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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: EMB (CAeditome ID:133418)

Gene summary for EMB

check button Gene summary
Gene informationGene symbol

EMB

Gene ID

133418

Gene nameembigin
SynonymsGP70
Cytomap

5q11.1

Type of geneprotein-coding
Descriptionembiginembigin homolog
Modification date20210518
UniProtAcc

Q6PCB8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for EMB

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000170571.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_406414(50413578, -), CAediting_406415(50413586, -), CAediting_406416(50413591, -), CAediting_406417(50413592, -), CAediting_406418(50413597, -), CAediting_406419(50413603, -), CAediting_406420(50413641, -), CAediting_406421(50413643, -), CAediting_406422(50413648, -), CAediting_406423(50413652, -), CAediting_406424(50413659, -), CAediting_406425(50413672, -), CAediting_406426(50413687, -), CAediting_406427(50413708, -), CAediting_406428(50413713, -), CAediting_406429(50413714, -), CAediting_406430(50413724, -), CAediting_406431(50413740, -), CAediting_406432(50413744, -), CAediting_406433(50413749, -), CAediting_406434(50413755, -), CAediting_406435(50413757, -), CAediting_406436(50413771, -), CAediting_406437(50413772, -), CAediting_406438(50413781, -), CAediting_406439(50413782, -), CAediting_406440(50413791, -), CAediting_406441(50413794, -), CAediting_406442(50413796, -), CAediting_406443(50413805, -), CAediting_406444(50413810, -), CAediting_406445(50413828, -), CAediting_406446(50413829, -), CAediting_406447(50413834, -), CAediting_406448(50414267, -), CAediting_406449(50414279, -), CAediting_406450(50414289, -), CAediting_406451(50414307, -), CAediting_406452(50414308, -), CAediting_406453(50414333, -), CAediting_406454(50414345, -), CAediting_406455(50414352, -), CAediting_406456(50414355, -), CAediting_406457(50414378, -), CAediting_406458(50414388, -), CAediting_406459(50414395, -), CAediting_406460(50414403, -), CAediting_406461(50414415, -), CAediting_406462(50414425, -), CAediting_406463(50414431, -), CAediting_406464(50414443, -), CAediting_406465(50414444, -), CAediting_406466(50414456, -), CAediting_406467(50414457, -), CAediting_406468(50414463, -), CAediting_406469(50414468, -), CAediting_406470(50414473, -), CAediting_406471(50414478, -), CAediting_406472(50414484, -), CAediting_406473(50414519, -), CAediting_406474(50427705, -), CAediting_406475(50429089, -), CAediting_406476(50429166, -), CAediting_406477(50437267, -), CAediting_406478(50437269, -), CAediting_406479(50438349, -), CAediting_406480(50439342, -), CAediting_406481(50439407, -), CAediting_406482(50439408, -), CAediting_406483(50439455, -), CAediting_406484(50439526, -), CAediting_406485(50440349, -),

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RNA editing positional annotations for EMB using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_406414chr5_50413578_-ncRNA_intronic
CAediting_406415chr5_50413586_-ncRNA_intronic
CAediting_406416chr5_50413591_-ncRNA_intronic
CAediting_406417chr5_50413592_-ncRNA_intronic
CAediting_406418chr5_50413597_-ncRNA_intronic
CAediting_406419chr5_50413603_-ncRNA_intronic
CAediting_406420chr5_50413641_-ncRNA_intronic
CAediting_406421chr5_50413643_-ncRNA_intronic
CAediting_406422chr5_50413648_-ncRNA_intronic
CAediting_406423chr5_50413652_-ncRNA_intronic
CAediting_406424chr5_50413659_-ncRNA_intronic
CAediting_406425chr5_50413672_-ncRNA_intronic
CAediting_406426chr5_50413687_-ncRNA_intronic
CAediting_406427chr5_50413708_-ncRNA_intronic
CAediting_406428chr5_50413713_-ncRNA_intronic
CAediting_406429chr5_50413714_-ncRNA_intronic
CAediting_406430chr5_50413724_-ncRNA_intronic
CAediting_406431chr5_50413740_-ncRNA_intronic
CAediting_406432chr5_50413744_-ncRNA_intronic
CAediting_406433chr5_50413749_-ncRNA_intronic
CAediting_406434chr5_50413755_-ncRNA_intronic
CAediting_406435chr5_50413757_-ncRNA_intronic
CAediting_406436chr5_50413771_-ncRNA_intronic
CAediting_406437chr5_50413772_-ncRNA_intronic
CAediting_406438chr5_50413781_-ncRNA_intronic
CAediting_406439chr5_50413782_-ncRNA_intronic
CAediting_406440chr5_50413791_-ncRNA_intronic
CAediting_406441chr5_50413794_-ncRNA_intronic
CAediting_406442chr5_50413796_-ncRNA_intronic
CAediting_406443chr5_50413805_-ncRNA_intronic
CAediting_406444chr5_50413810_-ncRNA_intronic
CAediting_406445chr5_50413828_-ncRNA_intronic
CAediting_406446chr5_50413829_-ncRNA_intronic
CAediting_406447chr5_50413834_-ncRNA_intronic
CAediting_406448chr5_50414267_-ncRNA_intronic
CAediting_406449chr5_50414279_-ncRNA_intronic
CAediting_406450chr5_50414289_-ncRNA_intronic
CAediting_406451chr5_50414307_-ncRNA_intronic
CAediting_406452chr5_50414308_-ncRNA_intronic
CAediting_406453chr5_50414333_-ncRNA_intronic
CAediting_406454chr5_50414345_-ncRNA_intronic
CAediting_406455chr5_50414352_-ncRNA_intronic
CAediting_406456chr5_50414355_-ncRNA_intronic
CAediting_406457chr5_50414378_-ncRNA_intronic
CAediting_406458chr5_50414388_-ncRNA_intronic
CAediting_406459chr5_50414395_-ncRNA_intronic
CAediting_406460chr5_50414403_-ncRNA_intronic
CAediting_406461chr5_50414415_-ncRNA_intronic
CAediting_406462chr5_50414425_-ncRNA_intronic
CAediting_406463chr5_50414431_-ncRNA_intronic
CAediting_406464chr5_50414443_-ncRNA_intronic
CAediting_406465chr5_50414444_-ncRNA_intronic
CAediting_406466chr5_50414456_-ncRNA_intronic
CAediting_406467chr5_50414457_-ncRNA_intronic
CAediting_406468chr5_50414463_-ncRNA_intronic
CAediting_406469chr5_50414468_-ncRNA_intronic
CAediting_406470chr5_50414473_-ncRNA_intronic
CAediting_406471chr5_50414478_-ncRNA_intronic
CAediting_406472chr5_50414484_-ncRNA_intronic
CAediting_406473chr5_50414519_-ncRNA_intronic
CAediting_406474chr5_50427705_-ncRNA_intronic
CAediting_406475chr5_50429089_-ncRNA_intronic
CAediting_406476chr5_50429166_-ncRNA_intronic
CAediting_406477chr5_50437267_-ncRNA_intronic
CAediting_406478chr5_50437269_-ncRNA_intronic
CAediting_406479chr5_50438349_-ncRNA_intronic
CAediting_406480chr5_50439342_-ncRNA_intronic
CAediting_406481chr5_50439407_-ncRNA_intronic
CAediting_406482chr5_50439408_-ncRNA_intronic
CAediting_406483chr5_50439455_-ncRNA_intronic
CAediting_406484chr5_50439526_-ncRNA_intronic
CAediting_406485chr5_50440349_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_406414chr5_50413578_-SINEAluAluSx1
CAediting_406415chr5_50413586_-SINEAluAluSx1
CAediting_406416chr5_50413591_-SINEAluAluSx1
CAediting_406417chr5_50413592_-SINEAluAluSx1
CAediting_406418chr5_50413597_-SINEAluAluSx1
CAediting_406419chr5_50413603_-SINEAluAluSx1
CAediting_406420chr5_50413641_-SINEAluAluSx1
CAediting_406421chr5_50413643_-SINEAluAluSx1
CAediting_406422chr5_50413648_-SINEAluAluSx1
CAediting_406423chr5_50413652_-SINEAluAluSx1
CAediting_406424chr5_50413659_-SINEAluAluSx1
CAediting_406425chr5_50413672_-SINEAluAluSx1
CAediting_406426chr5_50413687_-SINEAluAluSx1
CAediting_406427chr5_50413708_-SINEAluAluSx1
CAediting_406428chr5_50413713_-SINEAluAluSx1
CAediting_406429chr5_50413714_-SINEAluAluSx1
CAediting_406430chr5_50413724_-SINEAluAluSx1
CAediting_406431chr5_50413740_-SINEAluAluSx1
CAediting_406432chr5_50413744_-SINEAluAluSx1
CAediting_406433chr5_50413749_-SINEAluAluSx1
CAediting_406434chr5_50413755_-SINEAluAluSx1
CAediting_406435chr5_50413757_-SINEAluAluSx1
CAediting_406436chr5_50413771_-SINEAluAluSx1
CAediting_406437chr5_50413772_-SINEAluAluSx1
CAediting_406438chr5_50413781_-SINEAluAluSx1
CAediting_406439chr5_50413782_-SINEAluAluSx1
CAediting_406440chr5_50413791_-SINEAluAluSx1
CAediting_406441chr5_50413794_-SINEAluAluSx1
CAediting_406442chr5_50413796_-SINEAluAluSx1
CAediting_406443chr5_50413805_-SINEAluAluSx1
CAediting_406444chr5_50413810_-SINEAluAluSx1
CAediting_406445chr5_50413828_-SINEAluAluSx1
CAediting_406446chr5_50413829_-SINEAluAluSx1
CAediting_406447chr5_50413834_-SINEAluAluSx1
CAediting_406448chr5_50414267_-SINEAluAluJo
CAediting_406449chr5_50414279_-SINEAluAluJo
CAediting_406450chr5_50414289_-SINEAluAluJo
CAediting_406451chr5_50414307_-SINEAluAluJo
CAediting_406452chr5_50414308_-SINEAluAluJo
CAediting_406453chr5_50414333_-SINEAluAluJo
CAediting_406454chr5_50414345_-SINEAluAluJo
CAediting_406455chr5_50414352_-SINEAluAluJo
CAediting_406456chr5_50414355_-SINEAluAluJo
CAediting_406457chr5_50414378_-SINEAluAluJo
CAediting_406458chr5_50414388_-SINEAluAluJo
CAediting_406459chr5_50414395_-SINEAluAluJo
CAediting_406460chr5_50414403_-SINEAluAluJo
CAediting_406461chr5_50414415_-SINEAluAluJo
CAediting_406462chr5_50414425_-SINEAluAluJo
CAediting_406463chr5_50414431_-SINEAluAluJo
CAediting_406464chr5_50414443_-SINEAluAluJo
CAediting_406465chr5_50414444_-SINEAluAluJo
CAediting_406466chr5_50414456_-SINEAluAluJo
CAediting_406467chr5_50414457_-SINEAluAluJo
CAediting_406468chr5_50414463_-SINEAluAluJo
CAediting_406469chr5_50414468_-SINEAluAluJo
CAediting_406470chr5_50414473_-SINEAluAluJo
CAediting_406471chr5_50414478_-SINEAluAluJo
CAediting_406472chr5_50414484_-SINEAluAluJo
CAediting_406473chr5_50414519_-SINEAluAluJo
CAediting_406474chr5_50427705_-SINEAluAluSx1
CAediting_406475chr5_50429089_-SINEAluAluSc
CAediting_406476chr5_50429166_-SINEAluAluSc
CAediting_406477chr5_50437267_-SINEAluAluJb
CAediting_406478chr5_50437269_-SINEAluAluJb
CAediting_406479chr5_50438349_-SINEAluAluJb
CAediting_406480chr5_50439342_-SINEAluAluJo
CAediting_406481chr5_50439407_-SINEAluAluJo
CAediting_406482chr5_50439408_-SINEAluAluJo
CAediting_406483chr5_50439455_-SINEAluAluJo
CAediting_406484chr5_50439526_-SINEAluAluJo
CAediting_406485chr5_50440349_-SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for EMB

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000170571.10.EMB.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000170571.10.EMB.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EMB

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for EMB

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for EMB

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50398453503984597mer-m85039845250398477145-14.26
CAediting_1229414chr17_67471546_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50399014503990207mer-m85039901350399038160-11.13
CAediting_1229415chr17_67471547_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50397293503972997mer-m85039729250397317163-11.98
CAediting_117844chr1_162342605_+ENSG00000170571.10ENST00000303221hsa-miR-556-3p50397380503973867mer-m85039737950397405153-14.66
CAediting_442554chr5_154685830_+ENSG00000170571.10ENST00000303221hsa-miR-130350396642503966498mer-1a5039664250396664145-11.47
CAediting_1229414chr17_67471546_+ENSG00000170571.10ENST00000508934hsa-miR-548aa50399014503990207mer-m85039901350399038160-11.13
CAediting_1229414chr17_67471546_+ENSG00000170571.10ENST00000514111hsa-miR-548aa50399014503990207mer-m85039901350399038160-11.13

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50397748503977547mer-m85039774750397771146-5.61
CAediting_1229414chr17_67471546_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50397748503977547mer-m85039774750397771146-5.61
CAediting_1229415chr17_67471547_+ENSG00000170571.10ENST00000303221hsa-miR-548aa50397748503977547mer-m85039774750397771146-5.61
CAediting_117844chr1_162342605_+ENSG00000170571.10ENST00000303221hsa-miR-556-3p50397670503976767mer-m85039766950397688145-10.68

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EMB

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for EMB

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LAMLCAediting_406451chr5_50414307_-0.002966781561482010.252041391932945..0.01854239677983880.200952155787027
LAMLCAediting_406455chr5_50414352_-..0.03551642324422420.195434856382957..
LAMLCAediting_406472chr5_50414484_-0.02855932232231780.229621745450254....

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Relation with cancer stages for EMB

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
ESCApathologic_stageCAediting_406426chr5_50413687_-2.95792752542477e-050.574671507835544

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Relation with survival for EMB

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for EMB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EMB

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
EMBC0023893Liver Cirrhosis, Experimental1CTD_human
EMBC0162820Dermatitis, Allergic Contact1CTD_human