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Editing gene: SMCR8 (CAeditome ID:140775)

Gene summary for SMCR8

Gene summary

Gene information	Gene symbol	SMCR8
	Gene ID	140775
	Gene name	SMCR8-C9orf72 complex subunit
	Synonyms	DENND8A
	Cytomap	17p11.2
	Type of gene	protein-coding
	Description	guanine nucleotide exchange protein SMCR8Smith-Magenis syndrome chromosome region, candidate 8smith-Magenis syndrome chromosomal region candidate gene 8 protein
	Modification date	20210518
	UniProtAcc	Q8TEV9
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SMCR8	GO:0005085	Guanine nucleotide exchange protein SMCR8	27103069
SMCR8	GO:0005085	Guanine nucleotide exchange protein SMCR8	27103069
SMCR8	GO:0005085	Guanine nucleotide exchange protein SMCR8	27617292
SMCR8	GO:0000785	Guanine nucleotide exchange protein SMCR8	28195531
SMCR8	GO:0005654	Guanine nucleotide exchange protein SMCR8	0000052
SMCR8	GO:0005654	Guanine nucleotide exchange protein SMCR8	28195531
SMCR8	GO:0005737	Guanine nucleotide exchange protein SMCR8	27193190
SMCR8	GO:0005737	Guanine nucleotide exchange protein SMCR8	28195531
SMCR8	GO:0032045	Guanine nucleotide exchange protein SMCR8	27103069
SMCR8	GO:1990316	Guanine nucleotide exchange protein SMCR8	28195531

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RNA A-to-I events for SMCR8

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000176994.10

RNA A-to-I editing events in Cancer.

CAediting_1167949(18317462, +), CAediting_1167950(18318521, +), CAediting_1167951(18318543, +), CAediting_1167952(18318587, +), CAediting_1167953(18319814, +), CAediting_1167954(18319838, +), CAediting_1167955(18319850, +), CAediting_1167956(18319904, +), CAediting_1167957(18319910, +), CAediting_1167958(18319959, +), CAediting_1167959(18319972, +), CAediting_1167960(18321584, +), CAediting_1167961(18321585, +), CAediting_1167962(18321606, +), CAediting_1167963(18321638, +), CAediting_1167964(18321658, +), CAediting_1167965(18321662, +), CAediting_1167966(18321718, +), CAediting_1167967(18321728, +), CAediting_1167968(18321733, +), CAediting_1167969(18321734, +), CAediting_1167970(18321802, +), CAediting_1167971(18322129, +), CAediting_1167972(18322218, +), CAediting_1167973(18322273, +), CAediting_1167974(18322285, +), CAediting_1167975(18325805, +), CAediting_1167976(18325813, +), CAediting_1167977(18325853, +), CAediting_1167978(18325859, +), CAediting_1167979(18325861, +), CAediting_1167980(18325873, +), CAediting_1167981(18325876, +), CAediting_1167982(18325883, +), CAediting_1167983(18325884, +), CAediting_1167984(18325889, +), CAediting_1167985(18325916, +), CAediting_1167986(18325920, +), CAediting_1167987(18325943, +), CAediting_1167988(18325952, +), CAediting_1167989(18325969, +), CAediting_1167990(18325972, +), CAediting_1167991(18325978, +), CAediting_1167992(18325984, +), CAediting_1167993(18325988, +), CAediting_1167994(18325995, +), CAediting_1167995(18326002, +), CAediting_1167996(18326033, +),

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RNA editing positional annotations for SMCR8 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1167949	chr17_18317462_+	exonic
CAediting_1167950	chr17_18318521_+	intronic
CAediting_1167951	chr17_18318543_+	intronic
CAediting_1167952	chr17_18318587_+	intronic
CAediting_1167953	chr17_18319814_+	intronic
CAediting_1167954	chr17_18319838_+	intronic
CAediting_1167955	chr17_18319850_+	intronic
CAediting_1167956	chr17_18319904_+	intronic
CAediting_1167957	chr17_18319910_+	intronic
CAediting_1167958	chr17_18319959_+	intronic
CAediting_1167959	chr17_18319972_+	intronic
CAediting_1167960	chr17_18321584_+	intronic
CAediting_1167961	chr17_18321585_+	intronic
CAediting_1167962	chr17_18321606_+	intronic
CAediting_1167963	chr17_18321638_+	intronic
CAediting_1167964	chr17_18321658_+	intronic
CAediting_1167965	chr17_18321662_+	intronic
CAediting_1167966	chr17_18321718_+	intronic
CAediting_1167967	chr17_18321728_+	intronic
CAediting_1167968	chr17_18321733_+	intronic
CAediting_1167969	chr17_18321734_+	intronic
CAediting_1167970	chr17_18321802_+	intronic
CAediting_1167971	chr17_18322129_+	intronic
CAediting_1167972	chr17_18322218_+	intronic
CAediting_1167973	chr17_18322273_+	intronic
CAediting_1167974	chr17_18322285_+	intronic
CAediting_1167975	chr17_18325805_+	UTR3
CAediting_1167976	chr17_18325813_+	UTR3
CAediting_1167977	chr17_18325853_+	UTR3
CAediting_1167978	chr17_18325859_+	UTR3
CAediting_1167979	chr17_18325861_+	UTR3
CAediting_1167980	chr17_18325873_+	UTR3
CAediting_1167981	chr17_18325876_+	UTR3
CAediting_1167982	chr17_18325883_+	UTR3
CAediting_1167983	chr17_18325884_+	UTR3
CAediting_1167984	chr17_18325889_+	UTR3
CAediting_1167985	chr17_18325916_+	UTR3
CAediting_1167986	chr17_18325920_+	UTR3
CAediting_1167987	chr17_18325943_+	UTR3
CAediting_1167988	chr17_18325952_+	UTR3
CAediting_1167989	chr17_18325969_+	UTR3
CAediting_1167990	chr17_18325972_+	UTR3
CAediting_1167991	chr17_18325978_+	UTR3
CAediting_1167992	chr17_18325984_+	UTR3
CAediting_1167993	chr17_18325988_+	UTR3
CAediting_1167994	chr17_18325995_+	UTR3
CAediting_1167995	chr17_18326002_+	UTR3
CAediting_1167996	chr17_18326033_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1167950	chr17_18318521_+	SINE	Alu	AluSq10
CAediting_1167951	chr17_18318543_+	SINE	Alu	AluSq10
CAediting_1167952	chr17_18318587_+	SINE	Alu	AluSq10
CAediting_1167953	chr17_18319814_+	SINE	Alu	AluSg
CAediting_1167954	chr17_18319838_+	SINE	Alu	AluSg
CAediting_1167955	chr17_18319850_+	SINE	Alu	AluSg
CAediting_1167956	chr17_18319904_+	SINE	Alu	AluSg
CAediting_1167957	chr17_18319910_+	SINE	Alu	AluSg
CAediting_1167958	chr17_18319959_+	SINE	Alu	AluSg
CAediting_1167959	chr17_18319972_+	SINE	Alu	AluSg
CAediting_1167960	chr17_18321584_+	SINE	Alu	AluJo
CAediting_1167961	chr17_18321585_+	SINE	Alu	AluJo
CAediting_1167962	chr17_18321606_+	SINE	Alu	AluJo
CAediting_1167963	chr17_18321638_+	SINE	Alu	AluJo
CAediting_1167964	chr17_18321658_+	SINE	Alu	AluJo
CAediting_1167965	chr17_18321662_+	SINE	Alu	AluJo
CAediting_1167966	chr17_18321718_+	SINE	Alu	AluJo
CAediting_1167967	chr17_18321728_+	SINE	Alu	AluJo
CAediting_1167968	chr17_18321733_+	SINE	Alu	AluJo
CAediting_1167969	chr17_18321734_+	SINE	Alu	AluJo
CAediting_1167970	chr17_18321802_+	SINE	Alu	AluJo
CAediting_1167971	chr17_18322129_+	SINE	Alu	AluY
CAediting_1167972	chr17_18322218_+	SINE	Alu	AluY
CAediting_1167973	chr17_18322273_+	SINE	Alu	AluY
CAediting_1167974	chr17_18322285_+	SINE	Alu	AluY
CAediting_1167975	chr17_18325805_+	SINE	Alu	AluSq
CAediting_1167976	chr17_18325813_+	SINE	Alu	AluSq
CAediting_1167977	chr17_18325853_+	SINE	Alu	AluSq
CAediting_1167978	chr17_18325859_+	SINE	Alu	AluSq
CAediting_1167979	chr17_18325861_+	SINE	Alu	AluSq
CAediting_1167980	chr17_18325873_+	SINE	Alu	AluSq
CAediting_1167981	chr17_18325876_+	SINE	Alu	AluSq
CAediting_1167982	chr17_18325883_+	SINE	Alu	AluSq
CAediting_1167983	chr17_18325884_+	SINE	Alu	AluSq
CAediting_1167984	chr17_18325889_+	SINE	Alu	AluSq
CAediting_1167985	chr17_18325916_+	SINE	Alu	AluSq
CAediting_1167986	chr17_18325920_+	SINE	Alu	AluSq
CAediting_1167987	chr17_18325943_+	SINE	Alu	AluSq
CAediting_1167988	chr17_18325952_+	SINE	Alu	AluSq
CAediting_1167989	chr17_18325969_+	SINE	Alu	AluSq
CAediting_1167990	chr17_18325972_+	SINE	Alu	AluSq
CAediting_1167991	chr17_18325978_+	SINE	Alu	AluSq
CAediting_1167992	chr17_18325984_+	SINE	Alu	AluSq
CAediting_1167993	chr17_18325988_+	SINE	Alu	AluSq
CAediting_1167994	chr17_18325995_+	SINE	Alu	AluSq
CAediting_1167995	chr17_18326002_+	SINE	Alu	AluSq
CAediting_1167996	chr17_18326033_+	SINE	Alu	AluSq

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RNA A-to-I editing events in the alternative splicing sites for SMCR8

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000176994.10.SMCR8.

Correlation between RNA A-to-I editing and PSI for ENSG00000176994.10.SMCR8.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SMCR8

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SMCR8

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SMCR8

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SMCR8

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for SMCR8

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SMCR8

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SMCR8

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SMCR8

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SMCR8

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene