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Editing gene: ZNF491 (CAeditome ID:126069)

Gene summary for ZNF491

Gene summary

Gene information	Gene symbol	ZNF491
	Gene ID	126069
	Gene name	zinc finger protein 491
	Synonyms	-
	Cytomap	19p13.2
	Type of gene	protein-coding
	Description	zinc finger protein 491
	Modification date	20210518
	UniProtAcc	Q8N8L2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ZNF491

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000177599.11

RNA A-to-I editing events in Cancer.

CAediting_1298537(11799678, +), CAediting_1298538(11799680, +), CAediting_1298539(11799681, +), CAediting_1298540(11799750, +), CAediting_1298541(11799835, +), CAediting_1298542(11799840, +), CAediting_1298543(11800660, +), CAediting_1298544(11800745, +), CAediting_1298545(11800790, +), CAediting_1298546(11800844, +), CAediting_1298547(11800893, +), CAediting_1298548(11800938, +), CAediting_1298549(11802053, +), CAediting_1298550(11802071, +), CAediting_1298551(11803257, +), CAediting_1298552(11803949, +), CAediting_1298553(11803950, +), CAediting_1298554(11803956, +), CAediting_1298555(11803993, +), CAediting_1298556(11804185, +), CAediting_1298557(11805726, +), CAediting_1298558(11807297, +), CAediting_1298559(11807306, +), CAediting_1298560(11807317, +), CAediting_1298561(11808120, +), CAediting_1298562(11808128, +), CAediting_1298563(11808129, +), CAediting_1298564(11808137, +), CAediting_1298565(11808195, +), CAediting_1298566(11808196, +), CAediting_1298567(11808200, +), CAediting_1298568(11808205, +), CAediting_1298569(11808206, +), CAediting_1298570(11808211, +), CAediting_1298571(11808223, +), CAediting_1298572(11808235, +), CAediting_1298573(11808253, +), CAediting_1298574(11808255, +), CAediting_1298575(11808261, +), CAediting_1298576(11808262, +), CAediting_1298577(11808267, +), CAediting_1298578(11808271, +), CAediting_1298579(11808278, +), CAediting_1298580(11808288, +), CAediting_1298581(11808323, +), CAediting_1298582(11808327, +), CAediting_1298583(11808331, +), CAediting_1298584(11808332, +), CAediting_1298585(11808337, +), CAediting_1298586(11808640, +), CAediting_1298587(11808655, +), CAediting_1298588(11808681, +), CAediting_1298589(11808686, +), CAediting_1298590(11808696, +), CAediting_1298591(11808716, +), CAediting_1298592(11808717, +), CAediting_1298593(11808721, +), CAediting_1298594(11808734, +), CAediting_1298595(11808756, +), CAediting_1298596(11808758, +), CAediting_1298597(11808766, +), CAediting_1298598(11808782, +), CAediting_1298599(11808800, +), CAediting_1298600(11808810, +), CAediting_1298601(11808820, +), CAediting_1298602(11808834, +), CAediting_1298603(11808859, +), CAediting_1298604(11808872, +), CAediting_1298605(11808881, +), CAediting_1298606(11808882, +), CAediting_1298607(11808889, +), CAediting_1298608(11808894, +), CAediting_1298609(11808903, +),

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RNA editing positional annotations for ZNF491 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1298537	chr19_11799678_+	ncRNA_intronic
CAediting_1298538	chr19_11799680_+	ncRNA_intronic
CAediting_1298539	chr19_11799681_+	ncRNA_intronic
CAediting_1298540	chr19_11799750_+	ncRNA_intronic
CAediting_1298541	chr19_11799835_+	ncRNA_intronic
CAediting_1298542	chr19_11799840_+	ncRNA_intronic
CAediting_1298543	chr19_11800660_+	ncRNA_intronic
CAediting_1298544	chr19_11800745_+	ncRNA_intronic
CAediting_1298545	chr19_11800790_+	ncRNA_intronic
CAediting_1298546	chr19_11800844_+	ncRNA_intronic
CAediting_1298547	chr19_11800893_+	ncRNA_intronic
CAediting_1298548	chr19_11800938_+	ncRNA_intronic
CAediting_1298549	chr19_11802053_+	ncRNA_intronic
CAediting_1298550	chr19_11802071_+	ncRNA_intronic
CAediting_1298551	chr19_11803257_+	ncRNA_intronic
CAediting_1298552	chr19_11803949_+	ncRNA_intronic
CAediting_1298553	chr19_11803950_+	ncRNA_intronic
CAediting_1298554	chr19_11803956_+	ncRNA_intronic
CAediting_1298555	chr19_11803993_+	ncRNA_intronic
CAediting_1298556	chr19_11804185_+	ncRNA_intronic
CAediting_1298557	chr19_11805726_+	ncRNA_intronic
CAediting_1298558	chr19_11807297_+	ncRNA_intronic
CAediting_1298559	chr19_11807306_+	ncRNA_intronic
CAediting_1298560	chr19_11807317_+	ncRNA_intronic
CAediting_1298561	chr19_11808120_+	ncRNA_intronic
CAediting_1298562	chr19_11808128_+	ncRNA_intronic
CAediting_1298563	chr19_11808129_+	ncRNA_intronic
CAediting_1298564	chr19_11808137_+	ncRNA_intronic
CAediting_1298565	chr19_11808195_+	ncRNA_intronic
CAediting_1298566	chr19_11808196_+	ncRNA_intronic
CAediting_1298567	chr19_11808200_+	ncRNA_intronic
CAediting_1298568	chr19_11808205_+	ncRNA_intronic
CAediting_1298569	chr19_11808206_+	ncRNA_intronic
CAediting_1298570	chr19_11808211_+	ncRNA_intronic
CAediting_1298571	chr19_11808223_+	ncRNA_intronic
CAediting_1298572	chr19_11808235_+	ncRNA_intronic
CAediting_1298573	chr19_11808253_+	ncRNA_intronic
CAediting_1298574	chr19_11808255_+	ncRNA_intronic
CAediting_1298575	chr19_11808261_+	ncRNA_intronic
CAediting_1298576	chr19_11808262_+	ncRNA_intronic
CAediting_1298577	chr19_11808267_+	ncRNA_intronic
CAediting_1298578	chr19_11808271_+	ncRNA_intronic
CAediting_1298579	chr19_11808278_+	ncRNA_intronic
CAediting_1298580	chr19_11808288_+	ncRNA_intronic
CAediting_1298581	chr19_11808323_+	ncRNA_intronic
CAediting_1298582	chr19_11808327_+	ncRNA_intronic
CAediting_1298583	chr19_11808331_+	ncRNA_intronic
CAediting_1298584	chr19_11808332_+	ncRNA_intronic
CAediting_1298585	chr19_11808337_+	ncRNA_intronic
CAediting_1298586	chr19_11808640_+	ncRNA_intronic
CAediting_1298587	chr19_11808655_+	ncRNA_intronic
CAediting_1298588	chr19_11808681_+	ncRNA_intronic
CAediting_1298589	chr19_11808686_+	ncRNA_intronic
CAediting_1298590	chr19_11808696_+	ncRNA_intronic
CAediting_1298591	chr19_11808716_+	ncRNA_intronic
CAediting_1298592	chr19_11808717_+	ncRNA_intronic
CAediting_1298593	chr19_11808721_+	ncRNA_intronic
CAediting_1298594	chr19_11808734_+	ncRNA_intronic
CAediting_1298595	chr19_11808756_+	ncRNA_intronic
CAediting_1298596	chr19_11808758_+	ncRNA_intronic
CAediting_1298597	chr19_11808766_+	ncRNA_intronic
CAediting_1298598	chr19_11808782_+	ncRNA_intronic
CAediting_1298599	chr19_11808800_+	ncRNA_intronic
CAediting_1298600	chr19_11808810_+	ncRNA_intronic
CAediting_1298601	chr19_11808820_+	ncRNA_intronic
CAediting_1298602	chr19_11808834_+	ncRNA_intronic
CAediting_1298603	chr19_11808859_+	ncRNA_intronic
CAediting_1298604	chr19_11808872_+	ncRNA_intronic
CAediting_1298605	chr19_11808881_+	ncRNA_intronic
CAediting_1298606	chr19_11808882_+	ncRNA_intronic
CAediting_1298607	chr19_11808889_+	ncRNA_intronic
CAediting_1298608	chr19_11808894_+	ncRNA_intronic
CAediting_1298609	chr19_11808903_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1298537	chr19_11799678_+	SINE	Alu	AluSg
CAediting_1298538	chr19_11799680_+	SINE	Alu	AluSg
CAediting_1298539	chr19_11799681_+	SINE	Alu	AluSg
CAediting_1298540	chr19_11799750_+	SINE	Alu	AluSg
CAediting_1298541	chr19_11799835_+	SINE	Alu	AluSg
CAediting_1298542	chr19_11799840_+	SINE	Alu	AluSg
CAediting_1298543	chr19_11800660_+	SINE	Alu	AluSx
CAediting_1298544	chr19_11800745_+	SINE	Alu	AluJo
CAediting_1298545	chr19_11800790_+	SINE	Alu	AluJo
CAediting_1298546	chr19_11800844_+	SINE	Alu	AluJo
CAediting_1298547	chr19_11800893_+	SINE	Alu	AluJo
CAediting_1298548	chr19_11800938_+	SINE	Alu	AluJo
CAediting_1298549	chr19_11802053_+	SINE	Alu	AluJo
CAediting_1298550	chr19_11802071_+	SINE	Alu	AluJo
CAediting_1298551	chr19_11803257_+	SINE	Alu	AluSx1
CAediting_1298552	chr19_11803949_+	SINE	Alu	AluSg
CAediting_1298553	chr19_11803950_+	SINE	Alu	AluSg
CAediting_1298554	chr19_11803956_+	SINE	Alu	AluSg
CAediting_1298555	chr19_11803993_+	SINE	Alu	AluSg
CAediting_1298556	chr19_11804185_+	SINE	Alu	AluSg
CAediting_1298557	chr19_11805726_+	SINE	Alu	AluJr
CAediting_1298558	chr19_11807297_+	SINE	Alu	AluJr
CAediting_1298559	chr19_11807306_+	SINE	Alu	AluJr
CAediting_1298560	chr19_11807317_+	SINE	Alu	AluJr
CAediting_1298561	chr19_11808120_+	SINE	Alu	AluSg
CAediting_1298562	chr19_11808128_+	SINE	Alu	AluSg
CAediting_1298563	chr19_11808129_+	SINE	Alu	AluSg
CAediting_1298564	chr19_11808137_+	SINE	Alu	AluSg
CAediting_1298565	chr19_11808195_+	SINE	Alu	AluSg
CAediting_1298566	chr19_11808196_+	SINE	Alu	AluSg
CAediting_1298567	chr19_11808200_+	SINE	Alu	AluSg
CAediting_1298568	chr19_11808205_+	SINE	Alu	AluSg
CAediting_1298569	chr19_11808206_+	SINE	Alu	AluSg
CAediting_1298570	chr19_11808211_+	SINE	Alu	AluSg
CAediting_1298571	chr19_11808223_+	SINE	Alu	AluSg
CAediting_1298572	chr19_11808235_+	SINE	Alu	AluSg
CAediting_1298573	chr19_11808253_+	SINE	Alu	AluSg
CAediting_1298574	chr19_11808255_+	SINE	Alu	AluSg
CAediting_1298575	chr19_11808261_+	SINE	Alu	AluSg
CAediting_1298576	chr19_11808262_+	SINE	Alu	AluSg
CAediting_1298577	chr19_11808267_+	SINE	Alu	AluSg
CAediting_1298578	chr19_11808271_+	SINE	Alu	AluSg
CAediting_1298579	chr19_11808278_+	SINE	Alu	AluSg
CAediting_1298580	chr19_11808288_+	SINE	Alu	AluSg
CAediting_1298581	chr19_11808323_+	SINE	Alu	AluSg
CAediting_1298582	chr19_11808327_+	SINE	Alu	AluSg
CAediting_1298583	chr19_11808331_+	SINE	Alu	AluSg
CAediting_1298584	chr19_11808332_+	SINE	Alu	AluSg
CAediting_1298585	chr19_11808337_+	SINE	Alu	AluSg
CAediting_1298586	chr19_11808640_+	SINE	Alu	AluJo
CAediting_1298587	chr19_11808655_+	SINE	Alu	AluJo
CAediting_1298588	chr19_11808681_+	SINE	Alu	AluJo
CAediting_1298589	chr19_11808686_+	SINE	Alu	AluJo
CAediting_1298590	chr19_11808696_+	SINE	Alu	AluJo
CAediting_1298591	chr19_11808716_+	SINE	Alu	AluJo
CAediting_1298592	chr19_11808717_+	SINE	Alu	AluJo
CAediting_1298593	chr19_11808721_+	SINE	Alu	AluJo
CAediting_1298594	chr19_11808734_+	SINE	Alu	AluJo
CAediting_1298595	chr19_11808756_+	SINE	Alu	AluJo
CAediting_1298596	chr19_11808758_+	SINE	Alu	AluJo
CAediting_1298597	chr19_11808766_+	SINE	Alu	AluJo
CAediting_1298598	chr19_11808782_+	SINE	Alu	AluJo
CAediting_1298599	chr19_11808800_+	SINE	Alu	AluJo
CAediting_1298600	chr19_11808810_+	SINE	Alu	AluJo
CAediting_1298601	chr19_11808820_+	SINE	Alu	AluJo
CAediting_1298602	chr19_11808834_+	SINE	Alu	AluJo
CAediting_1298603	chr19_11808859_+	SINE	Alu	AluJo
CAediting_1298604	chr19_11808872_+	SINE	Alu	AluJo
CAediting_1298605	chr19_11808881_+	SINE	Alu	AluJo
CAediting_1298606	chr19_11808882_+	SINE	Alu	AluJo
CAediting_1298607	chr19_11808889_+	SINE	Alu	AluJo
CAediting_1298608	chr19_11808894_+	SINE	Alu	AluJo
CAediting_1298609	chr19_11808903_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for ZNF491

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000177599.11.ZNF491.

Correlation between RNA A-to-I editing and PSI for ENSG00000177599.11.ZNF491.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF491

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

PRAD.CAediting_1298576.ENSG00000177599.ZNF491.png
Soverview

THYM.CAediting_1298576.ENSG00000177599.ZNF491.png
Soverview

THYM.CAediting_1298589.ENSG00000177599.ZNF491.png
Soverview

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Protein coding region RNA A-to-I editings for ZNF491

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZNF491

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF491

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZNF491

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
PRAD	CAediting_1298575	chr19_11808261_+	0.0169170691164707	0.307316844808245	.	.	.	.
PCPG	CAediting_1298576	chr19_11808262_+	0.013817261918467	0.327262039587463	.	.	.	.
THYM	CAediting_1298576	chr19_11808262_+	0.0312835359051109	0.26337774477893	.	.	.	.
LGG	CAediting_1298577	chr19_11808267_+	0.0172906024377677	0.254673214615995	.	.	0.0150132616292844	0.260003467428486

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Relation with cancer stages for ZNF491

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_1298595	chr19_11808756_+	0.00534609709218435	0.370619592914263

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Relation with survival for ZNF491

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ZNF491

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF491

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene