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Editing gene: SMIM19 (CAeditome ID:114926)

Gene summary for SMIM19

Gene summary

Gene information	Gene symbol	SMIM19
	Gene ID	114926
	Gene name	small integral membrane protein 19
	Synonyms	C8orf40
	Cytomap	8p11.21
	Type of gene	protein-coding
	Description	small integral membrane protein 19UPF0697 protein C8orf40
	Modification date	20210518
	UniProtAcc	Q96E16
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for SMIM19

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000176209.10

RNA A-to-I editing events in Cancer.

CAediting_634810(42542711, +), CAediting_634811(42542859, +), CAediting_634812(42544156, +), CAediting_634813(42544157, +), CAediting_634814(42544290, +), CAediting_634815(42544300, +), CAediting_634816(42545586, +), CAediting_634817(42545587, +), CAediting_634818(42545605, +), CAediting_634819(42545611, +), CAediting_634820(42545630, +), CAediting_634821(42545692, +), CAediting_634822(42545720, +), CAediting_634823(42545728, +), CAediting_634824(42545731, +), CAediting_634825(42545736, +), CAediting_634826(42545804, +), CAediting_634827(42547240, +), CAediting_634828(42547275, +), CAediting_634829(42547281, +), CAediting_634830(42553077, +), CAediting_634831(42553091, +), CAediting_634832(42553093, +), CAediting_634833(42553111, +), CAediting_634834(42553112, +), CAediting_634835(42553122, +), CAediting_634836(42553128, +), CAediting_634837(42553134, +), CAediting_634838(42553147, +), CAediting_634839(42553148, +), CAediting_634840(42553149, +), CAediting_634841(42553152, +), CAediting_634842(42553165, +), CAediting_634843(42553727, +), CAediting_634844(42553728, +), CAediting_634845(42553821, +), CAediting_634846(42553862, +), CAediting_634847(42553867, +), CAediting_634848(42553875, +), CAediting_634849(42553878, +), CAediting_634850(42553884, +), CAediting_634851(42553891, +), CAediting_634852(42553894, +), CAediting_634853(42553902, +), CAediting_634854(42553908, +), CAediting_634855(42553910, +), CAediting_634856(42553923, +), CAediting_634857(42553927, +), CAediting_634858(42553931, +), CAediting_634859(42553932, +), CAediting_634860(42553934, +), CAediting_634861(42553937, +), CAediting_634862(42553939, +), CAediting_634863(42553942, +), CAediting_634864(42553957, +), CAediting_634865(42553987, +), CAediting_634866(42553988, +), CAediting_634867(42553989, +), CAediting_634868(42553990, +), CAediting_634869(42553991, +), CAediting_634870(42553992, +),

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RNA editing positional annotations for SMIM19 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_634810	chr8_42542711_+	ncRNA_intronic
CAediting_634811	chr8_42542859_+	ncRNA_intronic
CAediting_634812	chr8_42544156_+	ncRNA_intronic
CAediting_634813	chr8_42544157_+	ncRNA_intronic
CAediting_634814	chr8_42544290_+	ncRNA_intronic
CAediting_634815	chr8_42544300_+	ncRNA_intronic
CAediting_634816	chr8_42545586_+	ncRNA_intronic
CAediting_634817	chr8_42545587_+	ncRNA_intronic
CAediting_634818	chr8_42545605_+	ncRNA_intronic
CAediting_634819	chr8_42545611_+	ncRNA_intronic
CAediting_634820	chr8_42545630_+	ncRNA_intronic
CAediting_634821	chr8_42545692_+	ncRNA_intronic
CAediting_634822	chr8_42545720_+	ncRNA_intronic
CAediting_634823	chr8_42545728_+	ncRNA_intronic
CAediting_634824	chr8_42545731_+	ncRNA_intronic
CAediting_634825	chr8_42545736_+	ncRNA_intronic
CAediting_634826	chr8_42545804_+	ncRNA_intronic
CAediting_634827	chr8_42547240_+	ncRNA_intronic
CAediting_634828	chr8_42547275_+	ncRNA_intronic
CAediting_634829	chr8_42547281_+	ncRNA_intronic
CAediting_634830	chr8_42553077_+	UTR3
CAediting_634831	chr8_42553091_+	UTR3
CAediting_634832	chr8_42553093_+	UTR3
CAediting_634833	chr8_42553111_+	UTR3
CAediting_634834	chr8_42553112_+	UTR3
CAediting_634835	chr8_42553122_+	UTR3
CAediting_634836	chr8_42553128_+	UTR3
CAediting_634837	chr8_42553134_+	UTR3
CAediting_634838	chr8_42553147_+	UTR3
CAediting_634839	chr8_42553148_+	UTR3
CAediting_634840	chr8_42553149_+	UTR3
CAediting_634841	chr8_42553152_+	UTR3
CAediting_634842	chr8_42553165_+	UTR3
CAediting_634843	chr8_42553727_+	UTR3
CAediting_634844	chr8_42553728_+	UTR3
CAediting_634845	chr8_42553821_+	UTR3
CAediting_634846	chr8_42553862_+	UTR3
CAediting_634847	chr8_42553867_+	UTR3
CAediting_634848	chr8_42553875_+	UTR3
CAediting_634849	chr8_42553878_+	UTR3
CAediting_634850	chr8_42553884_+	UTR3
CAediting_634851	chr8_42553891_+	UTR3
CAediting_634852	chr8_42553894_+	UTR3
CAediting_634853	chr8_42553902_+	UTR3
CAediting_634854	chr8_42553908_+	UTR3
CAediting_634855	chr8_42553910_+	UTR3
CAediting_634856	chr8_42553923_+	UTR3
CAediting_634857	chr8_42553927_+	UTR3
CAediting_634858	chr8_42553931_+	UTR3
CAediting_634859	chr8_42553932_+	UTR3
CAediting_634860	chr8_42553934_+	UTR3
CAediting_634861	chr8_42553937_+	UTR3
CAediting_634862	chr8_42553939_+	UTR3
CAediting_634863	chr8_42553942_+	UTR3
CAediting_634864	chr8_42553957_+	UTR3
CAediting_634865	chr8_42553987_+	UTR3
CAediting_634866	chr8_42553988_+	UTR3
CAediting_634867	chr8_42553989_+	UTR3
CAediting_634868	chr8_42553990_+	UTR3
CAediting_634869	chr8_42553991_+	UTR3
CAediting_634870	chr8_42553992_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_634810	chr8_42542711_+	SINE	Alu	AluJb
CAediting_634811	chr8_42542859_+	SINE	Alu	AluJb
CAediting_634812	chr8_42544156_+	SINE	Alu	AluY
CAediting_634813	chr8_42544157_+	SINE	Alu	AluY
CAediting_634814	chr8_42544290_+	SINE	Alu	AluY
CAediting_634815	chr8_42544300_+	SINE	Alu	AluY
CAediting_634816	chr8_42545586_+	SINE	Alu	AluSx1
CAediting_634817	chr8_42545587_+	SINE	Alu	AluSx1
CAediting_634818	chr8_42545605_+	SINE	Alu	AluSx1
CAediting_634819	chr8_42545611_+	SINE	Alu	AluSx1
CAediting_634820	chr8_42545630_+	SINE	Alu	AluSx1
CAediting_634821	chr8_42545692_+	SINE	Alu	AluSx1
CAediting_634822	chr8_42545720_+	SINE	Alu	AluSx1
CAediting_634823	chr8_42545728_+	SINE	Alu	AluSx1
CAediting_634824	chr8_42545731_+	SINE	Alu	AluSx1
CAediting_634825	chr8_42545736_+	SINE	Alu	AluSx1
CAediting_634826	chr8_42545804_+	SINE	Alu	AluSx1
CAediting_634827	chr8_42547240_+	SINE	Alu	AluSx
CAediting_634828	chr8_42547275_+	SINE	Alu	AluSx
CAediting_634829	chr8_42547281_+	SINE	Alu	AluSx
CAediting_634830	chr8_42553077_+	SINE	Alu	AluSx3
CAediting_634831	chr8_42553091_+	SINE	Alu	AluSx3
CAediting_634832	chr8_42553093_+	SINE	Alu	AluSx3
CAediting_634833	chr8_42553111_+	SINE	Alu	AluSx3
CAediting_634834	chr8_42553112_+	SINE	Alu	AluSx3
CAediting_634835	chr8_42553122_+	SINE	Alu	AluSx3
CAediting_634836	chr8_42553128_+	SINE	Alu	AluSx3
CAediting_634837	chr8_42553134_+	SINE	Alu	AluSx3
CAediting_634838	chr8_42553147_+	SINE	Alu	AluSx3
CAediting_634839	chr8_42553148_+	SINE	Alu	AluSx3
CAediting_634840	chr8_42553149_+	SINE	Alu	AluSx3
CAediting_634841	chr8_42553152_+	SINE	Alu	AluSx3
CAediting_634842	chr8_42553165_+	SINE	Alu	AluSx3
CAediting_634843	chr8_42553727_+	SINE	Alu	AluSg
CAediting_634844	chr8_42553728_+	SINE	Alu	AluSg
CAediting_634845	chr8_42553821_+	SINE	Alu	AluSg
CAediting_634846	chr8_42553862_+	SINE	Alu	AluSg
CAediting_634847	chr8_42553867_+	SINE	Alu	AluSg
CAediting_634848	chr8_42553875_+	SINE	Alu	AluSg
CAediting_634849	chr8_42553878_+	SINE	Alu	AluSg
CAediting_634850	chr8_42553884_+	SINE	Alu	AluSg
CAediting_634851	chr8_42553891_+	SINE	Alu	AluSg
CAediting_634852	chr8_42553894_+	SINE	Alu	AluSg
CAediting_634853	chr8_42553902_+	SINE	Alu	AluSg
CAediting_634854	chr8_42553908_+	SINE	Alu	AluSg
CAediting_634855	chr8_42553910_+	SINE	Alu	AluSg
CAediting_634856	chr8_42553923_+	SINE	Alu	AluSg
CAediting_634857	chr8_42553927_+	SINE	Alu	AluSg
CAediting_634858	chr8_42553931_+	SINE	Alu	AluSg
CAediting_634859	chr8_42553932_+	SINE	Alu	AluSg
CAediting_634860	chr8_42553934_+	SINE	Alu	AluSg
CAediting_634861	chr8_42553937_+	SINE	Alu	AluSg
CAediting_634862	chr8_42553939_+	SINE	Alu	AluSg
CAediting_634863	chr8_42553942_+	SINE	Alu	AluSg
CAediting_634864	chr8_42553957_+	SINE	Alu	AluSg
CAediting_634865	chr8_42553987_+	SINE	Alu	AluSg
CAediting_634866	chr8_42553988_+	SINE	Alu	AluSg
CAediting_634867	chr8_42553989_+	SINE	Alu	AluSg
CAediting_634868	chr8_42553990_+	SINE	Alu	AluSg
CAediting_634869	chr8_42553991_+	SINE	Alu	AluSg
CAediting_634870	chr8_42553992_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for SMIM19

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000176209.10.SMIM19.

Correlation between RNA A-to-I editing and PSI for ENSG00000176209.10.SMIM19.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SMIM19

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SMIM19

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SMIM19

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_634838	chr8_42553147_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6715b-3p	42553141	42553148	8mer-1a	42553125	42553148	147.00	-16.00
CAediting_634840	chr8_42553149_+	ENSG00000176209.10	ENST00000438528	hsa-miR-302a-5p	42553142	42553148	7mer-m8	42553126	42553149	151.00	-13.22
CAediting_634841	chr8_42553152_+	ENSG00000176209.10	ENST00000438528	hsa-miR-451a	42553147	42553153	7mer-m8	42553133	42553154	144.00	-13.17
CAediting_634841	chr8_42553152_+	ENSG00000176209.10	ENST00000438528	hsa-miR-589-5p	42553150	42553156	7mer-m8	42553136	42553157	144.00	-13.22
CAediting_634841	chr8_42553152_+	ENSG00000176209.10	ENST00000438528	hsa-miR-7153-5p	42553151	42553156	6mer	42553134	42553157	140.00	-21.97
CAediting_634858	chr8_42553931_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4638-5p	42553926	42553933	8mer-1a	42553914	42553933	146.00	-18.23
CAediting_634859	chr8_42553932_+	ENSG00000176209.10	ENST00000438528	hsa-miR-149-5p	42553925	42553931	7mer-m8	42553907	42553932	155.00	-26.97
CAediting_634830	chr8_42553077_+	ENSG00000176209.10	ENST00000438528	hsa-miR-340-3p	42553071	42553078	8mer-1a	42553057	42553078	146.00	-18.22
CAediting_634830	chr8_42553077_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6827-3p	42553071	42553078	8mer-1a	42553058	42553078	140.00	-14.67
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6512-3p	42553091	42553097	7mer-m8	42553077	42553098	146.00	-17.18
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-661	42553087	42553093	7mer-m8	42553070	42553094	154.00	-25.83
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6720-5p	42553091	42553097	7mer-m8	42553076	42553098	152.00	-23.56
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6849-3p	42553090	42553097	8mer-1a	42553077	42553097	150.00	-18.26
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-939-3p	42553086	42553092	7mer-m8	42553072	42553093	147.00	-20.81
CAediting_634834	chr8_42553112_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6529-3p	42553105	42553111	7mer-m8	42553090	42553112	156.00	-18.52
CAediting_634834	chr8_42553112_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6889-3p	42553105	42553111	7mer-m8	42553092	42553112	156.00	-22.51
CAediting_634834	chr8_42553112_+	ENSG00000176209.10	ENST00000438528	hsa-miR-7157-3p	42553106	42553111	6mer	42553091	42553112	147.00	-24.30
CAediting_634834	chr8_42553112_+	ENSG00000176209.10	ENST00000438528	hsa-miR-873-3p	42553109	42553115	7mer-m8	42553090	42553116	141.00	-22.89
CAediting_634842	chr8_42553165_+	ENSG00000176209.10	ENST00000438528	hsa-miR-132-5p	42553159	42553165	7mer-m8	42553144	42553166	150.00	-20.20
CAediting_634845	chr8_42553821_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1238-3p	42553817	42553823	7mer-m8	42553805	42553824	145.00	-12.58
CAediting_634846	chr8_42553862_+	ENSG00000176209.10	ENST00000438528	hsa-miR-8052	42553860	42553866	7mer-1a	42553846	42553866	153.00	-27.23
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-125a-5p	42553871	42553877	7mer-m8	42553855	42553878	141.00	-17.93
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-125b-5p	42553871	42553877	7mer-m8	42553857	42553878	141.00	-16.11
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-125b-5p	42553871	42553877	7mer-m8	42553857	42553878	141.00	-16.11
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3943	42553875	42553881	7mer-m8	42553862	42553882	150.00	-22.11
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4313	42553874	42553880	7mer-m8	42553862	42553881	146.00	-21.10
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4319	42553871	42553877	7mer-m8	42553862	42553878	142.00	-17.68
CAediting_634850	chr8_42553884_+	ENSG00000176209.10	ENST00000438528	hsa-miR-18a-3p	42553883	42553888	6mer	42553869	42553889	142.00	-24.70
CAediting_634850	chr8_42553884_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1913	42553882	42553888	7mer-m8	42553870	42553889	148.00	-25.01
CAediting_634850	chr8_42553884_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6849-3p	42553877	42553883	7mer-m8	42553862	42553884	141.00	-14.90
CAediting_634851	chr8_42553891_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6752-3p	42553884	42553890	7mer-m8	42553872	42553891	152.00	-24.77
CAediting_634851	chr8_42553891_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6801-3p	42553885	42553892	8mer-1a	42553873	42553892	148.00	-24.49
CAediting_634851	chr8_42553891_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6810-3p	42553885	42553892	8mer-1a	42553870	42553892	146.00	-24.94
CAediting_634852	chr8_42553894_+	ENSG00000176209.10	ENST00000438528	hsa-miR-891b	42553892	42553897	6mer	42553877	42553898	150.00	-18.80
CAediting_634853	chr8_42553902_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4454	42553898	42553904	7mer-m8	42553886	42553905	148.00	-19.26
CAediting_634857	chr8_42553927_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4641	42553923	42553928	6mer	42553907	42553929	140.00	-25.60
CAediting_634860	chr8_42553934_+	ENSG00000176209.10	ENST00000438528	hsa-miR-212-5p	42553927	42553933	7mer-m8	42553912	42553934	153.00	-22.24
CAediting_634860	chr8_42553934_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6808-3p	42553932	42553938	7mer-m8	42553918	42553939	150.00	-22.14
CAediting_634860	chr8_42553934_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6813-3p	42553928	42553934	7mer-m8	42553915	42553935	149.00	-15.57
CAediting_634866	chr8_42553988_+	ENSG00000176209.10	ENST00000438528	hsa-miR-627-3p	42553981	42553988	8mer-1a	42553971	42553988	152.00	-14.81
CAediting_634844	chr8_42553728_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4518	42553722	42553728	7mer-1a	42553702	42553728	143.00	-31.13
CAediting_634844	chr8_42553728_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4695-3p	42553724	42553730	7mer-m8	42553708	42553731	145.00	-18.06
CAediting_634844	chr8_42553728_+	ENSG00000176209.10	ENST00000438528	hsa-miR-638	42553727	42553733	7mer-1a	42553709	42553733	143.00	-31.44

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_634846	chr8_42553862_+	ENSG00000176209.10	ENST00000438528	hsa-miR-10399-5p	42553856	42553862	7mer-m8	42553842	42553863	144	-11.52
CAediting_634853	chr8_42553902_+	ENSG00000176209.10	ENST00000438528	hsa-miR-10b-3p	42553900	42553907	8mer-1a	42553886	42553907	150	-15.54
CAediting_634848	chr8_42553875_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1200	42553871	42553877	7mer-m8	42553857	42553878	141	-17.86
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1200	42553871	42553877	7mer-m8	42553857	42553878	141	-17.86
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-12114	42553130	42553136	7mer-m8	42553115	42553137	155	-23.61
CAediting_634856	chr8_42553923_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1912-5p	42553920	42553926	7mer-m8	42553906	42553927	145	-15.81
CAediting_634857	chr8_42553927_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1912-5p	42553920	42553926	7mer-m8	42553906	42553927	145	-15.81
CAediting_634843	chr8_42553727_+	ENSG00000176209.10	ENST00000438528	hsa-miR-205-3p	42553723	42553729	7mer-m8	42553712	42553730	149	-16.47
CAediting_634844	chr8_42553728_+	ENSG00000176209.10	ENST00000438528	hsa-miR-205-3p	42553723	42553729	7mer-m8	42553712	42553730	149	-16.47
CAediting_634843	chr8_42553727_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3167	42553725	42553731	7mer-m8	42553711	42553732	150	-14.31
CAediting_634844	chr8_42553728_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3167	42553725	42553731	7mer-m8	42553711	42553732	150	-14.31
CAediting_634835	chr8_42553122_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3174	42553118	42553123	6mer	42553103	42553124	145	-23.46
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3190-3p	42553128	42553134	7mer-m8	42553112	42553135	154	-23.21
CAediting_634830	chr8_42553077_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3664-5p	42553074	42553080	7mer-m8	42553060	42553081	153	-15.28
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3689d	42553132	42553138	7mer-m8	42553119	42553139	146	-18.02
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-3689d	42553132	42553138	7mer-m8	42553119	42553139	146	-18.02
CAediting_634854	chr8_42553908_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4330	42553902	42553909	8mer-1a	42553891	42553909	154	-16.51
CAediting_634830	chr8_42553077_+	ENSG00000176209.10	ENST00000438528	hsa-miR-4522	42553075	42553081	7mer-m8	42553062	42553082	148	-12.83
CAediting_634836	chr8_42553128_+	ENSG00000176209.10	ENST00000438528	hsa-miR-495-5p	42553124	42553130	7mer-m8	42553110	42553131	140	-11.04
CAediting_634846	chr8_42553862_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5089-5p	42553860	42553866	7mer-m8	42553849	42553867	148	-15.16
CAediting_634847	chr8_42553867_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5089-5p	42553860	42553866	7mer-m8	42553849	42553867	148	-15.16
CAediting_634833	chr8_42553111_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5186	42553109	42553115	7mer-m8	42553096	42553116	140	-12.96
CAediting_634834	chr8_42553112_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5186	42553109	42553115	7mer-m8	42553096	42553116	140	-12.96
CAediting_634831	chr8_42553091_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5189-5p	42553085	42553092	8mer-1a	42553068	42553092	152	-27.34
CAediting_634851	chr8_42553891_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5571-5p	42553889	42553895	7mer-m8	42553874	42553896	142	-24.8
CAediting_634852	chr8_42553894_+	ENSG00000176209.10	ENST00000438528	hsa-miR-5571-5p	42553889	42553895	7mer-m8	42553874	42553896	142	-24.8
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6134	42553131	42553137	7mer-m8	42553121	42553138	155	-22.32
CAediting_634831	chr8_42553091_+	ENSG00000176209.10	ENST00000438528	hsa-miR-622	42553089	42553095	7mer-m8	42553076	42553096	140	-14.41
CAediting_634832	chr8_42553093_+	ENSG00000176209.10	ENST00000438528	hsa-miR-622	42553089	42553095	7mer-m8	42553076	42553096	140	-14.41
CAediting_634847	chr8_42553867_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6506-5p	42553861	42553867	7mer-m8	42553847	42553868	147	-16.54
CAediting_634836	chr8_42553128_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6516-5p	42553121	42553127	7mer-m8	42553106	42553128	152	-16.92
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6791-3p	42553874	42553880	7mer-m8	42553861	42553881	154	-17.64
CAediting_634854	chr8_42553908_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6800-3p	42553906	42553912	7mer-m8	42553895	42553913	142	-19.11
CAediting_634855	chr8_42553910_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6800-3p	42553906	42553912	7mer-m8	42553895	42553913	142	-19.11
CAediting_634849	chr8_42553878_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6829-3p	42553874	42553880	7mer-m8	42553862	42553881	155	-20.58
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6851-5p	42553132	42553138	7mer-m8	42553117	42553139	154	-23.89
CAediting_634831	chr8_42553091_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6860	42553085	42553092	8mer-1a	42553069	42553092	151	-21.98
CAediting_634848	chr8_42553875_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6869-5p	42553868	42553874	7mer-m8	42553851	42553875	149	-22.74
CAediting_634837	chr8_42553134_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6880-5p	42553130	42553135	6mer	42553112	42553136	142	-25.51
CAediting_634842	chr8_42553165_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6884-5p	42553163	42553169	7mer-m8	42553148	42553170	152	-22.46
CAediting_634830	chr8_42553077_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6888-3p	42553072	42553078	7mer-m8	42553059	42553079	151	-14.42
CAediting_634842	chr8_42553165_+	ENSG00000176209.10	ENST00000438528	hsa-miR-7974	42553161	42553167	7mer-m8	42553145	42553168	140	-18.58

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000176209.10	ENST00000438528	hsa-miR-548aa	42554828	42554835	8mer-1a	42554811	42554835	147	-9.05
CAediting_1399425	chr20_1392958_-	ENSG00000176209.10	ENST00000438528	hsa-miR-6869-5p	42554732	42554739	8mer-1a	42554717	42554739	158	-26.62
CAediting_442554	chr5_154685830_+	ENSG00000176209.10	ENST00000438528	hsa-miR-1303	42552766	42552772	7mer-m8	42552752	42552773	148	-12.28
CAediting_580943	chr7_100356700_+	ENSG00000176209.10	ENST00000438528	hsa-miR-6840-3p	42553136	42553142	7mer-m8	42553118	42553143	143	-24.66
CAediting_442554	chr5_154685830_+	ENSG00000176209.10	ENST00000414154	hsa-miR-1303	42552766	42552772	7mer-m8	42552752	42552773	148	-12.28
CAediting_1229414	chr17_67471546_+	ENSG00000176209.10	ENST00000498447	hsa-miR-548aa	42548541	42548547	7mer-m8	42548525	42548548	161	-15.44
CAediting_442554	chr5_154685830_+	ENSG00000176209.10	ENST00000498447	hsa-miR-1303	42552766	42552772	7mer-m8	42552752	42552773	148	-12.28

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000176209.10	ENST00000438528	hsa-miR-1304-3p	42552880	42552887	8mer-1a	42552863	42552887	147	-17.78
CAediting_117844	chr1_162342605_+	ENSG00000176209.10	ENST00000438528	hsa-miR-556-3p	42553615	42553621	7mer-m8	42553599	42553622	154	-13.85
CAediting_1399425	chr20_1392958_-	ENSG00000176209.10	ENST00000438528	hsa-miR-6869-5p	42553868	42553874	7mer-m8	42553851	42553875	149	-22.74
CAediting_228905	chr2_188297554_+	ENSG00000176209.10	ENST00000498447	hsa-miR-561-3p	42548702	42548708	7mer-m8	42548688	42548709	140	-12.06

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SMIM19

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000438528.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_634830	ENST00000438528.6	chr8_42553077_+	-871.90	-866.70	-902.00
CAediting_634831	ENST00000438528.6	chr8_42553091_+	-866.90	-866.70	-902.00
CAediting_634832	ENST00000438528.6	chr8_42553093_+	-873.90	-866.70	-902.00
CAediting_634833	ENST00000438528.6	chr8_42553111_+	-870.10	-866.70	-902.00
CAediting_634834	ENST00000438528.6	chr8_42553112_+	-867.00	-866.70	-902.00
CAediting_634835	ENST00000438528.6	chr8_42553122_+	-866.00	-866.70	-902.00
CAediting_634836	ENST00000438528.6	chr8_42553128_+	-866.70	-866.70	-902.00
CAediting_634837	ENST00000438528.6	chr8_42553134_+	-866.30	-866.70	-902.00
CAediting_634838	ENST00000438528.6	chr8_42553147_+	-872.00	-866.70	-902.00
CAediting_634839	ENST00000438528.6	chr8_42553148_+	-868.30	-866.70	-902.00
CAediting_634840	ENST00000438528.6	chr8_42553149_+	-873.00	-866.70	-902.00
CAediting_634841	ENST00000438528.6	chr8_42553152_+	-866.20	-866.70	-902.00
CAediting_634842	ENST00000438528.6	chr8_42553165_+	-866.00	-866.70	-902.00
CAediting_634843	ENST00000438528.6	chr8_42553727_+	-868.40	-866.70	-902.00
CAediting_634844	ENST00000438528.6	chr8_42553728_+	-866.70	-866.70	-902.00
CAediting_634845	ENST00000438528.6	chr8_42553821_+	-868.40	-866.70	-902.00
CAediting_634846	ENST00000438528.6	chr8_42553862_+	-867.30	-866.70	-902.00
CAediting_634847	ENST00000438528.6	chr8_42553867_+	-866.00	-866.70	-902.00
CAediting_634848	ENST00000438528.6	chr8_42553875_+	-866.00	-866.70	-902.00
CAediting_634849	ENST00000438528.6	chr8_42553878_+	-865.80	-866.70	-902.00
CAediting_634850	ENST00000438528.6	chr8_42553884_+	-867.10	-866.70	-902.00
CAediting_634851	ENST00000438528.6	chr8_42553891_+	-865.80	-866.70	-902.00
CAediting_634852	ENST00000438528.6	chr8_42553894_+	-866.70	-866.70	-902.00
CAediting_634853	ENST00000438528.6	chr8_42553902_+	-866.30	-866.70	-902.00
CAediting_634854	ENST00000438528.6	chr8_42553908_+	-873.60	-866.70	-902.00
CAediting_634855	ENST00000438528.6	chr8_42553910_+	-865.80	-866.70	-902.00
CAediting_634856	ENST00000438528.6	chr8_42553923_+	-866.00	-866.70	-902.00
CAediting_634857	ENST00000438528.6	chr8_42553927_+	-865.80	-866.70	-902.00
CAediting_634858	ENST00000438528.6	chr8_42553931_+	-870.20	-866.70	-902.00
CAediting_634859	ENST00000438528.6	chr8_42553932_+	-866.20	-866.70	-902.00
CAediting_634860	ENST00000438528.6	chr8_42553934_+	-866.10	-866.70	-902.00
CAediting_634861	ENST00000438528.6	chr8_42553937_+	-867.50	-866.70	-902.00
CAediting_634862	ENST00000438528.6	chr8_42553939_+	-870.40	-866.70	-902.00
CAediting_634863	ENST00000438528.6	chr8_42553942_+	-866.30	-866.70	-902.00
CAediting_634864	ENST00000438528.6	chr8_42553957_+	-873.30	-866.70	-902.00
CAediting_634865	ENST00000438528.6	chr8_42553987_+	-866.80	-866.70	-902.00
CAediting_634866	ENST00000438528.6	chr8_42553988_+	-866.80	-866.70	-902.00
CAediting_634867	ENST00000438528.6	chr8_42553989_+	-866.80	-866.70	-902.00
CAediting_634868	ENST00000438528.6	chr8_42553990_+	-866.80	-866.70	-902.00
CAediting_634869	ENST00000438528.6	chr8_42553991_+	-866.80	-866.70	-902.00
CAediting_634870	ENST00000438528.6	chr8_42553992_+	-866.80	-866.70	-902.00

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Relation with ADAR for SMIM19

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_634840	chr8_42553149_+	0.00222542804425226	0.235801016320422	.	.	.	.
THCA	CAediting_634840	chr8_42553149_+	0.035366979508053	0.187652530096025	.	.	.	.
BRCA	CAediting_634859	chr8_42553932_+	0.00231368345933626	0.312213424942477	.	.	.	.

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Relation with cancer stages for SMIM19

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SMIM19

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
BRCA	CAediting_634839	chr8_42553148_+	0.047089967789262	0.0200249	2.61199e-11

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RelatedDrugs for SMIM19

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SMIM19

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene