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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: DIS3L2 (CAeditome ID:129563)

Gene summary for DIS3L2

check button Gene summary
Gene informationGene symbol

DIS3L2

Gene ID

129563

Gene nameDIS3 like 3'-5' exoribonuclease 2
SynonymsFAM6A|PRLMNS|hDIS3L2
Cytomap

2q37.1

Type of geneprotein-coding
DescriptionDIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A
Modification date20210518
UniProtAcc

Q8IYB7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DIS3L2

GO:0000175

DIS3-like exonuclease 2

23756462

DIS3L2

GO:0000175

DIS3-like exonuclease 2

24141620

DIS3L2

GO:0000287

DIS3-like exonuclease 2

24141620

DIS3L2

GO:0004540

DIS3-like exonuclease 2

22306653

DIS3L2

GO:0008266

DIS3-like exonuclease 2

24141620

DIS3L2

GO:0010587

DIS3-like exonuclease 2

24141620

DIS3L2

GO:0000932

DIS3-like exonuclease 2

23756462

DIS3L2

GO:0005737

DIS3-like exonuclease 2

22306653

DIS3L2

GO:0005737

DIS3-like exonuclease 2

23756462

DIS3L2

GO:0005737

DIS3-like exonuclease 2

24141620


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RNA A-to-I events for DIS3L2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000144535.18

check button RNA A-to-I editing events in Cancer.
CAediting_248415(231975562, +), CAediting_248416(232052140, +), CAediting_248417(232052152, +), CAediting_248418(232052162, +), CAediting_248419(232071264, +), CAediting_248420(232071267, +), CAediting_248421(232071401, +), CAediting_248422(232079479, +), CAediting_248423(232080645, +), CAediting_248424(232080686, +), CAediting_248425(232080730, +), CAediting_248426(232089953, +), CAediting_248427(232089961, +), CAediting_248428(232089978, +), CAediting_248429(232089999, +), CAediting_248430(232090149, +), CAediting_248431(232090196, +), CAediting_248432(232090197, +), CAediting_248433(232094476, +), CAediting_248434(232094536, +), CAediting_248435(232094622, +), CAediting_248436(232094628, +), CAediting_248437(232094640, +), CAediting_248438(232094651, +), CAediting_248439(232099425, +), CAediting_248440(232099476, +), CAediting_248441(232131348, +), CAediting_248442(232131421, +), CAediting_248443(232131441, +), CAediting_248444(232131457, +), CAediting_248445(232131467, +), CAediting_248446(232131476, +), CAediting_248447(232131479, +), CAediting_248448(232131521, +), CAediting_248449(232131534, +), CAediting_248450(232131544, +), CAediting_248451(232133721, +), CAediting_248452(232133729, +), CAediting_248453(232133730, +), CAediting_248454(232133751, +), CAediting_248455(232133752, +), CAediting_248456(232133776, +), CAediting_248457(232133784, +), CAediting_248458(232133810, +), CAediting_248459(232133824, +), CAediting_248460(232133828, +), CAediting_248461(232133829, +), CAediting_248462(232133832, +), CAediting_248463(232133836, +), CAediting_248464(232133837, +), CAediting_248465(232133838, +), CAediting_248466(232133841, +), CAediting_248467(232133857, +), CAediting_248468(232133868, +), CAediting_248469(232133877, +), CAediting_248470(232133900, +), CAediting_248471(232133908, +), CAediting_248472(232133913, +), CAediting_248473(232133939, +), CAediting_248474(232133940, +), CAediting_248475(232133970, +), CAediting_248476(232133975, +), CAediting_248477(232133976, +), CAediting_248478(232134561, +), CAediting_248479(232134569, +), CAediting_248480(232134570, +), CAediting_248481(232134575, +), CAediting_248482(232134578, +), CAediting_248483(232134591, +), CAediting_248484(232134592, +), CAediting_248485(232134615, +), CAediting_248486(232134618, +), CAediting_248487(232134660, +), CAediting_248488(232134663, +), CAediting_248489(232134664, +), CAediting_248490(232134668, +), CAediting_248491(232134675, +), CAediting_248492(232134678, +), CAediting_248493(232134705, +), CAediting_248494(232134725, +), CAediting_248495(232134728, +), CAediting_248496(232134733, +), CAediting_248497(232134738, +), CAediting_248498(232134752, +), CAediting_248499(232134753, +), CAediting_248500(232134760, +), CAediting_248501(232134781, +), CAediting_248502(232134782, +), CAediting_248503(232134787, +), CAediting_248504(232134789, +), CAediting_248505(232134836, +), CAediting_248506(232165551, +), CAediting_248507(232165556, +), CAediting_248508(232165624, +), CAediting_248509(232165666, +), CAediting_248510(232174410, +), CAediting_248511(232176652, +), CAediting_248512(232176666, +), CAediting_248513(232184530, +), CAediting_248514(232184542, +), CAediting_248515(232184565, +), CAediting_248516(232185751, +), CAediting_248517(232186083, +), CAediting_248518(232208943, +), CAediting_248519(232224696, +), CAediting_248520(232224718, +), CAediting_248521(232224719, +), CAediting_248522(232226905, +), CAediting_248523(232259748, +), CAediting_248524(232300703, +), CAediting_248525(232302585, +), CAediting_248526(232302758, +), CAediting_248527(232302763, +), CAediting_248528(232303746, +), CAediting_248529(232319178, +), CAediting_248530(232336818, +),

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RNA editing positional annotations for DIS3L2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_248415chr2_231975562_+intronic
CAediting_248416chr2_232052140_+ncRNA_intronic
CAediting_248417chr2_232052152_+ncRNA_intronic
CAediting_248418chr2_232052162_+ncRNA_intronic
CAediting_248419chr2_232071264_+ncRNA_intronic
CAediting_248420chr2_232071267_+ncRNA_intronic
CAediting_248421chr2_232071401_+ncRNA_intronic
CAediting_248422chr2_232079479_+ncRNA_intronic
CAediting_248423chr2_232080645_+ncRNA_intronic
CAediting_248424chr2_232080686_+ncRNA_intronic
CAediting_248425chr2_232080730_+ncRNA_intronic
CAediting_248426chr2_232089953_+ncRNA_intronic
CAediting_248427chr2_232089961_+ncRNA_intronic
CAediting_248428chr2_232089978_+ncRNA_intronic
CAediting_248429chr2_232089999_+ncRNA_intronic
CAediting_248430chr2_232090149_+ncRNA_intronic
CAediting_248431chr2_232090196_+ncRNA_intronic
CAediting_248432chr2_232090197_+ncRNA_intronic
CAediting_248433chr2_232094476_+ncRNA_intronic
CAediting_248434chr2_232094536_+ncRNA_intronic
CAediting_248435chr2_232094622_+ncRNA_intronic
CAediting_248436chr2_232094628_+ncRNA_intronic
CAediting_248437chr2_232094640_+ncRNA_intronic
CAediting_248438chr2_232094651_+ncRNA_intronic
CAediting_248439chr2_232099425_+ncRNA_intronic
CAediting_248440chr2_232099476_+ncRNA_intronic
CAediting_248441chr2_232131348_+UTR3
CAediting_248442chr2_232131421_+UTR3
CAediting_248443chr2_232131441_+UTR3
CAediting_248444chr2_232131457_+UTR3
CAediting_248445chr2_232131467_+UTR3
CAediting_248446chr2_232131476_+UTR3
CAediting_248447chr2_232131479_+UTR3
CAediting_248448chr2_232131521_+UTR3
CAediting_248449chr2_232131534_+UTR3
CAediting_248450chr2_232131544_+UTR3
CAediting_248451chr2_232133721_+intronic
CAediting_248452chr2_232133729_+intronic
CAediting_248453chr2_232133730_+intronic
CAediting_248454chr2_232133751_+intronic
CAediting_248455chr2_232133752_+intronic
CAediting_248456chr2_232133776_+intronic
CAediting_248457chr2_232133784_+intronic
CAediting_248458chr2_232133810_+intronic
CAediting_248459chr2_232133824_+intronic
CAediting_248460chr2_232133828_+intronic
CAediting_248461chr2_232133829_+intronic
CAediting_248462chr2_232133832_+intronic
CAediting_248463chr2_232133836_+intronic
CAediting_248464chr2_232133837_+intronic
CAediting_248465chr2_232133838_+intronic
CAediting_248466chr2_232133841_+intronic
CAediting_248467chr2_232133857_+intronic
CAediting_248468chr2_232133868_+intronic
CAediting_248469chr2_232133877_+intronic
CAediting_248470chr2_232133900_+intronic
CAediting_248471chr2_232133908_+intronic
CAediting_248472chr2_232133913_+intronic
CAediting_248473chr2_232133939_+intronic
CAediting_248474chr2_232133940_+intronic
CAediting_248475chr2_232133970_+intronic
CAediting_248476chr2_232133975_+intronic
CAediting_248477chr2_232133976_+intronic
CAediting_248478chr2_232134561_+intronic
CAediting_248479chr2_232134569_+intronic
CAediting_248480chr2_232134570_+intronic
CAediting_248481chr2_232134575_+intronic
CAediting_248482chr2_232134578_+intronic
CAediting_248483chr2_232134591_+intronic
CAediting_248484chr2_232134592_+intronic
CAediting_248485chr2_232134615_+intronic
CAediting_248486chr2_232134618_+intronic
CAediting_248487chr2_232134660_+intronic
CAediting_248488chr2_232134663_+intronic
CAediting_248489chr2_232134664_+intronic
CAediting_248490chr2_232134668_+intronic
CAediting_248491chr2_232134675_+intronic
CAediting_248492chr2_232134678_+intronic
CAediting_248493chr2_232134705_+intronic
CAediting_248494chr2_232134725_+intronic
CAediting_248495chr2_232134728_+intronic
CAediting_248496chr2_232134733_+intronic
CAediting_248497chr2_232134738_+intronic
CAediting_248498chr2_232134752_+intronic
CAediting_248499chr2_232134753_+intronic
CAediting_248500chr2_232134760_+intronic
CAediting_248501chr2_232134781_+intronic
CAediting_248502chr2_232134782_+intronic
CAediting_248503chr2_232134787_+intronic
CAediting_248504chr2_232134789_+intronic
CAediting_248505chr2_232134836_+intronic
CAediting_248506chr2_232165551_+intronic
CAediting_248507chr2_232165556_+intronic
CAediting_248508chr2_232165624_+intronic
CAediting_248509chr2_232165666_+intronic
CAediting_248510chr2_232174410_+intronic
CAediting_248511chr2_232176652_+intronic
CAediting_248512chr2_232176666_+intronic
CAediting_248513chr2_232184530_+intronic
CAediting_248514chr2_232184542_+intronic
CAediting_248515chr2_232184565_+intronic
CAediting_248516chr2_232185751_+intronic
CAediting_248517chr2_232186083_+intronic
CAediting_248518chr2_232208943_+intronic
CAediting_248519chr2_232224696_+intronic
CAediting_248520chr2_232224718_+intronic
CAediting_248521chr2_232224719_+intronic
CAediting_248522chr2_232226905_+intronic
CAediting_248523chr2_232259748_+ncRNA_intronic
CAediting_248524chr2_232300703_+ncRNA_intronic
CAediting_248525chr2_232302585_+ncRNA_intronic
CAediting_248526chr2_232302758_+ncRNA_intronic
CAediting_248527chr2_232302763_+ncRNA_intronic
CAediting_248528chr2_232303746_+ncRNA_intronic
CAediting_248529chr2_232319178_+intronic
CAediting_248530chr2_232336818_+ncRNA_exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_248415chr2_231975562_+SINEAluAluY
CAediting_248416chr2_232052140_+SINEAluAluSx1
CAediting_248417chr2_232052152_+SINEAluAluSx1
CAediting_248418chr2_232052162_+SINEAluAluSx1
CAediting_248419chr2_232071264_+SINEAluAluJb
CAediting_248420chr2_232071267_+SINEAluAluJb
CAediting_248421chr2_232071401_+SINEAluAluJb
CAediting_248422chr2_232079479_+SINEAluAluY
CAediting_248423chr2_232080645_+SINEAluAluJb
CAediting_248424chr2_232080686_+SINEAluAluJb
CAediting_248425chr2_232080730_+SINEAluAluJb
CAediting_248426chr2_232089953_+SINEAluAluJo
CAediting_248427chr2_232089961_+SINEAluAluJo
CAediting_248428chr2_232089978_+SINEAluAluJo
CAediting_248429chr2_232089999_+SINEAluAluJo
CAediting_248430chr2_232090149_+SINEAluAluJo
CAediting_248431chr2_232090196_+SINEAluAluJo
CAediting_248432chr2_232090197_+SINEAluAluJo
CAediting_248433chr2_232094476_+SINEAluAluSz
CAediting_248434chr2_232094536_+SINEAluAluSz
CAediting_248435chr2_232094622_+SINEAluAluSz
CAediting_248436chr2_232094628_+SINEAluAluSz
CAediting_248437chr2_232094640_+SINEAluAluSz
CAediting_248438chr2_232094651_+SINEAluAluSz
CAediting_248439chr2_232099425_+SINEAluAluSz6
CAediting_248440chr2_232099476_+SINEAluAluSz6
CAediting_248441chr2_232131348_+SINEAluAluSx3
CAediting_248442chr2_232131421_+SINEAluAluSx3
CAediting_248443chr2_232131441_+SINEAluAluSx3
CAediting_248444chr2_232131457_+SINEAluAluSx3
CAediting_248445chr2_232131467_+SINEAluAluSx3
CAediting_248446chr2_232131476_+SINEAluAluSx3
CAediting_248447chr2_232131479_+SINEAluAluSx3
CAediting_248448chr2_232131521_+SINEAluAluSx3
CAediting_248449chr2_232131534_+SINEAluAluSx3
CAediting_248450chr2_232131544_+SINEAluAluSx3
CAediting_248451chr2_232133721_+SINEAluAluSz
CAediting_248452chr2_232133729_+SINEAluAluSz
CAediting_248453chr2_232133730_+SINEAluAluSz
CAediting_248454chr2_232133751_+SINEAluAluSz
CAediting_248455chr2_232133752_+SINEAluAluSz
CAediting_248456chr2_232133776_+SINEAluAluSz
CAediting_248457chr2_232133784_+SINEAluAluSz
CAediting_248458chr2_232133810_+SINEAluAluSz
CAediting_248459chr2_232133824_+SINEAluAluSz
CAediting_248460chr2_232133828_+SINEAluAluSz
CAediting_248461chr2_232133829_+SINEAluAluSz
CAediting_248462chr2_232133832_+SINEAluAluSz
CAediting_248463chr2_232133836_+SINEAluAluSz
CAediting_248464chr2_232133837_+SINEAluAluSz
CAediting_248465chr2_232133838_+SINEAluAluSz
CAediting_248466chr2_232133841_+SINEAluAluSz
CAediting_248467chr2_232133857_+SINEAluAluSz
CAediting_248468chr2_232133868_+SINEAluAluSz
CAediting_248469chr2_232133877_+SINEAluAluSz
CAediting_248470chr2_232133900_+SINEAluAluSz
CAediting_248471chr2_232133908_+SINEAluAluSz
CAediting_248472chr2_232133913_+SINEAluAluSz
CAediting_248473chr2_232133939_+SINEAluAluSz
CAediting_248474chr2_232133940_+SINEAluAluSz
CAediting_248475chr2_232133970_+SINEAluAluSz
CAediting_248476chr2_232133975_+SINEAluAluSz
CAediting_248477chr2_232133976_+SINEAluAluSz
CAediting_248478chr2_232134561_+SINEAluAluSz
CAediting_248479chr2_232134569_+SINEAluAluSz
CAediting_248480chr2_232134570_+SINEAluAluSz
CAediting_248481chr2_232134575_+SINEAluAluSz
CAediting_248482chr2_232134578_+SINEAluAluSz
CAediting_248483chr2_232134591_+SINEAluAluSz
CAediting_248484chr2_232134592_+SINEAluAluSz
CAediting_248485chr2_232134615_+SINEAluAluSz
CAediting_248486chr2_232134618_+SINEAluAluSz
CAediting_248487chr2_232134660_+SINEAluAluSz
CAediting_248488chr2_232134663_+SINEAluAluSz
CAediting_248489chr2_232134664_+SINEAluAluSz
CAediting_248490chr2_232134668_+SINEAluAluSz
CAediting_248491chr2_232134675_+SINEAluAluSz
CAediting_248492chr2_232134678_+SINEAluAluSz
CAediting_248493chr2_232134705_+SINEAluAluSz
CAediting_248494chr2_232134725_+SINEAluAluSz
CAediting_248495chr2_232134728_+SINEAluAluSz
CAediting_248496chr2_232134733_+SINEAluAluSz
CAediting_248497chr2_232134738_+SINEAluAluSz
CAediting_248498chr2_232134752_+SINEAluAluSz
CAediting_248499chr2_232134753_+SINEAluAluSz
CAediting_248500chr2_232134760_+SINEAluAluSz
CAediting_248501chr2_232134781_+SINEAluAluSz
CAediting_248502chr2_232134782_+SINEAluAluSz
CAediting_248503chr2_232134787_+SINEAluAluSz
CAediting_248504chr2_232134789_+SINEAluAluSz
CAediting_248505chr2_232134836_+SINEAluAluSz
CAediting_248506chr2_232165551_+SINEAluAluJr
CAediting_248507chr2_232165556_+SINEAluAluJr
CAediting_248508chr2_232165624_+SINEAluAluJr
CAediting_248509chr2_232165666_+SINEAluAluJr
CAediting_248510chr2_232174410_+SINEAluAluSx1
CAediting_248511chr2_232176652_+SINEAluAluSc8
CAediting_248512chr2_232176666_+SINEAluAluSc8
CAediting_248513chr2_232184530_+SINEAluAluJo
CAediting_248514chr2_232184542_+SINEAluAluJo
CAediting_248515chr2_232184565_+SINEAluAluJo
CAediting_248516chr2_232185751_+SINEAluAluSz
CAediting_248517chr2_232186083_+SINEAluAluJo
CAediting_248518chr2_232208943_+SINEAluAluJr
CAediting_248519chr2_232224696_+SINEAluAluSz6
CAediting_248520chr2_232224718_+SINEAluAluSz6
CAediting_248521chr2_232224719_+SINEAluAluSz6
CAediting_248522chr2_232226905_+SINEAluAluJo
CAediting_248523chr2_232259748_+SINEAluAluSz
CAediting_248524chr2_232300703_+SINEAluAluJr
CAediting_248525chr2_232302585_+SINEAluAluSq2
CAediting_248526chr2_232302758_+SINEAluAluSq2
CAediting_248527chr2_232302763_+SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for DIS3L2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000144535.18.DIS3L2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000144535.18.DIS3L2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DIS3L2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for DIS3L2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for DIS3L2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000390005hsa-miR-42902323368142323368207mer-m8232336803232336821165.00-28.73
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000433430hsa-miR-42902323368142323368207mer-m8232336803232336821165.00-28.73
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000418143hsa-miR-42902323368142323368207mer-m8232336803232336821165.00-28.73
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000417808hsa-miR-42902323368142323368207mer-m8232336803232336821165.00-28.73
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-324-3p2321313442321313507mer-m8232131329232131351148.00-24.15
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-42522321313452321313528mer-1a232131332232131352149.00-22.82
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-4793-3p2321313412321313477mer-m8232131326232131348149.00-19.36
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-6807-3p2321313432321313486mer232131327232131349164.00-33.60
CAediting_248442chr2_232131421_+ENSG00000144535.18ENST00000409401hsa-miR-4691-3p2321314182321314247mer-m8232131398232131425150.00-26.62
CAediting_248443chr2_232131441_+ENSG00000144535.18ENST00000409401hsa-miR-891a-3p2321314382321314447mer-m8232131424232131445171.00-25.96
CAediting_248444chr2_232131457_+ENSG00000144535.18ENST00000409401hsa-miR-3157-5p2321314512321314577mer-m8232131436232131458163.00-24.33
CAediting_248444chr2_232131457_+ENSG00000144535.18ENST00000409401hsa-miR-34a-3p2321314532321314597mer-m8232131438232131460153.00-11.29
CAediting_248445chr2_232131467_+ENSG00000144535.18ENST00000409401hsa-miR-48012321314622321314676mer232131445232131468150.00-17.68
CAediting_248447chr2_232131479_+ENSG00000144535.18ENST00000409401hsa-miR-3675-3p2321314742321314807mer-m8232131460232131481145.00-12.58
CAediting_248447chr2_232131479_+ENSG00000144535.18ENST00000409401hsa-miR-4684-5p2321314732321314797mer-m8232131458232131480159.00-15.49
CAediting_248450chr2_232131544_+ENSG00000144535.18ENST00000409401hsa-miR-3189-3p2321315382321315447mer-m8232131526232131545149.00-25.49
CAediting_248450chr2_232131544_+ENSG00000144535.18ENST00000409401hsa-miR-6813-3p2321315392321315457mer-m8232131526232131546140.00-11.59

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_248448chr2_232131521_+ENSG00000144535.18ENST00000409401hsa-miR-1288-5p2321315182321315247mer-m8232131503232131525147-15.56
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-32-5p2321313422321313487mer-m8232131328232131349144-12.53
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-363-3p2321313422321313487mer-m8232131328232131349147-16.12
CAediting_248449chr2_232131534_+ENSG00000144535.18ENST00000409401hsa-miR-44782321315312321315377mer-m8232131523232131538149-22.23
CAediting_248449chr2_232131534_+ENSG00000144535.18ENST00000409401hsa-miR-4649-3p2321315282321315347mer-m8232131515232131535147-15.95
CAediting_248449chr2_232131534_+ENSG00000144535.18ENST00000409401hsa-miR-485-5p2321315322321315387mer-m8232131517232131539145-15.4
CAediting_248442chr2_232131421_+ENSG00000144535.18ENST00000409401hsa-miR-56902321314182321314247mer-m8232131405232131425145-17.72
CAediting_248449chr2_232131534_+ENSG00000144535.18ENST00000409401hsa-miR-6765-5p2321315282321315336mer232131507232131534142-26.4
CAediting_248449chr2_232131534_+ENSG00000144535.18ENST00000409401hsa-miR-7160-5p2321315292321315357mer-m8232131518232131536150-20.62
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-92a-3p2321313422321313487mer-m8232131332232131349155-26.92
CAediting_248441chr2_232131348_+ENSG00000144535.18ENST00000409401hsa-miR-92a-3p2321313422321313487mer-m8232131332232131349155-26.92
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000390005hsa-miR-3614-3p2323368152323368217mer-m8232336800232336822140-14.97
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000390005hsa-miR-42972323368142323368207mer-m8232336806232336821150-16.93
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000390005hsa-miR-5581-5p2323368142323368207mer-m8232336800232336821140-15.52
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000433430hsa-miR-3614-3p2323368152323368217mer-m8232336800232336822140-14.97
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000433430hsa-miR-42972323368142323368207mer-m8232336806232336821150-16.93
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000433430hsa-miR-5581-5p2323368142323368207mer-m8232336800232336821140-15.52
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000418143hsa-miR-3614-3p2323368152323368217mer-m8232336800232336822140-14.97
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000418143hsa-miR-42972323368142323368207mer-m8232336806232336821150-16.93
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000418143hsa-miR-5581-5p2323368142323368207mer-m8232336800232336821140-15.52
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000417808hsa-miR-3614-3p2323368152323368217mer-m8232336800232336822140-14.97
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000417808hsa-miR-42972323368142323368207mer-m8232336806232336821150-16.93
CAediting_248530chr2_232336818_+ENSG00000144535.18ENST00000417808hsa-miR-5581-5p2323368142323368207mer-m8232336800232336821140-15.52

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000144535.18ENST00000409401hsa-miR-200b-3p2321309972321310037mer-m8232130982232131004157-13.29
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000390005hsa-miR-605-3p2323369022323369087mer-m8232336888232336909149-18.68
CAediting_688080chr9_63819626_+ENSG00000144535.18ENST00000445090hsa-miR-4477b2321635722321635787mer-m8232163554232163579149-12.17
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000445090hsa-miR-605-3p2322103762322103827mer-m8232210361232210383162-20.93
CAediting_846604chr11_93733708_-ENSG00000144535.18ENST00000445090hsa-miR-1304-3p2322633432322633497mer-m8232263328232263350150-17.9
CAediting_688080chr9_63819626_+ENSG00000144535.18ENST00000433430hsa-miR-4477b2321635722321635787mer-m8232163554232163579149-12.17
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000433430hsa-miR-605-3p2321986122321986198mer-1a232198599232198619150-20.48
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000433430hsa-miR-605-3p2322103762322103827mer-m8232210361232210383162-20.93
CAediting_980496chr14_31014685_-ENSG00000144535.18ENST00000433430hsa-miR-624-3p2322600652322600717mer-m8232260051232260072146-20.35
CAediting_846604chr11_93733708_-ENSG00000144535.18ENST00000433430hsa-miR-1304-3p2322633432322633497mer-m8232263328232263350150-17.9
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000433430hsa-miR-605-3p2323369022323369087mer-m8232336888232336909149-18.68
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000418143hsa-miR-605-3p2323369022323369087mer-m8232336888232336909149-18.68
CAediting_748296chr10_51299626_+ENSG00000144535.18ENST00000417808hsa-miR-605-3p2323369022323369087mer-m8232336888232336909149-18.68
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000390005hsa-miR-45122323368532323368608mer-1a232336838232336860149-19.66
CAediting_1229415chr17_67471547_+ENSG00000144535.18ENST00000390005hsa-miR-548aa2323366802323366878mer-1a232336663232336687140-7.55
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000390005hsa-miR-46352323365212323365277mer-m8232336508232336528144-11.75
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000445090hsa-miR-46352321635732321635797mer-m8232163561232163580143-15.34
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000445090hsa-miR-46352323000782323000847mer-m8232300068232300085146-19.63
CAediting_1368054chr19_46709310_-ENSG00000144535.18ENST00000445090hsa-miR-320e2323360122323360198mer-1a232336002232336019145-16.69
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000445090hsa-miR-46352323365212323365277mer-m8232336508232336528144-11.75
CAediting_580943chr7_100356700_+ENSG00000144535.18ENST00000445090hsa-miR-6840-3p2323359872323359937mer-m8232335970232335994158-32.15
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000433430hsa-miR-46352321635732321635797mer-m8232163561232163580143-15.34
CAediting_77128chr1_85133844_+ENSG00000144535.18ENST00000433430hsa-miR-4423-3p2321987512321987577mer-m8232198737232198758149-17.45
CAediting_228905chr2_188297554_+ENSG00000144535.18ENST00000433430hsa-miR-561-3p2321987322321987387mer-m8232198718232198739140-6.62
CAediting_86358chr1_109598906_+ENSG00000144535.18ENST00000433430hsa-miR-197-5p2322598712322598777mer-m8232259856232259878140-24.31
CAediting_524911chr7_5495852_-ENSG00000144535.18ENST00000433430hsa-miR-589-3p2322606692322606757mer-m8232260653232260676150-15.06
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000433430hsa-miR-46352323000782323000847mer-m8232300068232300085146-19.63
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000433430hsa-miR-45122323368532323368608mer-1a232336838232336860149-19.66
CAediting_1229415chr17_67471547_+ENSG00000144535.18ENST00000433430hsa-miR-548aa2323366802323366878mer-1a232336663232336687140-7.55
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000433430hsa-miR-46352323365212323365277mer-m8232336508232336528144-11.75
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000418143hsa-miR-45122323368532323368608mer-1a232336838232336860149-19.66
CAediting_1229415chr17_67471547_+ENSG00000144535.18ENST00000418143hsa-miR-548aa2323366802323366878mer-1a232336663232336687140-7.55
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000417808hsa-miR-45122323368532323368608mer-1a232336838232336860149-19.66
CAediting_1229415chr17_67471547_+ENSG00000144535.18ENST00000417808hsa-miR-548aa2323366802323366878mer-1a232336663232336687140-7.55
CAediting_396018chr5_1062918_-ENSG00000144535.18ENST00000417808hsa-miR-46352323365212323365277mer-m8232336508232336528144-11.75
CAediting_468389chr6_31355314_-ENSG00000144535.18ENST00000390005hsa-miR-6891-5p2323369052323369117mer-m8232336894232336912153-25.94
CAediting_468389chr6_31355314_-ENSG00000144535.18ENST00000433430hsa-miR-6891-5p2323369052323369117mer-m8232336894232336912153-25.94
CAediting_468389chr6_31355314_-ENSG00000144535.18ENST00000418143hsa-miR-6891-5p2323369052323369117mer-m8232336894232336912153-25.94
CAediting_468389chr6_31355314_-ENSG00000144535.18ENST00000417808hsa-miR-6891-5p2323369052323369117mer-m8232336894232336912153-25.94

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_604450chr7_133034877_-ENSG00000144535.18ENST00000273009hsa-miR-36542323436652323436728mer-1a232343654232343672140-16.87
CAediting_1524209chrX_134546392_-ENSG00000144535.18ENST00000390005hsa-miR-503-5p2323370642323370707mer-m8232337047232337071147-21.84
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000445090hsa-miR-45122323362332323362397mer-m8232336219232336240140-17.37
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000445090hsa-miR-45122323364252323364317mer-m8232336412232336432148-21.44
CAediting_573001chr7_92204086_-ENSG00000144535.18ENST00000433430hsa-miR-1285-5p2322605362322605427mer-m8232260523232260543141-15.23
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000433430hsa-miR-45122323364252323364317mer-m8232336412232336432148-21.44
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000433430hsa-miR-45122323362332323362397mer-m8232336219232336240140-17.37
CAediting_1054808chr15_66496985_-ENSG00000144535.18ENST00000417808hsa-miR-45122323364252323364317mer-m8232336412232336432148-21.44

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DIS3L2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000325385.10protein_codingSoverviewSoverview
ENST00000390005.8nonsense_mediated_decaySoverviewSoverview
ENST00000409401.6protein_codingSoverviewSoverview
ENST00000433430.4nonsense_mediated_decaySoverviewSoverview
ENST00000417808.1protein_codingSoverviewSoverview
ENST00000418143.1protein_codingSoverviewSoverview
ENST00000429283.2retained_intronSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_248530ENST00000325385.10chr2_232336818_+-1290.10-1283.50-1290.10
CAediting_248530ENST00000390005.8chr2_232336818_+-1214.70-1208.10-1214.70
CAediting_248441ENST00000409401.6chr2_232131348_+-608.20-605.80-615.60
CAediting_248442ENST00000409401.6chr2_232131421_+-610.00-605.80-615.60
CAediting_248443ENST00000409401.6chr2_232131441_+-605.80-605.80-615.60
CAediting_248444ENST00000409401.6chr2_232131457_+-606.00-605.80-615.60
CAediting_248445ENST00000409401.6chr2_232131467_+-605.70-605.80-615.60
CAediting_248446ENST00000409401.6chr2_232131476_+-605.40-605.80-615.60
CAediting_248447ENST00000409401.6chr2_232131479_+-605.80-605.80-615.60
CAediting_248448ENST00000409401.6chr2_232131521_+-606.80-605.80-615.60
CAediting_248449ENST00000409401.6chr2_232131534_+-606.60-605.80-615.60
CAediting_248450ENST00000409401.6chr2_232131544_+-606.00-605.80-615.60
CAediting_248530ENST00000433430.4chr2_232336818_+-1698.40-1691.80-1698.40
CAediting_248530ENST00000417808.1chr2_232336818_+-392.00-385.40-392.00
CAediting_248530ENST00000418143.1chr2_232336818_+-371.40-364.80-371.40
CAediting_248530ENST00000429283.2chr2_232336818_+-1942.20-1935.60-1942.20

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Relation with ADAR for DIS3L2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for DIS3L2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for DIS3L2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for DIS3L2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIS3L2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
DIS3L2C0796113Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor6CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT