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Editing gene: ADH5 (CAeditome ID:128)

Gene summary for ADH5

Gene summary

Gene information	Gene symbol	ADH5
	Gene ID	128
	Gene name	alcohol dehydrogenase 5 (class III), chi polypeptide
	Synonyms	ADH-3\|ADHX\|AMEDS\|BMFS7\|FALDH\|FDH\|GSH-FDH\|GSNOR\|HEL-S-60p
	Cytomap	4q23
	Type of gene	protein-coding
	Description	alcohol dehydrogenase class-3S-(hydroxymethyl)glutathione dehydrogenaseS-nitrosoglutathione reductasealcohol dehydrogenase (class III), chi polypeptidealcohol dehydrogenase class chi chainalcohol dehydrogenase class-IIIepididymis secretory sperm bin
	Modification date	20210518
	UniProtAcc	P11766
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ADH5	GO:0005504	Alcohol dehydrogenase class-3	8460164
ADH5	GO:0008270	Alcohol dehydrogenase class-3	6375718
ADH5	GO:0018467	Alcohol dehydrogenase class-3	8460164
ADH5	GO:0010430	Alcohol dehydrogenase class-3	16081420
ADH5	GO:0051775	Alcohol dehydrogenase class-3	8460164

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RNA A-to-I events for ADH5

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000197894.9

RNA A-to-I editing events in Cancer.

CAediting_377624(99073226, -), CAediting_377625(99076736, -), CAediting_377626(99077287, -), CAediting_377627(99077351, -), CAediting_377628(99077371, -), CAediting_377629(99077473, -), CAediting_377630(99077481, -), CAediting_377631(99078501, -), CAediting_377632(99078504, -), CAediting_377633(99078565, -), CAediting_377634(99078660, -),

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RNA editing positional annotations for ADH5 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_377625	chr4_99076736_-	nonsynonymous SNV	ENST00000296412.11	c.A532G	p.T178A	D	D	D
CAediting_377625	chr4_99076736_-	nonsynonymous SNV	ENST00000503130.4	c.A493G	p.T165A	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_377624	chr4_99073226_-	ncRNA_intronic
CAediting_377625	chr4_99076736_-	exonic
CAediting_377626	chr4_99077287_-	ncRNA_intronic
CAediting_377627	chr4_99077351_-	ncRNA_intronic
CAediting_377628	chr4_99077371_-	ncRNA_intronic
CAediting_377629	chr4_99077473_-	ncRNA_intronic
CAediting_377630	chr4_99077481_-	ncRNA_intronic
CAediting_377631	chr4_99078501_-	ncRNA_intronic
CAediting_377632	chr4_99078504_-	ncRNA_intronic
CAediting_377633	chr4_99078565_-	ncRNA_intronic
CAediting_377634	chr4_99078660_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_377624	chr4_99073226_-	SINE	Alu	AluY
CAediting_377626	chr4_99077287_-	SINE	Alu	AluJr
CAediting_377627	chr4_99077351_-	SINE	Alu	AluJr
CAediting_377628	chr4_99077371_-	SINE	Alu	AluJr
CAediting_377629	chr4_99077473_-	SINE	Alu	AluJr
CAediting_377630	chr4_99077481_-	SINE	Alu	AluJr
CAediting_377631	chr4_99078501_-	SINE	Alu	AluJb
CAediting_377632	chr4_99078504_-	SINE	Alu	AluJb
CAediting_377633	chr4_99078565_-	SINE	Alu	AluJb
CAediting_377634	chr4_99078660_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for ADH5

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000197894.9.ADH5.

Correlation between RNA A-to-I editing and PSI for ENSG00000197894.9.ADH5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADH5

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ADH5

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ADH5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000197894.9	ENST00000296412	hsa-miR-200b-3p	99071827	99071833	7mer-m8	99071826	99071849	154	-13.95
CAediting_688080	chr9_63819626_+	ENSG00000197894.9	ENST00000296412	hsa-miR-4477b	99071212	99071218	7mer-m8	99071211	99071232	148	-12.09
CAediting_77128	chr1_85133844_+	ENSG00000197894.9	ENST00000505652	hsa-miR-4423-3p	99079963	99079969	7mer-m8	99079962	99079982	140	-13.04

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ADH5

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000296412.11	protein_coding
ENST00000512621.4	retained_intron
ENST00000626055.1	protein_coding
ENST00000502590.4	nonsense_mediated_decay
ENST00000503130.4	protein_coding
ENST00000508511.4	retained_intron
ENST00000512659.4	nonsense_mediated_decay
ENST00000512991.4	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_377625	ENST00000296412.11	chr4_99076736_-	-735.50	-733.20	-735.50
CAediting_377625	ENST00000512621.4	chr4_99076736_-	-452.60	-450.30	-452.60
CAediting_377625	ENST00000626055.1	chr4_99076736_-	-381.40	-379.40	-381.40
CAediting_377625	ENST00000502590.4	chr4_99076736_-	-220.50	-217.70	-220.50
CAediting_377625	ENST00000503130.4	chr4_99076736_-	-255.80	-253.50	-255.80
CAediting_377625	ENST00000508511.4	chr4_99076736_-	-557.67	-555.37	-557.67
CAediting_377625	ENST00000512659.4	chr4_99076736_-	-264.20	-263.20	-264.20
CAediting_377625	ENST00000512991.4	chr4_99076736_-	-281.60	-281.90	-281.60

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Relation with ADAR for ADH5

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ADH5

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ADH5

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ADH5

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
ADH5	P11766	DB03017	Lauric acid	Alcohol dehydrogenase class-3	SmallMoleculeDrug	approved\|experimental
ADH5	P11766	DB00157	NADH	Alcohol dehydrogenase class-3	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for ADH5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ADH5	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene