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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CLTC (CAeditome ID:1213)

Gene summary for CLTC

check button Gene summary
Gene informationGene symbol

CLTC

Gene ID

1213

Gene nameclathrin heavy chain
SynonymsCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56
Cytomap

17q23.1

Type of geneprotein-coding
Descriptionclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2
Modification date20210518
UniProtAcc

Q00610

Context- 29769406(Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CLTC

GO:0003725

Clathrin heavy chain 1

21266579

CLTC

GO:1900126

Clathrin heavy chain 1

24251095

CLTC

GO:0005764

Clathrin heavy chain 1

0000052

CLTC

GO:0005768

Clathrin heavy chain 1

0000052

CLTC

GO:0005819

Clathrin heavy chain 1

15858577

CLTC

GO:0030136

Clathrin heavy chain 1

19478182

CLTC

GO:0072686

Clathrin heavy chain 1

0000052

CLTC

GO:1990498

Clathrin heavy chain 1

21297582

CLTC

GO:0032991

Clathrin heavy chain 1

21266579

CLTC

GO:0071439

Clathrin heavy chain 1

4066749


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RNA A-to-I events for CLTC

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000141367.10

check button RNA A-to-I editing events in Cancer.
CAediting_1218128(59622490, +), CAediting_1218129(59624859, +), CAediting_1218130(59625543, +), CAediting_1218131(59625559, +), CAediting_1218132(59625560, +), CAediting_1218133(59625608, +), CAediting_1218134(59625618, +), CAediting_1218135(59631812, +), CAediting_1218136(59631813, +), CAediting_1218137(59631823, +), CAediting_1218138(59631849, +), CAediting_1218139(59631885, +), CAediting_1218140(59631890, +), CAediting_1218141(59631899, +), CAediting_1218142(59631914, +), CAediting_1218143(59633399, +), CAediting_1218144(59633928, +), CAediting_1218145(59633948, +), CAediting_1218146(59634109, +), CAediting_1218147(59637044, +), CAediting_1218148(59637679, +), CAediting_1218149(59637680, +), CAediting_1218150(59639708, +), CAediting_1218151(59639821, +), CAediting_1218152(59639825, +), CAediting_1218153(59639843, +), CAediting_1218154(59640497, +), CAediting_1218155(59640605, +), CAediting_1218156(59641039, +), CAediting_1218157(59641430, +), CAediting_1218158(59641439, +), CAediting_1218159(59641440, +), CAediting_1218160(59641490, +), CAediting_1218161(59641503, +), CAediting_1218162(59641507, +), CAediting_1218163(59641516, +), CAediting_1218164(59653677, +), CAediting_1218165(59654670, +), CAediting_1218166(59656722, +), CAediting_1218167(59656774, +), CAediting_1218168(59656777, +), CAediting_1218169(59656799, +), CAediting_1218170(59656813, +), CAediting_1218171(59656854, +), CAediting_1218172(59656934, +), CAediting_1218173(59657505, +), CAediting_1218174(59657511, +), CAediting_1218175(59657517, +), CAediting_1218176(59657542, +), CAediting_1218177(59657565, +), CAediting_1218178(59657566, +), CAediting_1218179(59657581, +), CAediting_1218180(59657591, +), CAediting_1218181(59657606, +), CAediting_1218182(59657607, +), CAediting_1218183(59657611, +), CAediting_1218184(59657614, +), CAediting_1218185(59657621, +), CAediting_1218186(59657647, +), CAediting_1218187(59657648, +), CAediting_1218188(59657657, +), CAediting_1218189(59657674, +), CAediting_1218190(59657675, +), CAediting_1218191(59657676, +), CAediting_1218192(59657677, +), CAediting_1218193(59657680, +), CAediting_1218194(59657683, +), CAediting_1218195(59657738, +), CAediting_1218196(59658056, +), CAediting_1218197(59658273, +), CAediting_1218198(59658306, +), CAediting_1218199(59664302, +), CAediting_1218200(59664406, +), CAediting_1218201(59664534, +),

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RNA editing positional annotations for CLTC using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1218128chr17_59622490_+intronic
CAediting_1218129chr17_59624859_+intronic
CAediting_1218130chr17_59625543_+intronic
CAediting_1218131chr17_59625559_+intronic
CAediting_1218132chr17_59625560_+intronic
CAediting_1218133chr17_59625608_+intronic
CAediting_1218134chr17_59625618_+intronic
CAediting_1218135chr17_59631812_+intronic
CAediting_1218136chr17_59631813_+intronic
CAediting_1218137chr17_59631823_+intronic
CAediting_1218138chr17_59631849_+intronic
CAediting_1218139chr17_59631885_+intronic
CAediting_1218140chr17_59631890_+intronic
CAediting_1218141chr17_59631899_+intronic
CAediting_1218142chr17_59631914_+intronic
CAediting_1218143chr17_59633399_+intronic
CAediting_1218144chr17_59633928_+intronic
CAediting_1218145chr17_59633948_+intronic
CAediting_1218146chr17_59634109_+intronic
CAediting_1218147chr17_59637044_+intronic
CAediting_1218148chr17_59637679_+intronic
CAediting_1218149chr17_59637680_+intronic
CAediting_1218150chr17_59639708_+intronic
CAediting_1218151chr17_59639821_+intronic
CAediting_1218152chr17_59639825_+intronic
CAediting_1218153chr17_59639843_+intronic
CAediting_1218154chr17_59640497_+intronic
CAediting_1218155chr17_59640605_+intronic
CAediting_1218156chr17_59641039_+intronic
CAediting_1218157chr17_59641430_+intronic
CAediting_1218158chr17_59641439_+intronic
CAediting_1218159chr17_59641440_+intronic
CAediting_1218160chr17_59641490_+intronic
CAediting_1218161chr17_59641503_+intronic
CAediting_1218162chr17_59641507_+intronic
CAediting_1218163chr17_59641516_+intronic
CAediting_1218164chr17_59653677_+ncRNA_intronic
CAediting_1218165chr17_59654670_+ncRNA_intronic
CAediting_1218166chr17_59656722_+intronic
CAediting_1218167chr17_59656774_+intronic
CAediting_1218168chr17_59656777_+intronic
CAediting_1218169chr17_59656799_+intronic
CAediting_1218170chr17_59656813_+intronic
CAediting_1218171chr17_59656854_+intronic
CAediting_1218172chr17_59656934_+intronic
CAediting_1218173chr17_59657505_+intronic
CAediting_1218174chr17_59657511_+intronic
CAediting_1218175chr17_59657517_+intronic
CAediting_1218176chr17_59657542_+intronic
CAediting_1218177chr17_59657565_+intronic
CAediting_1218178chr17_59657566_+intronic
CAediting_1218179chr17_59657581_+intronic
CAediting_1218180chr17_59657591_+intronic
CAediting_1218181chr17_59657606_+intronic
CAediting_1218182chr17_59657607_+intronic
CAediting_1218183chr17_59657611_+intronic
CAediting_1218184chr17_59657614_+intronic
CAediting_1218185chr17_59657621_+intronic
CAediting_1218186chr17_59657647_+intronic
CAediting_1218187chr17_59657648_+intronic
CAediting_1218188chr17_59657657_+intronic
CAediting_1218189chr17_59657674_+intronic
CAediting_1218190chr17_59657675_+intronic
CAediting_1218191chr17_59657676_+intronic
CAediting_1218192chr17_59657677_+intronic
CAediting_1218193chr17_59657680_+intronic
CAediting_1218194chr17_59657683_+intronic
CAediting_1218195chr17_59657738_+intronic
CAediting_1218196chr17_59658056_+intronic
CAediting_1218197chr17_59658273_+intronic
CAediting_1218198chr17_59658306_+intronic
CAediting_1218199chr17_59664302_+intronic
CAediting_1218200chr17_59664406_+intronic
CAediting_1218201chr17_59664534_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1218128chr17_59622490_+SINEAluAluJb
CAediting_1218129chr17_59624859_+SINEAluAluJo
CAediting_1218130chr17_59625543_+SINEAluAluJo
CAediting_1218131chr17_59625559_+SINEAluAluJo
CAediting_1218132chr17_59625560_+SINEAluAluJo
CAediting_1218133chr17_59625608_+SINEAluAluJo
CAediting_1218134chr17_59625618_+SINEAluAluJo
CAediting_1218135chr17_59631812_+SINEAluAluJb
CAediting_1218136chr17_59631813_+SINEAluAluJb
CAediting_1218137chr17_59631823_+SINEAluAluJb
CAediting_1218138chr17_59631849_+SINEAluAluJb
CAediting_1218139chr17_59631885_+SINEAluAluJb
CAediting_1218140chr17_59631890_+SINEAluAluJb
CAediting_1218141chr17_59631899_+SINEAluAluJb
CAediting_1218142chr17_59631914_+SINEAluAluJb
CAediting_1218143chr17_59633399_+SINEAluAluSz
CAediting_1218144chr17_59633928_+SINEAluAluJo
CAediting_1218145chr17_59633948_+SINEAluAluJo
CAediting_1218146chr17_59634109_+SINEAluAluJo
CAediting_1218147chr17_59637044_+SINEAluAluSq2
CAediting_1218148chr17_59637679_+SINEAluAluJb
CAediting_1218149chr17_59637680_+SINEAluAluJb
CAediting_1218150chr17_59639708_+SINEAluAluJb
CAediting_1218151chr17_59639821_+SINEAluAluJb
CAediting_1218152chr17_59639825_+SINEAluAluJb
CAediting_1218153chr17_59639843_+SINEAluAluJb
CAediting_1218154chr17_59640497_+SINEAluAluSc8
CAediting_1218155chr17_59640605_+SINEAluAluSc8
CAediting_1218156chr17_59641039_+SINEAluAluSc
CAediting_1218157chr17_59641430_+SINEAluAluSx3
CAediting_1218158chr17_59641439_+SINEAluAluSx3
CAediting_1218159chr17_59641440_+SINEAluAluSx3
CAediting_1218160chr17_59641490_+SINEAluAluSx3
CAediting_1218161chr17_59641503_+SINEAluAluSx3
CAediting_1218162chr17_59641507_+SINEAluAluSx3
CAediting_1218163chr17_59641516_+SINEAluAluSx3
CAediting_1218164chr17_59653677_+SINEAluAluJr4
CAediting_1218165chr17_59654670_+SINEAluAluSx
CAediting_1218166chr17_59656722_+SINEAluAluSg4
CAediting_1218167chr17_59656774_+SINEAluAluSg4
CAediting_1218168chr17_59656777_+SINEAluAluSg4
CAediting_1218169chr17_59656799_+SINEAluAluSg4
CAediting_1218170chr17_59656813_+SINEAluAluSg4
CAediting_1218171chr17_59656854_+SINEAluAluSg4
CAediting_1218172chr17_59656934_+SINEAluAluSg4
CAediting_1218173chr17_59657505_+SINEAluAluSx
CAediting_1218174chr17_59657511_+SINEAluAluSx
CAediting_1218175chr17_59657517_+SINEAluAluSx
CAediting_1218176chr17_59657542_+SINEAluAluSx
CAediting_1218177chr17_59657565_+SINEAluAluSx
CAediting_1218178chr17_59657566_+SINEAluAluSx
CAediting_1218179chr17_59657581_+SINEAluAluSx
CAediting_1218180chr17_59657591_+SINEAluAluSx
CAediting_1218181chr17_59657606_+SINEAluAluSx
CAediting_1218182chr17_59657607_+SINEAluAluSx
CAediting_1218183chr17_59657611_+SINEAluAluSx
CAediting_1218184chr17_59657614_+SINEAluAluSx
CAediting_1218185chr17_59657621_+SINEAluAluSx
CAediting_1218186chr17_59657647_+SINEAluAluSx
CAediting_1218187chr17_59657648_+SINEAluAluSx
CAediting_1218188chr17_59657657_+SINEAluAluSx
CAediting_1218189chr17_59657674_+SINEAluAluSx
CAediting_1218190chr17_59657675_+SINEAluAluSx
CAediting_1218191chr17_59657676_+SINEAluAluSx
CAediting_1218192chr17_59657677_+SINEAluAluSx
CAediting_1218193chr17_59657680_+SINEAluAluSx
CAediting_1218194chr17_59657683_+SINEAluAluSx
CAediting_1218195chr17_59657738_+SINEAluAluSx
CAediting_1218196chr17_59658056_+SINEAluAluSx1
CAediting_1218197chr17_59658273_+SINEAluAluJo
CAediting_1218198chr17_59658306_+SINEAluAluJo
CAediting_1218199chr17_59664302_+SINEAluAluJb
CAediting_1218200chr17_59664406_+SINEAluAluJb
CAediting_1218201chr17_59664534_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for CLTC

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000141367.10.CLTC.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000141367.10.CLTC.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLTC

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CLTC

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CLTC

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000141367.10ENST00000621829hsa-miR-624-3p59695880596958867mer-m85969586759695887147-18.27
CAediting_1160181chr17_7017644_-ENSG00000141367.10ENST00000621829hsa-miR-195-3p59695862596958698mer-1a5969584959695869150-13.17
CAediting_1368054chr19_46709310_-ENSG00000141367.10ENST00000621829hsa-miR-320e59695197596952037mer-m85969518759695204155-19.05
CAediting_77128chr1_85133844_+ENSG00000141367.10ENST00000621829hsa-miR-4423-3p59695146596951538mer-1a5969513359695153145-16.32
CAediting_228905chr2_188297554_+ENSG00000141367.10ENST00000621829hsa-miR-561-3p59694187596941948mer-1a5969417159694194147-9.06
CAediting_442554chr5_154685830_+ENSG00000141367.10ENST00000621829hsa-miR-130359695002596950087mer-m85969498859695009154-20
CAediting_573001chr7_92204086_-ENSG00000141367.10ENST00000621829hsa-miR-1285-5p59695650596956556mer5969563659695656151-30.19

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000141367.10ENST00000621829hsa-miR-195-3p59694194596942018mer-1a5969418059694201149-9.49
CAediting_1160181chr17_7017644_-ENSG00000141367.10ENST00000621829hsa-miR-195-3p59694690596946967mer-m85969467659694697143-6.57
CAediting_228905chr2_188297554_+ENSG00000141367.10ENST00000621829hsa-miR-561-3p59696844596968518mer-1a5969683059696851140-8.47
CAediting_1399425chr20_1392958_-ENSG00000141367.10ENST00000621829hsa-miR-6869-5p59695544596955507mer-m85969553059695551152-17.23

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CLTC

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CLTC

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CLTC

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CLTC

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CLTC

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLTC

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
CLTCC4518356MiT family translocation renal cell carcinoma2ORPHANET
CLTCC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
CLTCC0079744Diffuse Large B-Cell Lymphoma1CTD_human
CLTCC0334121Inflammatory Myofibroblastic Tumor1ORPHANET