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Editing gene: METTL23 (CAeditome ID:124512)

Gene summary for METTL23

Gene summary

Gene information	Gene symbol	METTL23
	Gene ID	124512
	Gene name	methyltransferase like 23
	Synonyms	C17orf95\|MRT44
	Cytomap	17q25.1
	Type of gene	protein-coding
	Description	methyltransferase-like protein 23spike binding protein 1
	Modification date	20210518
	UniProtAcc	Q86XA0
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
METTL23	GO:0005634	Methyltransferase-like protein 23	24501276
METTL23	GO:0005737	Methyltransferase-like protein 23	23349634
METTL23	GO:0005737	Methyltransferase-like protein 23	24501276
METTL23	GO:0032991	Methyltransferase-like protein 23	23349634

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RNA A-to-I events for METTL23

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000181038.12

RNA A-to-I editing events in Cancer.

CAediting_1239694(76727398, +), CAediting_1239695(76727401, +), CAediting_1239696(76727434, +), CAediting_1239697(76727435, +), CAediting_1239698(76727439, +), CAediting_1239699(76727461, +), CAediting_1239700(76727462, +), CAediting_1239701(76727468, +), CAediting_1239702(76727474, +), CAediting_1239703(76727750, +), CAediting_1239704(76727800, +), CAediting_1239705(76727811, +), CAediting_1239706(76727831, +), CAediting_1239707(76727852, +), CAediting_1239708(76728001, +), CAediting_1239709(76728030, +), CAediting_1239710(76728058, +), CAediting_1239711(76728064, +), CAediting_1239712(76728097, +), CAediting_1239713(76728115, +), CAediting_1239714(76728125, +), CAediting_1239715(76728145, +), CAediting_1239716(76728156, +), CAediting_1239717(76728185, +), CAediting_1239718(76728191, +), CAediting_1239719(76728196, +), CAediting_1239720(76728205, +), CAediting_1239721(76728243, +), CAediting_1239722(76728246, +), CAediting_1239723(76728247, +), CAediting_1239724(76728310, +), CAediting_1239725(76728311, +), CAediting_1239726(76728317, +), CAediting_1239727(76728322, +), CAediting_1239728(76728335, +), CAediting_1239729(76728336, +), CAediting_1239730(76728353, +), CAediting_1239731(76728362, +), CAediting_1239732(76728365, +), CAediting_1239733(76728366, +), CAediting_1239734(76728370, +), CAediting_1239735(76728393, +), CAediting_1239736(76728611, +), CAediting_1239737(76728621, +), CAediting_1239738(76728633, +), CAediting_1239739(76728874, +), CAediting_1239740(76728911, +), CAediting_1239741(76728923, +), CAediting_1239742(76729278, +), CAediting_1239743(76729286, +), CAediting_1239744(76730077, +), CAediting_1239745(76730105, +), CAediting_1239746(76730136, +), CAediting_1239747(76730171, +), CAediting_1239748(76730172, +), CAediting_1239749(76730209, +), CAediting_1239750(76730210, +), CAediting_1239751(76730228, +), CAediting_1239752(76730238, +), CAediting_1239753(76730332, +), CAediting_1239754(76730341, +), CAediting_1239755(76730347, +), CAediting_1239756(76730348, +), CAediting_1239757(76730378, +), CAediting_1239758(76730383, +), CAediting_1239759(76730713, +), CAediting_1239760(76731168, +), CAediting_1239761(76731181, +), CAediting_1239762(76732111, +), CAediting_1239763(76732182, +), CAediting_1239764(76732229, +), CAediting_1239765(76732248, +), CAediting_1239766(76732253, +), CAediting_1239767(76732298, +), CAediting_1239768(76732314, +), CAediting_1239769(76732380, +), CAediting_1239770(76732381, +), CAediting_1239771(76732439, +), CAediting_1239772(76732447, +), CAediting_1239773(76732448, +), CAediting_1239774(76732455, +), CAediting_1239775(76732536, +), CAediting_1239776(76732549, +), CAediting_1239777(76732563, +), CAediting_1239778(76732584, +), CAediting_1239779(76732588, +), CAediting_1239780(76732600, +), CAediting_1239781(76732630, +),

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RNA editing positional annotations for METTL23 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1239694	chr17_76727398_+	intronic
CAediting_1239695	chr17_76727401_+	intronic
CAediting_1239696	chr17_76727434_+	intronic
CAediting_1239697	chr17_76727435_+	intronic
CAediting_1239698	chr17_76727439_+	intronic
CAediting_1239699	chr17_76727461_+	intronic
CAediting_1239700	chr17_76727462_+	intronic
CAediting_1239701	chr17_76727468_+	intronic
CAediting_1239702	chr17_76727474_+	intronic
CAediting_1239703	chr17_76727750_+	intronic
CAediting_1239704	chr17_76727800_+	intronic
CAediting_1239705	chr17_76727811_+	intronic
CAediting_1239706	chr17_76727831_+	intronic
CAediting_1239707	chr17_76727852_+	intronic
CAediting_1239708	chr17_76728001_+	intronic
CAediting_1239709	chr17_76728030_+	intronic
CAediting_1239710	chr17_76728058_+	intronic
CAediting_1239711	chr17_76728064_+	intronic
CAediting_1239712	chr17_76728097_+	intronic
CAediting_1239713	chr17_76728115_+	intronic
CAediting_1239714	chr17_76728125_+	intronic
CAediting_1239715	chr17_76728145_+	intronic
CAediting_1239716	chr17_76728156_+	intronic
CAediting_1239717	chr17_76728185_+	intronic
CAediting_1239718	chr17_76728191_+	intronic
CAediting_1239719	chr17_76728196_+	intronic
CAediting_1239720	chr17_76728205_+	intronic
CAediting_1239721	chr17_76728243_+	intronic
CAediting_1239722	chr17_76728246_+	intronic
CAediting_1239723	chr17_76728247_+	intronic
CAediting_1239724	chr17_76728310_+	intronic
CAediting_1239725	chr17_76728311_+	intronic
CAediting_1239726	chr17_76728317_+	intronic
CAediting_1239727	chr17_76728322_+	intronic
CAediting_1239728	chr17_76728335_+	intronic
CAediting_1239729	chr17_76728336_+	intronic
CAediting_1239730	chr17_76728353_+	intronic
CAediting_1239731	chr17_76728362_+	intronic
CAediting_1239732	chr17_76728365_+	intronic
CAediting_1239733	chr17_76728366_+	intronic
CAediting_1239734	chr17_76728370_+	intronic
CAediting_1239735	chr17_76728393_+	intronic
CAediting_1239736	chr17_76728611_+	intronic
CAediting_1239737	chr17_76728621_+	intronic
CAediting_1239738	chr17_76728633_+	intronic
CAediting_1239739	chr17_76728874_+	intronic
CAediting_1239740	chr17_76728911_+	intronic
CAediting_1239741	chr17_76728923_+	intronic
CAediting_1239742	chr17_76729278_+	intronic
CAediting_1239743	chr17_76729286_+	intronic
CAediting_1239744	chr17_76730077_+	ncRNA_intronic
CAediting_1239745	chr17_76730105_+	ncRNA_intronic
CAediting_1239746	chr17_76730136_+	ncRNA_intronic
CAediting_1239747	chr17_76730171_+	ncRNA_intronic
CAediting_1239748	chr17_76730172_+	ncRNA_intronic
CAediting_1239749	chr17_76730209_+	ncRNA_intronic
CAediting_1239750	chr17_76730210_+	ncRNA_intronic
CAediting_1239751	chr17_76730228_+	ncRNA_intronic
CAediting_1239752	chr17_76730238_+	ncRNA_intronic
CAediting_1239753	chr17_76730332_+	ncRNA_intronic
CAediting_1239754	chr17_76730341_+	ncRNA_intronic
CAediting_1239755	chr17_76730347_+	ncRNA_intronic
CAediting_1239756	chr17_76730348_+	ncRNA_intronic
CAediting_1239757	chr17_76730378_+	ncRNA_intronic
CAediting_1239758	chr17_76730383_+	ncRNA_intronic
CAediting_1239759	chr17_76730713_+	ncRNA_intronic
CAediting_1239760	chr17_76731168_+	ncRNA_intronic
CAediting_1239761	chr17_76731181_+	ncRNA_intronic
CAediting_1239762	chr17_76732111_+	ncRNA_intronic
CAediting_1239763	chr17_76732182_+	ncRNA_intronic
CAediting_1239764	chr17_76732229_+	ncRNA_intronic
CAediting_1239765	chr17_76732248_+	ncRNA_intronic
CAediting_1239766	chr17_76732253_+	ncRNA_intronic
CAediting_1239767	chr17_76732298_+	ncRNA_intronic
CAediting_1239768	chr17_76732314_+	ncRNA_intronic
CAediting_1239769	chr17_76732380_+	ncRNA_intronic
CAediting_1239770	chr17_76732381_+	ncRNA_intronic
CAediting_1239771	chr17_76732439_+	ncRNA_intronic
CAediting_1239772	chr17_76732447_+	ncRNA_intronic
CAediting_1239773	chr17_76732448_+	ncRNA_intronic
CAediting_1239774	chr17_76732455_+	ncRNA_intronic
CAediting_1239775	chr17_76732536_+	ncRNA_intronic
CAediting_1239776	chr17_76732549_+	ncRNA_intronic
CAediting_1239777	chr17_76732563_+	ncRNA_intronic
CAediting_1239778	chr17_76732584_+	ncRNA_intronic
CAediting_1239779	chr17_76732588_+	ncRNA_intronic
CAediting_1239780	chr17_76732600_+	ncRNA_intronic
CAediting_1239781	chr17_76732630_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1239694	chr17_76727398_+	SINE	Alu	AluJb
CAediting_1239695	chr17_76727401_+	SINE	Alu	AluJb
CAediting_1239696	chr17_76727434_+	SINE	Alu	AluJb
CAediting_1239697	chr17_76727435_+	SINE	Alu	AluJb
CAediting_1239698	chr17_76727439_+	SINE	Alu	AluJb
CAediting_1239699	chr17_76727461_+	SINE	Alu	AluJb
CAediting_1239700	chr17_76727462_+	SINE	Alu	AluJb
CAediting_1239701	chr17_76727468_+	SINE	Alu	AluJb
CAediting_1239702	chr17_76727474_+	SINE	Alu	AluJb
CAediting_1239703	chr17_76727750_+	SINE	Alu	AluJr
CAediting_1239704	chr17_76727800_+	SINE	Alu	AluJr
CAediting_1239705	chr17_76727811_+	SINE	Alu	AluJr
CAediting_1239706	chr17_76727831_+	SINE	Alu	AluJr
CAediting_1239707	chr17_76727852_+	SINE	Alu	AluJr
CAediting_1239708	chr17_76728001_+	SINE	Alu	AluJr
CAediting_1239709	chr17_76728030_+	SINE	Alu	AluJr
CAediting_1239710	chr17_76728058_+	SINE	Alu	AluJr
CAediting_1239711	chr17_76728064_+	SINE	Alu	AluJr
CAediting_1239712	chr17_76728097_+	SINE	Alu	AluJr
CAediting_1239713	chr17_76728115_+	SINE	Alu	AluJr
CAediting_1239714	chr17_76728125_+	SINE	Alu	AluJr
CAediting_1239715	chr17_76728145_+	SINE	Alu	AluJr
CAediting_1239716	chr17_76728156_+	SINE	Alu	AluJr
CAediting_1239717	chr17_76728185_+	SINE	Alu	AluJr
CAediting_1239718	chr17_76728191_+	SINE	Alu	AluJr
CAediting_1239719	chr17_76728196_+	SINE	Alu	AluJr
CAediting_1239720	chr17_76728205_+	SINE	Alu	AluJr
CAediting_1239721	chr17_76728243_+	SINE	Alu	AluJr
CAediting_1239722	chr17_76728246_+	SINE	Alu	AluJr
CAediting_1239723	chr17_76728247_+	SINE	Alu	AluJr
CAediting_1239724	chr17_76728310_+	SINE	Alu	AluJr
CAediting_1239725	chr17_76728311_+	SINE	Alu	AluJr
CAediting_1239726	chr17_76728317_+	SINE	Alu	AluJr
CAediting_1239727	chr17_76728322_+	SINE	Alu	AluJr
CAediting_1239728	chr17_76728335_+	SINE	Alu	AluJr
CAediting_1239729	chr17_76728336_+	SINE	Alu	AluJr
CAediting_1239730	chr17_76728353_+	SINE	Alu	AluJr
CAediting_1239731	chr17_76728362_+	SINE	Alu	AluJr
CAediting_1239732	chr17_76728365_+	SINE	Alu	AluJr
CAediting_1239733	chr17_76728366_+	SINE	Alu	AluJr
CAediting_1239734	chr17_76728370_+	SINE	Alu	AluJr
CAediting_1239735	chr17_76728393_+	SINE	Alu	AluJr
CAediting_1239736	chr17_76728611_+	SINE	Alu	AluSx1
CAediting_1239737	chr17_76728621_+	SINE	Alu	AluSx1
CAediting_1239738	chr17_76728633_+	SINE	Alu	AluSx1
CAediting_1239739	chr17_76728874_+	SINE	Alu	AluY
CAediting_1239740	chr17_76728911_+	SINE	Alu	AluY
CAediting_1239741	chr17_76728923_+	SINE	Alu	AluY
CAediting_1239742	chr17_76729278_+	SINE	Alu	AluSx
CAediting_1239743	chr17_76729286_+	SINE	Alu	AluSx
CAediting_1239744	chr17_76730077_+	SINE	Alu	AluSz
CAediting_1239745	chr17_76730105_+	SINE	Alu	AluSz
CAediting_1239746	chr17_76730136_+	SINE	Alu	AluSz
CAediting_1239747	chr17_76730171_+	SINE	Alu	AluSz
CAediting_1239748	chr17_76730172_+	SINE	Alu	AluSz
CAediting_1239749	chr17_76730209_+	SINE	Alu	AluSz
CAediting_1239750	chr17_76730210_+	SINE	Alu	AluSz
CAediting_1239751	chr17_76730228_+	SINE	Alu	AluSz
CAediting_1239752	chr17_76730238_+	SINE	Alu	AluSz
CAediting_1239753	chr17_76730332_+	SINE	Alu	FLAM_C
CAediting_1239754	chr17_76730341_+	SINE	Alu	FLAM_C
CAediting_1239755	chr17_76730347_+	SINE	Alu	FLAM_C
CAediting_1239756	chr17_76730348_+	SINE	Alu	FLAM_C
CAediting_1239757	chr17_76730378_+	SINE	Alu	FLAM_C
CAediting_1239758	chr17_76730383_+	SINE	Alu	FLAM_C
CAediting_1239759	chr17_76730713_+	SINE	Alu	AluSx
CAediting_1239760	chr17_76731168_+	SINE	Alu	AluSx
CAediting_1239761	chr17_76731181_+	SINE	Alu	AluSx
CAediting_1239762	chr17_76732111_+	SINE	Alu	AluSx1
CAediting_1239763	chr17_76732182_+	SINE	Alu	AluSx1
CAediting_1239764	chr17_76732229_+	SINE	Alu	AluSp
CAediting_1239765	chr17_76732248_+	SINE	Alu	AluSp
CAediting_1239766	chr17_76732253_+	SINE	Alu	AluSp
CAediting_1239767	chr17_76732298_+	SINE	Alu	AluSp
CAediting_1239768	chr17_76732314_+	SINE	Alu	AluSp
CAediting_1239769	chr17_76732380_+	SINE	Alu	AluSp
CAediting_1239770	chr17_76732381_+	SINE	Alu	AluSp
CAediting_1239771	chr17_76732439_+	SINE	Alu	AluSp
CAediting_1239772	chr17_76732447_+	SINE	Alu	AluSp
CAediting_1239773	chr17_76732448_+	SINE	Alu	AluSp
CAediting_1239774	chr17_76732455_+	SINE	Alu	AluSp
CAediting_1239775	chr17_76732536_+	SINE	Alu	AluSx1
CAediting_1239776	chr17_76732549_+	SINE	Alu	AluSx1
CAediting_1239777	chr17_76732563_+	SINE	Alu	AluSx1
CAediting_1239778	chr17_76732584_+	SINE	Alu	AluSx1
CAediting_1239779	chr17_76732588_+	SINE	Alu	AluSx1
CAediting_1239780	chr17_76732600_+	SINE	Alu	AluSx1
CAediting_1239781	chr17_76732630_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for METTL23

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000181038.12.METTL23.

Correlation between RNA A-to-I editing and PSI for ENSG00000181038.12.METTL23.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for METTL23

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for METTL23

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for METTL23

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1399425	chr20_1392958_-	ENSG00000181038.12	ENST00000589977	hsa-miR-6869-5p	76733429	76733435	7mer-m8	76733413	76733436	150	-19.45
CAediting_1399425	chr20_1392958_-	ENSG00000181038.12	ENST00000591571	hsa-miR-6869-5p	76733429	76733435	7mer-m8	76733413	76733436	150	-19.45

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for METTL23

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for METTL23

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_1239701	chr17_76727468_+	0.0429045402795705	0.174536222860358	.	.	.	.
GBM	CAediting_1239701	chr17_76727468_+	.	.	0.0230107786764425	0.308968796598887	.	.
STAD	CAediting_1239701	chr17_76727468_+	.	.	0.000835144005547115	0.281191368698655	.	.

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Relation with cancer stages for METTL23

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
ESCA	pathologic_stage	CAediting_1239700	chr17_76727462_+	0.00716859357229415	0.372120849063091
ESCA	pathologic_stage	CAediting_1239701	chr17_76727468_+	0.011096194274256	0.284341499318338

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Relation with survival for METTL23

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for METTL23

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for METTL23

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
METTL23	C4014745	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 44	2	CTD_human;GENOMICS_ENGLAND
METTL23	C0020796	Profound Mental Retardation	1	CTD_human
METTL23	C0025363	Mental Retardation, Psychosocial	1	CTD_human
METTL23	C0917816	Mental deficiency	1	CTD_human
METTL23	C3714756	Intellectual Disability	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene