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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ACSM2A (CAeditome ID:123876)

Gene summary for ACSM2A

check button Gene summary
Gene informationGene symbol

ACSM2A

Gene ID

123876

Gene nameacyl-CoA synthetase medium chain family member 2A
SynonymsA-923A4.1|ACSM2
Cytomap

16p12.3

Type of geneprotein-coding
Descriptionacyl-coenzyme A synthetase ACSM2A, mitochondrialacyl-CoA synthetase medium-chain family member 2benzoate--CoA ligasebutyrate--CoA ligase 2Abutyryl-coenzyme A synthetase 2Amiddle-chain acyl-CoA synthetase 2A
Modification date20210518
UniProtAcc

Q08AH3

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ACSM2A

GO:0047760

Acyl-coenzyme A synthetase ACSM2A, mitochondrial

19345228

ACSM2A

GO:0036112

Acyl-coenzyme A synthetase ACSM2A, mitochondrial

19345228


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RNA A-to-I events for ACSM2A

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000183747.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1098175(20460702, +), CAediting_1098176(20463363, +), CAediting_1098177(20463399, +), CAediting_1098178(20463561, +), CAediting_1098179(20463594, +), CAediting_1098180(20463595, +), CAediting_1098181(20463604, +), CAediting_1098182(20463615, +), CAediting_1098183(20463618, +), CAediting_1098184(20463621, +), CAediting_1098185(20463631, +), CAediting_1098186(20463663, +), CAediting_1098187(20463671, +), CAediting_1098188(20463673, +), CAediting_1098189(20463685, +), CAediting_1098190(20463687, +), CAediting_1098191(20463688, +), CAediting_1098192(20463689, +), CAediting_1098193(20463692, +), CAediting_1098194(20463706, +), CAediting_1098195(20464342, +), CAediting_1098196(20464343, +), CAediting_1098197(20464347, +), CAediting_1098198(20464349, +), CAediting_1098199(20464356, +), CAediting_1098200(20464359, +), CAediting_1098201(20464363, +), CAediting_1098202(20464370, +), CAediting_1098203(20464371, +), CAediting_1098204(20464372, +), CAediting_1098205(20464375, +), CAediting_1098206(20464376, +), CAediting_1098207(20464377, +), CAediting_1098208(20464385, +), CAediting_1098209(20464395, +), CAediting_1098210(20464396, +), CAediting_1098211(20464406, +), CAediting_1098212(20464411, +), CAediting_1098213(20464413, +), CAediting_1098214(20464417, +), CAediting_1098215(20464431, +), CAediting_1098216(20464442, +), CAediting_1098217(20464453, +), CAediting_1098218(20464454, +), CAediting_1098219(20464458, +), CAediting_1098220(20464462, +), CAediting_1098221(20464464, +), CAediting_1098222(20464468, +), CAediting_1098223(20464476, +), CAediting_1098224(20464482, +), CAediting_1098225(20464495, +), CAediting_1098226(20464508, +), CAediting_1098227(20464520, +), CAediting_1098228(20464532, +), CAediting_1098229(20464586, +), CAediting_1098230(20464599, +), CAediting_1098231(20464600, +), CAediting_1098232(20464608, +), CAediting_1098233(20464611, +), CAediting_1098234(20464619, +), CAediting_1098235(20464632, +), CAediting_1098236(20464646, +), CAediting_1098237(20464647, +), CAediting_1098238(20468477, +), CAediting_1098239(20468540, +), CAediting_1098240(20468544, +), CAediting_1098241(20482159, +),

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RNA editing positional annotations for ACSM2A using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1098175chr16_20460702_+ncRNA_intronic
CAediting_1098176chr16_20463363_+ncRNA_intronic
CAediting_1098177chr16_20463399_+ncRNA_intronic
CAediting_1098178chr16_20463561_+ncRNA_intronic
CAediting_1098179chr16_20463594_+ncRNA_intronic
CAediting_1098180chr16_20463595_+ncRNA_intronic
CAediting_1098181chr16_20463604_+ncRNA_intronic
CAediting_1098182chr16_20463615_+ncRNA_intronic
CAediting_1098183chr16_20463618_+ncRNA_intronic
CAediting_1098184chr16_20463621_+ncRNA_intronic
CAediting_1098185chr16_20463631_+ncRNA_intronic
CAediting_1098186chr16_20463663_+ncRNA_intronic
CAediting_1098187chr16_20463671_+ncRNA_intronic
CAediting_1098188chr16_20463673_+ncRNA_intronic
CAediting_1098189chr16_20463685_+ncRNA_intronic
CAediting_1098190chr16_20463687_+ncRNA_intronic
CAediting_1098191chr16_20463688_+ncRNA_intronic
CAediting_1098192chr16_20463689_+ncRNA_intronic
CAediting_1098193chr16_20463692_+ncRNA_intronic
CAediting_1098194chr16_20463706_+ncRNA_intronic
CAediting_1098195chr16_20464342_+ncRNA_intronic
CAediting_1098196chr16_20464343_+ncRNA_intronic
CAediting_1098197chr16_20464347_+ncRNA_intronic
CAediting_1098198chr16_20464349_+ncRNA_intronic
CAediting_1098199chr16_20464356_+ncRNA_intronic
CAediting_1098200chr16_20464359_+ncRNA_intronic
CAediting_1098201chr16_20464363_+ncRNA_intronic
CAediting_1098202chr16_20464370_+ncRNA_intronic
CAediting_1098203chr16_20464371_+ncRNA_intronic
CAediting_1098204chr16_20464372_+ncRNA_intronic
CAediting_1098205chr16_20464375_+ncRNA_intronic
CAediting_1098206chr16_20464376_+ncRNA_intronic
CAediting_1098207chr16_20464377_+ncRNA_intronic
CAediting_1098208chr16_20464385_+ncRNA_intronic
CAediting_1098209chr16_20464395_+ncRNA_intronic
CAediting_1098210chr16_20464396_+ncRNA_intronic
CAediting_1098211chr16_20464406_+ncRNA_intronic
CAediting_1098212chr16_20464411_+ncRNA_intronic
CAediting_1098213chr16_20464413_+ncRNA_intronic
CAediting_1098214chr16_20464417_+ncRNA_intronic
CAediting_1098215chr16_20464431_+ncRNA_intronic
CAediting_1098216chr16_20464442_+ncRNA_intronic
CAediting_1098217chr16_20464453_+ncRNA_intronic
CAediting_1098218chr16_20464454_+ncRNA_intronic
CAediting_1098219chr16_20464458_+ncRNA_intronic
CAediting_1098220chr16_20464462_+ncRNA_intronic
CAediting_1098221chr16_20464464_+ncRNA_intronic
CAediting_1098222chr16_20464468_+ncRNA_intronic
CAediting_1098223chr16_20464476_+ncRNA_intronic
CAediting_1098224chr16_20464482_+ncRNA_intronic
CAediting_1098225chr16_20464495_+ncRNA_intronic
CAediting_1098226chr16_20464508_+ncRNA_intronic
CAediting_1098227chr16_20464520_+ncRNA_intronic
CAediting_1098228chr16_20464532_+ncRNA_intronic
CAediting_1098229chr16_20464586_+ncRNA_intronic
CAediting_1098230chr16_20464599_+ncRNA_intronic
CAediting_1098231chr16_20464600_+ncRNA_intronic
CAediting_1098232chr16_20464608_+ncRNA_intronic
CAediting_1098233chr16_20464611_+ncRNA_intronic
CAediting_1098234chr16_20464619_+ncRNA_intronic
CAediting_1098235chr16_20464632_+ncRNA_intronic
CAediting_1098236chr16_20464646_+ncRNA_intronic
CAediting_1098237chr16_20464647_+ncRNA_intronic
CAediting_1098238chr16_20468477_+ncRNA_intronic
CAediting_1098239chr16_20468540_+ncRNA_intronic
CAediting_1098240chr16_20468544_+ncRNA_intronic
CAediting_1098241chr16_20482159_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1098175chr16_20460702_+SINEAluAluJr
CAediting_1098176chr16_20463363_+LTRERVL-MaLRMSTB
CAediting_1098177chr16_20463399_+LTRERVL-MaLRMSTB
CAediting_1098178chr16_20463561_+LTRERVL-MaLRMSTB
CAediting_1098179chr16_20463594_+LTRERVL-MaLRMSTB
CAediting_1098180chr16_20463595_+LTRERVL-MaLRMSTB
CAediting_1098181chr16_20463604_+LTRERVL-MaLRMSTB
CAediting_1098182chr16_20463615_+LTRERVL-MaLRMSTB
CAediting_1098183chr16_20463618_+LTRERVL-MaLRMSTB
CAediting_1098184chr16_20463621_+LTRERVL-MaLRMSTB
CAediting_1098185chr16_20463631_+LTRERVL-MaLRMSTB
CAediting_1098186chr16_20463663_+LTRERVL-MaLRMSTB
CAediting_1098187chr16_20463671_+LTRERVL-MaLRMSTB
CAediting_1098188chr16_20463673_+LTRERVL-MaLRMSTB
CAediting_1098189chr16_20463685_+LTRERVL-MaLRMSTB
CAediting_1098190chr16_20463687_+LTRERVL-MaLRMSTB
CAediting_1098191chr16_20463688_+LTRERVL-MaLRMSTB
CAediting_1098192chr16_20463689_+LTRERVL-MaLRMSTB
CAediting_1098193chr16_20463692_+LTRERVL-MaLRMSTB
CAediting_1098194chr16_20463706_+LTRERVL-MaLRMSTB
CAediting_1098195chr16_20464342_+LTRERVL-MaLRMSTB
CAediting_1098196chr16_20464343_+LTRERVL-MaLRMSTB
CAediting_1098197chr16_20464347_+LTRERVL-MaLRMSTB
CAediting_1098198chr16_20464349_+LTRERVL-MaLRMSTB
CAediting_1098199chr16_20464356_+LTRERVL-MaLRMSTB
CAediting_1098200chr16_20464359_+LTRERVL-MaLRMSTB
CAediting_1098201chr16_20464363_+LTRERVL-MaLRMSTB
CAediting_1098202chr16_20464370_+LTRERVL-MaLRMSTB
CAediting_1098203chr16_20464371_+LTRERVL-MaLRMSTB
CAediting_1098204chr16_20464372_+LTRERVL-MaLRMSTB
CAediting_1098205chr16_20464375_+LTRERVL-MaLRMSTB
CAediting_1098206chr16_20464376_+LTRERVL-MaLRMSTB
CAediting_1098207chr16_20464377_+LTRERVL-MaLRMSTB
CAediting_1098208chr16_20464385_+LTRERVL-MaLRMSTB
CAediting_1098209chr16_20464395_+LTRERVL-MaLRMSTB
CAediting_1098210chr16_20464396_+LTRERVL-MaLRMSTB
CAediting_1098211chr16_20464406_+LTRERVL-MaLRMSTB
CAediting_1098212chr16_20464411_+LTRERVL-MaLRMSTB
CAediting_1098213chr16_20464413_+LTRERVL-MaLRMSTB
CAediting_1098214chr16_20464417_+LTRERVL-MaLRMSTB
CAediting_1098215chr16_20464431_+LTRERVL-MaLRMSTB
CAediting_1098216chr16_20464442_+LTRERVL-MaLRMSTB
CAediting_1098217chr16_20464453_+LTRERVL-MaLRMSTB
CAediting_1098218chr16_20464454_+LTRERVL-MaLRMSTB
CAediting_1098219chr16_20464458_+LTRERVL-MaLRMSTB
CAediting_1098220chr16_20464462_+LTRERVL-MaLRMSTB
CAediting_1098221chr16_20464464_+LTRERVL-MaLRMSTB
CAediting_1098222chr16_20464468_+LTRERVL-MaLRMSTB
CAediting_1098223chr16_20464476_+LTRERVL-MaLRMSTB
CAediting_1098224chr16_20464482_+LTRERVL-MaLRMSTB
CAediting_1098225chr16_20464495_+LTRERVL-MaLRMSTB
CAediting_1098226chr16_20464508_+LTRERVL-MaLRMSTB
CAediting_1098227chr16_20464520_+LTRERVL-MaLRMSTB
CAediting_1098228chr16_20464532_+LTRERVL-MaLRMSTB
CAediting_1098229chr16_20464586_+LTRERVL-MaLRMSTB
CAediting_1098230chr16_20464599_+LTRERVL-MaLRMSTB
CAediting_1098231chr16_20464600_+LTRERVL-MaLRMSTB
CAediting_1098232chr16_20464608_+LTRERVL-MaLRMSTB
CAediting_1098233chr16_20464611_+LTRERVL-MaLRMSTB
CAediting_1098234chr16_20464619_+LTRERVL-MaLRMSTB
CAediting_1098235chr16_20464632_+LTRERVL-MaLRMSTB
CAediting_1098236chr16_20464646_+LTRERVL-MaLRMSTB
CAediting_1098237chr16_20464647_+LTRERVL-MaLRMSTB
CAediting_1098238chr16_20468477_+SINEAluAluSz
CAediting_1098239chr16_20468540_+SINEAluAluSz
CAediting_1098240chr16_20468544_+SINEAluAluSz
CAediting_1098241chr16_20482159_+SINEAluAluSg4

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RNA A-to-I editing events in the alternative splicing sites for ACSM2A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1098186chr16_20463663_+20463657:204636655SS0+4iACTGTGAGC4.2ACTGTGGGC-1.2
IRCAediting_1098186chr16_20463663_+20463657:204636655SS0+4iACTGTGAGC4.2ACTGTGGGC-1.2

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000183747.10.ACSM2A.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000183747.10.ACSM2A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACSM2A

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
KIRP.CAediting_1098178.ENSG00000183747.ACSM2A.png
Soverview
LIHC.CAediting_1098179.ENSG00000183747.ACSM2A.png
Soverview

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Protein coding region RNA A-to-I editings for ACSM2A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ACSM2A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229414chr17_67471546_+ENSG00000183747.10ENST00000574692hsa-miR-548aa20471150204711567mer-m82047113320471157148-17.61
CAediting_396018chr5_1062918_-ENSG00000183747.10ENST00000574692hsa-miR-463520471192204711987mer-m82047117920471199150-19.71
CAediting_1399425chr20_1392958_-ENSG00000183747.10ENST00000396104hsa-miR-6869-5p20487597204876037mer-m82048758320487604143-18.36
CAediting_414656chr5_72878640_+ENSG00000183747.10ENST00000396104hsa-miR-4804-3p20487294204873018mer-1a2048728120487301154-15.2

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ACSM2A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ACSM2A

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
KIRPCAediting_1098177chr16_20463399_+..0.00138536227245370.332087432623935..
KIRCCAediting_1098178chr16_20463561_+0.02198475280981040.158774671866213....
KIRPCAediting_1098178chr16_20463561_+0.02877111185152060.183556485666877....
KIRCCAediting_1098180chr16_20463595_+..0.0001028406381792080.315870928837302..
KIRPCAediting_1098183chr16_20463618_+0.01059111433185950.2825688335689530.004128739402069570.315408641853104..
KIRPCAediting_1098189chr16_20463685_+0.0005268786448012210.3421828436148740.006269506849918340.272941109499133..
KIRCCAediting_1098191chr16_20463688_+0.0002336882573447040.323461564414612....
KIRPCAediting_1098191chr16_20463688_+0.003202112697532020.333890332614372....
KIRCCAediting_1098198chr16_20464349_+..0.03759966491745580.219553365922322..
KIRPCAediting_1098200chr16_20464359_+..3.93208918903347e-060.372583428230512..
KIRCCAediting_1098203chr16_20464371_+..0.04003020032775960.239300990792185..
KIRPCAediting_1098207chr16_20464377_+2.51139377188951e-050.435315465644302....
LIHCCAediting_1098218chr16_20464454_+0.01803922870981090.333242215876553....
KIRPCAediting_1098220chr16_20464462_+..0.006946300101666630.211321286613543..
KIRPCAediting_1098222chr16_20464468_+..8.6310643402802e-120.713461933676764..
KIRPCAediting_1098230chr16_20464599_+0.02864762399433640.241771865429427....
KIRCCAediting_1098232chr16_20464608_+..0.0003516575539213960.306466211439981..
KIRPCAediting_1098232chr16_20464608_+..5.10359946564557e-150.654369026286163..
KIRCCAediting_1098237chr16_20464647_+..0.003839194384896390.28947728080752..
KIRPCAediting_1098237chr16_20464647_+..1.03555556224259e-100.679078279107799..

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Relation with cancer stages for ACSM2A

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
KIRCpathologic_stageCAediting_1098189chr16_20463685_+0.04431539513719510.166136042513736
KIRCpathologic_stageCAediting_1098197chr16_20464347_+0.0250719499058040.289095823310131
KIRCpathologic_stageCAediting_1098218chr16_20464454_+0.01929466298320330.152226807929281
KIRCpathologic_stageCAediting_1098225chr16_20464495_+0.02803042083353660.173175900094086
KIRPclinical_stageCAediting_1098232chr16_20464608_+0.03533570385077090.24846140824816
KIRPpathologic_stageCAediting_1098182chr16_20463615_+0.0266917893691530.316552725307997

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Relation with survival for ACSM2A

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
KIRCCAediting_1098183chr16_20463618_+0.01986163084092250.0421951224.495
KIRCCAediting_1098225chr16_20464495_+0.02444446016528550.00822357.0477

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RelatedDrugs for ACSM2A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACSM2A

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource