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Editing gene: ZC3H18 (CAeditome ID:124245)

Gene summary for ZC3H18

Gene summary

Gene information	Gene symbol	ZC3H18
	Gene ID	124245
	Gene name	zinc finger CCCH-type containing 18
	Synonyms	NHN1
	Cytomap	16q24.2
	Type of gene	protein-coding
	Description	zinc finger CCCH domain-containing protein 18conserved nuclear protein NHN1nuclear protein NHN1
	Modification date	20210518
	UniProtAcc	Q86VM9
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ZC3H18	GO:0030674	Zinc finger CCCH domain-containing protein 18	28297668
ZC3H18	GO:0140262	Zinc finger CCCH domain-containing protein 18	28297668
ZC3H18	GO:0016607	Zinc finger CCCH domain-containing protein 18	0000052
ZC3H18	GO:0032991	Zinc finger CCCH domain-containing protein 18	23793891
ZC3H18	GO:1990904	Zinc finger CCCH domain-containing protein 18	28297668

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RNA A-to-I events for ZC3H18

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000158545.14

RNA A-to-I editing events in Cancer.

CAediting_1143215(88590019, +), CAediting_1143216(88590021, +), CAediting_1143217(88590080, +), CAediting_1143218(88590150, +), CAediting_1143219(88590155, +), CAediting_1143220(88590180, +), CAediting_1143221(88590187, +), CAediting_1143222(88591132, +), CAediting_1143223(88591155, +), CAediting_1143224(88591177, +), CAediting_1143225(88591232, +), CAediting_1143226(88591244, +), CAediting_1143227(88591317, +), CAediting_1143228(88591318, +), CAediting_1143229(88591321, +), CAediting_1143230(88591387, +), CAediting_1143231(88591396, +), CAediting_1143232(88591397, +), CAediting_1143233(88591408, +), CAediting_1143234(88591413, +), CAediting_1143235(88591414, +), CAediting_1143236(88591417, +), CAediting_1143237(88591438, +), CAediting_1143238(88591452, +), CAediting_1143239(88596352, +), CAediting_1143240(88602774, +), CAediting_1143241(88604097, +), CAediting_1143242(88612435, +), CAediting_1143243(88612450, +), CAediting_1143244(88612454, +), CAediting_1143245(88612530, +), CAediting_1143246(88612792, +), CAediting_1143247(88612869, +), CAediting_1143248(88620369, +), CAediting_1143249(88620374, +), CAediting_1143250(88620379, +), CAediting_1143251(88620388, +), CAediting_1143252(88620470, +), CAediting_1143253(88620474, +), CAediting_1143254(88620515, +), CAediting_1143255(88620558, +), CAediting_1143256(88621693, +), CAediting_1143257(88625515, +), CAediting_1143258(88625722, +), CAediting_1143259(88625736, +), CAediting_1143260(88625738, +), CAediting_1143261(88625750, +), CAediting_1143262(88625761, +), CAediting_1143263(88625766, +), CAediting_1143264(88625767, +), CAediting_1143265(88625771, +), CAediting_1143266(88625807, +), CAediting_1143267(88625886, +), CAediting_1143268(88625940, +), CAediting_1143269(88625952, +), CAediting_1143270(88625957, +), CAediting_1143271(88625964, +), CAediting_1143272(88626006, +), CAediting_1143273(88626032, +), CAediting_1143274(88626052, +), CAediting_1143275(88626057, +), CAediting_1143276(88626070, +), CAediting_1143277(88626085, +), CAediting_1143278(88626094, +), CAediting_1143279(88626186, +), CAediting_1143280(88626214, +), CAediting_1143281(88626226, +), CAediting_1143282(88626228, +), CAediting_1143283(88626270, +), CAediting_1143284(88626302, +), CAediting_1143285(88626306, +), CAediting_1143286(88626318, +), CAediting_1143287(88626319, +), CAediting_1143288(88626329, +), CAediting_1143289(88626339, +), CAediting_1143290(88626342, +), CAediting_1143291(88626381, +), CAediting_1143292(88626396, +), CAediting_1143293(88626536, +), CAediting_1143294(88627113, +), CAediting_1143295(88627120, +), CAediting_1143296(88627131, +), CAediting_1143297(88627169, +), CAediting_1143298(88627187, +), CAediting_1143299(88627199, +), CAediting_1143300(88627209, +), CAediting_1143301(88627211, +), CAediting_1143302(88627253, +), CAediting_1143303(88627270, +), CAediting_1143304(88627280, +), CAediting_1143305(88627327, +), CAediting_1143306(88627355, +), CAediting_1143307(88627363, +), CAediting_1143308(88627365, +), CAediting_1143309(88629339, +),

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RNA editing positional annotations for ZC3H18 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1143215	chr16_88590019_+	intronic
CAediting_1143216	chr16_88590021_+	intronic
CAediting_1143217	chr16_88590080_+	intronic
CAediting_1143218	chr16_88590150_+	intronic
CAediting_1143219	chr16_88590155_+	intronic
CAediting_1143220	chr16_88590180_+	intronic
CAediting_1143221	chr16_88590187_+	intronic
CAediting_1143222	chr16_88591132_+	intronic
CAediting_1143223	chr16_88591155_+	intronic
CAediting_1143224	chr16_88591177_+	intronic
CAediting_1143225	chr16_88591232_+	intronic
CAediting_1143226	chr16_88591244_+	intronic
CAediting_1143227	chr16_88591317_+	intronic
CAediting_1143228	chr16_88591318_+	intronic
CAediting_1143229	chr16_88591321_+	intronic
CAediting_1143230	chr16_88591387_+	intronic
CAediting_1143231	chr16_88591396_+	intronic
CAediting_1143232	chr16_88591397_+	intronic
CAediting_1143233	chr16_88591408_+	intronic
CAediting_1143234	chr16_88591413_+	intronic
CAediting_1143235	chr16_88591414_+	intronic
CAediting_1143236	chr16_88591417_+	intronic
CAediting_1143237	chr16_88591438_+	intronic
CAediting_1143238	chr16_88591452_+	intronic
CAediting_1143239	chr16_88596352_+	intronic
CAediting_1143240	chr16_88602774_+	ncRNA_intronic
CAediting_1143241	chr16_88604097_+	ncRNA_intronic
CAediting_1143242	chr16_88612435_+	ncRNA_intronic
CAediting_1143243	chr16_88612450_+	ncRNA_intronic
CAediting_1143244	chr16_88612454_+	ncRNA_intronic
CAediting_1143245	chr16_88612530_+	ncRNA_intronic
CAediting_1143246	chr16_88612792_+	ncRNA_intronic
CAediting_1143247	chr16_88612869_+	ncRNA_intronic
CAediting_1143248	chr16_88620369_+	ncRNA_intronic
CAediting_1143249	chr16_88620374_+	ncRNA_intronic
CAediting_1143250	chr16_88620379_+	ncRNA_intronic
CAediting_1143251	chr16_88620388_+	ncRNA_intronic
CAediting_1143252	chr16_88620470_+	ncRNA_intronic
CAediting_1143253	chr16_88620474_+	ncRNA_intronic
CAediting_1143254	chr16_88620515_+	ncRNA_intronic
CAediting_1143255	chr16_88620558_+	ncRNA_intronic
CAediting_1143256	chr16_88621693_+	ncRNA_intronic
CAediting_1143257	chr16_88625515_+	ncRNA_exonic
CAediting_1143258	chr16_88625722_+	ncRNA_exonic
CAediting_1143259	chr16_88625736_+	ncRNA_exonic
CAediting_1143260	chr16_88625738_+	ncRNA_exonic
CAediting_1143261	chr16_88625750_+	ncRNA_exonic
CAediting_1143262	chr16_88625761_+	ncRNA_exonic
CAediting_1143263	chr16_88625766_+	ncRNA_exonic
CAediting_1143264	chr16_88625767_+	ncRNA_exonic
CAediting_1143265	chr16_88625771_+	ncRNA_exonic
CAediting_1143266	chr16_88625807_+	ncRNA_exonic
CAediting_1143267	chr16_88625886_+	ncRNA_exonic
CAediting_1143268	chr16_88625940_+	ncRNA_exonic
CAediting_1143269	chr16_88625952_+	ncRNA_exonic
CAediting_1143270	chr16_88625957_+	ncRNA_exonic
CAediting_1143271	chr16_88625964_+	ncRNA_exonic
CAediting_1143272	chr16_88626006_+	ncRNA_exonic
CAediting_1143273	chr16_88626032_+	ncRNA_exonic
CAediting_1143274	chr16_88626052_+	ncRNA_exonic
CAediting_1143275	chr16_88626057_+	ncRNA_exonic
CAediting_1143276	chr16_88626070_+	ncRNA_exonic
CAediting_1143277	chr16_88626085_+	ncRNA_exonic
CAediting_1143278	chr16_88626094_+	ncRNA_exonic
CAediting_1143279	chr16_88626186_+	ncRNA_exonic
CAediting_1143280	chr16_88626214_+	ncRNA_exonic
CAediting_1143281	chr16_88626226_+	ncRNA_exonic
CAediting_1143282	chr16_88626228_+	ncRNA_exonic
CAediting_1143283	chr16_88626270_+	ncRNA_exonic
CAediting_1143284	chr16_88626302_+	ncRNA_exonic
CAediting_1143285	chr16_88626306_+	ncRNA_exonic
CAediting_1143286	chr16_88626318_+	ncRNA_exonic
CAediting_1143287	chr16_88626319_+	ncRNA_exonic
CAediting_1143288	chr16_88626329_+	ncRNA_exonic
CAediting_1143289	chr16_88626339_+	ncRNA_exonic
CAediting_1143290	chr16_88626342_+	ncRNA_exonic
CAediting_1143291	chr16_88626381_+	ncRNA_exonic
CAediting_1143292	chr16_88626396_+	ncRNA_exonic
CAediting_1143293	chr16_88626536_+	ncRNA_exonic
CAediting_1143294	chr16_88627113_+	ncRNA_exonic
CAediting_1143295	chr16_88627120_+	ncRNA_exonic
CAediting_1143296	chr16_88627131_+	ncRNA_exonic
CAediting_1143297	chr16_88627169_+	ncRNA_exonic
CAediting_1143298	chr16_88627187_+	ncRNA_exonic
CAediting_1143299	chr16_88627199_+	ncRNA_exonic
CAediting_1143300	chr16_88627209_+	ncRNA_exonic
CAediting_1143301	chr16_88627211_+	ncRNA_exonic
CAediting_1143302	chr16_88627253_+	ncRNA_exonic
CAediting_1143303	chr16_88627270_+	ncRNA_exonic
CAediting_1143304	chr16_88627280_+	ncRNA_exonic
CAediting_1143305	chr16_88627327_+	ncRNA_exonic
CAediting_1143306	chr16_88627355_+	ncRNA_exonic
CAediting_1143307	chr16_88627363_+	ncRNA_exonic
CAediting_1143308	chr16_88627365_+	ncRNA_exonic
CAediting_1143309	chr16_88629339_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1143215	chr16_88590019_+	SINE	Alu	AluJo
CAediting_1143216	chr16_88590021_+	SINE	Alu	AluJo
CAediting_1143217	chr16_88590080_+	SINE	Alu	AluJo
CAediting_1143218	chr16_88590150_+	SINE	Alu	AluJr4
CAediting_1143219	chr16_88590155_+	SINE	Alu	AluJr4
CAediting_1143220	chr16_88590180_+	SINE	Alu	AluJr4
CAediting_1143221	chr16_88590187_+	SINE	Alu	AluJr4
CAediting_1143222	chr16_88591132_+	SINE	Alu	AluY
CAediting_1143223	chr16_88591155_+	SINE	Alu	AluY
CAediting_1143224	chr16_88591177_+	SINE	Alu	AluY
CAediting_1143225	chr16_88591232_+	SINE	Alu	AluY
CAediting_1143226	chr16_88591244_+	SINE	Alu	AluY
CAediting_1143227	chr16_88591317_+	SINE	Alu	AluSz
CAediting_1143228	chr16_88591318_+	SINE	Alu	AluSz
CAediting_1143229	chr16_88591321_+	SINE	Alu	AluSz
CAediting_1143230	chr16_88591387_+	SINE	Alu	AluSz
CAediting_1143231	chr16_88591396_+	SINE	Alu	AluSz
CAediting_1143232	chr16_88591397_+	SINE	Alu	AluSz
CAediting_1143233	chr16_88591408_+	SINE	Alu	AluSz
CAediting_1143234	chr16_88591413_+	SINE	Alu	AluSz
CAediting_1143235	chr16_88591414_+	SINE	Alu	AluSz
CAediting_1143236	chr16_88591417_+	SINE	Alu	AluSz
CAediting_1143237	chr16_88591438_+	SINE	Alu	AluSz
CAediting_1143238	chr16_88591452_+	SINE	Alu	AluSz
CAediting_1143240	chr16_88602774_+	SINE	Alu	FLAM_C
CAediting_1143241	chr16_88604097_+	SINE	Alu	AluSz6
CAediting_1143242	chr16_88612435_+	SINE	Alu	AluJr
CAediting_1143243	chr16_88612450_+	SINE	Alu	AluJr
CAediting_1143244	chr16_88612454_+	SINE	Alu	AluJr
CAediting_1143245	chr16_88612530_+	SINE	Alu	AluJr
CAediting_1143246	chr16_88612792_+	SINE	Alu	AluJb
CAediting_1143247	chr16_88612869_+	SINE	Alu	AluJb
CAediting_1143248	chr16_88620369_+	SINE	Alu	AluJr
CAediting_1143249	chr16_88620374_+	SINE	Alu	AluJr
CAediting_1143250	chr16_88620379_+	SINE	Alu	AluJr
CAediting_1143251	chr16_88620388_+	SINE	Alu	AluJr
CAediting_1143252	chr16_88620470_+	SINE	Alu	AluJr
CAediting_1143253	chr16_88620474_+	SINE	Alu	AluJr
CAediting_1143254	chr16_88620515_+	SINE	Alu	AluJr
CAediting_1143255	chr16_88620558_+	SINE	Alu	AluJr
CAediting_1143256	chr16_88621693_+	SINE	Alu	AluSz
CAediting_1143258	chr16_88625722_+	SINE	Alu	AluJo
CAediting_1143259	chr16_88625736_+	SINE	Alu	AluJo
CAediting_1143260	chr16_88625738_+	SINE	Alu	AluJo
CAediting_1143261	chr16_88625750_+	SINE	Alu	AluJo
CAediting_1143262	chr16_88625761_+	SINE	Alu	AluJo
CAediting_1143263	chr16_88625766_+	SINE	Alu	AluJo
CAediting_1143264	chr16_88625767_+	SINE	Alu	AluJo
CAediting_1143265	chr16_88625771_+	SINE	Alu	AluJo
CAediting_1143266	chr16_88625807_+	SINE	Alu	AluJo
CAediting_1143267	chr16_88625886_+	SINE	Alu	AluSq2
CAediting_1143268	chr16_88625940_+	SINE	Alu	AluSq2
CAediting_1143269	chr16_88625952_+	SINE	Alu	AluSq2
CAediting_1143270	chr16_88625957_+	SINE	Alu	AluSq2
CAediting_1143271	chr16_88625964_+	SINE	Alu	AluSq2
CAediting_1143272	chr16_88626006_+	SINE	Alu	AluSq2
CAediting_1143273	chr16_88626032_+	SINE	Alu	AluSq2
CAediting_1143274	chr16_88626052_+	SINE	Alu	AluSq2
CAediting_1143275	chr16_88626057_+	SINE	Alu	AluSq2
CAediting_1143276	chr16_88626070_+	SINE	Alu	AluSq2
CAediting_1143277	chr16_88626085_+	SINE	Alu	AluSq2
CAediting_1143278	chr16_88626094_+	SINE	Alu	AluSq2
CAediting_1143279	chr16_88626186_+	SINE	Alu	AluSx
CAediting_1143280	chr16_88626214_+	SINE	Alu	AluSx
CAediting_1143281	chr16_88626226_+	SINE	Alu	AluSx
CAediting_1143282	chr16_88626228_+	SINE	Alu	AluSx
CAediting_1143283	chr16_88626270_+	SINE	Alu	AluSc5
CAediting_1143284	chr16_88626302_+	SINE	Alu	AluSc5
CAediting_1143285	chr16_88626306_+	SINE	Alu	AluSc5
CAediting_1143286	chr16_88626318_+	SINE	Alu	AluJb
CAediting_1143287	chr16_88626319_+	SINE	Alu	AluJb
CAediting_1143288	chr16_88626329_+	SINE	Alu	AluJb
CAediting_1143289	chr16_88626339_+	SINE	Alu	AluJb
CAediting_1143290	chr16_88626342_+	SINE	Alu	AluJb
CAediting_1143291	chr16_88626381_+	SINE	Alu	AluJb
CAediting_1143293	chr16_88626536_+	SINE	Alu	AluJo
CAediting_1143294	chr16_88627113_+	SINE	Alu	AluSq2
CAediting_1143295	chr16_88627120_+	SINE	Alu	AluSq2
CAediting_1143296	chr16_88627131_+	SINE	Alu	AluSq2
CAediting_1143297	chr16_88627169_+	SINE	Alu	AluSq2
CAediting_1143298	chr16_88627187_+	SINE	Alu	AluSq2
CAediting_1143299	chr16_88627199_+	SINE	Alu	AluSq2
CAediting_1143300	chr16_88627209_+	SINE	Alu	AluSq2
CAediting_1143301	chr16_88627211_+	SINE	Alu	AluSq2
CAediting_1143302	chr16_88627253_+	SINE	Alu	AluSq2
CAediting_1143303	chr16_88627270_+	SINE	Alu	AluSq2
CAediting_1143304	chr16_88627280_+	SINE	Alu	AluSq2
CAediting_1143305	chr16_88627327_+	SINE	Alu	AluSq2
CAediting_1143306	chr16_88627355_+	SINE	Alu	AluSq2
CAediting_1143307	chr16_88627363_+	SINE	Alu	AluSq2
CAediting_1143308	chr16_88627365_+	SINE	Alu	AluSq2
CAediting_1143309	chr16_88629339_+	SINE	Alu	AluSq2

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RNA A-to-I editing events in the alternative splicing sites for ZC3H18

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000158545.14.ZC3H18.

Correlation between RNA A-to-I editing and PSI for ENSG00000158545.14.ZC3H18.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZC3H18

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZC3H18

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZC3H18

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000158545.14	ENST00000565583	hsa-miR-320e	88631634	88631640	7mer-m8	88631624	88631641	145	-17.62
CAediting_468389	chr6_31355314_-	ENSG00000158545.14	ENST00000564341	hsa-miR-6891-5p	88631725	88631730	6mer	88631713	88631731	152	-24.65
CAediting_468389	chr6_31355314_-	ENSG00000158545.14	ENST00000565583	hsa-miR-6891-5p	88631725	88631730	6mer	88631713	88631731	152	-24.65

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZC3H18

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZC3H18

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ZC3H18

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ZC3H18

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ZC3H18

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZC3H18

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene