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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: STK35 (CAeditome ID:140901)

Gene summary for STK35

check button Gene summary
Gene informationGene symbol

STK35

Gene ID

140901

Gene nameserine/threonine kinase 35
SynonymsCLIK1|STK35L1
Cytomap

20p13

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase 35CLIK-1CLP-36 interacting kinaseCLP-36-interacting kinase 1PDLIM1-interacting kinase 1serine threonine kinase 35 long formserine/threonine-protein kinase 35 L1
Modification date20210518
UniProtAcc

Q8TDR2

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
STK35

GO:0005654

Serine/threonine-protein kinase 35

0000052

STK35

GO:0016604

Serine/threonine-protein kinase 35

0000052


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RNA A-to-I events for STK35

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000125834.11

check button RNA A-to-I editing events in Cancer.
CAediting_1399696(2117455, +), CAediting_1399697(2117457, +), CAediting_1399698(2117459, +), CAediting_1399699(2117467, +), CAediting_1399700(2117584, +), CAediting_1399701(2117628, +), CAediting_1399702(2117645, +), CAediting_1399703(2117719, +), CAediting_1399704(2118788, +), CAediting_1399705(2118827, +), CAediting_1399706(2118830, +), CAediting_1399707(2118837, +), CAediting_1399708(2118845, +), CAediting_1399709(2118852, +), CAediting_1399710(2118854, +), CAediting_1399711(2118857, +), CAediting_1399712(2118894, +), CAediting_1399713(2118910, +), CAediting_1399714(2118912, +), CAediting_1399715(2122063, +), CAediting_1399716(2122218, +), CAediting_1399717(2122252, +), CAediting_1399718(2122253, +), CAediting_1399719(2131130, +), CAediting_1399720(2131147, +), CAediting_1399721(2131197, +), CAediting_1399722(2131205, +), CAediting_1399723(2131217, +), CAediting_1399724(2131240, +), CAediting_1399725(2131242, +), CAediting_1399726(2131358, +), CAediting_1399727(2131380, +), CAediting_1399728(2131389, +), CAediting_1399729(2131394, +), CAediting_1399730(2142541, +), CAediting_1399731(2147823, +),

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RNA editing positional annotations for STK35 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1399696chr20_2117455_+intronic
CAediting_1399697chr20_2117457_+intronic
CAediting_1399698chr20_2117459_+intronic
CAediting_1399699chr20_2117467_+intronic
CAediting_1399700chr20_2117584_+intronic
CAediting_1399701chr20_2117628_+intronic
CAediting_1399702chr20_2117645_+intronic
CAediting_1399703chr20_2117719_+intronic
CAediting_1399704chr20_2118788_+intronic
CAediting_1399705chr20_2118827_+intronic
CAediting_1399706chr20_2118830_+intronic
CAediting_1399707chr20_2118837_+intronic
CAediting_1399708chr20_2118845_+intronic
CAediting_1399709chr20_2118852_+intronic
CAediting_1399710chr20_2118854_+intronic
CAediting_1399711chr20_2118857_+intronic
CAediting_1399712chr20_2118894_+intronic
CAediting_1399713chr20_2118910_+intronic
CAediting_1399714chr20_2118912_+intronic
CAediting_1399715chr20_2122063_+intronic
CAediting_1399716chr20_2122218_+intronic
CAediting_1399717chr20_2122252_+intronic
CAediting_1399718chr20_2122253_+intronic
CAediting_1399719chr20_2131130_+intronic
CAediting_1399720chr20_2131147_+intronic
CAediting_1399721chr20_2131197_+intronic
CAediting_1399722chr20_2131205_+intronic
CAediting_1399723chr20_2131217_+intronic
CAediting_1399724chr20_2131240_+intronic
CAediting_1399725chr20_2131242_+intronic
CAediting_1399726chr20_2131358_+intronic
CAediting_1399727chr20_2131380_+intronic
CAediting_1399728chr20_2131389_+intronic
CAediting_1399729chr20_2131394_+intronic
CAediting_1399730chr20_2142541_+intronic
CAediting_1399731chr20_2147823_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1399696chr20_2117455_+SINEAluAluSx1
CAediting_1399697chr20_2117457_+SINEAluAluSx1
CAediting_1399698chr20_2117459_+SINEAluAluSx1
CAediting_1399699chr20_2117467_+SINEAluAluSx1
CAediting_1399700chr20_2117584_+SINEAluAluSx1
CAediting_1399701chr20_2117628_+SINEAluAluSx1
CAediting_1399702chr20_2117645_+SINEAluAluSx1
CAediting_1399703chr20_2117719_+SINEAluAluSx1
CAediting_1399704chr20_2118788_+DNATcMar-TiggerTigger3a
CAediting_1399705chr20_2118827_+DNATcMar-TiggerTigger3a
CAediting_1399706chr20_2118830_+DNATcMar-TiggerTigger3a
CAediting_1399707chr20_2118837_+DNATcMar-TiggerTigger3a
CAediting_1399708chr20_2118845_+DNATcMar-TiggerTigger3a
CAediting_1399709chr20_2118852_+DNATcMar-TiggerTigger3a
CAediting_1399710chr20_2118854_+DNATcMar-TiggerTigger3a
CAediting_1399711chr20_2118857_+DNATcMar-TiggerTigger3a
CAediting_1399712chr20_2118894_+DNATcMar-TiggerTigger3a
CAediting_1399713chr20_2118910_+DNATcMar-TiggerTigger3a
CAediting_1399714chr20_2118912_+DNATcMar-TiggerTigger3a
CAediting_1399715chr20_2122063_+SINEAluAluSz
CAediting_1399716chr20_2122218_+SINEAluAluSz
CAediting_1399717chr20_2122252_+SINEAluAluSz
CAediting_1399718chr20_2122253_+SINEAluAluSz
CAediting_1399719chr20_2131130_+DNATcMar-TiggerTigger3
CAediting_1399720chr20_2131147_+DNATcMar-TiggerTigger3
CAediting_1399721chr20_2131197_+DNATcMar-TiggerTigger3
CAediting_1399722chr20_2131205_+DNATcMar-TiggerTigger3
CAediting_1399723chr20_2131217_+DNATcMar-TiggerTigger3
CAediting_1399724chr20_2131240_+DNATcMar-TiggerTigger3
CAediting_1399725chr20_2131242_+DNATcMar-TiggerTigger3
CAediting_1399726chr20_2131358_+SINEAluAluJo
CAediting_1399727chr20_2131380_+SINEAluAluJo
CAediting_1399728chr20_2131389_+SINEAluAluJo
CAediting_1399729chr20_2131394_+SINEAluAluJo
CAediting_1399730chr20_2142541_+SINEAluAluJr

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RNA A-to-I editing events in the alternative splicing sites for STK35

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000125834.11.STK35.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000125834.11.STK35.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STK35

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for STK35

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for STK35

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000125834.11ENST00000381482hsa-miR-605-3p214493721449448mer-1a21449232144944140-14.11
CAediting_748296chr10_51299626_+ENSG00000125834.11ENST00000381482hsa-miR-605-3p214797521479828mer-1a21479612147982142-15.7
CAediting_980496chr14_31014685_-ENSG00000125834.11ENST00000381482hsa-miR-624-3p214705821470647mer-m821470472147065151-11.73
CAediting_980496chr14_31014685_-ENSG00000125834.11ENST00000381482hsa-miR-624-3p214721721472237mer-m821472062147224147-18.09
CAediting_1054808chr15_66496985_-ENSG00000125834.11ENST00000381482hsa-miR-4512214714821471547mer-1a21471332147154148-24.74
CAediting_1229415chr17_67471547_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214847821484836mer21484602148484147-13.44
CAediting_1160181chr17_7017644_-ENSG00000125834.11ENST00000381482hsa-miR-195-3p214781321478186mer21477992147819150-18.15
CAediting_228905chr2_188297554_+ENSG00000125834.11ENST00000381482hsa-miR-561-3p214461721446237mer-m821446032144624140-6.49
CAediting_414656chr5_72878640_+ENSG00000125834.11ENST00000381482hsa-miR-4804-3p214489121448977mer-m821448782144898144-14.93
CAediting_1368054chr19_46709310_-ENSG00000125834.11ENST00000493263hsa-miR-320e217699321769997mer-m821769832177000147-16.21
CAediting_604450chr7_133034877_-ENSG00000125834.11ENST00000493263hsa-miR-3654217699121769977mer-m821769802176998140-17.88
CAediting_468389chr6_31355314_-ENSG00000125834.11ENST00000381482hsa-miR-6891-5p214725621472627mer-m821472462147263143-24.89
CAediting_468389chr6_31355314_-ENSG00000125834.11ENST00000381482hsa-miR-6891-5p214381621438216mer21438032143822140-21.04

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000125834.11ENST00000381482hsa-miR-320e214630321463097mer-m821462942146310146-16.31
CAediting_688080chr9_63819626_+ENSG00000125834.11ENST00000381482hsa-miR-4477b214731121473177mer-m821472992147318148-11.37
CAediting_688081chr9_63819627_+ENSG00000125834.11ENST00000381482hsa-miR-4477b214731121473177mer-m821472992147318148-11.37
CAediting_1054808chr15_66496985_-ENSG00000125834.11ENST00000381482hsa-miR-4512214561221456187mer-m821456002145619147-19.67
CAediting_1229413chr17_67471544_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214652821465347mer-m821465082146535145-10.14
CAediting_1229414chr17_67471546_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214652821465347mer-m821465082146535145-10.14
CAediting_1229415chr17_67471547_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214652821465347mer-m821465082146535145-10.14
CAediting_1229413chr17_67471544_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214772321477297mer-m821477042147730142-8.22
CAediting_1229414chr17_67471546_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214772321477297mer-m821477042147730142-8.22
CAediting_1229415chr17_67471547_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214772321477297mer-m821477042147730142-8.22
CAediting_1229413chr17_67471544_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214811821481247mer-m821481012148125140-11.65
CAediting_1229414chr17_67471546_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214811821481247mer-m821481012148125140-11.65
CAediting_1229415chr17_67471547_+ENSG00000125834.11ENST00000381482hsa-miR-548aa214811821481247mer-m821481012148125140-11.65
CAediting_228905chr2_188297554_+ENSG00000125834.11ENST00000381482hsa-miR-561-3p214555121455577mer-m821455402145558142-3.42
CAediting_580943chr7_100356700_+ENSG00000125834.11ENST00000381482hsa-miR-6840-3p214777021477778mer-1a21477512147777150-28.25
CAediting_468389chr6_31355314_-ENSG00000125834.11ENST00000381482hsa-miR-6891-5p214712521471328mer-1a21471142147132140-17.67

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for STK35

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for STK35

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_1399731chr20_2147823_+0.002216629712619590.331315347261525....
BRCACAediting_1399731chr20_2147823_+3.93076422684991e-070.299110739783567....
LIHCCAediting_1399731chr20_2147823_+0.02771381791331250.21591327148468....
LUADCAediting_1399731chr20_2147823_+4.08985448610858e-070.437868548725307....
LUSCCAediting_1399731chr20_2147823_+5.01301667818228e-060.480093053830847....
UCECCAediting_1399731chr20_2147823_+0.004339645489016680.306438569936573....
PCPGCAediting_1399731chr20_2147823_+0.004246609477192350.328687051499054....

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Relation with cancer stages for STK35

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
KIRCpathologic_stageCAediting_1399731chr20_2147823_+0.03326491784899580.221005196167431

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Relation with survival for STK35

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LIHCCAediting_1399731chr20_2147823_+0.002202137478034770.002889046773.17
KIRCCAediting_1399731chr20_2147823_+0.023112276071050.008616637797.22

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RelatedDrugs for STK35

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
STK35Q8TDR2DB12010FostamatinibSerine/threonine-protein kinase 35 SmallMoleculeDrugapproved|investigational

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RelatedDiseases for STK35

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource