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Editing gene: CSK (CAeditome ID:1445)

Gene summary for CSK

Gene summary

Gene information	Gene symbol	CSK
	Gene ID	1445
	Gene name	C-terminal Src kinase
	Synonyms	-
	Cytomap	15q24.1
	Type of gene	protein-coding
	Description	tyrosine-protein kinase CSKC-Src kinaseCSK, non-receptor tyrosine kinasec-src tyrosine kinaseprotein-tyrosine kinase CYL
	Modification date	20210529
	UniProtAcc	P41240
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CSK	GO:0042997	Tyrosine-protein kinase CSK	20605918

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RNA A-to-I events for CSK

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000103653.15

RNA A-to-I editing events in Cancer.

CAediting_1060723(74795956, +), CAediting_1060724(74795963, +), CAediting_1060725(74795968, +), CAediting_1060726(74796040, +), CAediting_1060727(74796042, +), CAediting_1060728(74796059, +), CAediting_1060729(74796107, +), CAediting_1060730(74796111, +), CAediting_1060731(74796119, +), CAediting_1060732(74796120, +), CAediting_1060733(74796127, +), CAediting_1060734(74796130, +), CAediting_1060735(74796133, +), CAediting_1060736(74796139, +), CAediting_1060737(74796165, +), CAediting_1060738(74796166, +), CAediting_1060739(74796235, +), CAediting_1060740(74796487, +), CAediting_1060741(74796500, +), CAediting_1060742(74796515, +), CAediting_1060743(74796519, +), CAediting_1060744(74796539, +), CAediting_1060745(74796546, +), CAediting_1060746(74796549, +), CAediting_1060747(74796576, +), CAediting_1060748(74796972, +), CAediting_1060749(74796984, +), CAediting_1060750(74797015, +), CAediting_1060751(74797027, +), CAediting_1060752(74797041, +), CAediting_1060753(74797071, +), CAediting_1060754(74797081, +), CAediting_1060755(74797083, +), CAediting_1060756(74797084, +), CAediting_1060757(74797107, +), CAediting_1060758(74797108, +), CAediting_1060759(74797116, +), CAediting_1060760(74797122, +), CAediting_1060761(74797125, +), CAediting_1060762(74797142, +), CAediting_1060763(74797151, +), CAediting_1060764(74797197, +), CAediting_1060765(74797206, +), CAediting_1060766(74797207, +), CAediting_1060767(74797214, +), CAediting_1060768(74797219, +), CAediting_1060769(74797221, +), CAediting_1060770(74797241, +), CAediting_1060771(74797282, +), CAediting_1060772(74797300, +), CAediting_1060773(74797301, +), CAediting_1060774(74797306, +), CAediting_1060775(74797323, +), CAediting_1060776(74797403, +), CAediting_1060777(74797406, +), CAediting_1060778(74797409, +), CAediting_1060779(74797427, +), CAediting_1060780(74797435, +), CAediting_1060781(74797441, +), CAediting_1060782(74797445, +), CAediting_1060783(74797465, +), CAediting_1060784(74797489, +), CAediting_1060785(74797532, +),

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RNA editing positional annotations for CSK using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1060723	chr15_74795956_+	ncRNA_intronic
CAediting_1060724	chr15_74795963_+	ncRNA_intronic
CAediting_1060725	chr15_74795968_+	ncRNA_intronic
CAediting_1060726	chr15_74796040_+	ncRNA_intronic
CAediting_1060727	chr15_74796042_+	ncRNA_intronic
CAediting_1060728	chr15_74796059_+	ncRNA_intronic
CAediting_1060729	chr15_74796107_+	ncRNA_intronic
CAediting_1060730	chr15_74796111_+	ncRNA_intronic
CAediting_1060731	chr15_74796119_+	ncRNA_intronic
CAediting_1060732	chr15_74796120_+	ncRNA_intronic
CAediting_1060733	chr15_74796127_+	ncRNA_intronic
CAediting_1060734	chr15_74796130_+	ncRNA_intronic
CAediting_1060735	chr15_74796133_+	ncRNA_intronic
CAediting_1060736	chr15_74796139_+	ncRNA_intronic
CAediting_1060737	chr15_74796165_+	ncRNA_intronic
CAediting_1060738	chr15_74796166_+	ncRNA_intronic
CAediting_1060739	chr15_74796235_+	ncRNA_intronic
CAediting_1060740	chr15_74796487_+	ncRNA_intronic
CAediting_1060741	chr15_74796500_+	ncRNA_intronic
CAediting_1060742	chr15_74796515_+	ncRNA_intronic
CAediting_1060743	chr15_74796519_+	ncRNA_intronic
CAediting_1060744	chr15_74796539_+	ncRNA_intronic
CAediting_1060745	chr15_74796546_+	ncRNA_intronic
CAediting_1060746	chr15_74796549_+	ncRNA_intronic
CAediting_1060747	chr15_74796576_+	ncRNA_intronic
CAediting_1060748	chr15_74796972_+	ncRNA_intronic
CAediting_1060749	chr15_74796984_+	ncRNA_intronic
CAediting_1060750	chr15_74797015_+	ncRNA_intronic
CAediting_1060751	chr15_74797027_+	ncRNA_intronic
CAediting_1060752	chr15_74797041_+	ncRNA_intronic
CAediting_1060753	chr15_74797071_+	ncRNA_intronic
CAediting_1060754	chr15_74797081_+	ncRNA_intronic
CAediting_1060755	chr15_74797083_+	ncRNA_intronic
CAediting_1060756	chr15_74797084_+	ncRNA_intronic
CAediting_1060757	chr15_74797107_+	ncRNA_intronic
CAediting_1060758	chr15_74797108_+	ncRNA_intronic
CAediting_1060759	chr15_74797116_+	ncRNA_intronic
CAediting_1060760	chr15_74797122_+	ncRNA_intronic
CAediting_1060761	chr15_74797125_+	ncRNA_intronic
CAediting_1060762	chr15_74797142_+	ncRNA_intronic
CAediting_1060763	chr15_74797151_+	ncRNA_intronic
CAediting_1060764	chr15_74797197_+	ncRNA_intronic
CAediting_1060765	chr15_74797206_+	ncRNA_intronic
CAediting_1060766	chr15_74797207_+	ncRNA_intronic
CAediting_1060767	chr15_74797214_+	ncRNA_intronic
CAediting_1060768	chr15_74797219_+	ncRNA_intronic
CAediting_1060769	chr15_74797221_+	ncRNA_intronic
CAediting_1060770	chr15_74797241_+	ncRNA_intronic
CAediting_1060771	chr15_74797282_+	ncRNA_intronic
CAediting_1060772	chr15_74797300_+	ncRNA_intronic
CAediting_1060773	chr15_74797301_+	ncRNA_intronic
CAediting_1060774	chr15_74797306_+	ncRNA_intronic
CAediting_1060775	chr15_74797323_+	ncRNA_intronic
CAediting_1060776	chr15_74797403_+	ncRNA_intronic
CAediting_1060777	chr15_74797406_+	ncRNA_intronic
CAediting_1060778	chr15_74797409_+	ncRNA_intronic
CAediting_1060779	chr15_74797427_+	ncRNA_intronic
CAediting_1060780	chr15_74797435_+	ncRNA_intronic
CAediting_1060781	chr15_74797441_+	ncRNA_intronic
CAediting_1060782	chr15_74797445_+	ncRNA_intronic
CAediting_1060783	chr15_74797465_+	ncRNA_intronic
CAediting_1060784	chr15_74797489_+	ncRNA_intronic
CAediting_1060785	chr15_74797532_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1060723	chr15_74795956_+	SINE	Alu	AluSz6
CAediting_1060724	chr15_74795963_+	SINE	Alu	AluSz6
CAediting_1060725	chr15_74795968_+	SINE	Alu	AluSz6
CAediting_1060726	chr15_74796040_+	SINE	Alu	AluSz6
CAediting_1060727	chr15_74796042_+	SINE	Alu	AluSz6
CAediting_1060728	chr15_74796059_+	SINE	Alu	AluSz6
CAediting_1060729	chr15_74796107_+	SINE	Alu	AluSz6
CAediting_1060730	chr15_74796111_+	SINE	Alu	AluSz6
CAediting_1060731	chr15_74796119_+	SINE	Alu	AluSz6
CAediting_1060732	chr15_74796120_+	SINE	Alu	AluSz6
CAediting_1060733	chr15_74796127_+	SINE	Alu	AluSz6
CAediting_1060734	chr15_74796130_+	SINE	Alu	AluSz6
CAediting_1060735	chr15_74796133_+	SINE	Alu	AluSz6
CAediting_1060736	chr15_74796139_+	SINE	Alu	AluSz6
CAediting_1060737	chr15_74796165_+	SINE	Alu	AluSz6
CAediting_1060738	chr15_74796166_+	SINE	Alu	AluSz6
CAediting_1060739	chr15_74796235_+	SINE	Alu	AluSz6
CAediting_1060740	chr15_74796487_+	SINE	Alu	AluJo
CAediting_1060741	chr15_74796500_+	SINE	Alu	AluJo
CAediting_1060742	chr15_74796515_+	SINE	Alu	AluJo
CAediting_1060743	chr15_74796519_+	SINE	Alu	AluJo
CAediting_1060744	chr15_74796539_+	SINE	Alu	AluJo
CAediting_1060745	chr15_74796546_+	SINE	Alu	AluJo
CAediting_1060746	chr15_74796549_+	SINE	Alu	AluJo
CAediting_1060747	chr15_74796576_+	SINE	Alu	AluJo
CAediting_1060748	chr15_74796972_+	SINE	Alu	AluJb
CAediting_1060749	chr15_74796984_+	SINE	Alu	AluJb
CAediting_1060750	chr15_74797015_+	SINE	Alu	AluJb
CAediting_1060751	chr15_74797027_+	SINE	Alu	AluJb
CAediting_1060752	chr15_74797041_+	SINE	Alu	AluJb
CAediting_1060753	chr15_74797071_+	SINE	Alu	AluJb
CAediting_1060754	chr15_74797081_+	SINE	Alu	AluJb
CAediting_1060755	chr15_74797083_+	SINE	Alu	AluJb
CAediting_1060756	chr15_74797084_+	SINE	Alu	AluJb
CAediting_1060757	chr15_74797107_+	SINE	Alu	AluJb
CAediting_1060758	chr15_74797108_+	SINE	Alu	AluJb
CAediting_1060759	chr15_74797116_+	SINE	Alu	AluJb
CAediting_1060760	chr15_74797122_+	SINE	Alu	AluJb
CAediting_1060761	chr15_74797125_+	SINE	Alu	AluJb
CAediting_1060762	chr15_74797142_+	SINE	Alu	AluJb
CAediting_1060763	chr15_74797151_+	SINE	Alu	AluJb
CAediting_1060764	chr15_74797197_+	SINE	Alu	AluJb
CAediting_1060765	chr15_74797206_+	SINE	Alu	AluJb
CAediting_1060766	chr15_74797207_+	SINE	Alu	AluJb
CAediting_1060767	chr15_74797214_+	SINE	Alu	AluJb
CAediting_1060768	chr15_74797219_+	SINE	Alu	AluJb
CAediting_1060769	chr15_74797221_+	SINE	Alu	AluJb
CAediting_1060770	chr15_74797241_+	SINE	Alu	AluJb
CAediting_1060771	chr15_74797282_+	SINE	Alu	AluSx
CAediting_1060772	chr15_74797300_+	SINE	Alu	AluSx
CAediting_1060773	chr15_74797301_+	SINE	Alu	AluSx
CAediting_1060774	chr15_74797306_+	SINE	Alu	AluSx
CAediting_1060775	chr15_74797323_+	SINE	Alu	AluSx
CAediting_1060776	chr15_74797403_+	SINE	Alu	AluSx
CAediting_1060777	chr15_74797406_+	SINE	Alu	AluSx
CAediting_1060778	chr15_74797409_+	SINE	Alu	AluSx
CAediting_1060779	chr15_74797427_+	SINE	Alu	AluSx
CAediting_1060780	chr15_74797435_+	SINE	Alu	AluSx
CAediting_1060781	chr15_74797441_+	SINE	Alu	AluSx
CAediting_1060782	chr15_74797445_+	SINE	Alu	AluSx
CAediting_1060783	chr15_74797465_+	SINE	Alu	AluSx
CAediting_1060784	chr15_74797489_+	SINE	Alu	AluSx
CAediting_1060785	chr15_74797532_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for CSK

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103653.15.CSK.

Correlation between RNA A-to-I editing and PSI for ENSG00000103653.15.CSK.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CSK

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CSK

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CSK

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1351755	chr19_40282625_-	ENSG00000103653.15	ENST00000220003	hsa-miR-641	74803010	74803015	6mer	74802992	74803016	152	-20.07
CAediting_1351755	chr19_40282625_-	ENSG00000103653.15	ENST00000567571	hsa-miR-641	74803010	74803015	6mer	74802992	74803016	152	-20.07
CAediting_1524209	chrX_134546392_-	ENSG00000103653.15	ENST00000220003	hsa-miR-503-5p	74803105	74803112	8mer-1a	74803088	74803112	154	-23.8
CAediting_1524209	chrX_134546392_-	ENSG00000103653.15	ENST00000567571	hsa-miR-503-5p	74803105	74803112	8mer-1a	74803088	74803112	154	-23.8

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CSK

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CSK

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CSK

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CSK

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CSK

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CSK	P41240	DB01254	Dasatinib	Tyrosine-protein kinase CSK	SmallMoleculeDrug	approved\|investigational
CSK	P41240	DB12010	Fostamatinib	Tyrosine-protein kinase CSK	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for CSK

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CSK	C0020429	Hyperalgesia	1	CTD_human
CSK	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
CSK	C0242380	Libman-Sacks Disease	1	CTD_human
CSK	C0458247	Allodynia	1	CTD_human
CSK	C0751211	Hyperalgesia, Primary	1	CTD_human
CSK	C0751212	Hyperalgesia, Secondary	1	CTD_human
CSK	C0751213	Tactile Allodynia	1	CTD_human
CSK	C0751214	Hyperalgesia, Thermal	1	CTD_human
CSK	C2936719	Mechanical Allodynia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene