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Editing gene: COX7A2 (CAeditome ID:1347)

Gene summary for COX7A2

Gene summary

Gene information	Gene symbol	COX7A2
	Gene ID	1347
	Gene name	cytochrome c oxidase subunit 7A2
	Synonyms	COX7AL\|COX7AL1\|COXVIIAL\|COXVIIa-L\|VIIAL
	Cytomap	6q14.1
	Type of gene	protein-coding
	Description	cytochrome c oxidase subunit 7A2, mitochondrialcytochrome c oxidase polypeptide 7A2, mitochondrialcytochrome c oxidase polypeptide VIIa-liver/heartcytochrome c oxidase subunit VIIa polypeptide 2 (liver)cytochrome c oxidase subunit VIIa-Lcytochrome c
	Modification date	20210518
	UniProtAcc	P14406
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for COX7A2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000112695.10

RNA A-to-I editing events in Cancer.

CAediting_490248(75238451, -), CAediting_490249(75238463, -), CAediting_490250(75238491, -), CAediting_490251(75238503, -), CAediting_490252(75238555, -), CAediting_490253(75238582, -), CAediting_490254(75238592, -), CAediting_490255(75238622, -), CAediting_490256(75238628, -), CAediting_490257(75238641, -), CAediting_490258(75238657, -), CAediting_490259(75238817, -), CAediting_490260(75238831, -), CAediting_490261(75238833, -), CAediting_490262(75238838, -), CAediting_490263(75238849, -), CAediting_490264(75238851, -), CAediting_490265(75238881, -), CAediting_490266(75238883, -), CAediting_490267(75238905, -), CAediting_490268(75238911, -), CAediting_490269(75238912, -), CAediting_490270(75238923, -), CAediting_490271(75238926, -), CAediting_490272(75238930, -), CAediting_490273(75238935, -), CAediting_490274(75238936, -), CAediting_490275(75238943, -), CAediting_490276(75238947, -), CAediting_490277(75238953, -), CAediting_490278(75238959, -), CAediting_490279(75238963, -), CAediting_490280(75238968, -), CAediting_490281(75238982, -), CAediting_490282(75238983, -), CAediting_490283(75238984, -), CAediting_490284(75238985, -), CAediting_490285(75238986, -), CAediting_490286(75238991, -), CAediting_490287(75238992, -), CAediting_490288(75238993, -), CAediting_490289(75238994, -), CAediting_490290(75239008, -), CAediting_490291(75239009, -), CAediting_490292(75239010, -), CAediting_490293(75239016, -), CAediting_490294(75239031, -), CAediting_490295(75239033, -), CAediting_490296(75239034, -), CAediting_490297(75239042, -), CAediting_490298(75239052, -), CAediting_490299(75239057, -), CAediting_490300(75239087, -), CAediting_490301(75239088, -), CAediting_490302(75239096, -), CAediting_490303(75239115, -), CAediting_490304(75239836, -), CAediting_490305(75239857, -), CAediting_490306(75239858, -), CAediting_490307(75239859, -), CAediting_490308(75239867, -), CAediting_490309(75239890, -), CAediting_490310(75239897, -), CAediting_490311(75239936, -), CAediting_490312(75239945, -), CAediting_490313(75239979, -), CAediting_490314(75239989, -), CAediting_490315(75239992, -), CAediting_490316(75240001, -), CAediting_490317(75240018, -), CAediting_490318(75240019, -), CAediting_490319(75240062, -), CAediting_490320(75240063, -), CAediting_490321(75240075, -),

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RNA editing positional annotations for COX7A2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_490248	chr6_75238451_-	intronic
CAediting_490249	chr6_75238463_-	intronic
CAediting_490250	chr6_75238491_-	intronic
CAediting_490251	chr6_75238503_-	intronic
CAediting_490252	chr6_75238555_-	intronic
CAediting_490253	chr6_75238582_-	intronic
CAediting_490254	chr6_75238592_-	intronic
CAediting_490255	chr6_75238622_-	intronic
CAediting_490256	chr6_75238628_-	intronic
CAediting_490257	chr6_75238641_-	intronic
CAediting_490258	chr6_75238657_-	intronic
CAediting_490259	chr6_75238817_-	intronic
CAediting_490260	chr6_75238831_-	intronic
CAediting_490261	chr6_75238833_-	intronic
CAediting_490262	chr6_75238838_-	intronic
CAediting_490263	chr6_75238849_-	intronic
CAediting_490264	chr6_75238851_-	intronic
CAediting_490265	chr6_75238881_-	intronic
CAediting_490266	chr6_75238883_-	intronic
CAediting_490267	chr6_75238905_-	intronic
CAediting_490268	chr6_75238911_-	intronic
CAediting_490269	chr6_75238912_-	intronic
CAediting_490270	chr6_75238923_-	intronic
CAediting_490271	chr6_75238926_-	intronic
CAediting_490272	chr6_75238930_-	intronic
CAediting_490273	chr6_75238935_-	intronic
CAediting_490274	chr6_75238936_-	intronic
CAediting_490275	chr6_75238943_-	intronic
CAediting_490276	chr6_75238947_-	intronic
CAediting_490277	chr6_75238953_-	intronic
CAediting_490278	chr6_75238959_-	intronic
CAediting_490279	chr6_75238963_-	intronic
CAediting_490280	chr6_75238968_-	intronic
CAediting_490281	chr6_75238982_-	intronic
CAediting_490282	chr6_75238983_-	intronic
CAediting_490283	chr6_75238984_-	intronic
CAediting_490284	chr6_75238985_-	intronic
CAediting_490285	chr6_75238986_-	intronic
CAediting_490286	chr6_75238991_-	intronic
CAediting_490287	chr6_75238992_-	intronic
CAediting_490288	chr6_75238993_-	intronic
CAediting_490289	chr6_75238994_-	intronic
CAediting_490290	chr6_75239008_-	intronic
CAediting_490291	chr6_75239009_-	intronic
CAediting_490292	chr6_75239010_-	intronic
CAediting_490293	chr6_75239016_-	intronic
CAediting_490294	chr6_75239031_-	intronic
CAediting_490295	chr6_75239033_-	intronic
CAediting_490296	chr6_75239034_-	intronic
CAediting_490297	chr6_75239042_-	intronic
CAediting_490298	chr6_75239052_-	intronic
CAediting_490299	chr6_75239057_-	intronic
CAediting_490300	chr6_75239087_-	intronic
CAediting_490301	chr6_75239088_-	intronic
CAediting_490302	chr6_75239096_-	intronic
CAediting_490303	chr6_75239115_-	intronic
CAediting_490304	chr6_75239836_-	intronic
CAediting_490305	chr6_75239857_-	intronic
CAediting_490306	chr6_75239858_-	intronic
CAediting_490307	chr6_75239859_-	intronic
CAediting_490308	chr6_75239867_-	intronic
CAediting_490309	chr6_75239890_-	intronic
CAediting_490310	chr6_75239897_-	intronic
CAediting_490311	chr6_75239936_-	intronic
CAediting_490312	chr6_75239945_-	intronic
CAediting_490313	chr6_75239979_-	intronic
CAediting_490314	chr6_75239989_-	intronic
CAediting_490315	chr6_75239992_-	intronic
CAediting_490316	chr6_75240001_-	intronic
CAediting_490317	chr6_75240018_-	intronic
CAediting_490318	chr6_75240019_-	intronic
CAediting_490319	chr6_75240062_-	intronic
CAediting_490320	chr6_75240063_-	intronic
CAediting_490321	chr6_75240075_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_490248	chr6_75238451_-	SINE	Alu	AluSp
CAediting_490249	chr6_75238463_-	SINE	Alu	AluSp
CAediting_490250	chr6_75238491_-	SINE	Alu	AluSp
CAediting_490251	chr6_75238503_-	SINE	Alu	AluSp
CAediting_490252	chr6_75238555_-	SINE	Alu	AluSp
CAediting_490253	chr6_75238582_-	SINE	Alu	AluSp
CAediting_490254	chr6_75238592_-	SINE	Alu	AluSp
CAediting_490255	chr6_75238622_-	SINE	Alu	AluSp
CAediting_490256	chr6_75238628_-	SINE	Alu	AluSp
CAediting_490257	chr6_75238641_-	SINE	Alu	AluSp
CAediting_490258	chr6_75238657_-	SINE	Alu	AluSp
CAediting_490259	chr6_75238817_-	SINE	Alu	AluSx
CAediting_490260	chr6_75238831_-	SINE	Alu	AluSx
CAediting_490261	chr6_75238833_-	SINE	Alu	AluSx
CAediting_490262	chr6_75238838_-	SINE	Alu	AluSx
CAediting_490263	chr6_75238849_-	SINE	Alu	AluSx
CAediting_490264	chr6_75238851_-	SINE	Alu	AluSx
CAediting_490265	chr6_75238881_-	SINE	Alu	AluSx
CAediting_490266	chr6_75238883_-	SINE	Alu	AluSx
CAediting_490267	chr6_75238905_-	SINE	Alu	AluSx
CAediting_490268	chr6_75238911_-	SINE	Alu	AluSx
CAediting_490269	chr6_75238912_-	SINE	Alu	AluSx
CAediting_490270	chr6_75238923_-	SINE	Alu	AluSx
CAediting_490271	chr6_75238926_-	SINE	Alu	AluSx
CAediting_490272	chr6_75238930_-	SINE	Alu	AluSx
CAediting_490273	chr6_75238935_-	SINE	Alu	AluSx
CAediting_490274	chr6_75238936_-	SINE	Alu	AluSx
CAediting_490275	chr6_75238943_-	SINE	Alu	AluSx
CAediting_490276	chr6_75238947_-	SINE	Alu	AluSx
CAediting_490277	chr6_75238953_-	SINE	Alu	AluSx
CAediting_490278	chr6_75238959_-	SINE	Alu	AluSx
CAediting_490279	chr6_75238963_-	SINE	Alu	AluSx
CAediting_490280	chr6_75238968_-	SINE	Alu	AluSx
CAediting_490281	chr6_75238982_-	SINE	Alu	AluSx
CAediting_490282	chr6_75238983_-	SINE	Alu	AluSx
CAediting_490283	chr6_75238984_-	SINE	Alu	AluSx
CAediting_490284	chr6_75238985_-	SINE	Alu	AluSx
CAediting_490285	chr6_75238986_-	SINE	Alu	AluSx
CAediting_490286	chr6_75238991_-	SINE	Alu	AluSx
CAediting_490287	chr6_75238992_-	SINE	Alu	AluSx
CAediting_490288	chr6_75238993_-	SINE	Alu	AluSx
CAediting_490289	chr6_75238994_-	SINE	Alu	AluSx
CAediting_490290	chr6_75239008_-	SINE	Alu	AluSx
CAediting_490291	chr6_75239009_-	SINE	Alu	AluSx
CAediting_490292	chr6_75239010_-	SINE	Alu	AluSx
CAediting_490293	chr6_75239016_-	SINE	Alu	AluSx
CAediting_490294	chr6_75239031_-	SINE	Alu	AluSx
CAediting_490295	chr6_75239033_-	SINE	Alu	AluSx
CAediting_490296	chr6_75239034_-	SINE	Alu	AluSx
CAediting_490297	chr6_75239042_-	SINE	Alu	AluSx
CAediting_490298	chr6_75239052_-	SINE	Alu	AluSx
CAediting_490299	chr6_75239057_-	SINE	Alu	AluSx
CAediting_490300	chr6_75239087_-	SINE	Alu	AluSx
CAediting_490301	chr6_75239088_-	SINE	Alu	AluSx
CAediting_490302	chr6_75239096_-	SINE	Alu	AluSx
CAediting_490304	chr6_75239836_-	SINE	Alu	AluSp
CAediting_490305	chr6_75239857_-	SINE	Alu	AluSp
CAediting_490306	chr6_75239858_-	SINE	Alu	AluSp
CAediting_490307	chr6_75239859_-	SINE	Alu	AluSp
CAediting_490308	chr6_75239867_-	SINE	Alu	AluSp
CAediting_490309	chr6_75239890_-	SINE	Alu	AluSp
CAediting_490310	chr6_75239897_-	SINE	Alu	AluSp
CAediting_490311	chr6_75239936_-	SINE	Alu	AluSp
CAediting_490312	chr6_75239945_-	SINE	Alu	AluSp
CAediting_490313	chr6_75239979_-	SINE	Alu	AluSp
CAediting_490314	chr6_75239989_-	SINE	Alu	AluSp
CAediting_490315	chr6_75239992_-	SINE	Alu	AluSp
CAediting_490316	chr6_75240001_-	SINE	Alu	AluSp
CAediting_490317	chr6_75240018_-	SINE	Alu	AluSp
CAediting_490318	chr6_75240019_-	SINE	Alu	AluSp
CAediting_490319	chr6_75240062_-	SINE	Alu	AluSp
CAediting_490320	chr6_75240063_-	SINE	Alu	AluSp
CAediting_490321	chr6_75240075_-	SINE	Alu	AluSp

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RNA A-to-I editing events in the alternative splicing sites for COX7A2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_490255	chr6_75238622_-	75238620:75238628	5SS	0+4i	AGGTTCAAG	-12.66	AGGTTCGAG	-17.82
ES	CAediting_490256	chr6_75238628_-	75238620:75238628	5SS	3+0i	AGGTTCAAG	-12.66	GGGTTCAAG	-15.39

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000112695.10.COX7A2.

Correlation between RNA A-to-I editing and PSI for ENSG00000112695.10.COX7A2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for COX7A2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for COX7A2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for COX7A2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000112695.10	ENST00000459637	hsa-miR-605-3p	75240335	75240341	7mer-m8	75240334	75240355	143	-15.08

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for COX7A2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for COX7A2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
KIRP	CAediting_490271	chr6_75238926_-	.	.	0.0231773151442634	0.285784420332352	0.0198895988667782	0.292757202690276
LUSC	CAediting_490275	chr6_75238943_-	.	.	.	.	0.0258875713725015	0.308864492265813
STAD	CAediting_490275	chr6_75238943_-	.	.	0.0486525682599773	0.264718933036264	.	.
KIRP	CAediting_490279	chr6_75238963_-	0.0201465981077497	0.27724775096866	.	.	.	.
BRCA	CAediting_490280	chr6_75238968_-	0.0395756293388376	0.289178479663853	.	.	.	.

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Relation with cancer stages for COX7A2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_490279	chr6_75238963_-	0.0243768517426185	0.27906163744852
LUSC	pathologic_stage	CAediting_490279	chr6_75238963_-	0.0185374217210328	0.275007106247698
UCEC	clinical_stage	CAediting_490275	chr6_75238943_-	0.0487503801756094	-0.269508596143501

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Relation with survival for COX7A2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for COX7A2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for COX7A2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene