Home

Download

Statistics

Examples

Help

Contact

Editing gene: JDP2 (CAeditome ID:122953)

Gene summary for JDP2

Gene summary

Gene information	Gene symbol	JDP2
	Gene ID	122953
	Gene name	Jun dimerization protein 2
	Synonyms	JUNDM2
	Cytomap	14q24.3
	Type of gene	protein-coding
	Description	jun dimerization protein 2progesterone receptor co-activator
	Modification date	20210518
	UniProtAcc	Q8WYK2
	Context	- 33108704(JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
JDP2	GO:0001227	Jun dimerization protein 2	18671972
JDP2	GO:1990837	Jun dimerization protein 2	28473536
JDP2	GO:0000122	Jun dimerization protein 2	18671972

Top

RNA A-to-I events for JDP2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000140044.11

RNA A-to-I editing events in Cancer.

CAediting_1006734(75433106, +), CAediting_1006735(75465390, +), CAediting_1006736(75465395, +), CAediting_1006737(75465474, +), CAediting_1006738(75465564, +), CAediting_1006739(75469385, +), CAediting_1006740(75469387, +), CAediting_1006741(75471813, +), CAediting_1006742(75473288, +),

Top

RNA editing positional annotations for JDP2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1006740	chr14_75469387_+	nonsynonymous SNV	ENST00000267569.5	c.A437G	p.H146R	D	P	D
CAediting_1006740	chr14_75469387_+	nonsynonymous SNV	ENST00000419727.5	c.A404G	p.H135R	D	P	D
CAediting_1006740	chr14_75469387_+	nonsynonymous SNV	ENST00000435893.5	c.A404G	p.H135R	D	P	D
CAediting_1006740	chr14_75469387_+	nonsynonymous SNV	ENST00000437176.4	c.A404G	p.H135R	D	P	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1006734	chr14_75433106_+	ncRNA_intronic
CAediting_1006735	chr14_75465390_+	intronic
CAediting_1006736	chr14_75465395_+	intronic
CAediting_1006737	chr14_75465474_+	intronic
CAediting_1006738	chr14_75465564_+	intronic
CAediting_1006739	chr14_75469385_+	exonic
CAediting_1006740	chr14_75469387_+	exonic
CAediting_1006741	chr14_75471813_+	UTR3
CAediting_1006742	chr14_75473288_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1006734	chr14_75433106_+	SINE	Alu	AluSp
CAediting_1006735	chr14_75465390_+	SINE	Alu	AluJo
CAediting_1006736	chr14_75465395_+	SINE	Alu	AluJo
CAediting_1006737	chr14_75465474_+	SINE	Alu	AluJo
CAediting_1006738	chr14_75465564_+	SINE	Alu	AluJo
CAediting_1006742	chr14_75473288_+	SINE	Alu	AluSc8

Top

RNA A-to-I editing events in the alternative splicing sites for JDP2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000140044.11.JDP2.

Correlation between RNA A-to-I editing and PSI for ENSG00000140044.11.JDP2.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for JDP2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for JDP2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for JDP2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1006742	chr14_75473288_+	ENSG00000140044.11	ENST00000435893	hsa-miR-4638-5p	75473283	75473290	8mer-1a	75473271	75473290	146.00	-20.28

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1006741	chr14_75471813_+	ENSG00000140044.11	ENST00000437176	hsa-miR-6890-3p	75471809	75471815	7mer-m8	75471798	75471816	148	-16.81
CAediting_1006741	chr14_75471813_+	ENSG00000140044.11	ENST00000435893	hsa-miR-6890-3p	75471809	75471815	7mer-m8	75471798	75471816	148	-16.81

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000140044.11	ENST00000437176	hsa-miR-200b-3p	75472143	75472149	7mer-m8	75472127	75472150	165	-18.89
CAediting_688081	chr9_63819627_+	ENSG00000140044.11	ENST00000437176	hsa-miR-4477b	75472686	75472693	8mer-1a	75472671	75472693	154	-11.41
CAediting_748296	chr10_51299626_+	ENSG00000140044.11	ENST00000435893	hsa-miR-605-3p	75472928	75472934	7mer-m8	75472914	75472935	164	-27.58
CAediting_980496	chr14_31014685_-	ENSG00000140044.11	ENST00000435893	hsa-miR-624-3p	75472805	75472812	8mer-1a	75472792	75472812	142	-14.13
CAediting_980496	chr14_31014685_-	ENSG00000140044.11	ENST00000435893	hsa-miR-624-3p	75473161	75473167	7mer-m8	75473146	75473168	153	-14.37
CAediting_393	chr1_1167164_+	ENSG00000140044.11	ENST00000435893	hsa-miR-200b-3p	75472143	75472149	7mer-m8	75472127	75472150	165	-18.89
CAediting_688081	chr9_63819627_+	ENSG00000140044.11	ENST00000435893	hsa-miR-4477b	75472686	75472693	8mer-1a	75472671	75472693	154	-11.41
CAediting_1160181	chr17_7017644_-	ENSG00000140044.11	ENST00000437176	hsa-miR-195-3p	75470436	75470442	7mer-m8	75470422	75470443	160	-14.58
CAediting_86358	chr1_109598906_+	ENSG00000140044.11	ENST00000437176	hsa-miR-197-5p	75471658	75471665	8mer-1a	75471644	75471665	167	-34.29
CAediting_442554	chr5_154685830_+	ENSG00000140044.11	ENST00000437176	hsa-miR-1303	75471993	75472000	8mer-1a	75471977	75472000	151	-20.21
CAediting_442554	chr5_154685830_+	ENSG00000140044.11	ENST00000437176	hsa-miR-1303	75472498	75472504	7mer-m8	75472483	75472505	153	-20.05
CAediting_604450	chr7_133034877_-	ENSG00000140044.11	ENST00000437176	hsa-miR-3654	75469999	75470005	7mer-m8	75469987	75470006	147	-20.15
CAediting_1229415	chr17_67471547_+	ENSG00000140044.11	ENST00000435893	hsa-miR-548aa	75473532	75473538	7mer-m8	75473511	75473539	157	-12.2
CAediting_1160181	chr17_7017644_-	ENSG00000140044.11	ENST00000435893	hsa-miR-195-3p	75470436	75470442	7mer-m8	75470422	75470443	160	-14.58
CAediting_86358	chr1_109598906_+	ENSG00000140044.11	ENST00000435893	hsa-miR-197-5p	75471658	75471665	8mer-1a	75471644	75471665	167	-34.29
CAediting_442554	chr5_154685830_+	ENSG00000140044.11	ENST00000435893	hsa-miR-1303	75471993	75472000	8mer-1a	75471977	75472000	151	-20.21
CAediting_442554	chr5_154685830_+	ENSG00000140044.11	ENST00000435893	hsa-miR-1303	75472498	75472504	7mer-m8	75472483	75472505	153	-20.05
CAediting_604450	chr7_133034877_-	ENSG00000140044.11	ENST00000435893	hsa-miR-3654	75469999	75470005	7mer-m8	75469987	75470006	147	-20.15
CAediting_1160181	chr17_7017644_-	ENSG00000140044.11	ENST00000267569	hsa-miR-195-3p	75470436	75470442	7mer-m8	75470422	75470443	160	-14.58
CAediting_604450	chr7_133034877_-	ENSG00000140044.11	ENST00000267569	hsa-miR-3654	75469999	75470005	7mer-m8	75469987	75470006	147	-20.15

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000437176	hsa-miR-4512	75470494	75470500	7mer-m8	75470478	75470501	151	-24.36
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000437176	hsa-miR-4512	75470685	75470691	7mer-m8	75470666	75470692	145	-26.96
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000437176	hsa-miR-4512	75469974	75469979	6mer	75469960	75469980	150	-36.05
CAediting_748296	chr10_51299626_+	ENSG00000140044.11	ENST00000437176	hsa-miR-605-3p	75471758	75471764	7mer-m8	75471744	75471765	141	-14.77
CAediting_468389	chr6_31355314_-	ENSG00000140044.11	ENST00000437176	hsa-miR-6891-5p	75472007	75472014	8mer-1a	75471996	75472014	140	-14.89
CAediting_846604	chr11_93733708_-	ENSG00000140044.11	ENST00000435893	hsa-miR-1304-3p	75473390	75473397	8mer-1a	75473375	75473397	149	-17.41
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000435893	hsa-miR-4512	75470494	75470500	7mer-m8	75470478	75470501	151	-24.36
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000435893	hsa-miR-4512	75470685	75470691	7mer-m8	75470666	75470692	145	-26.96
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000435893	hsa-miR-4512	75469974	75469979	6mer	75469960	75469980	150	-36.05
CAediting_117844	chr1_162342605_+	ENSG00000140044.11	ENST00000435893	hsa-miR-556-3p	75473804	75473810	7mer-m8	75473790	75473811	140	-7.92
CAediting_748296	chr10_51299626_+	ENSG00000140044.11	ENST00000435893	hsa-miR-605-3p	75471758	75471764	7mer-m8	75471744	75471765	141	-14.77
CAediting_468389	chr6_31355314_-	ENSG00000140044.11	ENST00000435893	hsa-miR-6891-5p	75472007	75472014	8mer-1a	75471996	75472014	140	-14.89
CAediting_1054808	chr15_66496985_-	ENSG00000140044.11	ENST00000267569	hsa-miR-4512	75469974	75469979	6mer	75469960	75469980	150	-36.05

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for JDP2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for JDP2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for JDP2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for JDP2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for JDP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
JDP2	Q8WYK2	DB00852	Pseudoephedrine	Jun dimerization protein 2	SmallMoleculeDrug	approved

Top

RelatedDiseases for JDP2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
JDP2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
JDP2	C2239176	Liver carcinoma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene