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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CLCN3 (CAeditome ID:1182)

Gene summary for CLCN3

check button Gene summary
Gene informationGene symbol

CLCN3

Gene ID

1182

Gene namechloride voltage-gated channel 3
SynonymsCLC3|ClC-3
Cytomap

4q33

Type of geneprotein-coding
DescriptionH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date20210522
UniProtAcc

P51790

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CLCN3

GO:0005254

H(+)/Cl(-) exchange transporter 3

11274166

CLCN3

GO:0030165

H(+)/Cl(-) exchange transporter 3

12471024

CLCN3

GO:1902476

H(+)/Cl(-) exchange transporter 3

11274166

CLCN3

GO:0005769

H(+)/Cl(-) exchange transporter 3

12471024

CLCN3

GO:0005770

H(+)/Cl(-) exchange transporter 3

12471024

CLCN3

GO:0005794

H(+)/Cl(-) exchange transporter 3

12471024

CLCN3

GO:0005886

H(+)/Cl(-) exchange transporter 3

11274166

CLCN3

GO:0008021

H(+)/Cl(-) exchange transporter 3

11182090

CLCN3

GO:0009897

H(+)/Cl(-) exchange transporter 3

11274166

CLCN3

GO:0012506

H(+)/Cl(-) exchange transporter 3

12471024

CLCN3

GO:0030141

H(+)/Cl(-) exchange transporter 3

16522634

CLCN3

GO:0031410

H(+)/Cl(-) exchange transporter 3

11274166

CLCN3

GO:0042581

H(+)/Cl(-) exchange transporter 3

16522634

CLCN3

GO:0043231

H(+)/Cl(-) exchange transporter 3

0000052

CLCN3

GO:0045335

H(+)/Cl(-) exchange transporter 3

16522634


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RNA A-to-I events for CLCN3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000109572.12

check button RNA A-to-I editing events in Cancer.
CAediting_392998(169631200, +), CAediting_392999(169632317, +), CAediting_393000(169632327, +), CAediting_393001(169632330, +), CAediting_393002(169632341, +), CAediting_393003(169632352, +), CAediting_393004(169632363, +), CAediting_393005(169632376, +), CAediting_393006(169632392, +), CAediting_393007(169632394, +), CAediting_393008(169632452, +), CAediting_393009(169632466, +), CAediting_393010(169632474, +), CAediting_393011(169632475, +), CAediting_393012(169632518, +), CAediting_393013(169632540, +), CAediting_393014(169632563, +), CAediting_393015(169632570, +), CAediting_393016(169632626, +), CAediting_393017(169632637, +), CAediting_393018(169632638, +), CAediting_393019(169633036, +), CAediting_393020(169633044, +), CAediting_393021(169633113, +), CAediting_393022(169633142, +), CAediting_393023(169633152, +), CAediting_393024(169633154, +), CAediting_393025(169633168, +), CAediting_393026(169633179, +), CAediting_393027(169633285, +), CAediting_393028(169642148, +), CAediting_393029(169642588, +), CAediting_393030(169642706, +), CAediting_393031(169642708, +), CAediting_393032(169644361, +), CAediting_393033(169644362, +), CAediting_393034(169644387, +), CAediting_393035(169644397, +), CAediting_393036(169644405, +), CAediting_393037(169644424, +), CAediting_393038(169644441, +), CAediting_393039(169644456, +), CAediting_393040(169646362, +), CAediting_393041(169646480, +), CAediting_393042(169646559, +), CAediting_393043(169646570, +), CAediting_393044(169647191, +), CAediting_393045(169647238, +), CAediting_393046(169647377, +), CAediting_393047(169648813, +), CAediting_393048(169648898, +), CAediting_393049(169648906, +), CAediting_393050(169648907, +), CAediting_393051(169648952, +), CAediting_393052(169648971, +), CAediting_393053(169653377, +), CAediting_393054(169653431, +), CAediting_393055(169653434, +), CAediting_393056(169653520, +), CAediting_393057(169653521, +), CAediting_393058(169653530, +), CAediting_393059(169653556, +), CAediting_393060(169655595, +), CAediting_393061(169656770, +), CAediting_393062(169656786, +), CAediting_393063(169667863, +), CAediting_393064(169672392, +), CAediting_393065(169681187, +), CAediting_393066(169681189, +), CAediting_393067(169683287, +), CAediting_393068(169683358, +), CAediting_393069(169683430, +), CAediting_393070(169683434, +), CAediting_393071(169683995, +), CAediting_393072(169685055, +), CAediting_393073(169685079, +), CAediting_393074(169686658, +), CAediting_393075(169686677, +), CAediting_393076(169687374, +), CAediting_393077(169699620, +), CAediting_393078(169699735, +), CAediting_393079(169699797, +), CAediting_393080(169699857, +), CAediting_393081(169699869, +), CAediting_393082(169700306, +), CAediting_393083(169700357, +), CAediting_393084(169700358, +), CAediting_393085(169700383, +), CAediting_393086(169700415, +), CAediting_393087(169700467, +), CAediting_393088(169700530, +), CAediting_393089(169702739, +), CAediting_393090(169704144, +), CAediting_393091(169710296, +), CAediting_393092(169710339, +), CAediting_393093(169710351, +), CAediting_393094(169710395, +), CAediting_393095(169710456, +), CAediting_393096(169719255, +), CAediting_393097(169719263, +), CAediting_393098(169719278, +), CAediting_393099(169719279, +), CAediting_393100(169719326, +), CAediting_393101(169719336, +), CAediting_393102(169719337, +), CAediting_393103(169719346, +), CAediting_393104(169719354, +), CAediting_393105(169719359, +), CAediting_393106(169719378, +), CAediting_393107(169719389, +), CAediting_393108(169719392, +), CAediting_393109(169721865, +), CAediting_393110(169721906, +), CAediting_393111(169721934, +), CAediting_393112(169721938, +), CAediting_393113(169721956, +), CAediting_393114(169722002, +), CAediting_393115(169722006, +), CAediting_393116(169722080, +),

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RNA editing positional annotations for CLCN3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_392998chr4_169631200_+intronic
CAediting_392999chr4_169632317_+intronic
CAediting_393000chr4_169632327_+intronic
CAediting_393001chr4_169632330_+intronic
CAediting_393002chr4_169632341_+intronic
CAediting_393003chr4_169632352_+intronic
CAediting_393004chr4_169632363_+intronic
CAediting_393005chr4_169632376_+intronic
CAediting_393006chr4_169632392_+intronic
CAediting_393007chr4_169632394_+intronic
CAediting_393008chr4_169632452_+intronic
CAediting_393009chr4_169632466_+intronic
CAediting_393010chr4_169632474_+intronic
CAediting_393011chr4_169632475_+intronic
CAediting_393012chr4_169632518_+intronic
CAediting_393013chr4_169632540_+intronic
CAediting_393014chr4_169632563_+intronic
CAediting_393015chr4_169632570_+intronic
CAediting_393016chr4_169632626_+intronic
CAediting_393017chr4_169632637_+intronic
CAediting_393018chr4_169632638_+intronic
CAediting_393019chr4_169633036_+intronic
CAediting_393020chr4_169633044_+intronic
CAediting_393021chr4_169633113_+intronic
CAediting_393022chr4_169633142_+intronic
CAediting_393023chr4_169633152_+intronic
CAediting_393024chr4_169633154_+intronic
CAediting_393025chr4_169633168_+intronic
CAediting_393026chr4_169633179_+intronic
CAediting_393027chr4_169633285_+intronic
CAediting_393028chr4_169642148_+ncRNA_intronic
CAediting_393029chr4_169642588_+ncRNA_intronic
CAediting_393030chr4_169642706_+ncRNA_splicing
CAediting_393031chr4_169642708_+ncRNA_exonic
CAediting_393032chr4_169644361_+intronic
CAediting_393033chr4_169644362_+intronic
CAediting_393034chr4_169644387_+intronic
CAediting_393035chr4_169644397_+intronic
CAediting_393036chr4_169644405_+intronic
CAediting_393037chr4_169644424_+intronic
CAediting_393038chr4_169644441_+intronic
CAediting_393039chr4_169644456_+intronic
CAediting_393040chr4_169646362_+intronic
CAediting_393041chr4_169646480_+intronic
CAediting_393042chr4_169646559_+intronic
CAediting_393043chr4_169646570_+intronic
CAediting_393044chr4_169647191_+intronic
CAediting_393045chr4_169647238_+intronic
CAediting_393046chr4_169647377_+intronic
CAediting_393047chr4_169648813_+intronic
CAediting_393048chr4_169648898_+intronic
CAediting_393049chr4_169648906_+intronic
CAediting_393050chr4_169648907_+intronic
CAediting_393051chr4_169648952_+intronic
CAediting_393052chr4_169648971_+intronic
CAediting_393053chr4_169653377_+intronic
CAediting_393054chr4_169653431_+intronic
CAediting_393055chr4_169653434_+intronic
CAediting_393056chr4_169653520_+intronic
CAediting_393057chr4_169653521_+intronic
CAediting_393058chr4_169653530_+intronic
CAediting_393059chr4_169653556_+intronic
CAediting_393060chr4_169655595_+intronic
CAediting_393061chr4_169656770_+intronic
CAediting_393062chr4_169656786_+intronic
CAediting_393063chr4_169667863_+intronic
CAediting_393064chr4_169672392_+intronic
CAediting_393065chr4_169681187_+intronic
CAediting_393066chr4_169681189_+intronic
CAediting_393067chr4_169683287_+intronic
CAediting_393068chr4_169683358_+intronic
CAediting_393069chr4_169683430_+intronic
CAediting_393070chr4_169683434_+intronic
CAediting_393071chr4_169683995_+intronic
CAediting_393072chr4_169685055_+intronic
CAediting_393073chr4_169685079_+intronic
CAediting_393074chr4_169686658_+intronic
CAediting_393075chr4_169686677_+intronic
CAediting_393076chr4_169687374_+intronic
CAediting_393077chr4_169699620_+intronic
CAediting_393078chr4_169699735_+intronic
CAediting_393079chr4_169699797_+intronic
CAediting_393080chr4_169699857_+intronic
CAediting_393081chr4_169699869_+intronic
CAediting_393082chr4_169700306_+intronic
CAediting_393083chr4_169700357_+intronic
CAediting_393084chr4_169700358_+intronic
CAediting_393085chr4_169700383_+intronic
CAediting_393086chr4_169700415_+intronic
CAediting_393087chr4_169700467_+intronic
CAediting_393088chr4_169700530_+intronic
CAediting_393089chr4_169702739_+intronic
CAediting_393090chr4_169704144_+exonic
CAediting_393091chr4_169710296_+intronic
CAediting_393092chr4_169710339_+intronic
CAediting_393093chr4_169710351_+intronic
CAediting_393094chr4_169710395_+intronic
CAediting_393095chr4_169710456_+intronic
CAediting_393096chr4_169719255_+intronic
CAediting_393097chr4_169719263_+intronic
CAediting_393098chr4_169719278_+intronic
CAediting_393099chr4_169719279_+intronic
CAediting_393100chr4_169719326_+intronic
CAediting_393101chr4_169719336_+intronic
CAediting_393102chr4_169719337_+intronic
CAediting_393103chr4_169719346_+intronic
CAediting_393104chr4_169719354_+intronic
CAediting_393105chr4_169719359_+intronic
CAediting_393106chr4_169719378_+intronic
CAediting_393107chr4_169719389_+intronic
CAediting_393108chr4_169719392_+intronic
CAediting_393109chr4_169721865_+UTR3
CAediting_393110chr4_169721906_+UTR3
CAediting_393111chr4_169721934_+UTR3
CAediting_393112chr4_169721938_+UTR3
CAediting_393113chr4_169721956_+UTR3
CAediting_393114chr4_169722002_+UTR3
CAediting_393115chr4_169722006_+UTR3
CAediting_393116chr4_169722080_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_392998chr4_169631200_+LINEL1L1PA16
CAediting_392999chr4_169632317_+LINEL1L1MD
CAediting_393000chr4_169632327_+LINEL1L1MD
CAediting_393001chr4_169632330_+LINEL1L1MD
CAediting_393002chr4_169632341_+LINEL1L1MD
CAediting_393003chr4_169632352_+LINEL1L1MD
CAediting_393004chr4_169632363_+LINEL1L1MD
CAediting_393005chr4_169632376_+LINEL1L1MD
CAediting_393006chr4_169632392_+LINEL1L1MD
CAediting_393007chr4_169632394_+LINEL1L1MD
CAediting_393008chr4_169632452_+SINEAluAluYc
CAediting_393009chr4_169632466_+SINEAluAluYc
CAediting_393010chr4_169632474_+SINEAluAluYc
CAediting_393011chr4_169632475_+SINEAluAluYc
CAediting_393012chr4_169632518_+SINEAluAluYc
CAediting_393013chr4_169632540_+SINEAluAluYc
CAediting_393014chr4_169632563_+SINEAluAluYc
CAediting_393015chr4_169632570_+SINEAluAluYc
CAediting_393016chr4_169632626_+SINEAluAluYc
CAediting_393017chr4_169632637_+SINEAluAluYc
CAediting_393018chr4_169632638_+SINEAluAluYc
CAediting_393019chr4_169633036_+SINEAluAluSx1
CAediting_393020chr4_169633044_+SINEAluAluSx1
CAediting_393021chr4_169633113_+SINEAluAluSx1
CAediting_393022chr4_169633142_+SINEAluAluSx1
CAediting_393023chr4_169633152_+SINEAluAluSx1
CAediting_393024chr4_169633154_+SINEAluAluSx1
CAediting_393025chr4_169633168_+SINEAluAluSx1
CAediting_393026chr4_169633179_+SINEAluAluSx1
CAediting_393027chr4_169633285_+SINEAluAluSx1
CAediting_393028chr4_169642148_+SINEAluAluJr
CAediting_393029chr4_169642588_+SINEAluAluJb
CAediting_393030chr4_169642706_+SINEAluAluJb
CAediting_393031chr4_169642708_+SINEAluAluJb
CAediting_393032chr4_169644361_+SINEAluAluSz
CAediting_393033chr4_169644362_+SINEAluAluSz
CAediting_393034chr4_169644387_+SINEAluAluSz
CAediting_393035chr4_169644397_+SINEAluAluSz
CAediting_393036chr4_169644405_+SINEAluAluSz
CAediting_393037chr4_169644424_+SINEAluAluSz
CAediting_393038chr4_169644441_+SINEAluAluSz
CAediting_393039chr4_169644456_+SINEAluAluSz
CAediting_393040chr4_169646362_+SINEAluAluSz6
CAediting_393041chr4_169646480_+SINEAluAluSz6
CAediting_393042chr4_169646559_+SINEAluAluSz6
CAediting_393043chr4_169646570_+SINEAluAluSz6
CAediting_393044chr4_169647191_+SINEAluAluJb
CAediting_393045chr4_169647238_+SINEAluAluJb
CAediting_393046chr4_169647377_+SINEAluAluJb
CAediting_393047chr4_169648813_+SINEAluAluSz6
CAediting_393048chr4_169648898_+SINEAluAluSz6
CAediting_393049chr4_169648906_+SINEAluAluSz6
CAediting_393050chr4_169648907_+SINEAluAluSz6
CAediting_393051chr4_169648952_+SINEAluAluSz6
CAediting_393052chr4_169648971_+SINEAluAluSz6
CAediting_393053chr4_169653377_+SINEAluAluSx1
CAediting_393054chr4_169653431_+SINEAluAluSx1
CAediting_393055chr4_169653434_+SINEAluAluSx1
CAediting_393056chr4_169653520_+SINEAluAluSx1
CAediting_393057chr4_169653521_+SINEAluAluSx1
CAediting_393058chr4_169653530_+SINEAluAluSx1
CAediting_393059chr4_169653556_+SINEAluAluSx1
CAediting_393060chr4_169655595_+SINEAluAluJr
CAediting_393061chr4_169656770_+SINEAluAluJr
CAediting_393062chr4_169656786_+SINEAluAluJr
CAediting_393063chr4_169667863_+SINEAluAluSx4
CAediting_393064chr4_169672392_+SINEAluAluSz
CAediting_393065chr4_169681187_+SINEAluAluSz6
CAediting_393066chr4_169681189_+SINEAluAluSz6
CAediting_393067chr4_169683287_+SINEAluAluJo
CAediting_393068chr4_169683358_+SINEAluAluJo
CAediting_393069chr4_169683430_+SINEAluAluJo
CAediting_393070chr4_169683434_+SINEAluAluJo
CAediting_393071chr4_169683995_+SINEAluAluSz6
CAediting_393072chr4_169685055_+SINEAluAluJr
CAediting_393073chr4_169685079_+SINEAluAluJr
CAediting_393074chr4_169686658_+SINEAluAluSg
CAediting_393075chr4_169686677_+SINEAluAluSg
CAediting_393076chr4_169687374_+SINEAluFLAM_C
CAediting_393077chr4_169699620_+SINEAluAluSc8
CAediting_393078chr4_169699735_+SINEAluAluSc8
CAediting_393079chr4_169699797_+SINEAluAluSc8
CAediting_393080chr4_169699857_+SINEAluAluSc8
CAediting_393081chr4_169699869_+SINEAluAluSc8
CAediting_393082chr4_169700306_+SINEAluAluSx
CAediting_393083chr4_169700357_+SINEAluAluSx
CAediting_393084chr4_169700358_+SINEAluAluSx
CAediting_393085chr4_169700383_+SINEAluAluSx
CAediting_393086chr4_169700415_+SINEAluAluSx
CAediting_393087chr4_169700467_+SINEAluAluSx
CAediting_393088chr4_169700530_+SINEAluAluSx
CAediting_393089chr4_169702739_+SINEAluAluJr
CAediting_393091chr4_169710296_+SINEAluAluJb
CAediting_393092chr4_169710339_+SINEAluAluJb
CAediting_393093chr4_169710351_+SINEAluAluJb
CAediting_393094chr4_169710395_+SINEAluAluJb
CAediting_393095chr4_169710456_+SINEAluAluJb
CAediting_393096chr4_169719255_+SINEAluAluSg
CAediting_393097chr4_169719263_+SINEAluAluSg
CAediting_393098chr4_169719278_+SINEAluAluSg
CAediting_393099chr4_169719279_+SINEAluAluSg
CAediting_393100chr4_169719326_+SINEAluAluSg
CAediting_393101chr4_169719336_+SINEAluAluSg
CAediting_393102chr4_169719337_+SINEAluAluSg
CAediting_393103chr4_169719346_+SINEAluAluSg
CAediting_393104chr4_169719354_+SINEAluAluSg
CAediting_393105chr4_169719359_+SINEAluAluSg
CAediting_393106chr4_169719378_+SINEAluAluSg
CAediting_393107chr4_169719389_+SINEAluAluSg
CAediting_393108chr4_169719392_+SINEAluAluSg
CAediting_393109chr4_169721865_+SINEAluAluJb
CAediting_393110chr4_169721906_+SINEAluAluJb
CAediting_393111chr4_169721934_+SINEAluAluJb
CAediting_393112chr4_169721938_+SINEAluAluJb
CAediting_393113chr4_169721956_+SINEAluAluJb
CAediting_393114chr4_169722002_+SINEAluAluJb
CAediting_393115chr4_169722006_+SINEAluAluJb
CAediting_393116chr4_169722080_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for CLCN3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000109572.12.CLCN3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000109572.12.CLCN3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLCN3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CLCN3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for CLCN3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000513761hsa-miR-1224-3p1697220031697220097mer-m8169721990169722010149.00-22.51
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000613795hsa-miR-1224-3p1697220031697220097mer-m8169721990169722010149.00-22.51
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000504131hsa-miR-1224-3p1697220031697220097mer-m8169721990169722010149.00-22.51
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000513761hsa-miR-500a-3p1697218641697218696mer169721849169721870141.00-16.45
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000613795hsa-miR-500a-3p1697218641697218696mer169721849169721870141.00-16.45
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000504131hsa-miR-500a-3p1697218641697218696mer169721849169721870141.00-16.45
CAediting_393112chr4_169721938_+ENSG00000109572.12ENST00000513761hsa-miR-1228-5p1697219351697219428mer-1a169721919169721942154.00-27.51
CAediting_393112chr4_169721938_+ENSG00000109572.12ENST00000613795hsa-miR-1228-5p1697219351697219428mer-1a169721919169721942154.00-27.51
CAediting_393112chr4_169721938_+ENSG00000109572.12ENST00000504131hsa-miR-1228-5p1697219351697219428mer-1a169721919169721942154.00-27.51
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000513761hsa-miR-3189-3p1697220741697220807mer-m8169722059169722081145.00-23.26
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000513761hsa-miR-6813-3p1697220751697220817mer-m8169722061169722082141.00-17.10
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000613795hsa-miR-3189-3p1697220741697220807mer-m8169722059169722081145.00-23.26
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000613795hsa-miR-6813-3p1697220751697220817mer-m8169722061169722082141.00-17.10
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000504131hsa-miR-3189-3p1697220741697220807mer-m8169722059169722081145.00-23.26
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000504131hsa-miR-6813-3p1697220751697220817mer-m8169722061169722082141.00-17.10
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000513761hsa-miR-39371697219031697219097mer-m8169721885169721910155.00-24.87
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000613795hsa-miR-39371697219031697219097mer-m8169721885169721910155.00-24.87
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000504131hsa-miR-39371697219031697219097mer-m8169721885169721910155.00-24.87

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000513761hsa-miR-1255b-2-3p1697220781697220847mer-m8169722063169722085150-17.83
CAediting_393113chr4_169721956_+ENSG00000109572.12ENST00000513761hsa-miR-142-3p1697219511697219566mer169721935169721957149-22.29
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000513761hsa-miR-323a-5p1697219011697219077mer-m8169721887169721908151-20.69
CAediting_393114chr4_169722002_+ENSG00000109572.12ENST00000513761hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000513761hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000513761hsa-miR-4649-3p1697219281697219347mer-m8169721915169721935147-13.09
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000513761hsa-miR-508-5p1697218601697218667mer-m8169721845169721867140-15.83
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000513761hsa-miR-6512-3p1697218581697218647mer-m8169721844169721865140-15.98
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000513761hsa-miR-6720-5p1697218581697218647mer-m8169721843169721865142-16.72
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000513761hsa-miR-6765-5p1697219271697219337mer-m8169721910169721934151-24.77
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000513761hsa-miR-7160-5p1697219291697219357mer-m8169721917169721936152-21.89
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000513761hsa-miR-766-3p1697218591697218657mer-m8169721845169721866147-17.29
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000613795hsa-miR-1255b-2-3p1697220781697220847mer-m8169722063169722085150-17.83
CAediting_393113chr4_169721956_+ENSG00000109572.12ENST00000613795hsa-miR-142-3p1697219511697219566mer169721935169721957149-22.29
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000613795hsa-miR-323a-5p1697219011697219077mer-m8169721887169721908151-20.69
CAediting_393114chr4_169722002_+ENSG00000109572.12ENST00000613795hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000613795hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000613795hsa-miR-4649-3p1697219281697219347mer-m8169721915169721935147-13.09
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000613795hsa-miR-508-5p1697218601697218667mer-m8169721845169721867140-15.83
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000613795hsa-miR-6512-3p1697218581697218647mer-m8169721844169721865140-15.98
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000613795hsa-miR-6720-5p1697218581697218647mer-m8169721843169721865142-16.72
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000613795hsa-miR-6765-5p1697219271697219337mer-m8169721910169721934151-24.77
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000613795hsa-miR-7160-5p1697219291697219357mer-m8169721917169721936152-21.89
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000613795hsa-miR-766-3p1697218591697218657mer-m8169721845169721866147-17.29
CAediting_393116chr4_169722080_+ENSG00000109572.12ENST00000504131hsa-miR-1255b-2-3p1697220781697220847mer-m8169722063169722085150-17.83
CAediting_393113chr4_169721956_+ENSG00000109572.12ENST00000504131hsa-miR-142-3p1697219511697219566mer169721935169721957149-22.29
CAediting_393110chr4_169721906_+ENSG00000109572.12ENST00000504131hsa-miR-323a-5p1697219011697219077mer-m8169721887169721908151-20.69
CAediting_393114chr4_169722002_+ENSG00000109572.12ENST00000504131hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393115chr4_169722006_+ENSG00000109572.12ENST00000504131hsa-miR-3675-3p1697220001697220067mer-m8169721986169722007145-12.58
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000504131hsa-miR-4649-3p1697219281697219347mer-m8169721915169721935147-13.09
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000504131hsa-miR-508-5p1697218601697218667mer-m8169721845169721867140-15.83
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000504131hsa-miR-6512-3p1697218581697218647mer-m8169721844169721865140-15.98
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000504131hsa-miR-6720-5p1697218581697218647mer-m8169721843169721865142-16.72
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000504131hsa-miR-6765-5p1697219271697219337mer-m8169721910169721934151-24.77
CAediting_393111chr4_169721934_+ENSG00000109572.12ENST00000504131hsa-miR-7160-5p1697219291697219357mer-m8169721917169721936152-21.89
CAediting_393109chr4_169721865_+ENSG00000109572.12ENST00000504131hsa-miR-766-3p1697218591697218657mer-m8169721845169721866147-17.29

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000109572.12ENST00000347613hsa-miR-195-3p1697203571697203637mer-m8169720343169720364150-14.54
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000513761hsa-miR-548aa1697218781697218847mer-m8169721863169721885148-18.31
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000513761hsa-miR-548aa1697236281697236347mer-m8169723610169723635156-16.21
CAediting_1160181chr17_7017644_-ENSG00000109572.12ENST00000513761hsa-miR-195-3p1697203571697203637mer-m8169720343169720364150-14.54
CAediting_1368054chr19_46709310_-ENSG00000109572.12ENST00000513761hsa-miR-320e1697220451697220517mer-1a169722031169722051142-19.59
CAediting_1368054chr19_46709310_-ENSG00000109572.12ENST00000513761hsa-miR-320e1697234621697234687mer-1a169723451169723468143-16.48
CAediting_442554chr5_154685830_+ENSG00000109572.12ENST00000513761hsa-miR-13031697224431697224497mer-m8169722429169722450140-12.2
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000613795hsa-miR-548aa1697218781697218847mer-m8169721863169721885148-18.31
CAediting_1160181chr17_7017644_-ENSG00000109572.12ENST00000613795hsa-miR-195-3p1697203571697203637mer-m8169720343169720364150-14.54
CAediting_1368054chr19_46709310_-ENSG00000109572.12ENST00000613795hsa-miR-320e1697220451697220517mer-1a169722031169722051142-19.59
CAediting_442554chr5_154685830_+ENSG00000109572.12ENST00000613795hsa-miR-13031697224431697224497mer-m8169722429169722450140-12.2
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000504131hsa-miR-548aa1697218781697218847mer-m8169721863169721885148-18.31
CAediting_1160181chr17_7017644_-ENSG00000109572.12ENST00000504131hsa-miR-195-3p1697203571697203637mer-m8169720343169720364150-14.54
CAediting_1368054chr19_46709310_-ENSG00000109572.12ENST00000504131hsa-miR-320e1697220451697220517mer-1a169722031169722051142-19.59
CAediting_442554chr5_154685830_+ENSG00000109572.12ENST00000504131hsa-miR-13031697224431697224497mer-m8169722429169722450140-12.2
CAediting_1524209chrX_134546392_-ENSG00000109572.12ENST00000513761hsa-miR-503-5p1697232341697232396mer169723217169723240142-17.86

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_396018chr5_1062918_-ENSG00000109572.12ENST00000513761hsa-miR-46351697223631697223697mer-m8169722350169722370152-14.21
CAediting_414656chr5_72878640_+ENSG00000109572.12ENST00000513761hsa-miR-4804-3p1697204861697204938mer-1a169720473169720493145-13.55
CAediting_1229413chr17_67471544_+ENSG00000109572.12ENST00000513761hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000513761hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229415chr17_67471547_+ENSG00000109572.12ENST00000513761hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_117844chr1_162342605_+ENSG00000109572.12ENST00000513761hsa-miR-556-3p1697232851697232928mer-1a169723271169723292147-10.33
CAediting_1351755chr19_40282625_-ENSG00000109572.12ENST00000513761hsa-miR-6411697235471697235537mer-m8169723531169723554152-11.74
CAediting_468389chr6_31355314_-ENSG00000109572.12ENST00000513761hsa-miR-6891-5p1697223501697223556mer169722335169722356140-22.32
CAediting_396018chr5_1062918_-ENSG00000109572.12ENST00000613795hsa-miR-46351697223631697223697mer-m8169722350169722370152-14.21
CAediting_414656chr5_72878640_+ENSG00000109572.12ENST00000613795hsa-miR-4804-3p1697204861697204938mer-1a169720473169720493145-13.55
CAediting_1229413chr17_67471544_+ENSG00000109572.12ENST00000613795hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000613795hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229415chr17_67471547_+ENSG00000109572.12ENST00000613795hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_468389chr6_31355314_-ENSG00000109572.12ENST00000613795hsa-miR-6891-5p1697223501697223556mer169722335169722356140-22.32
CAediting_396018chr5_1062918_-ENSG00000109572.12ENST00000504131hsa-miR-46351697223631697223697mer-m8169722350169722370152-14.21
CAediting_414656chr5_72878640_+ENSG00000109572.12ENST00000504131hsa-miR-4804-3p1697204861697204938mer-1a169720473169720493145-13.55
CAediting_1229413chr17_67471544_+ENSG00000109572.12ENST00000504131hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229414chr17_67471546_+ENSG00000109572.12ENST00000504131hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_1229415chr17_67471547_+ENSG00000109572.12ENST00000504131hsa-miR-548aa1697208301697208378mer-1a169720814169720837148-7.59
CAediting_468389chr6_31355314_-ENSG00000109572.12ENST00000504131hsa-miR-6891-5p1697223501697223556mer169722335169722356140-22.32

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CLCN3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000347613.7protein_codingSoverviewSoverview
ENST00000360642.6protein_codingSoverviewSoverview
ENST00000513761.4protein_codingSoverviewSoverview
ENST00000506924.1processed_transcriptSoverviewSoverview
ENST00000504131.5protein_codingSoverviewSoverview
ENST00000507875.4protein_codingSoverviewSoverview
ENST00000613795.3protein_codingSoverviewSoverview
ENST00000515420.1protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_393090ENST00000347613.7chr4_169704144_+-1083.70-1083.50-1083.70
CAediting_393090ENST00000360642.6chr4_169704144_+-964.00-963.80-964.00
CAediting_393090ENST00000513761.4chr4_169704144_+-1857.50-1857.30-1873.80
CAediting_393109ENST00000513761.4chr4_169721865_+-1857.90-1857.30-1873.80
CAediting_393110ENST00000513761.4chr4_169721906_+-1858.80-1857.30-1873.80
CAediting_393111ENST00000513761.4chr4_169721934_+-1858.40-1857.30-1873.80
CAediting_393112ENST00000513761.4chr4_169721938_+-1857.60-1857.30-1873.80
CAediting_393113ENST00000513761.4chr4_169721956_+-1860.20-1857.30-1873.80
CAediting_393114ENST00000513761.4chr4_169722002_+-1858.60-1857.30-1873.80
CAediting_393115ENST00000513761.4chr4_169722006_+-1864.30-1857.30-1873.80
CAediting_393116ENST00000513761.4chr4_169722080_+-1856.90-1857.30-1873.80
CAediting_393031ENST00000506924.1chr4_169642708_+-134.50-130.90-134.50
CAediting_393090ENST00000504131.5chr4_169704144_+-1519.60-1519.40-1535.90
CAediting_393109ENST00000504131.5chr4_169721865_+-1520.00-1519.40-1535.90
CAediting_393110ENST00000504131.5chr4_169721906_+-1520.90-1519.40-1535.90
CAediting_393111ENST00000504131.5chr4_169721934_+-1520.50-1519.40-1535.90
CAediting_393112ENST00000504131.5chr4_169721938_+-1519.70-1519.40-1535.90
CAediting_393113ENST00000504131.5chr4_169721956_+-1522.30-1519.40-1535.90
CAediting_393114ENST00000504131.5chr4_169722002_+-1520.70-1519.40-1535.90
CAediting_393115ENST00000504131.5chr4_169722006_+-1526.40-1519.40-1535.90
CAediting_393116ENST00000504131.5chr4_169722080_+-1519.00-1519.40-1535.90
CAediting_393090ENST00000507875.4chr4_169704144_+-747.70-747.50-747.70
CAediting_393090ENST00000613795.3chr4_169704144_+-1597.10-1596.90-1613.40
CAediting_393109ENST00000613795.3chr4_169721865_+-1597.50-1596.90-1613.40
CAediting_393110ENST00000613795.3chr4_169721906_+-1598.40-1596.90-1613.40
CAediting_393111ENST00000613795.3chr4_169721934_+-1598.00-1596.90-1613.40
CAediting_393112ENST00000613795.3chr4_169721938_+-1597.20-1596.90-1613.40
CAediting_393113ENST00000613795.3chr4_169721956_+-1599.80-1596.90-1613.40
CAediting_393114ENST00000613795.3chr4_169722002_+-1598.20-1596.90-1613.40
CAediting_393115ENST00000613795.3chr4_169722006_+-1603.90-1596.90-1613.40
CAediting_393116ENST00000613795.3chr4_169722080_+-1596.50-1596.90-1613.40
CAediting_393090ENST00000515420.1chr4_169704144_+-230.10-229.90-230.10

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Relation with ADAR for CLCN3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CLCN3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CLCN3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CLCN3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLCN3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
CLCN3C0017638Glioma1CTD_human
CLCN3C0024623Malignant neoplasm of stomach1CTD_human
CLCN3C0038356Stomach Neoplasms1CTD_human
CLCN3C0235874Disease Exacerbation1CTD_human
CLCN3C0259783mixed gliomas1CTD_human
CLCN3C0555198Malignant Glioma1CTD_human
CLCN3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
CLCN3C2931822Nasopharyngeal carcinoma1CTD_human