting_1223071(62412648, +), CAediting_1223072(62412650, +), CAediting_1223073(62412694, +), CAediting_1223074(62412695, +), CAediting_1223075(62412698, +), CAediting_1223076(62412703, +), CAediting_1223077(62412720, +), CAediting_1223078(62412721, +), CAediting_1223079(62412722, +), CAediting_1223080(62412740, +),

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RNA editing positional annotations for EFCAB3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1223038	chr17_62403839_+	intronic
CAediting_1223039	chr17_62411611_+	intronic
CAediting_1223040	chr17_62411614_+	intronic
CAediting_1223041	chr17_62411615_+	intronic
CAediting_1223042	chr17_62411636_+	intronic
CAediting_1223043	chr17_62411638_+	intronic
CAediting_1223044	chr17_62411646_+	intronic
CAediting_1223045	chr17_62411647_+	intronic
CAediting_1223046	chr17_62411656_+	intronic
CAediting_1223047	chr17_62412256_+	intronic
CAediting_1223048	chr17_62412268_+	intronic
CAediting_1223049	chr17_62412282_+	intronic
CAediting_1223050	chr17_62412291_+	intronic
CAediting_1223051	chr17_62412483_+	intronic
CAediting_1223052	chr17_62412485_+	intronic
CAediting_1223053	chr17_62412487_+	intronic
CAediting_1223054	chr17_62412496_+	intronic
CAediting_1223055	chr17_62412504_+	intronic
CAediting_1223056	chr17_62412520_+	intronic
CAediting_1223057	chr17_62412524_+	intronic
CAediting_1223058	chr17_62412531_+	intronic
CAediting_1223059	chr17_62412534_+	intronic
CAediting_1223060	chr17_62412539_+	intronic
CAediting_1223061	chr17_62412558_+	intronic
CAediting_1223062	chr17_62412565_+	intronic
CAediting_1223063	chr17_62412568_+	intronic
CAediting_1223064	chr17_62412577_+	intronic
CAediting_1223065	chr17_62412591_+	intronic
CAediting_1223066	chr17_62412594_+	intronic
CAediting_1223067	chr17_62412604_+	intronic
CAediting_1223068	chr17_62412626_+	intronic
CAediting_1223069	chr17_62412630_+	intronic
CAediting_1223070	chr17_62412639_+	intronic
CAediting_1223071	chr17_62412648_+	intronic
CAediting_1223072	chr17_62412650_+	intronic
CAediting_1223073	chr17_62412694_+	intronic
CAediting_1223074	chr17_62412695_+	intronic
CAediting_1223075	chr17_62412698_+	intronic
CAediting_1223076	chr17_62412703_+	intronic
CAediting_1223077	chr17_62412720_+	intronic
CAediting_1223078	chr17_62412721_+	intronic
CAediting_1223079	chr17_62412722_+	intronic
CAediting_1223080	chr17_62412740_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1223038	chr17_62403839_+	SINE	Alu	AluJb
CAediting_1223039	chr17_62411611_+	SINE	Alu	AluSx
CAediting_1223040	chr17_62411614_+	SINE	Alu	AluSx
CAediting_1223041	chr17_62411615_+	SINE	Alu	AluSx
CAediting_1223042	chr17_62411636_+	SINE	Alu	AluSx
CAediting_1223043	chr17_62411638_+	SINE	Alu	AluSx
CAediting_1223044	chr17_62411646_+	SINE	Alu	AluSx
CAediting_1223045	chr17_62411647_+	SINE	Alu	AluSx
CAediting_1223046	chr17_62411656_+	SINE	Alu	AluSx
CAediting_1223047	chr17_62412256_+	SINE	Alu	AluSx
CAediting_1223048	chr17_62412268_+	SINE	Alu	AluSx
CAediting_1223049	chr17_62412282_+	SINE	Alu	AluSx
CAediting_1223050	chr17_62412291_+	SINE	Alu	AluSx
CAediting_1223051	chr17_62412483_+	SINE	Alu	AluJb
CAediting_1223052	chr17_62412485_+	SINE	Alu	AluJb
CAediting_1223053	chr17_62412487_+	SINE	Alu	AluJb
CAediting_1223054	chr17_62412496_+	SINE	Alu	AluJb
CAediting_1223055	chr17_62412504_+	SINE	Alu	AluJb
CAediting_1223056	chr17_62412520_+	SINE	Alu	AluJb
CAediting_1223057	chr17_62412524_+	SINE	Alu	AluJb
CAediting_1223058	chr17_62412531_+	SINE	Alu	AluJb
CAediting_1223059	chr17_62412534_+	SINE	Alu	AluJb
CAediting_1223060	chr17_62412539_+	SINE	Alu	AluJb
CAediting_1223061	chr17_62412558_+	SINE	Alu	AluJb
CAediting_1223062	chr17_62412565_+	SINE	Alu	AluJb
CAediting_1223063	chr17_62412568_+	SINE	Alu	AluJb
CAediting_1223064	chr17_62412577_+	SINE	Alu	AluJb
CAediting_1223065	chr17_62412591_+	SINE	Alu	AluJb
CAediting_1223066	chr17_62412594_+	SINE	Alu	AluJb
CAediting_1223067	chr17_62412604_+	SINE	Alu	AluJb
CAediting_1223068	chr17_62412626_+	SINE	Alu	AluJb
CAediting_1223069	chr17_62412630_+	SINE	Alu	AluJb
CAediting_1223070	chr17_62412639_+	SINE	Alu	AluJb
CAediting_1223071	chr17_62412648_+	SINE	Alu	AluJb
CAediting_1223072	chr17_62412650_+	SINE	Alu	AluJb
CAediting_1223073	chr17_62412694_+	SINE	Alu	AluJb
CAediting_1223074	chr17_62412695_+	SINE	Alu	AluJb
CAediting_1223075	chr17_62412698_+	SINE	Alu	AluJb
CAediting_1223076	chr17_62412703_+	SINE	Alu	AluJb
CAediting_1223077	chr17_62412720_+	SINE	Alu	AluJb
CAediting_1223078	chr17_62412721_+	SINE	Alu	AluJb
CAediting_1223079	chr17_62412722_+	SINE	Alu	AluJb
CAediting_1223080	chr17_62412740_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for EFCAB3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172421.6.EFCAB3.

Correlation between RNA A-to-I editing and PSI for ENSG00000172421.6.EFCAB3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EFCAB3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for EFCAB3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for EFCAB3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EFCAB3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for EFCAB3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for EFCAB3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for EFCAB3

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
KIRC	CAediting_1223069	chr17_62412630_+	0.00832196183490619	0.0177114	157.567

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RelatedDrugs for EFCAB3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EFCAB3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene