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Editing gene: C2CD4A (CAeditome ID:145741)

Gene summary for C2CD4A

Gene summary

Gene information	Gene symbol	C2CD4A
	Gene ID	145741
	Gene name	C2 calcium dependent domain containing 4A
	Synonyms	FAM148A\|NLF1
	Cytomap	15q22.2
	Type of gene	protein-coding
	Description	C2 calcium-dependent domain-containing protein 4Afamily with sequence similarity 148, member Anuclear localized factor 1
	Modification date	20210518
	UniProtAcc	Q8NCU7
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
C2CD4A	GO:0002528	C2 calcium-dependent domain-containing protein 4A	15527968
C2CD4A	GO:0002675	C2 calcium-dependent domain-containing protein 4A	15527968
C2CD4A	GO:0030155	C2 calcium-dependent domain-containing protein 4A	15527968
C2CD4A	GO:0005634	C2 calcium-dependent domain-containing protein 4A	15527968

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RNA A-to-I events for C2CD4A

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000198535.5

RNA A-to-I editing events in Cancer.

CAediting_1047309(62069305, +), CAediting_1047310(62069328, +), CAediting_1047311(62069336, +), CAediting_1047312(62069497, +), CAediting_1047313(62069502, +), CAediting_1047314(62069527, +), CAediting_1047315(62069534, +), CAediting_1047316(62070327, +), CAediting_1047317(62070335, +), CAediting_1047318(62070359, +), CAediting_1047319(62070373, +), CAediting_1047320(62070378, +), CAediting_1047321(62070430, +), CAediting_1047322(62070436, +), CAediting_1047323(62070442, +),

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RNA editing positional annotations for C2CD4A using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1047309	chr15_62069305_+	UTR3
CAediting_1047310	chr15_62069328_+	UTR3
CAediting_1047311	chr15_62069336_+	UTR3
CAediting_1047312	chr15_62069497_+	UTR3
CAediting_1047313	chr15_62069502_+	UTR3
CAediting_1047314	chr15_62069527_+	UTR3
CAediting_1047315	chr15_62069534_+	UTR3
CAediting_1047316	chr15_62070327_+	UTR3
CAediting_1047317	chr15_62070335_+	UTR3
CAediting_1047318	chr15_62070359_+	UTR3
CAediting_1047319	chr15_62070373_+	UTR3
CAediting_1047320	chr15_62070378_+	UTR3
CAediting_1047321	chr15_62070430_+	UTR3
CAediting_1047322	chr15_62070436_+	UTR3
CAediting_1047323	chr15_62070442_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1047309	chr15_62069305_+	SINE	Alu	AluJb
CAediting_1047310	chr15_62069328_+	SINE	Alu	AluJb
CAediting_1047311	chr15_62069336_+	SINE	Alu	AluJb
CAediting_1047312	chr15_62069497_+	SINE	Alu	AluJb
CAediting_1047313	chr15_62069502_+	SINE	Alu	AluJb
CAediting_1047314	chr15_62069527_+	SINE	Alu	AluJb
CAediting_1047315	chr15_62069534_+	SINE	Alu	AluJb
CAediting_1047316	chr15_62070327_+	SINE	Alu	AluJr
CAediting_1047317	chr15_62070335_+	SINE	Alu	AluJr
CAediting_1047318	chr15_62070359_+	SINE	Alu	AluJr
CAediting_1047319	chr15_62070373_+	SINE	Alu	AluJr
CAediting_1047320	chr15_62070378_+	SINE	Alu	AluJr
CAediting_1047321	chr15_62070430_+	SINE	Alu	AluJr
CAediting_1047322	chr15_62070436_+	SINE	Alu	AluJr
CAediting_1047323	chr15_62070442_+	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for C2CD4A

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198535.5.C2CD4A.

Correlation between RNA A-to-I editing and PSI for ENSG00000198535.5.C2CD4A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for C2CD4A

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for C2CD4A

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for C2CD4A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518a-3p	62069333	62069339	7mer-m8	62069319	62069340	141.00	-16.88
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518a-3p	62069333	62069339	7mer-m8	62069319	62069340	141.00	-16.88
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518b	62069333	62069339	7mer-m8	62069320	62069340	146.00	-20.85
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518c-3p	62069333	62069339	7mer-m8	62069319	62069340	142.00	-18.71
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518d-3p	62069333	62069339	7mer-m8	62069320	62069340	141.00	-17.57
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-518f-3p	62069333	62069339	7mer-m8	62069320	62069340	141.00	-17.21
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-526a-3p	62069333	62069339	7mer-m8	62069320	62069340	142.00	-17.44
CAediting_1047322	chr15_62070436_+	ENSG00000198535.5	ENST00000355522	hsa-miR-383-3p	62070429	62070435	7mer-m8	62070418	62070436	140.00	-15.17
CAediting_1047322	chr15_62070436_+	ENSG00000198535.5	ENST00000355522	hsa-miR-7977	62070432	62070438	7mer-m8	62070422	62070439	140.00	-13.07
CAediting_1047309	chr15_62069305_+	ENSG00000198535.5	ENST00000355522	hsa-miR-500b-3p	62069302	62069308	7mer-m8	62069290	62069309	148.00	-16.05
CAediting_1047309	chr15_62069305_+	ENSG00000198535.5	ENST00000355522	hsa-miR-6849-3p	62069299	62069305	7mer-m8	62069286	62069306	148.00	-16.68
CAediting_1047310	chr15_62069328_+	ENSG00000198535.5	ENST00000355522	hsa-miR-4759	62069325	62069331	7mer-m8	62069312	62069332	149.00	-15.07
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-3136-3p	62069498	62069504	7mer-m8	62069484	62069505	147.00	-14.99
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-4747-3p	62069500	62069505	6mer	62069485	62069506	141.00	-22.19
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-7155-3p	62069498	62069504	7mer-m8	62069487	62069505	146.00	-18.33
CAediting_1047314	chr15_62069527_+	ENSG00000198535.5	ENST00000355522	hsa-miR-324-3p	62069520	62069526	7mer-m8	62069504	62069527	144.00	-25.50
CAediting_1047314	chr15_62069527_+	ENSG00000198535.5	ENST00000355522	hsa-miR-6075	62069524	62069531	8mer-1a	62069510	62069531	162.00	-28.15
CAediting_1047315	chr15_62069534_+	ENSG00000198535.5	ENST00000355522	hsa-miR-6790-3p	62069529	62069535	7mer-m8	62069516	62069536	150.00	-27.71
CAediting_1047319	chr15_62070373_+	ENSG00000198535.5	ENST00000355522	hsa-miR-6807-5p	62070371	62070377	7mer-m8	62070358	62070378	142.00	-16.88

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1047310	chr15_62069328_+	ENSG00000198535.5	ENST00000355522	hsa-miR-10399-5p	62069322	62069328	7mer-m8	62069309	62069329	140	-10.39
CAediting_1047317	chr15_62070335_+	ENSG00000198535.5	ENST00000355522	hsa-miR-1236-5p	62070331	62070337	7mer-m8	62070317	62070338	140	-11.37
CAediting_1047312	chr15_62069497_+	ENSG00000198535.5	ENST00000355522	hsa-miR-1245a	62069492	62069498	7mer-m8	62069479	62069499	149	-17.3
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-3155a	62069500	62069506	7mer-m8	62069489	62069507	145	-25.41
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-3155b	62069500	62069506	7mer-m8	62069492	62069507	145	-23.45
CAediting_1047320	chr15_62070378_+	ENSG00000198535.5	ENST00000355522	hsa-miR-3174	62070374	62070379	6mer	62070360	62070380	140	-19.25
CAediting_1047318	chr15_62070359_+	ENSG00000198535.5	ENST00000355522	hsa-miR-324-3p	62070356	62070362	7mer-m8	62070341	62070363	148	-24.11
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-373-3p	62069333	62069338	6mer	62069316	62069339	148	-22.09
CAediting_1047314	chr15_62069527_+	ENSG00000198535.5	ENST00000355522	hsa-miR-4284	62069523	62069529	7mer-m8	62069513	62069530	151	-15.56
CAediting_1047316	chr15_62070327_+	ENSG00000198535.5	ENST00000355522	hsa-miR-4312	62070324	62070330	7mer-m8	62070313	62070331	153	-13.64
CAediting_1047313	chr15_62069502_+	ENSG00000198535.5	ENST00000355522	hsa-miR-484	62069500	62069506	7mer-m8	62069484	62069507	150	-23.98
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-5006-5p	62069329	62069335	7mer-m8	62069316	62069336	154	-24.47
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-519d-3p	62069333	62069339	7mer-m8	62069320	62069340	146	-18.87
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-520g-3p	62069334	62069340	7mer-m8	62069319	62069341	147	-16.5
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-520h	62069334	62069340	7mer-m8	62069320	62069341	146	-14.81
CAediting_1047311	chr15_62069336_+	ENSG00000198535.5	ENST00000355522	hsa-miR-526b-3p	62069333	62069339	7mer-m8	62069320	62069340	142	-16.39
CAediting_1047317	chr15_62070335_+	ENSG00000198535.5	ENST00000355522	hsa-miR-5586-3p	62070332	62070338	7mer-m8	62070319	62070339	152	-18.86
CAediting_1047310	chr15_62069328_+	ENSG00000198535.5	ENST00000355522	hsa-miR-6504-3p	62069322	62069328	7mer-m8	62069308	62069329	141	-11.32
CAediting_1047317	chr15_62070335_+	ENSG00000198535.5	ENST00000355522	hsa-miR-759	62070333	62070339	7mer-m8	62070320	62070340	141	-14.61
CAediting_1047312	chr15_62069497_+	ENSG00000198535.5	ENST00000355522	hsa-miR-8079	62069492	62069498	7mer-m8	62069481	62069499	147	-13.75

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000198535.5	ENST00000355522	hsa-miR-624-3p	62069572	62069578	7mer-m8	62069559	62069579	146	-16
CAediting_393	chr1_1167164_+	ENSG00000198535.5	ENST00000355522	hsa-miR-200b-3p	62069727	62069733	7mer-m8	62069713	62069734	148	-11.56
CAediting_1229413	chr17_67471544_+	ENSG00000198535.5	ENST00000355522	hsa-miR-548aa	62070285	62070291	7mer-m8	62070268	62070292	140	-14.63
CAediting_396018	chr5_1062918_-	ENSG00000198535.5	ENST00000355522	hsa-miR-4635	62070792	62070798	7mer-m8	62070779	62070799	145	-13.7

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for C2CD4A

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for C2CD4A

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_1047317	chr15_62070335_+	3.18958344311927e-05	0.382287219553964	.	.	.	.
LUAD	CAediting_1047317	chr15_62070335_+	0.0393611500291311	0.178232724446438	.	.	.	.
LUSC	CAediting_1047317	chr15_62070335_+	0.00619393981222034	0.257173266019486	.	.	.	.
BRCA	CAediting_1047321	chr15_62070430_+	2.3227119684015e-08	0.38775950351658	.	.	.	.
LIHC	CAediting_1047321	chr15_62070430_+	3.69835574019318e-06	0.448172627439355	.	.	.	.
CESC	CAediting_1047321	chr15_62070430_+	0.0173549441506005	0.274036359066083	.	.	.	.
LUAD	CAediting_1047321	chr15_62070430_+	9.9552775813272e-12	0.430120193620798	.	.	.	.
COAD	CAediting_1047321	chr15_62070430_+	0.000112135323273369	0.30155029356848	0.0325454806520821	0.169634202865626	.	.
LUSC	CAediting_1047321	chr15_62070430_+	1.0257043936729e-05	0.3832672931437	.	.	.	.
STAD	CAediting_1047321	chr15_62070430_+	0.00982530622147879	0.198106901947802	.	.	.	.
THCA	CAediting_1047321	chr15_62070430_+	0.00204223362485838	0.222977560450761	.	.	.	.
UCEC	CAediting_1047321	chr15_62070430_+	0.012523378297257	0.20145194754333	.	.	.	.
ESCA	CAediting_1047321	chr15_62070430_+	8.76116759973641e-06	0.564462784116688	.	.	.	.
PAAD	CAediting_1047321	chr15_62070430_+	0.00493966653237876	0.380543388930189	.	.	.	.
PCPG	CAediting_1047321	chr15_62070430_+	5.50351289699246e-05	0.520347424012974	.	.	.	.

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Relation with cancer stages for C2CD4A

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
COAD	pathologic_stage	CAediting_1047317	chr15_62070335_+	0.0271927764961086	0.19918896790079
KIRP	pathologic_stage	CAediting_1047321	chr15_62070430_+	0.0336567934744216	0.301009230004838
PAAD	pathologic_stage	CAediting_1047321	chr15_62070430_+	0.0379776487477492	0.288624613493213

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Relation with survival for C2CD4A

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
COAD	CAediting_1047317	chr15_62070335_+	0.025425840665906	0.000649557	15962.4

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RelatedDrugs for C2CD4A

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for C2CD4A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
C2CD4A	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene