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Editing gene: SSX2IP (CAeditome ID:117178)

Gene summary for SSX2IP

Gene summary

Gene information	Gene symbol	SSX2IP
	Gene ID	117178
	Gene name	SSX family member 2 interacting protein
	Synonyms	ADIP\|hMsd1
	Cytomap	1p22.3
	Type of gene	protein-coding
	Description	afadin- and alpha-actinin-binding proteinSSX2-interacting proteinafadin DIL domain-interacting proteinsynovial sarcoma, X breakpoint 2 interacting protein
	Modification date	20210518
	UniProtAcc	Q9Y2D8
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SSX2IP	GO:0034451	Afadin- and alpha-actinin-binding protein	23816619
SSX2IP	GO:0034451	Afadin- and alpha-actinin-binding protein	24356449
SSX2IP	GO:0036064	Afadin- and alpha-actinin-binding protein	24356449
SSX2IP	GO:0032991	Afadin- and alpha-actinin-binding protein	0000054

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RNA A-to-I events for SSX2IP

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000117155.15

RNA A-to-I editing events in Cancer.

CAediting_77017(84651217, -), CAediting_77018(84651256, -), CAediting_77019(84651308, -), CAediting_77020(84656382, -), CAediting_77021(84656399, -), CAediting_77022(84662276, -), CAediting_77023(84676847, -),

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RNA editing positional annotations for SSX2IP using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_77017	chr1_84651217_-	ncRNA_intronic
CAediting_77018	chr1_84651256_-	ncRNA_intronic
CAediting_77019	chr1_84651308_-	ncRNA_intronic
CAediting_77020	chr1_84656382_-	exonic
CAediting_77021	chr1_84656399_-	exonic
CAediting_77022	chr1_84662276_-	exonic
CAediting_77023	chr1_84676847_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_77017	chr1_84651217_-	SINE	Alu	AluJo
CAediting_77018	chr1_84651256_-	SINE	Alu	AluJo
CAediting_77019	chr1_84651308_-	SINE	Alu	AluJo
CAediting_77023	chr1_84676847_-	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for SSX2IP

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000117155.15.SSX2IP.

Correlation between RNA A-to-I editing and PSI for ENSG00000117155.15.SSX2IP.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SSX2IP

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SSX2IP

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SSX2IP

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000117155.15	ENST00000437941	hsa-miR-624-3p	84646075	84646081	7mer-m8	84646074	84646095	146	-13.67
CAediting_688080	chr9_63819626_+	ENSG00000117155.15	ENST00000437941	hsa-miR-4477b	84644080	84644086	7mer-m8	84644079	84644100	142	-9.35
CAediting_1306323	chr19_13836462_-	ENSG00000117155.15	ENST00000437941	hsa-miR-27a-3p	84644700	84644707	8mer-1a	84644700	84644719	152	-19
CAediting_117844	chr1_162342605_+	ENSG00000117155.15	ENST00000437941	hsa-miR-556-3p	84646769	84646776	8mer-1a	84646769	84646790	140	-9.13
CAediting_228905	chr2_188297554_+	ENSG00000117155.15	ENST00000437941	hsa-miR-561-3p	84646333	84646339	7mer-m8	84646324	84646347	151	-17.01
CAediting_396018	chr5_1062918_-	ENSG00000117155.15	ENST00000437941	hsa-miR-4635	84644078	84644085	8mer-1a	84644078	84644098	154	-18.94
CAediting_86358	chr1_109598906_+	ENSG00000117155.15	ENST00000481102	hsa-miR-197-5p	84649861	84649867	7mer-m8	84649860	84649882	155	-22.67
CAediting_77128	chr1_85133844_+	ENSG00000117155.15	ENST00000481102	hsa-miR-4423-3p	84649895	84649902	8mer-1a	84649895	84649915	147	-12.33
CAediting_396018	chr5_1062918_-	ENSG00000117155.15	ENST00000481102	hsa-miR-4635	84649803	84649808	6mer	84649802	84649824	141	-19.36
CAediting_86358	chr1_109598906_+	ENSG00000117155.15	ENST00000603677	hsa-miR-197-5p	84649861	84649867	7mer-m8	84649860	84649882	155	-22.67
CAediting_77128	chr1_85133844_+	ENSG00000117155.15	ENST00000603677	hsa-miR-4423-3p	84649895	84649902	8mer-1a	84649895	84649915	147	-12.33
CAediting_396018	chr5_1062918_-	ENSG00000117155.15	ENST00000603677	hsa-miR-4635	84649803	84649808	6mer	84649802	84649824	141	-19.36
CAediting_1524209	chrX_134546392_-	ENSG00000117155.15	ENST00000437941	hsa-miR-503-5p	84644365	84644371	7mer-m8	84644364	84644384	145	-19.7

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000117155.15	ENST00000437941	hsa-miR-195-3p	84646762	84646769	8mer-1a	84646762	84646783	152	-8.64
CAediting_393	chr1_1167164_+	ENSG00000117155.15	ENST00000437941	hsa-miR-200b-3p	84644906	84644911	6mer	84644905	84644926	140	-7.73

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SSX2IP

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000342203.6	protein_coding
ENST00000437941.5	protein_coding
ENST00000476905.5	nonsense_mediated_decay
ENST00000481102.4	nonsense_mediated_decay
ENST00000605755.4	protein_coding
ENST00000460500.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_77020	ENST00000342203.6	chr1_84656382_-	-1461.00	-1460.00	-1462.90
CAediting_77021	ENST00000342203.6	chr1_84656399_-	-1461.00	-1460.00	-1462.90
CAediting_77022	ENST00000342203.6	chr1_84662276_-	-1461.00	-1460.00	-1462.90
CAediting_77020	ENST00000437941.5	chr1_84656382_-	-1512.40	-1511.40	-1514.30
CAediting_77021	ENST00000437941.5	chr1_84656399_-	-1512.40	-1511.40	-1514.30
CAediting_77022	ENST00000437941.5	chr1_84662276_-	-1512.40	-1511.40	-1514.30
CAediting_77020	ENST00000476905.5	chr1_84656382_-	-575.60	-574.10	-577.50
CAediting_77021	ENST00000476905.5	chr1_84656399_-	-575.00	-574.10	-577.50
CAediting_77022	ENST00000476905.5	chr1_84662276_-	-575.10	-574.10	-577.50
CAediting_77020	ENST00000481102.4	chr1_84656382_-	-635.40	-634.50	-637.40
CAediting_77021	ENST00000481102.4	chr1_84656399_-	-635.50	-634.50	-637.40
CAediting_77022	ENST00000481102.4	chr1_84662276_-	-635.50	-634.50	-637.40
CAediting_77020	ENST00000605755.4	chr1_84656382_-	-475.00	-471.80	-476.00
CAediting_77021	ENST00000605755.4	chr1_84656399_-	-472.80	-471.80	-476.00
CAediting_77022	ENST00000605755.4	chr1_84662276_-	-472.30	-471.80	-476.00
CAediting_77022	ENST00000460500.1	chr1_84662276_-	-510.00	-509.00	-510.00

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Relation with ADAR for SSX2IP

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SSX2IP

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SSX2IP

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SSX2IP

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SSX2IP

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene